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Yves Dory

Professeur, Faculté des sciences



Sujet de recherche

Supramolecules and Autoassembling, Pain, Antivirals, Cell Therapy of Cancer, Biomaterials

Disciplines de recherche

Chemistry, Biochemistry


cyclopeptides, enkephaline, enzyme inhibitor, mechanism, nanosphere, nanotube, organic chemistry, peptidomimetic, supramolecule, synthesis

Intérêts de recherche

I want to improve treatment of diseases by tackling pharmacodynamics or pharmacokinetics of drugs. I intend to develop new agonists of the delta receptor (treatment of pain) and inhibitors of convertases to cure cancer (furin), treat viral infections (PACE 4) and high level of cholesterol (PCSK9). I craft supramolecular containers that could transport drugs to the desired locations in bodies.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français


(1988). Design and synthesis of Valinomycins (Doctorate, Philosophy Doctorate). University of Southampton.

(1984). (Master's non-Thesis, Maîtrise). Université de Rennes I.

(1981). (Bachelor's, Licence). Université de Rennes I.


  • Grant. (Awarded). Principal Applicant. High affinity ligands of Bradykinin receptors with therapeutic implications for prostate cancer. Canadian Institutes of Health Research (CIHR). Team. 696 150 $. (2019-2025)
  • Grant. (Awarded). Co-applicant. Centre Québécois sur les Matériaux Fonctionnels / Québec Center for Advanced Materials.. Fonds de recherche du Québec - Nature et technologies (FRQNT). Regroupement stratégique. 600 000 $. (2017-2023)
  • Grant. (Awarded). Principal Applicant. Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grants Program - Individual. 140 000 $. (2017-2023)
  • Grant. (Awarded). Principal Applicant. Novel Supramolecular Drugs for a "Supramolecular" Disease. Fonds de recherche du Québec - Santé (FRQS). Bilateral research projects - "FRQ-FNRS Québec - Communauté française de Belgique. 4 500 000 $. (2019-2022)
  • Grant. (Awarded). Principal Applicant. Novel Supramolecular Drugs for a “Supramolecular” Disease. Institut de Pharmacologie de Sherbrooke. Projets IPS-Innovation 2018. 30 000 $. (2018-2020)
  • Grant. (Awarded). Co-applicant. The function and regulation of PCSK9: a novel modulator of LDLR activity. Fondation Leducq. Fondation Leducq Transatlantic Network. 6 000 000 $. (2013-2019)
  • Grant. (Declined). Co-applicant. A benchtop transmission electron microscope for materials research. Natural Sciences and Engineering Research Council of Canada (NSERC). Research Tools and Instruments. 150 000 $. (2017-2018)
  • Grant. (Awarded). Co-applicant. Operations and Maintenance Support: Regional Peptide Synthesis and Imaging Probes Synthesis Platform. Natural Sciences and Engineering Research Council of Canada (NSERC). Research Tools and Instruments. 150 000 $. (2017-2018)
  • Grant. (Awarded). Principal Applicant. Synthesis of Triozan™-Peptide conjugates as blood-brain-transient drug nanovectors.. Natural Sciences and Engineering Research Council of Canada (NSERC). Engage. 25 000 $. (2017-2018)
  • Grant. (Awarded). Co-applicant. A parallel evaporator for peptides, peptidomimetics and macrocycles. Natural Sciences and Engineering Research Council of Canada (NSERC). Research Tools and Instruments. 150 000 $. (2016-2017)


Articles de revue

  • Le Bras, L; Dory, Y; Champagne, B. (2021). Computational prediction of the supramolecularself-assembling properties of organic molecules:the role of conformational flexibility of amidemoieties. Phys. Chem. Chem. Phys. 23 20453-20465. (Published).
  • Lewandowska-Goch, MA; Kwiatkowska, A; Łepek, T; Ly, K; Navals, P*; Gagnon, H; Dory, YL; Prahl, A; Day, R. (2021). Design and structure–activity relationship of a potent furin inhibitor derived from influenza hemagglutinin. ACS Medicinal Chemistry Letters 12 (3), 365-372. (Published).
  • Alnahwi AH, Ait-Mohand S, Dumulon-Perreault V, Dory YL, Guérin B. (2020). Promising Performance of 4HMS, a New Zirconium-89 Octadentate Chelator. ACS Omega 5 10731-10739. DOI. (Published).
  • Kwiatkowska A, Couture F, Ait-Mohand S, Desjardins R, Dory YL, Guérin B, Day R. (2019). Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin bound tumor-targeting prodrug. Scientific Reports 9 (2118), 1-12. (Published).
  • Farnia F, Fan W, Dory YL, Zhao Y. (2019). Making Nanocomposites of Hydrophilic and Hydrophobic Polymers Using Gas-responsive Cellulose Nanocrystals. Macromol. Rapid Commun. 40 (12), 1-7. (Published).
  • Beaudeau J-L*, Blais V, Holleran BJ, Bergeron A, Piñeyro G, Guérin B, Gendron L, Dory YL. (2019). N-guanidyl and -tetrazole Leu-EnkephalinDerivatives: Efficient Delta Opioid Receptor Agonists with ImprovedPharmacological Properties. ACS Chemical Neuroscience 10 (3), 1615-1626. (Published).
  • Dory YL, Caron M, Duguay VO, Chicoine-Ouellet L, Fortin D, Baillargeon P. (2019). Preparation and Single Crystal Structure Determination of the First Biobased Furan-Polydiacetylene Using Topochemical Polymerization. Crystals 9 448-457. (Published).
  • Marmin T, Dory YL. (2019). Self?Assembly of C3 Symmetric Rigid Macrolactams into Very Polar and Porous Trigonal Crystals. Very Important Paper. Chem. Eur. J. 25 (27), 6707-6711. DOI. (Published).
  • Galstian T, Quémener M, Dory YL, Marmin T*, Laroche V*. (2018). Electrically controlled fluorescence in a nematic liquid crystal doped by a chiral fluorophore. Journal of Materials Science: Materials in Electronics 29 (23), 19768-19774. (Published).
  • Bella Ndong D*, Blais V, Holleran BJ, Proteau-Gagné A*, Cantin-Savoie I*, Robert W, Nadon J-F*, Beauchemin S*, Leduc R, Piñeyro G, Guérin B, Gendron L, Dory YL. (2018). Exploration of the fifth position of Leu-enkephalin and its role in binding and activating delta (DOP) and mu (MOP) opioid receptors. Journal of Peptide Science 2018 (e24070), 1-10. (Published).
  • Dianati V*, Navals P*, Couture F, Desjardins R, Dame A, Kwiatkowska A, Day R, Dory YL. (2018). Improving the Selectivity of PACE4 Inhibitorsthrough Modifications of the P1 Residue. Journal of Medicinal Chemistry 61 (24), 11250-11260. (Published).
  • Dianati V*, Kwiatkowska A, Couture F, Desjardins R, Dory YL, Day R. (2018). Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines. Journal of Medicinal Chemistry 61 (18), 8457-8467. (Published).
  • Baillargeon P, Rahem T, Amigo C, Fortin D, Dory YL. (2018). Polar crystal of vanillylformamide through replacement of the alkene by an isosteric formamide group. IUCrData 3 (12), 1-4. (Published).
  • Quémener M, Galstian T, Marmin T*, Laroche V*, Dory YL. (2017). Diffusion of chiral molecules and propagation of structural chirality in anisotropic liquids. Physical Review E 95 (5), 1-8. (Published).
  • Baillargeon P, Rahem T, Caron-Duval É*, Tremblay J, Fortin C, Blais É, Fan V, Fortin D, Dory YL. (2017). Isomorphous crystal structure of chlorodiacetylene and iodoacetylene derivatives: simultaneous hydrogen and halogen bonds on carbonyl. Acta Crystallographica Section E 73 1175-1179. (Published).
  • ?epek T, Kwiatkowska A, Couture F, Ly K, Desjardins R, Dory Y, Prahl A, Day R. (2017). Macrocyclization of a potent PACE4 inhibitor: benefits and limitations. European Journal of Cell Biology 96 (5), 476-485. (Published).
  • Dianati V*, Shamloo A, Kwiatkowska A, Desjardins R, Soldera A, Day R, Dory YL. (2017). Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3. ChemMedChem 12 (15), 1169-1172. (Published).
  • Pirisedigh A, Blais V, Ait-Mohand S, Abdallah K, Holleran BJ, Leduc R, Dory YL, Gendron L, Guérin B. (2017). Synthesis and Evaluation of 64Cu-Conjugate, a Selective ?-Opioid Receptor Positron Emission Tomography Imaging Agent. Organic Letters 19 (8), 2018-2021. (Published).
  • Susan-Resiga D, Girard E, Kiss R, Essalmani R, Hamelin J, Asselin M-C, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory Y, Baass A, Seidah N. (2017). The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation. A novel mechanism causing familial hypercholesterolemia. Journal of Biological Chemistry 292 (5), 1573-1590. (Published).
  • Nadon J-F*, Rochon K*,Grastilleur S, Langlois G*, Dao TTH*, Blais V, Guérin B, Gendron L, Dory YL. (2017). ZSynthesis of Gly-?[()CF=CH]-Phe, a fluoroalkene dipeptide isostere and its incorporation into a Leu-enkephalin peptidomimetic. ACS Chemical Neuroscience 8 (1), 40-49. (Published).
  • Baillargeon P, Caron-Duval É*, Pellerin É, Gagné S, Dory Y. (2016). Isomorphous crystals from diynes and bromodiynes involved in hydrogen and halogen bonds. Crystals 6 (4), 1-13. (Published).
  • Kwiatkowska A, Couture, F, Levesque C, Ly K, Beauchemin S*, Desjardins R, Neugebauer W, Dory YL, Day R. (2016). Novel insights into structure-activity relationships of N-terminally modified PACE4 inhibitors. ChemMedChem 11 (3), 289-301. (Published).
  • Zhang H, Marmin T*, Cuierrier É, Soldera A, Dory Y, Zhao, Y. (2015). A new comonomer design for enhancing the pH-triggered LCST shift of thermosensitive polymers. Polymer Chemistry 6 (37), 6644-6650. (Published).
  • Couture F, Kwiatkowska A, Dory Y L, Day R. (2015). Therapeutic uses of furin and its inhibitors: a patent review. Expert Opinion on Therapeutic Patents 25 (4), 379-396. (Published).
  • Yan L-H, Skiredj A, Dory Y, Delpech B, Poupon E. (2014). 5-Aminopenta-2,4-dienals: Synthesis, Activation towards Nucleophiles, Molecular Modeling and Biosynthetic Implications in Relation to the Manzamine Alkaloids. European Journal of Organic Chemistry 2014 (23), 4973-4984. (Published).
  • Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S*, Prahl A, Lammek B, Neugebauer W, Dory YL, Day R. (2014). Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. Journal of Medicinal Chemistry 57 (1), 98-109. (Published).
  • Baillargeon P, Lussier T*, Dory Y L. (2014). Hydrogen Bonds between Acidic Protons from Alkynes (C–H···O) and Amides (N–H···O) and Carbonyl Oxygen Atoms as Acceptor Partners. Journal of Crystallography 2014 1-5. (Published).
  • Gagnon H, Beauchemin S*, Kwiatkowska A, Couture F, D'Anjou F, Levesque C, Dufour F, Desbiens AR, Vaillancourt R, Bernard S*, Desjardins R, Malouin F , Dory YL, Day R. (2014). Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin. Journal of Medicinal Chemistry 57 (1), 29-41. (Published).
  • Kumar S*, Tong X, Dory YL, Lepage M, Zhao Y. (2013). A CO?-switchable polymer brush for reversible capture and release of proteins. Chemical Communications 49 (1), 90-92. (Published).
  • Rochon K*, Proteau-Gagné A*, Bourassa P*, Nadon J-F*, Côté J, Bournival V, Gobeil F, Guérin B, Dory YL, Gendron L. (2013). Preparation and Evaluation at the Delta Opioid Receptor of a Series of Linear Leu-Enkephalin Analogues Obtained by Systematic Replacement of the Amides. ACS Chemical Neuroscience 4 (8), 1204-1216. (Published).
  • Proteau-Gagné A*, Rochon K*, Roy M, Albert PJ, Guérin B, Gendron L, Dory YL. (2013). Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity. Bioorganic & Medicinal Chemistry Letters 23 (19), 5267-5269. (Published).
  • Kumar S*, Allard J-F, Morris D, Dory YL, Lepage M, Zhao Y. (2012). Near-Infrared Light Sensitive Polypeptide Block Copolymer Micelles for Drug Delivery. J. Mater. Chem. 22 7252-7257. (Published).
  • Levesque C , Fugère M , Kwiatkowska A , Couture F , Desjardins R , Routhier S , Moussette P , Prahl A , Lammek B , Appel JR , Houghten RA , D'Anjou F , Dory YL , Neugebauer W , Day R. (2012). The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. Journal of medicinal chemistry 55 (23), 10501-10511. (Published).
  • Proteau-Gagné A , Nadon J-F , Bernard S , Guérin B , Gendron L , Dory YD. (2011). Kinetic deconjugation: a gateway to the synthesis of Xxx-Gly (E)-alkene dipeptide isosteres. Tetrahedron Lett. 52 6603-6605. (Published).
  • Tong X , Bernard S , Dory YL , Zhao Y. (2011). Simultaneous chirality transfer and structured aggregation of a cyclopeptide in a liquid crystal. Langmuir : the ACS journal of surfaces and colloids 27 (7), 3867-3871. (Published).
  • Zhao Y , Kumar S , Dory YD , Lepage M. (2011). Surface-Grafted Stimuli-Responsive Block Copolymer Brushes for Thermo-, Photo- and pH-Sensitive Release of Dye Molecules. Macromolecules 44 7385-7393. (Published).
  • Proteau-Gagné A , St-Jean F , Morin C , Gendron L , Rousseau É , Dory YD. (2011). Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic. Chem. Nat. Comp. 46 841-847. (Published).
  • Proteau-Gagné A*, Bournival V, Rochon K*, Dory YL , Gendron L. (2010). Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the ?-Opioid Receptor. ACS chemical neuroscience 1 (11), 757-769. (Published).
  • Baillargeon P , Fortin D , Dory YD. (2010). Hierarchical self-assembly of lactams into supramolecular CO-spiked "sea urchins" then into a channelled crystal. Cryst. Growth Des. 10 4357-4362. (Published).
  • Baillargeon P , Dory YD , Decken A. (2009). Crystal Structure of Hydrated Potassium Pentafluoropheno­late : Interactions between Fluorine Atoms and Metal Ions. J. Chem. Crystallogr. 39 568-572. (Published).
  • Baillargeon P , Dory YL. (2009). Supramolecular Walls from Cyclic Peptides: Modulating Nature and Strength of Weak Interactions. Cryst. Growth Des. 9 3638-3645. (Published).

Chapitres de livre

  • Dao TTH, Marmin T, Dory YL. (2014). Transannular Electrophilic Cyclizations. Knochel P, Molander GA. Comprehensive Organic Synthesis (2, 293-336). United Kingdom : ELSEVIER. (Published).
  • Alex Li. (2012). E and Z secondary amides in supramolecular nanotubes and nanospheres. Pan Stanford Publishing Pte Ltd. Molecular Self-Assembly - Advances and Applications (37-75). United States : Pan Stanford. (Published).

Propriétés intellectuelles


  • Stable peptide-based PACE4 inhibitor. PCT/CA2012/050601. Canada. (Pending).
  • Stable peptide-based furin inhibitor. PCT/CA2012/050603. Canada. (Pending).
  • Stable peptide-based proprotein convertase inhibitors. US 61/530,478. Canada. (Granted/Issued).

Autres contributions


  • Dory YL, Champagne B. (2019). Novel Supramolecular Drugs for a "Supramolecular" Disease. Yearly Meeting FNRS/FRQ. Belgium
  • (2017). Self-Assembly of C3-Symmetric Macrocycles into Very Polar & Porous Crystals. 9th International Conference on Materials for Advanced Technologies - ICMAT 2017. Singapore
  • (2016). Nanotubes and Nanospheres from E and Z Lactams. Advanced Materials Annual Conference of CQMF (Centre Québecois des Matériaux Fonctionnels). Montréal, Canada
  • Dory YL, Langlois G, Rochon K, Proteau-Gagné A, Bourassa P, Bournival V, Guérin B, Gendron L. (2015). Finding the way Leu-Enkephalin binds to the delta Opioid Receptor. 14th international congress on amino acids, peptides and proteins. Vienna, Austria
  • (2014). Conception et Synthèse d'Analogues de Ligands Peptidiques: Cas des Agonistes Opïoides. 7e Colloque Annuel du CQMF (Centre Québecois des Matériaux Fonctionnels). Shawinigan, Canada
  • Gendron L, Guérin B, Langlois G, Proteau-Gagné A, Nadon J-F, Bella Ndong D, Rochon K. (2013). Finding the way Leu-Enkephalin binds to the Delta Opioid Receptor. 96th Canadian Chemistry Conference and Exhibition, Québec. Québec, Canada
  • (2012). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Energy, Materials and Nanotechnology (EMN). Chengdu, China
  • (2012). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Tsinghua University). Beijing, China
  • (2012). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Sichuan University). Chengdu, China
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université de Grenoble). Grenoble, France
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. XIX Mendeleev Congress (IUPAC). Volgograd, Russian Federation
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université de Bourgogne). Dijon, France
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université de Strasbourg). Strasbourg, France
  • (2011). Synthesis and Characterization of Supramolecular Platonic Solids. Department Conference (École de Chimie de Rennes, ENSCR). Rennes, France
  • (2010). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université Laval). Québec, Canada
  • (2010). Design and Synthesis of DOPr Agonists. Rencontres Sherbrooke-Montpellier 2010. Sherbrooke, Canada