Présentation

Sujets de recherche

Auto-Immune Diseases, Cancer of the Digestive System, Cell Signaling and Infectious and Immune Diseases, Cell Therapy of Cancer, Immune Mediators: Cytokines and Chemokines.

Disciplines de recherche

Cell Biology, Immunology.

Mots-clés

Animal models, Autoimmune diseases, Cellular immunology, Cellular signaling, Cytokines, Cytotoxic T lymphocytes, Flow cytometry, Hepatocellular carcinoma, Molecular biology, Tumor immunotherapy.

Intérêts de recherche

1) Cytokine-mediated modulation of CD8 T lymphocyte responses in autoimmunity and anti-tumor immunity. 2) Elucidating the role of SOCS1 in hepatocellular carcinoma.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Kannada, Tamoul/Tamil

Prix et distinctions

• Dr. A.J. Wilson Memorial Medal. Tamil Nadu Agricultural University. (Distinction).
• Prof. E.R.B. Shanmugasundaram Endowment Gold Medal. Madurai-Kamaraj University. (Distinction).

Publications

Articles de revue

• Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S and Ramanathan S. (2015). GIMAP5 deficiency isassociated with increased AKT activity in T lymphocytes. PlosONE, 10, e0139019. (Published).
• Tobelaim WS, Beaurivage C, Champagne A, Pomerleau V, Simoneau A, Chababi W, Yeganeh M, Thibault P, Klinck R, Carrier JC, Ferbeyre G, Ilangumaran S and Saucier C. (2015). Tumor-promoting roleof SOCS1 in colorectal cancer cells. Scientific Reports, (Published).
• Gui Y, Yeganeh M, Donates Y-C, Tobelaim W-S, Chababi W, Mayhue M, Yoshimura A, Ramanathan S, Saucier C and Ilangumaran S. (2015). Regulation of MET receptor tyrosine kinase signaling by Suppressor of cytokine signaling 1 in hepatocellular carcinoma. Oncogene, (In Press).
• Gui Y, Yeganeh M, Cepero-Donates Y, Ramanathan S, Saucier C, Ilangumaran S. (2014). Regulation of MET Receptor Signaling by SOCS1 and its Implications for Hepatocellular Carcinoma. Curr Pharm Des, 20, 2922-2933. (Published).
• Chen XL, Bobbala D, Cepero-Donates Y, Mayhue M, Ilangumaran S and Ramanathan S. (2014). IL-15 trans-presentation regulates homeostasis of CD4+ T lymphocytes. Cellular and Molecular Immunology, 11(4), 387-397. (Published).
• Chen XL, Bobbala D, Rodriguez GM, Mayhue M, Chen YG, Ilangumaran S, Ramanathan S. (2013). Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8(+) T cells. Clin Exp Immunol., 173(2), 184-94. (Published).
• Rodriguez GM, D'Urbano D, Bobbala D, Chen XL, Yeganeh M, Ramanathan S, Ilangumaran S. (2013). SOCS1 Prevents Potentially Skin-Reactive Cytotoxic T Lymphocytes from Gaining the Ability to Cause Inflammatory Lesions. J Invest Dermatol., 133(8), 2013-22. (Published).
• Chen XL , Serrano D , Mayhue M , Wieden HJ , Stankova J , Boulay G , Ilangumaran S , Ramanathan S. (2013). GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation. The Biochemical journal, 449(2), 353-364. (Published).
• Bobbala D , Chen XL , Leblanc C , Mayhue M , Stankova J , Tanaka T , Chen YG , Ilangumaran S , Ramanathan S. (2012). Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia, 55(11), 3010-3020. (Published).
• Gui Y , Yeganeh M , Ramanathan S , Leblanc C , Pomerleau V , Ferbeyre G , Saucier C , Ilangumaran S. (2011). SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. Journal of hepatology, 55(6), 1300-1308. (Published).
• Ramanathan S , Dubois S , Chen XL , Leblanc C , Ohashi PS , Ilangumaran S. (2011). Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950), 186(9), 5131-41. (Published).
• Ilangumaran S , Gagnon J , Leblanc C , Poussier P , Ramanathan S. (2010). Increased generation of CD8 single positive cells in SOCS1-deficient thymus does not proportionately increase their export. Immunology letters, 132(1-2), (Published).
• Ramanathan S , Dubois S , Gagnon J , Leblanc C , Mariathasan S , Ferbeyre G , Rottapel R , Ohashi PS , Ilangumaran S. (2010). Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. Journal of immunology (Baltimore, Md. : 1950), 185(1), 357-66. (Published).
• Mallette FA , Calabrese V , Ilangumaran S , Ferbeyre G. (2010). SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging, 2(7), (Published).
• Gagnon J , Chen XL , Forand-Boulerice M , Leblanc C , Raman C , Ramanathan S , Ilangumaran S. (2010). Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression. Immunology and cell biology, 88(4), 451-60. (Published).

Autres contributions

Présentations

• (2015). Role of NOD-like receptor family CARD domain-containing protein 5 (NLRC5) in anti-tumor immunity. 6th Congress of the Federation of Immunological Societies of Asia and Oceania (FIMSA-2015), Singapore. June 30- July 3, 2015. Singapore.
• (2014). Molecular mechanisms of the tumor suppressor function of Suppressor of cytokine signaling 1 (SOCS1) in the liver. 5th International conference on stem cells and cancer (ICSCC-2014), New Delhi, India. New Delhi.
• (2014). Interleukin-15 signalling promotes high fat diet-induced inflammation in the liver. 50th Annual meeting of the European Association for the Study of Diabetes. Vienna.
• (2013). Priming of CD8+ T lymphocytes by inflammatory cytokines: Implications for Autoimmunity and Tumor immunotherapy. Invited seminar series of the Department of Microbiology and Immunology, McGill University. Montreal.
• (2012). SOCS1 negatively regulates the hepatocyte growth factor receptor MET via ubiquitination and proteasomal degradation. 47th Anuual meeting of the European Association for the Study of the Liver. Barcelona.
• (2011). SOCS1 controls the pathogenicity of potentially autoreactive CD8+ T cells by regulating cytokine-driven proliferation and differentiation. 5 th Autoimmunity Congress Asia. Singapore.
• (2011). Inflammatory cytokines IL-21 and IL-15 enable the triggering of naïve autoreactive CD8 T lymphocytes by low affinity TCR ligands. 10th World Congress on Inflammation. Paris.