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Jean-François Lepage

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pédiatrie

Présentation

Sujet de recherche

Développement du système nerveux, Développement cognitif de l'enfant, Système moteur, Troubles d'inattention et d'hyperactivité, Polluants chimiques

Disciplines de recherche

Neurosciences, Psychologie

Mots-clés

Stimulation magnétique transcrânienne, Imagerie par résonance magnétique, Syndrome de Turner, Neurophysiologie motrice, Neuropsychologie, Développement, Cognition Sociale, Aneuploidies des chromosomes sexuels

Intérêts de recherche

Mes intérêts portent sur le développement et l'utilisation de nouvelles techniques d'imagerie et de stimulation pour étudier le développement cérébral humain de façon non-invasive. Mes études se déroulent principalement auprès de populations cliniques affectées par des troubles génétiques d'origines diverses (Syndrome de Turner, Klinefelter, X Fragile, Trouble du spectre autistique). Le but de mes recherches est d'identifier des marqueurs neurophysiologiques qui permettront la classification de troubles du cerveau non pas sur la base du phénotype clinique observable, mais en fonction des processus et mécanismes impliqués dans l'étiologie du trouble.

Centre de recherche

Centre de recherche du CHUS

Recherche clinique

Oui

Langues parlées et écrites

Anglais, Français

Diplômes

(2015). (Postdoctorat, Post-doctorat). Massachusetts General Hospital.

(2012). (Postdoctorat, Post-doctorat). Stanford University.

(2010). Développement et fonctionnement des mécanismes de résonance motrice chez l'humain (Doctorat, Ph.D). Université de Montréal.

(2009). (Maîtrise sans mémoire, Maîtrise en psychologie). Université de Montréal.

(2003). (Baccalauréat, Baccalaureat es art). McGill University.

Titres de compétence

(2012) Transcranial Direct Current Stimulation (TDCS) Certification. Harvard Medical School.

Clinical Neuropsychologist (Pediatric).

Transcranial Magnetic Stimulation Certification. Harvard Medical School.

Expérience académique

Associate professor. (2019-). Université de Sherbrooke. Canada.

Assistant professor. (2016-2019). Université de Sherbrooke. Canada.

Assistant Professor. (2015-2016). Université du Québec à Trois-Rivières. Canada.

Adjunct Professor. (2014-2015). Université du Québec à Trois-Rivières. Canada.

Post-doctoral research fellow. (2012-2015). Massachusetts General Hospital. États-Unis d'Amérique.

Post-doctoral research fellow. (2010-2012). Stanford University. États-Unis d'Amérique.

Prix et distinctions

  • (2020) Research Scholars – Junior 1 Award. Fonds de recherche du Québec - Santé (FRQS). (Prix).
  • (2015) Postdoctoral Award. Instituts de recherche en santé du Canada. (Prix).
  • (2012) Postdoctoral Award. Fonds de recherche du Québec - Santé (FRQS). (Prix).
  • (2010) Canada Graduate Scholarship - Doctoral Program. Instituts de recherche en santé du Canada. (Prix).
  • (2007) Graduate Scholarship – Doctoral Program. CHU Sainte-Justine. (Prix).
  • (2007) Graduate Scholarship – Doctoral Program (DECLINED). Fonds de recherche du Québec - Santé (FRQS). (Prix).
  • (2006) Graduate Scholarship – Master’s Program. CHU Sainte-Justine. (Prix).
  • (2003) Dean's Honor List. McGill University. (Distinction).
  • Most influential scientific article of 2011, CERNEC Research Center. Centre de recherche en neuropsychologie et cognition. (Prix).
  • Phd thesis, mention "Exceptional". Université de Montréal. (Distinction).

Financement

  • Subvention. (Obtenu). Cocandidat. Empowering Next-generation Researchers In Child Health (ENRICH). Instituts de Recherche en Santé du Canada (IRSC). Canadian Institutes of Health Research Training grant - Health Research Training Platform. 2 400 000 $. (2022-2027)
  • (Obtenu). Cocandidat. Empowering Next-generation Researchers In perinatal and Child Health (ENRICH). Instituts de Recherche en Santé du Canada (IRSC). Research Training grant. 2 400 000 $. (2022-2027)
  • Subvention. (Obtenu). Candidat principal. Targeting the endocannabinoid system to increase GABA signalling in patients with Fragile-X syndrome. Instituts de Recherche en Santé du Canada (IRSC). Project Grant. 532 000 $. (2021-2026)
  • (Obtenu). Candidat principal. Le système GABAergique dans les troubles neurodéveloppementaux. Fonds de la Recherche en Santé du Québec (FRSQ). Bourse Salariale Junior II. 286 986 $. (2020-2024)
  • (Obtenu). Candidat principal. Assessing the endocannbinoid and GABA systems in individuals with Trisomy 21. Fondation Jérome Lejeune. Research grant. 94 000 $. (2021-2023)
  • Subvention. (Obtenu). Cochercheur. Effects of Flame Retardants on brain function and attentional deficits in school-age children – brain imaging, neurobehavioral, and gut microbiome studies in a longitudinal birth cohort. National Institutes of Health (NIH) (USA). R01. 2 000 000 $. (2018-2023)
  • Subvention. (Obtenu). Chercheur principal. Development and validation of novel non-invasive brain stimulation techniques. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Subvention à la découverte. 150 000 $. (2017-2022)
  • Subvention. (Obtenu). Chercheur principal. Impacts of prenatal flame retardant exposure on brain development: a multimodal neuroimaging study. Sick Kids Foundation (SKF). New Investigator Research Grant. 294 500 $. (2016-2021)
  • Subvention. (Obtenu). Chercheur principal. Neurophysiological impacts of mTOR signaling dysregulation. Fondation des étoiles (La) (Qc). Research project. 33 000 $. (2019-2020)
  • Subvention. (Obtenu). Candidat principal. Leveraging the endocannabinoid system to correct GABA abnormalities in patients with Fragile-X syndrome. Pôle d’excellence en neurosciences du CRCHUS : NEUROPÔLE. Projets pilotes. 20 000 $. (2019-2020)
  • Subvention. (Obtenu). Cocandidat. Open-label trial of Metformin in children and adults with Fragile X Syndrome. Fraxa Research Foundation. Research project. 64 000 $. (2018-2020)
  • Subvention. (Obtenu). Cocandidat. Dosage sanguin des endocannabinoïdes avec la méthode SPOT. Neuropole. PIlot Project. 20 000 $. (2019-2020)
  • Bourse de recherche. (Obtenu). Candidat principal. La plasticité synaptique et la neurophysiologie chez les personnes présentant des anomalies des chromosomes sexuels: à la recherche de marqueurs neurophysiologiques du trouble du spectre autistique. Fonds de la Recherche en Santé du Québec (FRSQ). Chercheurs-boursiers – Junior 1. 240 000 $. (2016-2020)
  • Subvention. (Obtenu). Candidat principal. Établissement de jeunes chercheurs - La plasticité synaptique et la neurophysiologie chez les personnes présentant des anomalies des chromosomes sexuels. Fonds de recherche du Québec - Santé (FRQS). Établissement des jeunes chercheurs. 60 000 $. (2016-2019)
  • Subvention. (Obtenu). Candidat principal. MRI compatible trancranial alternating current stimulation. Centre de recherche du CHUS. PERC. 17 500 $. (2018-2019)
  • Subvention. (Obtenu). Cochercheur. Characterizing cerebral cholesterol metabolism in Fragile-X syndrome.. Fondation des étoiles (La) (Qc). Subvention à la recherche. 14 500 $. (2018-2019)
  • Subvention. (Obtenu). Chercheur principal. Multimodal study of the GABAergic system in Fragile-X syndrome and Neurofibromatosis type 1.. Fondation du Grand Défi Pierre Lavoie. Financement de recherche. 25 000 $. (2017-2018)
  • Subvention. (Obtenu). Chercheur principal. Synaptic plasticity in children with Fragile-X syndrome and neurofibromatosis 1 : predicting cognition variability and treatment response. Fondation des étoiles (La) (Qc). Subvention à la recherche. 10 000 $. (2017-2018)
  • Subvention. (Obtenu). Chercheur principal. Caractérisation de la plasticité synaptique et des voies de signalisation associées chez les enfants avec neurofibromatose et syndrome du X-fragile. Fondation des étoiles (La) (Qc). Concours Fondation des Étoiles 2017. 10 000 $. (2017-2018)
  • Subvention. (Obtenu). Chercheur principal. Multimodal intervention for children with dysphasia.. Mathematics of Information Technology and Complex Systems (MITACS). Mitacs Acceleration. 15 000 $. (2017-2018)
  • Subvention. (Obtenu). Chercheur principal. Non-invasive brain stimulation using focused ultrasound. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Programme de subventions d'outils et d'instruments de recherche. 150 000 $. (2017-2018)
  • Subvention. (Obtenu). Collaborateur. TMS inhibition of the superior temporal sulcus to reduce memory of pain. Centre d'excellence en neurosciences de l'Université de Sherbrooke. Pilot Project Program. 25 000 $. (2016-2017)
  • Subvention. (Obtenu). Candidat principal. Optimizing MRI preparation for individuals with moderate intellectual disability and motor mannerism. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Mother-Child Pilot Grants. 10 000 $. (2016-2017)
  • Subvention. (Obtenu). Candidat principal. Modulation of cerebral connectivity with transcranial magnetic stimulation. Québec Bio-Imaging Network (QBIN)). Pilot Project Competition. 10 000 $. (2015-2016)
  • (Obtenu). Chercheur principal. Puissance Dys: projet-pilote préscolaire utilisant des interventions éducatives intermodalitaires. Mathematics of Information Technology and Complex Systems (MITACS). Accélération. 15 000 $. (2016-2016)
  • Subvention. (Obtenu). Cocandidat. Biomarkers of treatment response in Fragile-X syndrome. Fraxa Research Foundation. Program Grant. 67 000 $. (2015-2016)
  • Subvention. (Obtenu). Collaborateur. Brain development and sex chromosomes: A comparative neuroimaging study of Turner and Klinefelter syndromes.. National Institutes of Mental Health (NIMH). NIH Exploratory/Developmental Research Grant Award (R21). 175 000 $. (2013-2015)
  • Bourse de recherche. (Terminé). Candidat principal. Empreinte génétique au sein du syndrome de Turner: neurophysiologie, neuropsychologie et anatomie de la cognition sociale. Instituts de Recherche en Santé du Canada (IRSC). Doctoral Fellowship. 90 000 $. (2007-2010)
  • Bourse de recherche. (Terminé). Candidat principal. Empreinte génétique au sein du syndrome de Turner: neurophysiologie, neuropsychologie et anatomie de la cognition sociale. Fonds de la Recherche en Santé du Québec (FRSQ). Doctoral Fellowship (declined). 60 000 $. (2007-2010)
  • Subvention. (En cours d’évaluation). Candidat principal. Establishing the clinical relevance of cannabidiol for Fragile-X. Fraxa Research Foundation. Project Grant. 70 000 $.
  • Subvention. (En cours d’évaluation). Chercheur principal. Using magnetic resonance spectroscopy to assess treatment responsiveness in patients with phenylketonuria: a clinical trial. Biomarin Pharmaceutical Inc.. Independent Researcher Program. 150 000 $.

Publications

Articles de revue

  • Bernard S, Bilodeau M, Masson P, Moreau F, Lepage JF, Micheau P, Quaegebeur N. (2023). Influence of plastination on ultrasound transmission through the human skull. Ultrasound in Medicine & Biology DOI.
  • Mabika M, Agbogba K, Côté S, Lippé S, Riou E, Cieuta C, Lepage JF. (2023). Neurophysiological assessment of cortical activity in DEPDC5- and NPRL3-related epileptic mTORopathies. Orphanet: Journal of Rare Diseases
  • Therrien-Blanchet JM, Ferland MC, Rousseau MA, Merabtine A, Boucher E, Badri M, Hoffman LH, Lepage JF, Théoret H. (2023). The neurophysiological aftereffects of brain stimulation in human primary motor cortex: a sham-controlled comparison of three protocols. Cerebral Cortex
  • Abolghesemi A, Carullo MP, Aguilera CE, Laroui A, Platefèvre ER, Rojas D, Benachou S, Proteau-Lemieux M, Lepage JF, Corbin F, Plourde M, Farez M, Cogram P, Çaku A. (2022). Alternation of fatty acids profile in Fragile-X syndrome. International Journal of Molecular Science DOI.
  • Hamel R, Lepage JF, Bernier PM. (2022). Anterograde Interference Emerges along a Gradient as a Function of Task Similarity. European Journal of Neuroscience 55 (1), 49-66. (Article publié).
  • Akremi A, Hamel R, Dumas A, Corriveau H, Camden C, Lepage JF. (2022). Cerebellar direct current stimulation in children with developmental coordination disorder: a randomized, double-blind, sham-controlled pilot study. Journal of Autism and Developmental Disorders x x. DOI. (Article publié).
  • Laroui A, Galarneau L, Abolghasemi A, Plantefeve R, Benachenhou S, Bouchouirab FZ, Lepage JF, Corbin F, Çaku A. (2022). Clinical significance of matrix metalloproteinase-9 in Fragile X Syndrome: a method comparison study. Scientific Reports DOI.
  • Champigny C, Morin-Parent F, Belhumeur-Lefebvre L, Lepage JF, Corbin F. (2022). Combining Lovastatin and Minocycline for the Treatment of Fragile X Syndrome: Results from the LovaMiX Clinical Trial. Frontiers in Psychiatry 12 762967. (Article publié).
  • Hall SS, Riley MJ, Weston RN, Lepage JF, Hong DS, jo B, Hallmayer J, Reiss AL. (2022). Effects of X-chromosome monosomy and genomic imprinting on observational marker of social anxiety in prepubertal girls with Turner syndrome. Journal of Autism and Developmental Disorders 52 (1), 16-27. (Article publié).
  • Lacroix A, Proteau-Lemieux M, Côté S, Near J, Hui S, Edden R, Lippé S, Çaku A, Corbin F, Lepage JF. (2022). Multimodal assessment of the GABA system in patients with Fragile-X syndrome and Neurofibromatosis type 1. Neurobiology of Disease DOI.
  • Hamel R, Demers O, Lepage JF, Bernier PM. (2022). The Effects of Post-Learning Alcohol Ingestionon Human Motor Memory Consolidation. European Journal of Neuroscience DOI.
  • Hamel R, Demers O, Boileau C, Roy ML, Théoret H, Bernier PM, Lepage JF. (2022). The neurophysiological markers of acute alcohol’s subjective effects in humans. Neuropsychopharmacology DOI.
  • Sussman TJ, Baker BH, Wakhloo A, Gillet V, Abdelouahab N, Whittingstall J, Lepage JF, St-Cyr L, Boivin A, Gagnon A, Baccarelli AA, Takser L, Posner J. (2022). The relationship between persistent organic pollutants and attention deficit hyperactivity disorder phenotypes: evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads. Environnemental Research 206 112593. (Article publié).
  • Pierrieau E, Kessouri S, Lepage JF, Bernier PM. (2022). Theta but not beta is modulated by freedom ofchoice during action selection. Scientific Reports DOI.
  • Gagnon A, Grenier G, Bocti C, Gillet V, Lepage JF, Baccarelli AA, Poser J, Descoteaux M, Takser. (2022). White matter microstructural variability linkedto attentional skills and impulsive behavior in a pediatric population. Cerebral Cortex DOI.
  • Pierrieau E, Lepage JF, Bernier PM. (2021). Action costs rapidly and automatically interfere with reward-based decision-making in a reaching task. eNeuro 8 (4), ENEURO.0247-21.2021. (Article publié).
  • Lachambre C, Proteau-Lemieux M, Lepage JF, Bussière EL, Lippé S. (2021). Attentional and executive functions in children and adolescents with developmental coordination disorder and the influence of comorbid disorders: A systematic review of the literature. PLOS ONE 16 (6), e0252043. (Article publié).
  • Hamel R, Dallaire-Jean L, De La Fontaine E, Lepage JF, Bernier PM. (2021). Learning twice the same motor task impairs its retention in a time- and dose-dependent manner. Proceedings of the Royal Society B 13 (288), 1942. (Article publié).
  • Lafleur LP, Murray A, Desforges M, Pachecos-Barrios K, Fregni F, Tremblay S, Saint-Amour D, Lepage JF, Théoret H. (2021). No aftereffects of 10Hz and 20Hz tACS on sensorimotor alpha and beta oscillations. Scientific Reports 11 (1), 21416. (Article publié).
  • Hamel R, De la Fontaine E, Lepage JF, Bernier. (2021). Punishments and Rewards both Modestly Impair Visuomotor Memory Retention. Neurobiology of Learning and Memory 185 107532. (Article publié).
  • Proteau-Lemieux M, Lacroix A, Galarneau L, Corbin F, Lepage JF*, Çaku A. (2021). Safety and efficacy of metformin in normoglycemic patients with Fragile-X syndrome: an open label study. Progress in Neuropsychopharmacology and Biological Psychiatry 30 (110), 110307. (Article publié).
  • Côté S, Butler R, Lavallée E, Croteau E, Mendrek A, Lepage JF, Whittingstall K. (2021). The regional effect of serum hormone levels on cerebral blood flow in healthy non-pregnant women. Human Brain Mapping 42 (17), 5677-88. (Article publié).
  • Maheux M, Trémolière B, Lepage JF, Blanchette I. (2020). Anodal stimulation of the left dorsolateral prefrontal cortex decreases the detrimental effect of stress on working memory. Psychology and Neuroscience - (-), -. (Article accepté).
  • Baker, Lugo-Candelas, Wu, Laue, Boivin, Gillet, Rahman, Aw, Lepage JF, Whittingstall, Bellenger, Posner, Takser, Baccarelli,. (2020). Association of prenatal acetaminophen measured in meconium with risk of attention deficit hyperactivity disorder: mediation by frontal parietal network brain connectivity. JAMA Pediatrics (IF: 13.14) - (-), -. (Article accepté).
  • Hamel R, De Lafontaine E, Bernier PM, Lepage JF. (2020). No influence of static magnetic stimulation applied for 30 minutes over the human primary motor cortex on corticospinal excitability. Brain Stimulation (IF: 6.919) 13 (3), 594-596. (Article accepté).
  • Hamel R, De la Fontaine E, Bernier PM, Lepage JF. (2020). Response to Significant influence of static magnetic stimulation applied over 30 minutes over the human M1 on corticospinal excitability. Brain Stimulation (IF: 7.076) - (13), 1157-1158. (Article publié).
  • Morin-Parent F*, Champigny C, Lacroix A*, Corbin F, Lepage JF. (2019). Hyperexcitability and impaired intracortical inhibition in patients with Fragile-X syndrome. Translational Psychiatry (IF:5.68) 9 (1), 312. DOI. (Article publié).
  • Lafleur LP, Klees-Themens G, Chouinard-Leclerc C, Larochelle-Brunet F, S Tremblay, Lepage JF, Théoret H. (2019). Neurophysiological aftereffects of 10 and 20Hz transcranial alternating current stimulation over bilateral primary motor cortex. Brain Research (IF: 2.97) 9 (14), 1727. DOI. (Article publié).
  • Hamel R*, Côté K*, Matte A*, Lepage JF, Bernier PM. (2019). Rewards interact with repetition-dependent learning to enhance long-termretention of motor memories. Annals of the New York Academy of Sciences (IF: 4.78) X (X), 1-18. (Article publié).
  • Lacroix A*, Hamel R*, Proulx-Bégin L*, De Beaumont L, Bernier PM, Lepage JF. (2019). Static magnetic stimulation of the primary motor cortex impairs motor learning. Scientific Reports (IF: 4.53) 9 (1), 9886. (Article publié).
  • Chromik LC, Quintin EM, Hurst K, Lepage JF, Reiss AL. (2019). The influence of hyperactivity, impulsivity, and attention problems on social functioning in adolescents and young adults with fragile X syndrome. Journal of Attention Disorders (IF: 3.8) 23 (2), 181-188. (Article publié).
  • Trémolière B, Maheux-Caron V*, Lepage JF, Blanchette I. (2018). TDCS stimulation of the dlPFC partlymoderates the detrimental impact of emotion on analytical reasoning. Frontiers in Psychology (IF: 2.87) X (9), 568. (Article publié).
  • Lortie M, Proulx-Bégin L*, Saint-Amour D, Cousineau D, Théoret H, Lepage JF. (2017). Biological sound processing in children with autism spectrum disorder. Journal of Autism and Developmental Disorders (IF: 3.5) 47 (6), 1904-1909. (Article publié).
  • Lafleur LP,* Tremblay S, Whittingstall K, Lepage JF. (2016). Assessment of effective connectivity and plasticity with dual-coil transcranial magnetic stimulation. Brain Stimulation (IF: 6.1) 9 (3), 347-55. (Article publié).
  • Beaulé V, Tremblay S, Lafleur LP*, Ferland MC, Lepage JF, Théoret H. (2016). Modulation of physiological mirror activity with transcranial direct current stimulation over dorsal premotor cortex. European Journal of Neuroscience (IF: 3.2) 44 (9), 2730-2734. (Article publié).
  • Morin-Parent F*, De Beaumont L, Théoret H, Lepage JF. (2016). Superior non-specific motor learning in the blind. Scientific Reports-Nature Publishing Group (IF: 5.2) 7 (1), 6003. (Article accepté).
  • Tremblay S, Larochelle FB, Lafleur LP*, El Mouderrib S, Lepage JF, Théoret H. (2016). Systematic assessment of duration and intensity of anodal tDCS on primary motor cortex excitability. European Journal of Neuroscience (IF:3.2) 44 (5), 2184-90. (Article publié).
  • Beaulé V, Tremblay S, Lafleur LP,* Tremblay S, Lassonde M, Lepage JF, Théoret H. (2015). Cortical thickness and tractography in adults with agenesis of the corpus callosum. Neuropsychologia (IF: 3.3) 77 359-365. (Article publié).
  • Bernier M, Gauvreau C*, Thériault D, Madrolle S, Lepage JF, Whittingstall K. (2015). Increased BOLD Activation in Left Parahippocampal Cortex after One Year of MedicalSchool: an Association with Cumulative Verbal Memory Learning. Neuroreport (IF:1.6) 27 (1), 45-49. (Article publié).
  • Bravo G, Pojet AB, Fernandes B, Villamar M, Luque L, Lepage JF, Stafford D, Fregni F, Butler MG. (2015). Transcranial Direct Current Stimulation Reduces Food-Craving and Hyperphagia Behavior inParticipants with Prader-Willi Syndrome and Non-syndromic Obesity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics (IF: 3.4) 171 (2), 266-75. (Article publié).
  • Morin-Moncet O, Beaumont V, De Beaumont L, Lepage JF, Théoret H. (2014). BDNF Val66 Met polymorphism is associated with abnormal interhemispheric transfer of a newly acquired motor skill. Journal of Neurophysiology (IF: 2.9) 111 (10), 2094. (Article publié).
  • Lepage JF, Hong DS, Raman M, Marzelli M, Roeltgen D, Song L, Ross J, Reiss AL. (2014). Brain morphology in children with 47,XYY syndrome: a voxel- and surface-based morphometric study. Genes, Brain and Behavior (IF: 3.6) 13 (2), 127. (Article publié).
  • Lepage JF, Clouchoux C, Lassonde M, Evans AC, Deal CL, Théoret H. (2014). Cortical correlates of socioemotional difficulties in Turner Syndrome. Psychoneuroendocrinology (IF: 4.9) 44 30. (Article publié).
  • Lepage JF, Lortie M, Deal C, Lassonde M, Théoret H. (2014). Empathy, autistic traits, and motor resonance in Turner syndrome. Social Neuroscience (IF: 2.6) 9 (6), 601. (Article publié).
  • Hong D, Hoeft F, Marzelli M, Lepage JF, Roeltgen D, Ross J, Reiss AL. (2014). Influence of the X-chromosome on brain development: evidence from Turner and Klinefelter syndromes. Journal of Neuroscience (IF: 6.7) 4 (10), 3509. (Article publié).
  • Saggar M, Shely EW, Lepage JF, Hoeft F, Reiss AL. (2014). Revealing the neural networks associated with processing of natural social interaction and the related effects of actor-orientation and face-visibility. NeuroImage (IF: 6.3) 84 648. (Article publié).
  • Landry S, Shiller D, Lepage JF, Théoret H, Champoux F. (2014). Sound imagery forces motor action. Neuroreport (IF:1.6) 26 (3), 101-06. (Article publié).
  • Tremblay S, Lepage JF, Latulipe-Loiselle A, Fregni F, Pascual-Leone A, Théoret H. (2014). The uncertain outcome of prefrontal tDCS. Brain Stimulation (IF:4.8) 7 (6), 773-83. (Article publié).
  • Tremblay S, Beaulé V, Lepage JF, Théoret H. (2013). Anodal transcranial direct current stimulation modulates GABAB-related intracortical inhibition in M1 in healthy subjects. Neuroreport (IF:1.6) 24 (1), 46. (Article publié).
  • Lepage JF , Mazaika PK , Hong DS , Raman M , Reiss AL. (2013). Cortical Brain Morphology in Young, Estrogen-Naive, and Adolescent, Estrogen-Treated Girls with Turner Syndrome. Cerebral Cortex (IF: 8.3) 23 (9), 2159-68. (Article publié).
  • Lepage JF, Clouchoux C, Lassonde M, Evans AC, Deal CL, Théoret H. (2013). Cortical thickness is associated with cortical excitability in X-monosomy. Human Brain Mapping (IF: 6.9) 34 (4), 936-44. (Article publié).
  • Lepage JF, Hong DS, Mazaika P, Raman M, Sheau K, Marzelli M, Hallmayer J, Reiss AL. (2013). Genomic imprinting effects of the X-chromosome on brain morphology. Journal of Neuroscience (IF: 6.7) 33 (19), 8567. (Article publié).
  • Désy M, Lepage JF. (2013). Skin color has no impact on motor resonance: evidence from mu rhythm suppression and imitation. Neuroscience Research (IF: 2.1) 77 (1), 58. (Article publié).
  • Lepage JF, Hong DS , Hallmayer J , Reiss AL. (2012). Genomic imprinting effects on cognitive and social abilities in prepubertal girls with Turner syndrome. The Journal of Clinical Endocrinology and Metabolism (IF: 6.4) 97 (3), 460-64. (Article publié).
  • Lepage JF, Dunkin B , Hong DS , Reiss AL. (2012). Impact of cognitive profile on social functioning in prepubescent females with Turner syndrome. Child Neuropsychology (IF: 2.2) 19 (2), 161-72. (Article publié).
  • Lepage JF , Beaulé V , Srour M , Rouleau G , Pascual-Leone A , Lassonde M , Théoret H. (2012). Neurophysiological investigation of congenital mirror movements in a patient with agenesis of the corpus callosum. Brain stimulation (IF:4.8) 5 (2), 137-40. (Article publié).
  • Lepage JF, Morin-Moncet O , Beaulé V , de Beaumont L , Champoux F , Théoret H. (2012). Occlusion of LTP-Like Plasticity in Human Primary Motor Cortex by Action Observation. PloS One (IF: 3.7) 7 (6), e38754. (Article publié).
  • Lepage JF , Dunkin B , Hong DS , Reiss AL. (2011). Contribution of executive functions to visuospatial difficulties in prepubertal girls with Turner syndrome. Developmental Neuropsychology (IF: 2.5) 36 (8), 988-1002. (Article publié).
  • Lepage JF , Tremblay S , Nguyen DK , Champoux F , Lassonde M , Théoret H. (2010). Action related sounds induce early and late modulations of motor cortex activity. Neuroreport (IF: 1.8) 21 (4), (Article publié).
  • Lepage JF , Théoret H. (2010). Brain connectivity: finding a cause. Current Biology (IF: 10.0) 20 (2), (Article publié).
  • de Guise E , Lepage JF , Tinawi S , LeBlanc J , Dagher J , Lamoureux J , Feyz M. (2010). Comprehensive clinical picture of patients with complicated vs uncomplicated mild traumatic brain injury. The Clinical Neuropsychologist (IF: 2.0) 24 (7), (Article publié).
  • Lepage JF , Tremblay S , Théoret H. (2010). Early non-specific modulation of corticospinal excitability during action observation. The European Journal of Neuroscience (IF: 3.6) 31 (5), (Article publié).
  • Lepage JF , Théoret H. (2010). Numerical processing: stimulating numbers. Current Biology (IF: 10.0) 20 (22), (Article publié).
  • Perreault R, Lepage JF, Théoret H. (2009). Motor resonance and empathy in children. Cognition Brain and Behavior 13 (4), 415-428. (Article publié).
  • Lepage JF, Lortie M, Taschereau-Dumouchel V, Théoret H. (2009). Validation of French-Canadian versions of the Empathy Quotient and Autism Spectrum Quotient. Canadian Journal of Behavioral Science 41 (4), 272-276. (Article publié).
  • Lepage JF , Lortie M , Champoux F. (2008). Action-coding neurons in primary motor cortex: making sense of M1 activity during action perception. The Journal of Neuroscience (IF: 7.4) 28 (9), (Article publié).
  • Lepage JF , Saint-Amour D , Théoret H. (2008). EEG and neuronavigated single-pulse TMS in the study of the observation/execution matching system: are both techniques measuring the same process?. Journal of Neuroscience Methods (IF: 2.0) 175 (1), (Article publié).
  • Lepage JF , Théoret H. (2007). The mirror neuron system: grasping others' actions from birth?. Developmental Science (IF: 3.2) 10 (5), (Article publié).
  • Fecteau S , Lepage JF , Théoret H. (2006). Autism spectrum disorder: seeing is not understanding. Current Biology (IF:10) 16 (4), (Article publié).
  • Lepage JF , Théoret H. (2006). EEG evidence for the presence of an action observation-execution matching system in children. The European journal of neuroscience (IF: 4.3) 23 (9), (Article publié).

Livres

  • Champoux F, Lepage JF, Désy MC, Lortie M, Théoret H. (2008). The neurophysiology of early motor resonance, in Mirror Neuron Systems. (Springer, Mirror Neuron System). États-Unis d'Amérique : Humana Press. (Article publié).

Articles de conférence

  • Lafleur LP*, Klees-Themens G, Lefebvre G, Lepage JF, Théoret H. (2017). Connectivity and interhemispheric inhibition between motor cortices: a study with transcranial alternating current stimulation. International Brain Stimulation Conference. (Article publié).
  • Morin-Parent F*, Champigny C, Corbin F, Lepage JF. (2017). Excitation/inhibitionimbalance in humans with Fragile-x syndrome. Society for Neuroscience. (Article publié).
  • Akremi H*, Corriveau H, Camden C, Lepage JF. (2017). La stimulation à courant direct pour améliorer l’apprentissage moteur chezl’enfant avec le TAC. 25e Journée Scientifique du CERNEC. (Article publié).
  • Morin-Parent F*, Champigny C, Corbin F, Lepage JF. (2017). Neurophysiological markers of response to a combined treatment of minocycline and lovastatin in patients with Fragile-X syndrome. 18th International Fragile X and Related Neurodevelopmental Disorders Workshop. (Article publié).
  • Cote S*, Butler R, Lepage JF, Mendrek A, Whittingstall K. (2017). Sex Differences in Stimulus Induced Blood Flow: The Importance of Sex Hormones. ISMRM-ESMRMB. (Article soumis).
  • Lacroix A*, Proulx-Bégin L*, Morin-Parent F*, Lepage JF. (2017). Static magnetic stimulation alters motor learning in humans. Society for Neuroscience. (Article publié).
  • Akremi H*, Lepage JF, Corriveau H, Camden C. (2017). TDCS improves motor learning in children with developmental coordination disorder. Provincial Meeting for Mother-Child Research. (Article publié).
  • Frasnelli J, Sufren S, Sauerwein CH, Lassonde M, Lepage JF. (2016). Odor Localization in the Absence of the Corpus Callosum. Ass. Chemoreception Science. (Article accepté).
  • Hong DS, Hoeft F, Lepage JF, Ross J, Reiss AL. (2013). Sex chromosome dosage effects in temporal lobe anatomy. Society for Neuroscience. (Article publié).
  • Hong DS, Lepage JF, Mazaika PK, Raman M, Reiss A. (2012). Developmental trajectories of cortical thickness in X-monosomy. Society for Neuroscience. (Article accepté).
  • Saggar M, Lepage JF, Quintin EM, Walter E, Reiss AL. (2012). Effect of sociality, body orientation, and face visibility on brain activity in individuals with Fragile-X syndrome, developmentally delayed, and healthy adults: A novel paradigm. Society for Neuroscience. (Article accepté).
  • Lepage JF, Hong DS, Mazaika PK, Raman M, Sheau K, Marzelli MJ, Hallmayer J, Reiss A. (2012). Genomic imprinting effects of the X chromosome on brain morphology. Society for Neuroscience. (Article accepté).
  • Chromik LC, Quintin EM, Lepage JF, Reiss AL. (2012). Influence of hyperactivity, impulsivity, and attention problems on social skills in adolescents and young adults with Fragile X syndrome. International Fragile X Conference. (Article publié).
  • Quintin EM, Chen K, Walter E, Hoeft F, Lepage JF, Patnaik S, Reiss AL. (2011). Neural correlates of executive dysfunctions in Fragile X syndrome and Turner syndrome. Society for Neuroscience. (Article publié).
  • Lepage JF, Patnaik S, Walter E, Quintin EM, Chen K, Hoeft F, Reiss AL. (2011). Neural correlates of familiarity for faces in females with Fragile X syndrome. Society for Neuroscience. (Article publié).
  • Beaulé V, Lepage JF, Srour M, Rouleau G, Pascual-Leone A, Lassonde M, Théoret H. (2011). Neurophysiological investigation of congenital mirror movements in DCC mutation carriers. OHBM. (Article publié).
  • Morin-Moncet O, Lepage JF, De Beaumont L, Théoret H. (2011). Occlusion of long-term potentiation from action observation: neurophysiology and genetics. 19e Journées Scientifique du CERNEC. (Article publié).
  • Désy MC, Lepage JF, Théoret H. (2011). The effect of physical similarity on motor resonance mechanisms: a behavioral and electrophysiological study. International Brain Research Organization (IBRO). (Article publié).
  • Lepage JF, Lassonde, M., Deal C, Evans A, Théoret H. (2010). Neuroanatomic correlates of socioemotional dysfunctions in Turner Syndrome. Society for Neuroscience. (Article publié).
  • Côté S*, Buttler R, Whittingstall K, Lepage JF. Cerebral blood-flow and paired-pulse TMS. BrainBox Initiative Conference.
  • Côté S*, Buttler R, Richard MA, Mendrek A, Lepage JF, Whittingstall K. Characterizationof menstrual cycle related changes in cerebral blood flow. OHBM.
  • Lacroix A*, Morin-Parent F*, Champigny C, Corbin F, Lepage JF. Combinedinterventions of minocycline and lovastatin correct GABAergic inhibition inpatients. Society for Neuroscience.
  • Paré M*, Lepage JF, Savoie A. Effects of a multimodal intervention on language in children at risk of neurodevelopmental disorder. Neuroscience and Education Meeting.
  • Mabika M*, Lacroix A*, Proteau-Lemieux M*, Maurice P, Corbin F, Lepage JF. Glutamate and GABA in Fragile-X syndrome and Neurofibromatosis type 1. Society for Neuroscience.
  • Paré M*, Lepage JF, Savoie A. Languageacquisition in children participating in a multimodal stimulation project. Colloque Europeen Translationel.
  • Morin-Parent F*, Champigny C, Corbin F, Lepage JF. Neurophysiologicalmarkers of response to a combined treatment of minocycline and lovastatin in patientswith Fragile-X syndrome. 18th International Fragile X and Related Neurodevelopmental Disorders Workshop.
  • Lacroix A*, Corbin F, Maurice P, Lepage JF. Neurophysiology of type 1 neurofibromatosis and fragile-x syndrome. Societé Québécoise de recherche en psychologie.
  • Mabika M*, Russel M, Côté S, Lepage JF. Prize winning)A non-invasive combination to investigate themechanisms of visual information processing (. Bishop's University Scientific Day.
  • Côté S*, Butler R, Richard MA, Mendrek A, Lepage JF, Whittingstall K. Progesterone,not estrogen, modulates cerebral blood flow across the menstrual cycle. ISMRM.
  • Loudghi A*, Morin-Parent F*, Champigny C, Corbin F, Lepage JF. Restingstate fMRI in Fragile-X syndrome: preliminary results from the LOVAmix clinicaltrial. Society for Neuroscience.
  • Hamel R*, Côté K*, Matte A*, Lepage JF, Bernier PM. Rewards undermine facilitating effects of practice on performance and retention. Canadian Society for Psychomotor Learning and Sport Psychology (SCAPPS).
  • Cote S*, Butler R, Lepage JF, Mendrek A, Whittingstall K. SexDifferences in Stimulus Induced Blood Flow: The Importance of Sex Hormones. ISMRM-ESMRMB.
  • Proteau-Lemieux M*, Lacroix A*, Morin-Parent F*, Champigny C, Corbin F, Lepage JF. The LOVAmix clinical trial: results from transcranial magnetic stimulation. SQRP.
  • Côté S, Lepage JF, Whittingstall K. Time of flight MRA derived probabilistic map of each major cerebral artery. Organization of Human Brain Mapping (OHBM).

Autres contributions

Cours enseignés

  • Practicum in clinical neuropsychology. PSY 7487. (2010-01-05 à 2010-05-21).Université de Montréal. Canada. (6CR).
  • Social Psychology. PSY 1075B. (2009-09-09 à 2009-12-11).Université de Montréal. Canada. (3CR).
  • Neuropsychological Assessment. PSY 7414. (2005-09-06 à 2007-12-06).Université de Montréal. Canada. (3CR).
  • Human Neuropsychology. PSY 3032. (2005-01-05 à 2009-04-17).Université de Montréal. Canada. (3CR).

Gestion d'évènements

  • Organisateur. (2016) 24th Annual CERNEC Scientific Retreat. (Conférence).
  • Co-Organisateur. (2015) Fragile-X syndrome symposium. (Conférence).

Présentations

  • (2019). Convergent evidence of GABA alterations in Fragile-X syndrome: a combined TMS/MRS study. MIND Institute Conference. États-Unis d'Amérique
  • (2019). GABA functions in autism: evidence from neurogenetic disorders. Conferences of NeuroQAM, Université du Québec à Montréal. Canada
  • (2019). Neurophysiology of sex chromosome aneuploidies. Annual Meeting of the Cytogenetics Association. Canada
  • (2019). The GABA system in Fragile-x syndrome: from animal models to clinical trials. Stanford University, Division of Interdisciplinary and Brain Sciences, California. États-Unis d'Amérique
  • (2018). TMS in translational research: the case of Fragile-x syndrome. BrainBox Initiative Workshop, University College London, Institute of Neurology. Royaume-Uni
  • Morin-Parent F, Champigny C, Corbin F, Lepage JF. (2017). Excitation/inhibition imbalance in humans with Fragile-x syndrome. Society for Neuroscience. Washington, États-Unis d'Amérique
  • Akremi H, Lepage JF, Dupont-Gauthier M, Fournier F, Lapierre-Fortin M, Laroche A, Turcotte M, Corriveau H, Camden C. (2017). Feasability of using non-invasive brain stimulation to improve motor learning in children with developmental coordination disorder: Results from a pilot RCT. World Confederation for Physical Therapy Congress. Johannesburg, Afrique du Sud, République d'
  • Lepage JF. (2017). La prise de risque et le cerveau adolescent,. Conférence invitée. Québec, Canada
  • Morin-Parent F, De Beaumont L, Théoret H, Lepage JF. (2017). Motor learning in the blind. 25th CERNEC Scientific Meeting. Saint-Sauver, Canada
  • (2017). Neurophysiology and neuropsychology of Fragile-X syndrome. CERNEC Conferences. Montréal, Canada
  • (2016). Clinical phenotypes of Turner syndrome: from epigenetics to hormonal factors. Pediatrics Grand Rounds, CHUS Fleurimont. Sherbrooke, Canada
  • (2016). Transcranial magnetic stimulation in the treatment of antenatal depression. Obstetrics and Gynaecology Dept. Scientific Day. Sherbrooke, Canada
  • (2015). Les aneuploidies sexuelles comme modèles pour étudier l’impact des chromosomes X et Y sur le développement du cerveau. CÉAMS' Scientific Conference. Montréal, Canada
  • (2015). Le syndrome de Turner chez l'enfant: forces et défis. Association du Syndrome de Turner du Québec. Sherbrooke, Canada
  • Cheri L. Deal. (2014). Cognitive rehabilitation in Turner syndrome : what can we learn from neuroanatomy?. 33rd Annual Turner Syndrome Society of Canada Conference. Montréal, Canada
  • (2014). Les modèles génétiques dans l’étude du dimorphisme sexuel cerebral: par delà les chromosomes sexuels. Département de psychologie, Université du Québec à Trois-Rivières. Trois-Rivières, Canada
  • (2014). Voir le développement du cerveau humain au travers des syndrome génétiques. CHU de l’Université de Sherbrooke. Sherbrooke, Canada
  • (2013). Empreinte génétique au sein du syndrome de Turner : effets sur la cognition, la neuroanatomie et la neurophysiologie. Centre de Recherche en Neuropsychologie et Cognition (CERNEC), Université de Montréal. Montréal, Canada
  • (2010). TMS investigation of motor neurophysiology in Turner Syndrome. The Fourth International Conference on Cognitive Science. Tomsk, Russie, Fédération de