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Alain Frigon

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Présentation

Sujet de recherche

Activité locomotrice / troubles du mouvement, Animal, Hémiplégie et paraplégie, Lésions musculosquelettiques et réparations, Maladies de la moelle épinière, Plasticité / régénération neuronale, Système moteur, Système musculaire, Système somato-sensoriel, Trauma/blessures

Disciplines de recherche

Biologie et autres sciences connexes, Kinésiologie, Neurosciences, Physiologie

Mots-clés

biomécanique, électromyographie, électrophysiologie, lésions spinales, locomotion, neurophysiologie, réflexe

Intérêts de recherche

Pendant la prochaine années, mes études tenteront d'élucider les mécanismes impliqués dans la reconfiguration de la circuiterie de la moelle épinière avec des agonistes noradrénergique et sérotoninergique chez le chat chronique spinale.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(2011). (Post-doctorat, Postdoctorat). Northwestern University.

(2009). (Post-doctorat, Postdoctorat). Université de Montréal.

(2008). (Doctorat, Ph.D.). Université de Montréal.

(2003). (Maîtrise avec mémoire, MSc - Maîtrise). University of Alberta.

(2001). (Baccalauréat, BSc (honours)). University of Western Ontario.

Prix et distinctions

  • (2019) New Investigator Award. Instituts de recherche en santé du Canada. (Prix / Récompense).
  • (2016) Chercheur-boursier Junior 1. (Prix / Récompense).
  • (2012) Postdoctoral fellowship. Instituts de recherche en santé du Canada. (Prix / Récompense).
  • (2010) Posdoctoral fellowship (declined). Conseil de recherches en sciences naturelles et en génie (CRSNG). (Prix / Récompense).
  • (2009) Postdoctoral fellowship. (Prix / Récompense).
  • (2007) Predoctoral scholarship. (Prix / Récompense).
  • (2006) Predoctoral scholarship. Conseil de recherches en sciences naturelles et en génie (CRSNG). (Prix / Récompense).
  • Best PhD thesis. Université de Montréal. (Prix / Récompense).
  • Beverly Petterson Bishop Award for Excellence in Neuroscience. (Prix / Récompense).
  • Editorial Board Member - Journal of Neurophysiology. (Distinction).
  • Most oustanding postdoctoral candidate in the Life Sciences and Psychology category. Conseil de recherches en sciences naturelles et en génie (CRSNG). (Distinction).
  • New investigator award. (Prix / Récompense).
  • Postdoctoral Trainee Travel Award. (Prix / Récompense).
  • Promising Young Scientist Award. (Prix / Récompense).
  • Scholarship of Excellence. Université de Montréal. (Prix / Récompense).
  • Scholarship of excellence. Université de Montréal. (Prix / Récompense).
  • Scholarship of excellence. Université de Montréal. (Prix / Récompense).
  • Star Reviewer - Journal of Neurophysiology. (Distinction).
  • Tomas Reader Prize for Spinal Cord Research. (Prix / Récompense).

Publications

Articles de revue

  • Thibaudier Y, Hurteau MF, Dambreville C, Chraibi A, Goetz L and Frigon A. (2015). Shaping and quantifying interlimb coordinationduring locomotion after an incomplete spinal cord injury. Journal of Neuroscience (Article soumis).
  • Zehr EP, Barss TS, Dragert K, Frigon A, Vasudevan EV, Haridas C, Hundza S, Kaupp C, Klarner T, Klimstra M, Komiyama T, Loadman PM, Mezzarane R, Nakajima T, Pearcey GEP, Sun Y. (2015). Neuromechanical interactions between the limbs during human locomotion - an evolutionary perspective and translation to rehabilitation. Experimental Brain Research (Article soumis).
  • Dambreville C, Labarre A, Thibaudier Y, Hurteau M-F and Frigon A. (2015). The spinal control of locomotion and step-to-step variability in left-right symmetry from slow tomoderate speeds. Journal of Neurophysiology 114 (2), 1119-1128. (Article publié).
  • Frigon A, Thibaudier Y, Hurteau M-F, Dambreville C, Telonio A, and Kuczynski V. (2015). Adaptive capacity for left-right coordination during locomotion by the adult mammalian spinal cord. Journal of Physiology tbd tbd. (Révisions requises).
  • Frigon A, Thibaudier Y, Hurteau MF. (2015). Modulation of forelimb and hindlimb muscle activity during quadrupedal tied-belt and split-belt locomotion in intact cats. Neuroscience 290C 266-278. (Article publié).
  • Hurteau MF, Thibaudier Y, Dambreville C, Desaulniers C, Frigon A. (2014). Effect of stimulating the lumbar skin caudal to a complete spinal cord injury on hindlimb locomotion. Journal of Neurophysiology 113 (2), 669-676. (Article publié).
  • D'Angelo G, Thibaudier Y, Telonio A, Hurteau MF, Kuczynski V, Dambreville C, and Frigon A. (2014). Modulation of phase durations, phase variations and temporal coordination of the four limbs during quadrupedal split-belt locomotion in intact adult cats. Journal of Neurophysiology 112 (8), 1825-1837. (Article publié).
  • Frigon A. (2014). Responders and non-responders in motor control research: a framework to study physiological mechanisms of inter-individual variability. Clinical Neurophysiology 126 (7), 1284-1285. (Article publié).
  • Thibaudier Y and Frigon A. (2014). Spatiotemporal control of interlimb coordination during transverse split-belt locomotion with 1:1 or 2:1 coupling patterns in intact adult cats. Journal of Neurophysiology 112 (8), 2006-2018. (Article publié).
  • Frigon A, D'Angelo G, Thibaudier Y, Hurteau MF, Telonio A, Kuczynski V, and Dambreville C. (2014). Speed-dependent modulation of phase variations on a step-by-step basis and its impact on the consistency of interlimb coordination during quadrupedal locomotion in intact adult cats. Journal of Neurophysiology 111 (9), 1885-1902. (Article publié).
  • Thibaudier Y , Hurteau MF , Telonio A , Frigon A. (2013). Coordination between the fore- and hindlimbs is bidirectional, asymmetrically organized, and flexible during quadrupedal locomotion in the intact adult cat. Neuroscience 240 13-26. (Article publié).
  • Sirois J , Frigon A , Gossard JP. (2013). Independent Control of Presynaptic Inhibition by Reticulospinal and Sensory Inputs at Rest and during Rhythmic Activities in the Cat. The Journal of neuroscience : the official journal of the Society for Neuroscience 33 (18), 8055-8067. (Article publié).
  • Frigon A , Hurteau MF , Thibaudier Y , Leblond H , Telonio A , D'Angelo G. (2013). Split-Belt Walking Alters the Relationship between Locomotor Phases and Cycle Duration across Speeds in Intact and Chronic Spinalized Adult Cats. The Journal of neuroscience : the official journal of the Society for Neuroscience 33 (19), 8559-8566. (Article publié).
  • Frigon A , Hurteau MF , Johnson MD , Heckman CJ , Telonio A , Thibaudier Y. (2012). Synchronous and asynchronous electrically evoked motor activities during wind-up stimulation are differentially modulated following an acute spinal transection. Journal of neurophysiology 108 (12), 3322-3332. (Article publié).
  • Slawinska U , Rossignol S , Bennett DJ , Schmidt BJ , Frigon A , Fouad K , Jordan LM. (2012). Comment on "Restoring voluntary control of locomotion after paralyzing spinal cord injury". Science (New York, N.Y.) 338 (6105), 328. (Article publié).
  • Frigon A , Thibaudier Y , Johnson MD , Heckman CJ , Hurteau MF. (2012). Cutaneous inputs from the back abolish locomotor-like activity and reduce spastic-like activity in the adult cat following complete spinal cord injury. Experimental neurology 235 (2), 588-598. (Article publié).
  • Frigon A. (2012). Central pattern generators of the mammalian spinal cord. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 18 (1), 56-69. (Article publié).
  • Frigon A , Johnson MD , Heckman CJ. (2012). Differential modulation of crossed and uncrossed reflex pathways by clonidine in adult cats following complete spinal cord injury. The Journal of physiology 590 (Pt 4), 973-989. (Article publié).
  • Frigon A , Johnson MD , Heckman CJ. (2011). Altered activation patterns by triceps surae stretch reflex pathways in acute and chronic spinal cord injury. Journal of neurophysiology 106 (4), 1669-1678. (Article publié).
  • Frigon A , Thompson CK , Johnson MD , Manuel M , Hornby TG , Heckman CJ. (2011). Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats. The Journal of neuroscience : the official journal of the Society for Neuroscience 31 (15), 5579-5588. (Article publié).
  • Gossard JP , Sirois J , Noué P , Côté MP , Ménard A , Leblond H , Frigon A. (2011). Chapter 2--the spinal generation of phases and cycle duration. Progress in brain research 188 15-29. (Article publié).
  • Frigon A. (2011). Chapter 7--interindividual variability and its implications for locomotor adaptation following peripheral nerve and/or spinal cord injury. Progress in brain research 188 101-118. (Article publié).
  • Rossignol S , Frigon A , Barrière G , Martinez M , Barthélemy D , Bouyer L , Bélanger M , Provencher J , Chau C , Brustein E , Barbeau H , Giroux N , Marcoux J , Langlet C , Alluin O. (2011). Chapter 16--spinal plasticity in the recovery of locomotion. Progress in brain research 188 229-241. (Article publié).
  • Rossignol S , Frigon A. (2011). Recovery of locomotion after spinal cord injury: some facts and mechanisms. Annual review of neuroscience 34 413-440. (Article publié).
  • Barrière G , Frigon A , Leblond H , Provencher J , Rossignol S. (2010). Dual spinal lesion paradigm in the cat: evolution of the kinematic locomotor pattern. Journal of neurophysiology 104 (2), 1119-1133. (Article publié).
  • Lungu O , Frigon A , Piché M , Rainville P , Rossignol S , Doyon J. (2010). Changes in spinal reflex excitability associated with motor sequence learning. Journal of neurophysiology 103 (5), 2675-2683. (Article publié).
  • Frigon A , Gossard JP. (2010). Evidence for specialized rhythm-generating mechanisms in the adult mammalian spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience 30 (20), 7061-7071. (Article publié).
  • Frigon A , Sirois J , Gossard JP. (2010). Effects of ankle and hip muscle afferent inputs on rhythm generation during fictive locomotion. Journal of neurophysiology 103 (3), 1591-1605. (Article publié).
  • Frigon A , Barrière G , Leblond H , Rossignol S. (2009). Asymmetric changes in cutaneous reflexes after a partial spinal lesion and retention following spinalization during locomotion in the cat. Journal of neurophysiology 102 (5), 2667-2080. (Article publié).
  • Frigon A , Gossard JP. (2009). Asymmetric control of cycle period by the spinal locomotor rhythm generator in the adult cat. The Journal of physiology 587 (Pt 19), 4617-4628. (Article publié).
  • Frigon A. (2009). Reconfiguration of the spinal interneuronal network during locomotion in vertebrates. Journal of neurophysiology 101 (5), 2201-2203. (Article publié).
  • Rossignol S , Barrière G , Alluin O , Frigon A. (2009). Re-expression of locomotor function after partial spinal cord injury. Physiology (Bethesda, Md.) 24 127-139. (Article publié).
  • Frigon A , Rossignol S. (2009). Partial denervation of ankle extensors prior to spinalization in cats impacts the expression of locomotion and the phasic modulation of reflexes. Neuroscience 158 (4), 1675-1690. (Article publié).
  • Frigon A , Rossignol S. (2008). Locomotor and reflex adaptation after partial denervation of ankle extensors in chronic spinal cats. Journal of neurophysiology 100 (3), 1513-1522. (Article publié).
  • Frigon A , Rossignol S. (2008). Adaptive changes of the locomotor pattern and cutaneous reflexes during locomotion studied in the same cats before and after spinalization. The Journal of physiology 586 (Pt 12), 2927-2945. (Article publié).
  • Frigon A , Yakovenko S , Gritsenko V , Tremblay ME , Barrière G. (2008). Strengthening corticospinal connections with chronic electrical stimulation after injury. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 (13), 3262-3263. (Article publié).
  • Frigon A , Rossignol S. (2008). Short-latency crossed inhibitory responses in extensor muscles during locomotion in the cat. Journal of neurophysiology 99 (2), 989-998. (Article publié).
  • Rossignol S , Barrière G , Frigon A , Barthélemy D , Bouyer L , Provencher J , Leblond H , Bernard G. (2008). Plasticity of locomotor sensorimotor interactions after peripheral and/or spinal lesions. Brain research reviews 57 (1), 228-240. (Article publié).
  • Frigon A , Rossignol S. (2007). Plasticity of reflexes from the foot during locomotion after denervating ankle extensors in intact cats. Journal of neurophysiology 98 (4), 2122-2132. (Article publié).
  • Frigon A , Carroll TJ , Jones KE , Zehr EP , Collins DF. (2007). Ankle position and voluntary contraction alter maximal M waves in soleus and tibialis anterior. Muscle & nerve 35 (6), 756-766. (Article publié).
  • Frigon A , Barrière G , Fénélon K , Yakovenko S. (2007). Conceptualizing the mammalian locomotor central pattern generator with modelling. The Journal of physiology 580 (Pt. 2), 363-364. (Article publié).
  • Frigon A , Rossignol S. (2006). Experiments and models of sensorimotor interactions during locomotion. Biological cybernetics 95 (6), 607-627. (Article publié).
  • Frigon A , Rossignol S. (2006). Functional plasticity following spinal cord lesions. Progress in brain research 157 231-260. (Article publié).
  • Zehr EP , Frigon A , Hoogenboom N , Collins DF. (2004). Facilitation of soleus H-reflex amplitude evoked by cutaneous nerve stimulation at the wrist is not suppressed by rhythmic arm movement. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 159 (3), 382-388. (Article publié).
  • Zehr EP , Carroll TJ , Chua R , Collins DF , Frigon A , Haridas C , Hundza SR , Thompson AK. (2004). Possible contributions of CPG activity to the control of rhythmic human arm movement. Canadian journal of physiology and pharmacology 82 (8-9), 556-568. (Article publié).
  • Frigon A , Collins DF , Zehr EP. (2004). Effect of rhythmic arm movement on reflexes in the legs: modulation of soleus H-reflexes and somatosensory conditioning. Journal of neurophysiology 91 (4), 1516-1523. (Article publié).
  • Zehr EP , Collins DF , Frigon A , Hoogenboom N. (2003). Neural control of rhythmic human arm movement: phase dependence and task modulation of hoffmann reflexes in forearm muscles. Journal of neurophysiology 89 (1), 12-21. (Article publié).

Chapitres de livre

  • Frigon A. (2013). The cat model of spinal cord injury. Animal Models of Spinal Cord Repair. (159-184). Humana Press. (Article publié).
  • Rossignol S, Frigon A. (2012). Spinal and supraspinal plasticity after spinal cord injury. Essentials of Spinal Cord Injury. (489-501). Thieme Publishers. (Article publié).

Articles de conférence

  • Hurteau MF, Thibaudier Y, Dambreville C, Kuczynski V and Frigon A. (2015). Ipsilateral and contralateral reflex modulation during tied-belt and split-belt locomotion in spinal-transected cats. Society for Neuroscience. (Article publié).
  • Kuczynski V, Thibaudier Y, Hurteau MF, Dambreville C, Telonio A and Frigon A. (2015). Lack of adaptation during prolonged split-belt locomotion in the intact and chronic spinal-transected adult cat. Society for Neuroscience. (Article publié).
  • Frigon A, Dambreville C, Thibaudier Y, Hurteau M-F, Kuczynski V and Rhodes E. (2015). Adaptive plasticity in the spinal control of left-right coordination during locomotion. The FASEB Journal, 656.9. (Article publié).
  • Hurteau M-F, Thibaudier Y, Dambreville C, Kuczynski V, Telonio A and Frigon A. (2014). Phasic modulation of cutaneous reflexes during split-belt locomotion in intact and chronic spinalized adult cats. Society for Neuroscience. (Article publié).
  • Thibaudier Y, Hurteau M-F, Dambreville C, Chraibi A, Telonio A and Frigon A. (2014). Spatiotemporal coordination during transverse split-belt locomotion in cats with bilateral serial hemisections of the spinal cord. Society for Neuroscience. (Article publié).
  • Dambreville C, Hurteau M-F, Thibaudier Y, Kuczynski V, Telonio A and Frigon A. (2014). The control of left-right coordination at slow locomotor speeds in chronic spinalized cats. Society for Neuroscience. (Article publié).
  • Frigon A, Thibaudier Y, Hurteau M-F, Telonio A, Dambreville C and Kuczynski V. (2014). The control of interlimb coordination during left-right and transverse split-belt locomotion in intact and spinal cord-injured cats. Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation. (Article publié).
  • D’Angelo G, Thibaudier Y, Hurteau M-F, Telonio A, Frigon A. (2013). Adjustments to split-belt locomotion before and after a lateral spinal hemisection in the adult cat. Society for Neuroscience. (Article publié).
  • Thibaudier Y, D’Angelo G, Hurteau M-F, Telonio A, and Frigon A. (2013). Adjustments to transverse split-belt locomotion in the adult cat before and after a lateral spinal hemisection. Society for Neuroscience. (Article publié).
  • Hurteau MF, Thibaudier Y, D’Angelo G, Telonio A, Frigon A. (2013). Modulation of the locomotor pattern and weight support by cutaneous stimulation of the lumbar back in chronic spinalized adult cats. Society for Neuroscience. (Article publié).
  • Frigon A, Dambreville C, Desaulniers C, Hurteau M-F, Thibaudier Y, D’Angelo G, Telonio A. (2013). Split-belt locomotion in chronic spinalized adult cats: Animal-to-animal variability in the functional dissociation of spinal locomotor networks. Society for Neuroscience. (Article publié).
  • Frigon A, Thibaudier Y, Hurteau MF, and Telonio A. (2013). Coordination between the fore- and hindlimbs is bidirectional, asymmetrically organized, and flexible during quadrupedal locomotion in the intact adult cat. International Society for Posture and Gait Research. (Article publié).
  • Frigon A, Hurteau MF, Thibaudier Y, and Telonio A. (2012). Split-belt walking reveals adaptive control of cycle duration by spinal locomotor patterns generators. Society for Neuroscience. (Article publié).
  • Thibaudier Y, Telonio A, Hurteau MF, and Frigon A. (2012). Transverse split-belt walking reveals an asymmetric adaptation of the fore- and hindlimbs during quadrupedal locomotion in the intact adult cat. Society for Neuroscience. (Article publié).
  • Frigon A, Johnson MD, and Heckman CJ. (2011). Altered activation patterns by triceps surae stretch reflex pathways in acute and chronic spinal cord injury. Society for Neuroscience. (Article publié).
  • Johnson MD, Frigon A, and Heckman CJ. (2011). Wind-up of reflex responses evoked by cutaneous nerve stimulation in acute and chronic spinal cord injury. Society for Neuroscience. (Article publié).
  • Stephens D, Frigon A, and Gluckman T. (2011). Peri-operative care and maintenance of paraplegic spinal cord-injured cats. American Association for Laboratory Animal Science. (Article publié).
  • Frigon A, and Gossard J-P. (2010). Intra-motoneuronal responses to hip and ankle muscle afferent stimulation during fictive locomotion in the cat. Society for Neuroscience. (Article publié).
  • Frigon A, Thompson CK, Heckman CJ, and Hornby TG. (2010). Joint angle-dependent modulation of plateau-like behaviour in human motoneurons. Society for Neuroscience. (Article publié).
  • Frigon A, Barrière G, Leblond H, Delivet-Mongrain H, and Rossignol S. (2009). Altered interactions between the spinal CPG and cutaneous reflexes parallel the recovery of hindlimb locomotion after lateral spinal hemisection. Society for Neuroscience. (Article publié).
  • Frigon A, Sirois J, and Gossard J-P. (2009). Different rhythm generators have specialized control mechanisms. Society for Neuroscience. (Article publié).
  • Sirois J, Frigon A, and Gossard J-P. (2009). Task-dependent primary afferent depolarization evoked by reticulospinal pathways in the cat. Society for Neuroscience. (Article publié).

Autres contributions

Cours enseignés

  • Hormones et système nerveux central. PHS 710. (2014-04-30).Université de Sherbrooke. Canada.
  • Pharmacologie du système nerveux. PHR 500. (2013-11-05).Université de Sherbrooke. Canada.
  • Physiologie des systèmes. PHS 708. (2013-09-04).Université de Sherbrooke. Canada.

Présentations

  • (2015). Adaptive capacity for left-right coordination during locomotion by the adult mammalian spinal cord. 8th SfN Satellite Symposium on Motor Systems. Chicago
  • (2015). Le contrôle de la coordination antéropostérieure pendant la marche après une lésion spinale partielle. Club de recherches cliniques du Québec. St-Alexis des Monts
  • (2015). Mécanismes de compensations neuromusculaires intrinsèques à la moelle épinière suite à une dénervation partielle des extenseurs de la cheville. 15e Journée de recherche du programme de résidence en orthopédie de Sherbrooke. Sherbrooke
  • (2015). Adaptive control of interlimb coordination during locomotion following spinal cord injury. University of Ottawa. Ottawa
  • (2015). The control of interlimb coordination during locomotion following spinal cord injury. Neuroscience, Cell Biology & Physiology Seminar. Dayton
  • (2015). Adaptive plasticity in the spinal control of left-right coordination during locomotion. Experimental Biology. Boston
  • (2014). Control and adaptation of interlimb coordination during locomotion by the adult mammalian spinal cord. Spinal Cord Plasticity in Motor Control. Washington
  • (2014). The neural control of interlimb coordination during locomotion and its recovery after spinal cord injury. The International Conference on NeuroRehabilitation. Aalborg
  • (2013). Spinal plasticity in the functional recovery of locomotion after an incomplete spinal cord injury: contributions and limitations. 15th International Symposium on Neural Regeneration. Pacific Grove
  • (2013). Le contrôle spinal de la coordination gauche-droite pendant la marche chez le chat adulte. 13e Journée de recherche du programme de résidence en orthopédie de Sherbrooke. Sherbrooke
  • (2013). The study of interlimb coordination during split-belt locomotion before and after spinal cord injury in the adult cat. International Society for Posture and Gait Research Meeting. Akita
  • (2013). Interlimb coordination during split-belt walking in the chronic spinalized adult cat. Will to win spinal cord symposium. Winnipeg
  • (2012). Pharmacological and sensory modulation of reflex and locomotor activity after complete spinal cord injury. Wings for Life Symposium. Salzburg
  • (2012). Functional changes in reflex pathways following spinal cord injury: pharmacological and somatosensory modulation. Wadsworth Center. Albany
  • (2011). La pharmacothérapie après une lésion de la moelle épinière pour promouvoir la récupération de fonctions motrices: drogues et mécanismes d’adaptations. Département de pharmacologie, Université de Sherbrooke. Sherbrooke
  • (2011). A new state of affairs: Understanding the new state of the spinal circuitry generated by pharmacotherapy after complete SCI. Wings for Life Symposium. Salzburg
  • (2011). Promouvoir la récupération de fonctions motrices chez les blessés médullaires: de la neurophysiologie fondamentale à la réadaptation en clinique. Centre des neurosciences de l’Université de Sherbrooke. Sherbrooke
  • (2011). Noradrenergic enhancement of spinal reflex excitability in the chronically injured spinal cord. Spinal cord research centre. University of Manitoba. Winnipeg
  • (2010). Circuiterie locomotrice de la moelle épinière: organisation et plasticité fonctionnelle avant et après une lésion spinale. Département de Physiologie et Biophysique, Université de Sherbrooke / Job talk. Sherbrooke
  • (2010). Re-expression of locomotion and reflex changes after various types of spinal lesions. Experimental Biology. Anaheim
  • (2009). Evidence for distinct rhythms generators within the mammalian spinal cord. Department of Physiology, Physical Medicine and Rehabilitation, Northwestern University / Job talk. Chicago
  • (2009). Sensorimotor interactions at the spinal level and their role in the recovery of locomotion after spinal cord injury. Brain Research Institute / Job talk. Zurich