Lavoie, Christine

Professeure, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Coordonnées

Courriel


819-821-8000, poste 72732

Diplômes

(2005) Post-doctorate (Postdoctorate fellowship training). University of California, San Diego.

(2000) Post-doctorate (Postdoctorate fellowship training). McGill University.

(1999) Doctorate (Doctorate in Philosophy (Ph.D)). Université de Montréal.

(1994) Master's Thesis (Masters of Science (M.Sc.) - Masters). Université de Montréal.

(1992) Bachelor's (Bachelors of Science). Université de Montréal.

Présentation

Sujets de recherche

Alzheimer's Disease, Cell Signaling, Cell Signaling and Cancer, Neurodegenerative Diseases, Receptors and Carriers.

Disciplines de recherche

Cell Biology, Molecular Biology.

Mots-clés

Cell biology, Electron microscopy, Endocytosis, Heterotrimeric G protein, IF microscopy, Intracellular trafficking, LDLR related protein, Molecular biology, receptor sorting.

Intérêts de recherche

Impaired receptor trafficking are frequently implicated in diseases such as neurodegenerative disorders. We are studying the novel role of the signaling Gα proteins and Calnuc (a Gα-binding protein) in the regulation of receptor trafficking. Our main goal is to understand the importance of these proteins in the regulation of normal and altered cellular responses in the context of neuropathogenic events.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2015) Publication award 2014. (Prize / Award).
  • (2015) Finalist for the "Prix Jean-de-Margerie" 2014 (Best biomedical science publication). Université de Sherbrooke. (Distinction).
  • (2003) Post-Doctoral Fellowship. Canadian Institutes of Health Research. (Distinction).
  • (1998) PhD Studentship. Canadian Institutes of Health Research. (Distinction).
  • (1994) MSc Studentship. Canadian Institutes of Health Research. (Distinction).
  • (1991) Summer Studentship. (Distinction).

Publications

Articles de revue

  • *Li, XZ, Lavigne, P. and Lavoie, C. (2015). GGA3 Mediates TrkA Endocytic Recycling to Promote Sustained Akt Phosphorylation and Cell Survival. Molecular Biology of the Cell, mbc.E15-02-0087, (In Press).
  • Larkin, H., Thériault, C., Costantino, S. and Lavoie, C. (2015). Calnuc function in endosomal sorting of lysosomal receptors. Traffic, In second revision (TRA-14-0452), (Revision Requested).
  • *Traboulsi, H., Larkin, H., Bonin, M-A, Lavoie, C. and Marsault, E. (2015). Macrocyclic Cell penetrating Peptides: a Study of Structure-Penetration Properties. Bioconjugate Chemistry 2015 Feb 5. [Epub ahead of print] PIMD:25654426., (In Press).
  • Beaudry, H., Mercier-Blais, AA., Delaygue, C., Lavoie, C., Parent, JL., Neugebauer, W., Gendron, L. (2015). Regulation of μ- and δ-OpioidReceptor Functions: Involvement of Cyclin-Dependent Kinase 5. Br J Pharmacol. 2015 Jan 19. doi: 10.1111/bph.13088. [Epub ahead of print), (In Press).
  • Roscigione, S., Thériault, C.,Boily, M.O, Paquette, M., and Lavoie, C. (2014). Gαs regulates the post-endocytic sorting of G protein-coupled receptors. Nature Communications, 5, 4556-4567. (Published).
  • Larkin H , Ribeiro MG , Lavoie C. (2013). Topology and Membrane Anchoring of the Lysosomal Storage Disease-Related Protein CLN5. Human mutation, 34(12), 1688-97. (Published).
  • Brodeur J , Thériault C , Lessard-Beaudoin M , Marcil A , Dahan S , Lavoie C. (2012). LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease. Molecular neurodegeneration, 7(1), 31. (Published).
  • *Montagne M , Beaudoin N , Fortin D , Lavoie CL , Klinck R , Lavigne P. (2012). The Max b-HLH-LZ can transduce into cells and inhibit c-Myc transcriptional activities. PLoS ONE, 7(2), e32172. (Published).
  • *Béliveau F , Brulé C , Désilets A , Zimmerman B , Laporte SA , Lavoie CL , Leduc R. (2011). Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality. The Journal of Biological Chemistry, 286(33), 29035-43. (Published).
  • Lavoie C , Roy L , Lanoix J , Taheri M , Young R , Thibault G , Farah CA , Leclerc N , Paiement J. (2011). Taking organelles apart, putting them back together and creating new ones: lessons from the endoplasmic reticulum. Progress in histochemistry and cytochemistry, 46(1), 1-48. (Published).
  • *Cayouette S , Bousquet SM , Francoeur N , Dupré E , Monet M , Gagnon H , Guedri YB , Lavoie C , Boulay G. (2010). Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6. Biochimica et biophysica acta, 1803(7), 805-812. (Published).
  • Rosciglione, S. and Lavoie, C. Gαs promotes CXCR4 degradation by modulating the ubiquitination of the ESCRT-0 endosomal sorting machinery. Submitted to Mol. Biol. Cell (E15-07-0506), (Submitted).

Documents de travail

  • Larkin, H. and Lavoie, C. Calnuc binds and regulates CLN3 and CLN5, two proteins involved in neuronal ceroid lipofuscinosis. In preparation.
  • Rosciglione, S. and Lavoie, C. Gas regulates the activity of the ubiquitin ligase DTX3L and the endosomal sorting of CXCR4. In preparation.

Articles de conférence

  • Traboulsi, H., Larkin, H., Bonin, M-A, Volvov, L., Lavoie, C. and Marsault, E. (2015). Macrocyclic Cell penetratingPeptides: a Study of Structure-Penetration Properties. «98th Canadian Chemistry Conference» in Ottawa, Ontario. (Accepted).
  • Rosciglione, S. and Lavoie, C. (2014). A new role for Gαs: regulation of the post-endocytic sorting of GPCRs. «15th GPCR Retreat» in Bromont, Quebec. (Accepted).
  • Larkin,H., Thériault,C., Costantino, S. and Lavoie, C. (2014). The implication of Calnuc in Neuronal Ceroid Lipofuscinosis pathogenesis. «14th International Conference on Neuronal Ceroid Lipofuscinoses (Batten Disease)&Patient Organization Meeting» in Corbora, Argentina. (Accepted).
  • Serrano, D., Chen, X., Lavoie, C. and Ramanathan, S. (2013). GIMAP5 affects T cell calcium regulation by argeting multiple organelles. «the American Society for Cell Biology Meeting» in New Orleans. (Published).
  • Duclos, C, Denault, JB and Lavoie, C. (2013). Developing imaging tools to study caspase-8 activation. « 8th General Meeting of the International Proteolysis Society » in Cape Town, Africa. (Accepted).
  • Roscigione, S., Thériault, C., Boily, M-O. and Lavoie. C. (2012). Gαs, a signaling protein involved in post-endocytic trafficking of GPCRs. «13th Annual GPCR Retreat» in London, Ontario. (Published).
  • Brodeur, J., Thériault, C. Lessard-Beaudoin, M. and Lavoie, C. (2012). LRP10 alters APP trafficking and processing: Evidence for a role in Alzheimer’s disease. the Alzheimer’s Association International Conference on Alzheimer’s Disease in Vancouver, Canada. (Published).
  • Larkin, H, Thériault, C. and Lavoie, C. (2012). Calnuc, a new protein involved in ceroid lipofuscinosis ?. « 13th International Conference on Neuronal Ceroid Lipofuscinoses (Batten Disease) » in London, United Kingdom. (Published).
  • Larkin, H, Thériault, C. and Lavoie, C. (2012). Using tags to clarify CLN5 topology, maturation and localization. « 13th International Conference on Neuronal Ceroid Lipofuscinoses (Batten Disease) » in London, England. (Published).
  • Béliveau,F., Brulé, C. Désilets, A., Zimmerman, B., Laporte, S.A., Lavoie, C. and Leduc, R. (2011). Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality. «the Seventh General Meeting of the International Proteolysis Society» in San Diego, California. (Published).
  • Brulé, C., Désilets, A., Leduc, R. and Lavoie, C.,. (2011). LRP10 interacts with the serine protease matriptase and affects its cellular localisation and function. «the Seventh General Meeting of the International Proteolysis Society» in San Diego, California. (Published).
  • Roscigione, S., Thériault, C., Boily, M-O. and Lavoie. C. (2011). Non-traditional aspects of Gαs: involvement in GPCR trafficking. “Great Lakes GPCR retreat” in Montebello, Québec. (Published).
  • Duclos, C., Denault, J-B and Lavoie, C. (2011). Spatiotemporal studies of the activation of caspase-8 in living cells. «the Seventh General Meeting of the International Proteolysis Society» in San Diego, California. (Published).
  • Brodeur, J., Thériault, C. and Lavoie, C. (2011). LRP10, a new regulator of APP trafficking and processing. «the Alzheimer’s Association International Conference on Alzheimer ‘s Disease» in Paris, France. (Published).
  • Rosciglione, S. and Lavoie, C. (2011). Gαs: une protéine de signalisation indispensable au trafic intracellulaire des GPCR. «Association francophone pour le savoir » in Sherbrooke, Quebec. (Published).
  • Larkin, H and Lavoie, C. (2011). Le rôle de Calnuc dans le triage endosomal des recepteurs lysosomiaux. «Association francophone pour le savoir » in Sherbrooke, Quebec. (Published).
  • Larkin, H., Costantino, S. and Lavoie, C. (2010). Calnuc function in endosomal sorting. «the American Society for Cell Biology Meeting» in Philadelphia. (Published).
  • Rosciglione, S. and Lavoie, C. (2010). Gαs: une protéine de signalisation indispensable au trafic intracellulaire des GPCR. « Colloque international sur les récepteurs couplés aux protéines G : perspectives montpelliéraines et sherbrookoises» in Sherbrooke, Quebec. (Published).
  • Larkin, H. and Lavoie, C. (2010). Fonction de Calnuc dans le transport du récepteur au mannose-6- phosphate. «Club de Recherche Clinique du Québec» in Bromont, Quebec. (Published).
  • Brodeur, J., Dupré, E. and Lavoie, C. (2010). LRP10, un nouvel acteur dans la maladie d’Alzheimer?. «Club de Recherche Clinique du Québec» in Bromont, Québec. (Published).
  • Duclos, C., Blais, V., Lavoie, C. and Denault, J-B. (2010). Études spatio-temporelles de la caspase-8. «Club de Recherche Clinique du Québec » in Bromont, Québec. (Published).
  • Brodeur, J. and Lavoie, C. (2010). Role of LRP9, a new member of the LRP family, in Alzheimer Disease. «the Alzheimer’s Association International Conference on Alzheimer’s Disease» in Honolulu, Hawaii. (Published).
  • Larkin, H., Thériault, C. and Lavoie, C. (2010). Calnuc binds to Sortilin and affects its endosomal sorting. «Sortilins in sorting and disease» in Aarhus, Denmark. (Published).
  • Larkin, H. and Lavoie, C. (2010). Calnuc Function in Mannose-6-Phosphate Receptor Endosomal Sorting. «IRIC international symposium (vesicular trafficking and cellular signaling)» in Montréal, Canada. (Published).
  • Rosciglione, S., Li, XZ and Lavoie, C. Gαs promotes CXCR4 degradation by modulating the ubiquitination of the ESCRT-0endosomal sorting machinery. “Great Lakes GPCR retreat” in Hockley Valley, Ontario. (Published).

Autres contributions

Gestion d'évènements

  • Chair. 15th Annual Joint Meeting of the Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec. (Conference).

Présentations

  • (2015). Gαs: un agent double dans la signalisation et le routage intracellulaire des GPCR. Seminar organized by the Department of Chemistry, UQAM. Montreal.
  • (2015). Defining the molecular mechanisms by which Galpha-s regulates GPCR endosomal sorting. “Great Lakes GPCR retreat” in Hockley Valley, Ontario. Toronto.
  • (2014). The implication of Calnuc in neuronal ceroid lipofuscinosis pathogenesis. 14th International Conference on Neuronal Ceroid Lipofuscinoses (Batten Disease). Corbora, Argentina.
  • (2014). A new role for Gαs: regulation of the post-endocytic sorting of GPCRs. «15th GPCR Retreat». Bromont.
  • (2013). Gαs, une protéine de signalisation impliquées dans le triage endosomal des GPCR. «Colloque international sur les GPCR: perspective montpelliéraines et sherbrookoises». Montpellier.
  • (2013). Gαs, a signaling protein involved in post-endocytic trafficking of GPCR. «Seminar organized by Department of Integrative Biology and Pharmacology, University of Texas Health Science Center». Houston.
  • (2012). Gαs, a signaling protein involved in post-endocytic trafficking of GPCRs. «13th Annual GPCR Retreat». London.
  • (2012). LDLR-related Protein 10 (LRP10) alters APP trafficking and processing : evidence for a role in Alzheimer’s disease. «Alzheimer’s Association International Conference». Vancouver.
  • (2012). Calnuc, a new protein involved in ceroid lipofuscinosis ?. «13th International Conference on Neuronal Ceroid Lipofuscinoses (Batten Disease)». London.