Richard J. Wagner

Financement

• Grant. (Awarded). Principal Applicant. Radical-mediated DNA damage: Product analysis, mechanistic studies, and biochemical processing. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery. 120 000 $. (2022-2027)
• Grant. (Under Review). Co-applicant. Dynamic light scattering for biomedical research innovations. Natural Sciences and Engineering Research Council of Canada (NSERC). Research Tools and Instruments. 132 390 $. (2022-2023)
• Grant. (Awarded). Principal Applicant. Product analysis and mechanistic studies of radical mediated DNA damage. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery. 230 000 $. (2016-2022)
• Grant. (Completed). Co-applicant. The great escape: improving the activity of chemotherapeutics delivered by antibody-drug conjugates with integrated endosome escape and nuclear-directional trafficking control capabilities.. Canadian Institutes of Health Research (CIHR). Project grants. 564 955 $. (2017-2020)
• Grant. (Completed). Co-applicant. Antibody-drug conjugates: effective increase in intracellular accumulation the next frontier. Cancer Research Society (The). Operating Grants. 120 000 $. (2016-2018)
• Grant. (Completed). Co-applicant. Secondary electron collision cross sections for use in radiotherapy and radioprotection. (2013-2018)
• Grant. (Completed). Principal Applicant. Biomarker analysis for research on aging/ Analyse de biomarqueurs dans la recherche sur le vieillissement. (2015-2016)
• Grant. (Completed). Principal Investigator. Mechanistic studies of radical-induced DNA damage. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery. 225 000 $. (2011-2016)
• Grant. (Completed). Principal Applicant. Effect of vitamin C on epigenetic marks of gene expression and neurodegeneration in the premature aging disorder, Werner syndrome, using knockout mice.. (2014-2015)
• Grant. (Completed). Co-applicant. Secondary electron collision cross sections for use in radiotherapy and radioprotection. (2008-2013)
• Grant. (Completed). Principal Investigator. DNA repair and mutagenic potential of oxidized cytosine and 5-methylcytosine. (2008-2012)
• Grant. (Completed). Principal Investigator. Mass spectrometry for the radiation sciences. (2008-2010)
• Grant. (Completed). Principal Investigator. Radical cation chemistry in DNA. (2005-2010)

Publications

Articles de revue

• *Lowry, C.M., Graham, R., Lebel, M., Wagner, J.R. (2022). Ascorbate supplements increases 5-hydroxymethylcytosine in brain cerebellum DNA of ascorbate knockout mice. Antioxidants (Submitted).
• Cadet, J., Angelov, D., Wagner, J.R. (2022). Hydroxyl radical is predominantly involved inoxidatively generated base damage to cellular DNA exposed to ionizing radiation. International Journal of Radiation Biology 98 1-7. (In Press).
• *Bhavini Kumari, *Alaa Huwaidi, *Gabriel Robert, Pierre Cloutier, Andrew Bass, Léon Sanche and J. Richard Wagner. (2022). Shape Resonances in DNA: Nucleobase Release, Reduction, and Dideoxynucleoside Products Induced by 1.3 to 2.3 eV Electrons. J. Phys. Chem. B 126 (28), 5175-5184. (Published).
• Pomerleau, J., Weidmann, C., Coutant, K., *Lowry, C.-M., Veilleux, M.-P., Berube, J., Wagner, J.R., Landreville, S. (2021). Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid. Experimental Eye Research 205 (108473), 1-5. (Published).
• Wagner, J.R., *Madugundu, G.S., Cadet, J. (2021). Ozone-induced DNA damage: A pandora box of oxidatively modified DNA bases. Chemical Research in Toxicology 34 (1), 80-90. (Published).
• *Huwaidi,A., *Kumari,B., *Robert,G., Guérin, B., Sanche, L. and Wagner, J.R. (2021). Profiling DNA damage induced by the irradiation of DNA with gold nanoparticles. Journal of Physical Chemistry Letters 12 (40), 9947-9954. (Published).
• Parent-Roberge H, Fontvieille A, Maréchal R, Wagner J.R, Fülöp T, Pavic M, Riesco E. (2020). Effects of combined exercise training on the inflammatory profile of older cancerpatients treatedwith systemic therapy. Brain, Behavior and Immunity – Health 2 100016. (Published).
• Behmand, B., Noronha, A.M., Wilds, C.J., Marignier, J.-L., Mostafavi, M., Wagner, J.R., Hunting, D.J., Sanche, L. (2020). Hydrated electrons induce the formation of interstrand cross-links in DNA modified bycisplatin adducts. Journal of Radiation Research 61 (3), 343-351. (Published).
• J. Richard Wagner and Paolo Di Mascio. (2020). Introduction to the Special Issue Dedicated to Jean Cadet. Photochemistry and Photobiology 98 519-522. (Published).
• Ahuie, G.K., Gagnon, H., Pace, P.E., Wagner, J.R., Naylor, S., Klarskov, K. (2020). Investigating protein thiol chemistry associated with dehydroascorbate, homocysteine andglutathione using mass spectrometry. Rapid Communications in Mass Spectrometry 34 (11), e8774. (Published).
• *Robert, G. and Wagner, J.R. (2020). ROS-induced DNA damage as an underlying cause of aging. Advances in Geriatric Medicine and Research 2 e200024. (Published).
• *Robert, G., Wagner, J.R. (2020). Tandem Lesions Arising from 5-(Uracilyl)methyl Peroxyl Radical Addition to Guanine:Product Analysis and Mechanistic Studies. Chemical Research in Toxicology 33 (2), 565-575. (Published).
• Cadet, J., Di Mascio, P., Wagner, J.R. (2019). (5′R)-and (5′S)-purine 5′,8-cyclo-2′-deoxyribonucleosides: reality or artifactual measurements? A reply to Chatgilialoglu’s comments (this issue). Free Radical Research 53 (9-10), 1014-1018. (Published).
• Cadet, J., Wagner, J.R., Angelov, D. (2019). BiphotonicIonization of DNA: From Model Studies to Cell. Photochemistry and Photobiology 95 (1), 59-72. (Published).
• *Belmouaddine, H., *Madugundu, G.S., Wagner, J.R., (...), Houde, D., Sanche, L. (2019). DNA Base Modifications Mediated by Femtosecond Laser-Induced Cold Low-Density Plasma in Aqueous Solutions. Journal of Physical Chemistry Letters 10 (11), 2753-2760. (Published).
• Ahuié Kouakou, G., Gagnon, H., Lacasse, V., Wagner, J.R., Naylor, S., Klarskov, K. (2019). Dehydroascorbicacid S-Thiolation of peptides and proteins: Role of homocysteine and glutathione. Free Radical Biology and Medicine 141 233-243. (Published).
• St-Pierre, V., Vandenberghe, C., *Lowry, C.-M., Fortier, M., Castellano, C.-A., Wagner, J.R., Cunnane, S.C. (2019). Plasma ketone and medium chain fatty acid response in humans consuming different medium chain triglycerides during a metabolic study day. Frontiers in Nutrition 6 Article 46. (Published).
• Cadet, J., Di Mascio, P., Wagner, J.R. (2019). Radiation-induced (5′R)-and (5′S)-purine 5′,8-cyclo-2′-deoxyribonucleosides in human cells: are visited analysis of HPLC-MS/MS measurements. Free Radical Research 53 (5), 574-577. (Published).
• *Khorsandgolchin, G., Lemelin, V., Cloutier, P., Sanche, L., Wagner, J.R. (2019). Strand Breaks Induced by Very Low Energy Electrons: Product Analysis and Mechanistic Insight into the Reaction with TpT. Journal of the American Chemical Society 141 (26), 10315-10323. (Published).
• Briedé, Jacob J.; Deferme, Lize; Wolters, Jarno E.J.;Claessen, Sandra M.H.; Beucken, Twan van den; Wagner, J. Richard; Bred, Simone G. van; Kleinjans, Jos C.S. (2018). A crossomics approach to investigate temporalgene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidativestress showed involvement of different regulatory kinases. Toxicology in Vitro 48 318-328. (Published).
• Papaluca, A., Wagner, J.R., Saragovi, H.U. and Ramotar, D. (2018). C.elegansUNG-1 and APN-1 are themajor enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in. Scientific Reports 8 6860. (Published).
• Lemelin, V., Bass, A., Wagner, J.R., Sanche, L. (2017). Absolute vibrationalexcitation cross sections for 1-18 eV electron scattering from condenseddimethyl phosphate (DMP). Journal of Chemical Physics 147 234305. (Published).
• Courchesne-Loyer, A.; *Lowry, C.M.; St-Pierre, V.; Vandenberghe, C.; Fortier, M.; Castellano, C.A.; Wagner, J. R.; Cunnane, S.C. (2017). Emulsification Increases the Acute Ketogenic Effect and Bioavailability of Medium-Chain Triglycerides in Humans: Protein, Carbohydrate, and Fat Metabolism. Current Developments in Nutrition 1 e000851. (Published).
• Cadet, J., Davies, K.J., Medeiros, M.H.G., DiMascio, P., Wagner, J. R. (2017). Formation and repair of oxidatively generated damage in cellular DNA. Free Radicals in Biology and Medicine 107 13-34. (Published).
• Drapeau, A. I.; Poirier, M.-B.; *Madugundu, G.S.; Wagner, J. R.; Fortin, D. (2017). Intra-arterial Temozolomide,Osmotic Blood-brain Barrier Disruption and Radiotherapy in a Rat F98-GliomaModel. Clinical Cancer Drugs 4 (2), 135-144. DOI. (Published).
• *Choofong, S., Cloutier, P., Sanche, L., Wagner, J.R. (2016). Base release and modification in solid-phase DNA exposed to low-energy electrons. Radiation Research 186 520-530. (Published).
• Deferme, L., Wolters, J., Claessen, S., Theunissen, D., van den Beucken, T., Wagner, J.R., van Breda, S., Kleinjans, J., Briede, J. (2016). Dynamic interplay between the transcriptome and methylome in response to oxidative and alkylating stress. Chemical Research in Toxicology 29 (9), 1428-1438. (Published).
• *Ali, A and Wagner, J.R. (2016). Isomerization of 5-hydroxy-5-methylhydantoin 2’-deoxynucleoside into ?-furanose, ?-furanose, ?-pyranose and ?-pyranoseanomers. Chemical Research in Toxicology 29 65-74. (Published).
• Cadet, J. and Wagner, J. R. (2016). Radiation-induced damage to cellular DNA: Chemical nature and mechanisms of lesion formation. Radiation Physics and Chemistry 128 54-59. (Published).
• Flandrin, A.; Allouche, S.; Rolland, Y.; McDuff, F.-O.; Wagner, J.R., Klarskov, K. (2015). Characterization of dehydroascorbate mediated modification of glutaredoxin by mass spectrometry. Journal of Mass Spectrometry 50 1358-1366. (Published).
• Behmand, B.,Marignier, J.-L., Mostafavi, M., Wagner, J.R., Hunting, D.J., Sanche, L. (2015). Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of PtI. Journal of Physical Chemistry B 119 (30), 9496-9500. (Published).
• *Behmand, B., Wagner, J.R., Sanche, L. and Hunting, D. J. (2014). Cisplatin intrastrand adducts sensitize DNA to base damage by hydrated electrons. Journal of Physical Chemistry B 118 (18), 4803-4808. (Published).
• *Madugundu, Guru S.; Cadet, Jean and Wagner, J.R. (2014). Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA. Nucleic Acids Research 42 (11), 7450-7460. (Published).
• Cadet J , Wagner JR , Shafirovich V , Geacintov NE. (2014). One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA. International Journal of Radiation Biology 90 (6), 423-432. (Published).
• Cadet, J and Wagner, J.R. (2014). Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: similarities and differences. Archives of Biochemistry and Biophysics 557 47-54. (Published).
• Cadet J , Wagner JR. (2014). TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine. Mutation Research 764-765 18-35. (Published).
• Alizadeh, E., *Sanz, A. G., García, G., Wagner J. R. and Sanche L. (2014). Thymidine decomposition induced by low-energy electrons and soft X-rays under N2 and O2 atmospheres. Radiation Research 181 (6), 629-640. (Published).
• González-Magaña, O., Tiemens, M., Reitsma, G., Boschman, L., Door, M., Bari, S., Lahaie, P.O., Wagner, J.R., Huels, M.A., Hoekstra, R., Schlathölter, T. (2013). Fragmentation of protonated oligonucleotides by energetic photons and Cq+ ions. Physical Review A - Atomic, Molecular, and Optical Physics 2013 (87), Article 032702. (Published).
• *Madugundu GS , Wagner JR , Cadet J , Kropachev K , Yun BH , Geacintov NE , Shafirovich V. (2013). Generation of Guanine-Thymine Cross-Links in Human Cells by One-Electron Oxidation Mechanisms. Chemical Research in Toxicology 26 (7), 1031-1033. (Published).
• *Behmand B , Cloutier P , Girouard S , Wagner JR , Sanche L , Hunting DJ. (2013). Hydrated electrons react with high specificity with cisplatin bound to single-stranded DNA. The Journal of Physical Chemistry. B 117 (50), 15994-15999. (Published).
• *Kay P , Wagner JR , Gagnon H , Day R , Klarskov K. (2013). Modification of peptide and protein cysteine thiol groups by conjugation with a degradation product of ascorbate. Chemical Research in Toxicology 26 (9), 1333-1339. (Published).
• Paquette B , Therriault H , Wagner JR. (2013). Role of interleukin-1? in radiation-enhancement of MDA-MB-231 breast cancer cell invasion. Radiation Research 180 (3), 292-298. (Published).
• *Park Y , Peoples AR , *Madugundu GS , Sanche L , Wagner JR. (2013). Side-by-side comparison of DNA damage induced by low-energy electrons and high-energy photons with solid TpTpT trinucleotide. Journal of Physical Chemistry. B 117 (35), 10122-10131. (Published).
• Cadet J., Loft S., Olinski R., Evans M.D., Bialkowski K., Wagner J.R., Dedon P.C., Møller, P., Greenberg M.M., and Cooke M.S. (2012). Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radical Research 46 367-381. (Published).
• Meesat R , Belmouaddine H , Allard JF , Tanguay-Renaud C , Lemay R , Brastaviceanu T , Tremblay L , Paquette B , Wagner JR , Jay-Gerin JP , Lepage M , Huels MA , Houde D. (2012). Cancer radiotherapy based on femtosecond IR laser-beam filamentation yielding ultra-high dose rates and zero entrance dose. Proceedings of the National Academy of Sciences of the United States of America 109 (38), E2508-25013. (Published).
• *Park Y , *Polska K , Rak J , Wagner JR , Sanche L. (2012). Fundamental mechanisms of DNA radiosensitization: damage induced by low-energy electrons in brominated oligonucleotide trimers. Journal of Physical Chemistry. B 116 (32), 9676-9682. (Published).
• Desmarais G , Fortin D , Bujold R , Wagner JR , Mathieu D , Paquette B. (2012). Infiltration of glioma cells in brain parenchyma stimulated by radiation in the F98/Fischer rat model. International Journal of Radiation Biology 88 (8), 565--574. (Published).
• Cadet J, Douki T, Gasparutto D, Ravanat JL, Wagner JR. (2012). Measurement of oxidatively generated base damage to nucleic acids in cells: facts and artifacts. Bioanalytical Review 4 55-74. (Published).
• *Samson-Thibault F, *Madugundu GS, *Gao S, Cadet J, Wagner JR. (2012). Profiling cytosine oxidation in DNA by LC-MS/MS. Chemical Research in Toxicology 25 (9), 1902-1911. (Published).
• *Madugundu GS , *Park Y , Sanche L , Wagner JR. (2012). Radiation-induced formation of 2',3'-dideoxyribonucleosides in DNA: a potential signature of low-energy electrons. Journal of the American Chemical Society 134 (42), 17366-17368. (Published).
• Khalil A , Gaudreau P , Cherki M , Wagner JR , Tessier DM , Fulop T , Shatenstein B. (2011). Antioxidant-rich food intakes and their association with blood total antioxidant status and vitamin C and E levels in community-dwelling seniors from the Quebec longitudinal study NuAge. Experimental Gerontology 46 (6), 475-481. (Published).
• Defoy D , Dansette PM , Neugebauer W , Wagner JR , Klarskov K. (2011). Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography-mass spectrometry to screen and characterize reactive drug metabolites. Chemical Research in Toxicology 24 (3), 412-417. (Published).
• *Li Z , Cloutier P , Sanche L , Wagner JR. (2011). Low-energy electron-induced damage in a trinucleotide containing 5-bromouracil. Journal of Physical Chemistry. B 115 (46), 13668-13673. (Published).
• *Park Y., *Li Z., Cloutier P., Sanche L., Wagner J.R. (2011). Low energy electron induced DNA damage: Conversion of thymine to 5,6-dihydrothymine in the oligonucleotide trimer TpTpT. Radiation Research 175 240-246. (Published).
• Paquette B , Therriault H , *Desmarais G , Wagner R , Royer R , Bujold R. (2011). Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor. British Journal of Cancer 105 (4), 534-541. (Published).
• Regulus P , Desilets JF , Klarskov K , Wagner JR. (2010). Characterization and detection in cells of a novel adduct derived from the conjugation of glutathione and dehydroascorbate. Free Radical Biology and Medicine 49 (6), 984-991. (Published).
• *Kuttappan-Nair V , *Samson-Thibault F , Wagner JR. (2010). Generation of 2'-deoxyadenosine N6-aminyl radicals from the photolysis of phenylhydrazone derivatives. Chemical Research in Toxicology 23 (1), 48-54. (Published).
• *Li Z , Cloutier P , Sanche L , Wagner JR. (2010). Low-energy electron-induced DNA damage: effect of base sequence in oligonucleotide trimers. Journal of the American Chemical Society 132 (15), 5422-5427. (Published).
• Wagner JR , Cadet J. (2010). Oxidation reactions of cytosine DNA components by hydroxyl radical and one-electron oxidants in aerated aqueous solutions. Accounts of Chemical Research 43 (4), 564-571. (Published).
• Cooke MS , Loft S , Olinski R , Evans MD , Bialkowski K , Wagner JR , Dedon PC , Møller P , Greenberg MM , Cadet J. (2010). Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA. Chemical Research in Toxicology 23 (4), 705-707. (Published).
• *Dextraze M.-E., Cecchini S., *Bergeron F., Girouard S., Wagner J.R., Hunting D.J. (2009). Reaching for the other side: generating sequence-dependent interstrand cross-links with 5-bromodeoxyuridine and gamma-rays. Biochemistry 48 2005-2011. (Published).
• Rivière, J., Ravanat, J.-L., Wagner, J.R. (2006). Ascorbate and H2O2 induced oxidative DNA damage in Jurkat cells. Free Radical Biology and Medicine 40 (12), 2071-2079. (Published).
• Lenton, K.J., Therriault, H., Cantin, A.M., Fülöp, T., Payette, H., Wagner, J.R. (2000). Direct correlation ofglutathione and ascorbate and their dependence on age and season in humanlymphocytes. American Journal of Clinical Nutrition 71 (5), 1194-1200. (Published).
• Lenton, K.J., Sané, A.T., Therriault, H., Cantin, A.M., Payette, H., Wagner, J.R. (2000). Vitamin C augmentslymphocyte glutathione in subjects with ascorbate deficiency. American Journal of Clinical Nutrition 77 (1), 189-195. (Published).

Chapitres de livre

• Jean Cadet and J. Richard Wagner. (2021). DNA repair | DNA oxidation. Joseph Jez. Encyclopedia of Biological Chemistry (Third, 4, 236-243). Netherlands : Elsevier. (Published).
• Cadet, J., Wagner, J.R. (2019). Carcinogenesis: Role of Reactive Oxygen and Nitrogen Species. Boffetta, P., Hainaut, P.. Encyclopedia of Cancer (3rd, 296-306). United States : Academic Press. (Published).
• Cadet, J., Wagner, J.R. (2017). Effet des radiations ionisantes sur les acides nucléiques: des composés modèles à la cellule. Fuchs, A., Bensasson, R.V.. Histoire de recherche contemporaine: Réactions induites par les rayonnements, étudiées en France du XIXe siècle à nos jours (Tome VI, 1, 71-80). France : CNRS Editions. (Published).
• Cadet J.; Wagner J.R. (2013). DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation. Friedberg, Errol C.; Elledge, Stephen J.; Lehmann, Alan R.; Lindahl, Tomas; Muzi-Falconi, Marco. DNA Repair, Mutagenesis, and Other Responses to DNA Damage. Cold Spring Harb Perspect Biol. (1-18). United States : Cold Spring Harbor Laboratory Press. (Published).
• Cadet, J., Douki, T., Gasparutto, D., Ravanat, J.-L. Wagner, J.R. (2012). Oxidatively Generated Nucleobase Modifications in Isolated and Cellular DNA. C.Chatgilialoglu and A.Studer. Encyclopedia of Radicals in Chemistry, Biology and Materials (3, 1319-1344). United States : John Wiley and Sons, Inc. (Published).
• Cadet, J., Douki, T., Gasparutto, D., Ravanat, J.-L. Wagner, J.R. (2010). Chemical reactions of the radical cations of nucleobases in isolated and cellular DNA. Formation of single-base lesions. Marc M. Greenberg. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry (Chapter 4). United States : John Wiley & Sons, Inc. (Published).

Articles de conférence

• *Kumari, B.,*Huwaidi, A.,*Robert, G., Cloutier, P., Sanche, L., Wagner, J.R. (2021). Very low energy electron (vLEE) induced DNA damage. 66th Radiation Research Society (virtual). (Submitted).
• *Huwaidi, A., Guerin, B., Wagner, J.R.,Sanche, L. (2021). X-ray irradiation of DNA in the presence gold nanoparticles promotes low energy electron induced DNA damage: LC-MS/MS study. XXII International Symposium on Electron-Molecule Collisions and Swarms (virtual). (Accepted).
• *Khorsandgolchin, G., Sanche, L., Cloutier, P., Wagner, J.R. (2019). DNA damage in TpT induced by very low energy electrons. International conference on radiation research. (Published).
• *Robert, G., Wagner, J.R. (2019). Fate of 5-methyl radicals of thymine within DNA in the presence of oxygen: Product analysis and mechanistic studies in the formation of tandem lesions with adjacent guanine. 1st Eastern Canada Mass Spectrometry Conference 10th International Symposium on Enabling TechnologiesThe 35th Trent Conference on Mass Spectrometry. (Published).
• *Robert, G. and Wagner, J.R. (2019). Fate of 5-methyl radicals of thymine within DNA in the presence of oxygen: Product analysis and mechanistic studies in the formation of tandem lesions with adjacent guanine. Canadian Chemistry Conference and Exhibition, 102nd edition. (Published).
• *Robert, G., Wagner, J.R. (2019). Formation of single and tandem base lesions by independently generated5-(uracilyl)methyl radicals (X) and the corresponding peroxyl radicals withinGXA. International conference on radiation research. (Published).
• *Huwaidi, A., *Robert, G., Cloutier, P., Guérin, B., Sanche L. and Wagner. J. R. (2019). Gold nanoparticles enhance X-ray-induced DNA damage arising from theemission of low energy electrons from the gold surface: a LC-MS/MS study of DNAdamage. 1st Eastern Canada Mass Spectrometry Conference 10th International Symposium on Enabling TechnologiesThe 35th Trent Conference on Mass Spectrometry. (Published).
• *Lowry, C.M., Lebel, M., Aumailley, L., Graham, R.K., Wagner, J.R. (2018). Ascorbate supplementation increases 5-hydroxymethylcytosine in brain cerebellum DNA ofascorbate knockout mice. 25th Annual Conference of the Society for Redox Biology and Medicine. (Published).
• *Korsandgolchin, G; Lemelin, V.; Cloutier, P.; Sanche, L.; Wagner, J.R. (2018). DNA damage in TpT induced by very low energy electrons. 15th International workshop on Radiation DNA to damage. (Published).
• *Robert, G.; *Madugundu, G. S; Wagner, J. R. (2017). Deamination of cytosine and 5-methylcytosine oxidation products in DNA. 6th EU-US Conference on Repair of endogenous DNA damage. (Published).
• *Lowry, C.-M.; Roy, L.O.; Fortin, D.; Wagner, J. R. (2017). Further studies on the loss of 5-hydroxymethylcytosine in brain tumors. 6th EU-US Conference on Repair of endogenous DNA damage. (Published).
• Belmouaddine, H., *Madugundu, G.S., Lefebvre, S., Wagner, J.R., Sanche, L., Houde, D. (2017). Oxidatively Generated Base Damage to DNA in Aqueous Solution by Femtosecond Laser-Induced Low Density Plasma Multi-Channels Controlled with a Spatial Light Modulator. 63rd Annual Meeting of the Radiation Research Society. (Published).
• *Lowry, M.C.; Roy, L.-O., Fortin; D., Poirier; M.B.; Wagner, j.R. (2016). Loss of 5-hydroxymethylcytosine in brain tumors related to variations in epigenetic marks. 9th Meeting of the Canadian Oxidative Stress Consortium. (Published).
• Wagner, J.R., *Lowry, C.M., Graham, R., Lebel, M. (2016). Role of Vitamin C in TET-mediated oxidation of 5-methylcytosine to 5-mhydroxymethylcytosine in the brain of young mice. 9th Meeting of the Canadian Oxidative Stress Consortium. (Published).
• *Choofong, S., Cloutier, P. Sanche, L. and Wagner, J.R. (2015). Low energy electron (LEE)-induced damage to DNA. 98th Canadian Chemistry Conference and Exhibition. (Published).
• Belmouaddine, H. *Madugundu, G.C., Wagner, J.R., Sanche, L., Houde, D. (2015). Low energy secondary electron-induced DNA damage through femtosecond laser pulse filamentation in aqueous solution. 15th international congress of radiation research. (Published).
• *Madugundu, G.S. and Wagner, J.R. (2015). Oxidation of DNA by peroxyl radicals: Product analyses and mechanistic studies. 98th Canadian Chemistry Conference and Exhibition. (Published).
• Cadet,J. *Madugundu, G.S., Wagner, J.R. (2015). Radiation-induced damage to cytosine and 5-methylcytosine in cellular DNA: final oxidation products and mechanistic insights. 15th international congress of radiation research. (Published).
• *Choofong, S., Cloutier, P., Sanche, L. and Wagner, J.R. (2015). Radiation damage to DNA and oligonucleotides specifically induced by low energy electrons (LEEs) under atmospheric conditions. 61th annual meeting of the Radiation Research Society. (Published).
• *Lowry, C.M., Poirier, M.-B., Fortin, D. and Wagner, J.R. (2014). Alterations in Epigenetic Markers Related to 5-Hydroxymethylcytosine in Brain Cancer. 21st Annual Meeting of the Society for Free Radical Biology and Medicine. (Published).
• *Madugundu, G.S. and Wagner, J.R. (2014). Analysis of DNA oxidation in cells by LC-ESI-MS/MS. 27th Workshop on Tandem Mass Spectrometry. (Published).
• *B. Behmand, P. Cloutier, J. R. Wagner, L. Sanche, D. Hunting, J. L. Marignier, M. Mostafavi. (2014). Cisplatin Adducts Sensitize DNA to Attack by Hydrated Electrons Leading to Cisplatin Detachmentand Base Damage. Annual Meeting of the Radiation Research Society. (Published).
• Brochu, R., Rolland, Y., Wagner, J.R. and Klarskov, K. (2014). Possible relationship between oxidized vitamin C and homocysteine thiolactone: S-versus N-homocysteinylation. 21st Annual Meeting of the Society for Free Radical Biology and Medicine. (Published).
• Wagner, J.R. (2014). Profiling radiation-induced DNA damage. 13th Interational Workshop on Radiation Damage to DNA. (Published).
• *Behmand, B., Marignier, J.-L.; Mostafavi, M., Wagner, J.R., Hunting, D. and Sanche, L. (2014). Radiosentization of DNA by cisplatin adducts results from an increase in rate constant for the reaction with hydrated electrons and formation of Pt (I). 60th Annual Meeting of the Radiation Research Society. (Published).
• Alizadeh, E., *Sanz, A.G., Garcia, G., Wagner, J.R. and Sanche, L. (2014). Thymidine decomposition induced by low-energy electrons and soft X-rays under N2 and O2 atmospheres. 97th Canadian Chemistry Conference and Exhibition. (Published).
• *Gao, S. *Madugundu, G.S., Poirier, M.B., D. Fortin, Wagner, J.R. (2013). Analysis of 5?Hydroxymethylcytosine as a Epigenetic Biomarker in Brain Cancer. 96th Canadian Chemistry Conference and Exhibition. (Published).
• Eloraby, G., McDuff, F.O.,Wagner, J.R., Klarskov,K. (2013). Ascorbylation and Glutathionylation of Glutaredoxin-1 by Dehydroascorbate. 10th International ISSX Meeting (International Society for the Study of Xenobiotics. (Published).
• *Ali, A. and Wagner, J.R. (2013). Conversion of 5?hydroxyl?5?methylhydantoin Nucleosides into a Mixture of Eight Isomers by Ring?chain Tautomerism, Alpha/Beta and Furanose/Pyranose Isomerization. 96th Canadian Chemistry Conference and Exhibition. (Published).
• Wagner, J.R. (2013). La formation des lésions instables dans l’ADN exposé aux radiations. 11ème Colloque International de Radiobiologie Fondamentale et Appliquée. (Published).
• *Madugundu, G.S. and Wagner J. R. (2013). Oxidation of the methyl group of thymine and 5-methylcytosine in DNA: product analyses by LC-MS/MS and mechanistic studies. 61st ASMS Conference on Mass Spectrometry. (Published).
• Klaus Klarskov; Aurore Flandrin; Francois-Olivier McDuff; J. Richard Wagner. (2013). Protein ascorbylation of human Glutaredoxin-1 by a reactive degradation product of oxidized ascorbate. 61st ASMS Conference on Mass Spectrometry. (Published).
• *Madugundu, G.S., *Thibault-Samson, F., *Gao, S., Cadet, J., Wagner, J.R. (2012). Analysis of 5-methylcytosine oxidation products in DNA by enzymatic digestion and HPLC-MS/MS. 60th ASMS Conference on Mass Spectrometry. (Published).
• *Kay, P.; Wagner, J.R.; Klarskov, K. (2012). Modification of peptide and protein cysteine thiol groups by reaction with oxidation products of vitamin C dehydroascorbate. 60th ASMS Conference on Mass Spectrometry. (Published).
• Wagner, J. R. (2012). Oxidation of cytosine and 5-methylcytosine. 57th Annual Meeting of the Radiation Research Society. (Published).
• *Kay, P., Wagner, J.R., Klarskov, K. (2011). Modification des thiols des cystéines des protéines et peptides en présence de déshydroascorbate. 79e Association canadienne-française pour l'avancement des sciences (ACFAS). (Published).
• *Park, Y., Sanche, L., Wagner, J.R. (2011). Mécanisme de modification de la thymidine par irradiation à l’aide d’électrons de basse énergie sur l’oligonucléotide TpTpT. 79e Association canadienne-française pour l'avancement des sciences (ACFAS). (Published).
• *Thibault-Samson, F., *Madugundu, G.S., Wagner, J.R. (2011). Oxydation de la cytosine dans l’ADN induits par les radicaux libres : Analyses des produits stables et les effets de la structure secondaire de l’ADN. 79e Association canadienne-française pour l'avancement des sciences (ACFAS). (Published).
• Defoy, D.; Dansette, P.M.; Neugebauer, W.; Wagner, J.R.; Klarskov, K. (2010). Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography mass spectrometry to screen and characterize reactive drug metabolites. Biological Reactive Intermediates VIII. (Published).
• *Park, Y.; *Li, Z.; Cloutier, P.; Sanche, L.; Wagner, J.R. (2010). Low energy electron induced DNA damage: Formation of thymine to 5,6-dihydrothymine as a major product in the irradiation of oligonucleotide trimer TpTpT. 56th Annual Meeting of the Radiation Research Society. (Published).
• Wagner, J. R. (2010). Low energy electron induced DNA damage: chemical mechanisms. 56th Annual Meeting of the Radiation Research Society. (Published).
• Wagner, J. R. (2010). Oxidative damage to cytosine and 5-methylcytosine. EUCHEM Conference on Organic Free Radicals. (Published).
• Wagner, J.R.; *Peggy Regulus; *Jean-Francois Desilets; Klaus Klarskov. (2009). Conjugation of glutathione with oxidized ascorbate: Structural analysis of an adduct and its detection in cells. 57th ASMS Conference on Mass Spectrometry. (Published).
• Wagner, J.R., *Belmadoui, N., Cadet, J. (2009). Free radical oxidation of cytosine and 5-methylcytoisine:Characterization of novel stable and unstable products. 8th Winter Research Conferences, Centre de l’École de Physique. (Published).
• Meesat, R., Allard, J.-F., Wagner, J.R., Jay-Gerin, J.-P., Tremblay, L., Lepage, M. and Houde, D. (2009). Fricke and polymer gel dosimetry of femtosecond laser pulse filamentation and radiation chemical effects of laser irradiation on thymidine solutions. 55th Annual Meeting of the Radiation Research Society. (Published).
• Wagner, J.R. (2009). Induction of interstrand cross-links by photosensitization. 13th Congress of the European Society for Photobiology. (Published).
• *Li, Z, Cloutier, P., Sanche, L. Wagner, J.R. (2009). Low Energy Electron Induced DNA Damage: Effect of Different Base Substitutions in Oligomer Trimers. 55th Annual Meeting of the Radiation Research Society. (Published).
• Cadet, J., Douki, T., Gasparrutto, D., Ravanat, J.-L., Wagner, J.R. (2009). Oxidatively generated damage to DNA: Recent mechanistic insights and perspectives. 8th Winter Research Conferences, Centre de l’École de Physique. (Published).
• Wagner, J.R. *Nair, V.K., *Samson-Thibault, F., *Belmadoui, N. (2009). Photolysis of 2’-deoxyhydrazones: Analysis of products from the reaction of adenine N6-aminyl radicals. Organic Free Radicals. (Published).

Autres contributions

Présentations

• (2014). Profiling radiation-induced DNA damage. 13th Interational Workshop on Radiation Damage to DNA. Boston, United States
• (2013). La formation des lésions instables dans l’ADN exposé aux radiations. 11ème Colloque International de Radiobiologie Fondamentale et Appliquée. La Grande Motte, France
• (2012). Oxidation of cytosine and 5-methylcytosine. 57th Annual Meeting of the Radiation Research Society. San Juan, United States
• (2010). Free radical oxidation of cytosine and 5-methylcytoisine:Characterization of novel stable and unstable products. 8th Winter Research Conferences, Centre de l’École de Physique, Les Houches, France. Les Houches, France
• (2010). Low energy electron induced DNA damage: chemical mechanisms. 56th Annual Meeting of the Radiation Research Society. Wailea-Makena, United States
• (2010). Oxidative damage to cytosine and 5-methylcytosine. EUCHEM Conference on Organic Free Radicals. Bologna, Italy
• (2009). Induction of interstrand cross-links by photosensitization. 13th Congress of the European Society for Photobiology. Wroclaw, Poland
• Wagner, J.R; Kuttappan-Nair, V.; Samson-Thibault, F.; Belmadoui, N. (2009). Photolysis of 2’-deoxyhydrazones: Analysis of products from the reaction of adenine N6-aminyl radicals. Organic Free Radicals-Tribute to Keith Ingold. Ottawa, Canada