Professeure, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire
(2016) Post-doctorate (Postdoctoral Fellowship). Ottawa Hospital Research Institute.
(2010) Doctorate (Ph.D. Thesis based). McGill University.
(2005) Diploma (Advanced Diploma in Applied Health Science). Michener Institute for Applied Health Sciences.
(2003) Bachelor's (Honours Bachelor's of Science). University of Toronto.
(2016) Assistant Professor. Université de Sherbrooke.
(2010-2016) Post-doctoral Fellow. Ottawa Hospital Research Institute.
(2015-2016) Research Associate. Ottawa Hospital Research Institute.
(2012) Lecturer - Innate Immunology. University of Ottawa.
(2005-2010) Ph.D. Candidate. McGill University.
(2009) Lecturer - Introductory Microbiology. McGill University.
(2009) Teaching Assistant - Introductory Microbiology. McGill University.
(2008) Teaching Assistant - Advanced Immunology. McGill University.
(2007) Teaching Assistant - Introductory Microbiology. McGill University.
(2007) Teaching Assistant - Biochemistry. McGill University.
(2006) Teaching Assistant - Introductory Microbiology. McGill University.
(2004-2005) Medical Lab Technologist. Michener Institute for Applied Health Sciences.
(2004) Medical Lab Technologist. Michener Institute for Applied Health Sciences.
Cell Therapy of Cancer, Host-Tumour Interaction, Immunotherapy, Vaccine and Cancer, Virus.
Immunology, Microbiology, Virology.
cancer immunology, cancer vaccines, immunotherapy, oncolytic viruses.
I propose to understand the mechanisms by which innate immune cells such as natural killer and myeloid regulatory cells modulate the tumor microenvironment and promote tumor metastases in the postoperative period. With this knowledge, I will target postoperative immune suppression with a rational combination of novel immunotherapies and standard-of-care treatments. This will be accomplished using in vivo mice tumor models of solid tumor (breast, bladder, pancreatic) and major surgery.
None
Anglais, Français
Grant. (Awarded). Co-investigator. Pioneering pre- and post-operative integrative care to improve thoracic cancer quality of care, the thoracic peri-operative integrative surgical care evaluation (POISE) trial.. Lotte & John Hecht Memorial Foundation. Clinical Research Grant. 3853888 $ (2014-2025).
Research Chair. (Awarded). Principal Applicant. CRMUS - Chair in Translational Immunotherapy Research. C.R.M.U.S. (Univ. Sherbrooke). CRMUS Research Chair. 240000 $ (2019-2024).
Grant. (Awarded). Principal Investigator. Targeting metastatic disease of triple negative breast cancer with an immunogenic cancer vaccine. Canadian Institutes of Health Research (CIHR). Project Grant. 703800 $ (2019-2024).
Grant. (Awarded). Principal Investigator. Cellular energetics in natural killer cell development and function. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant. 130000 $ (2017-2022).
Grant. (Awarded). Co-investigator. Pôle d’excellence en Neurosciences : Neuropôle. CRCHUS. Pole d'Excellence en Recherche au CRCHUS. 70000 $ (2019-2021).
Grant. (Awarded). Principal Applicant. CIHR New Investigator Award. Canadian Institutes of Health Research (CIHR). New Investigator Award. 300000 $ (2016-2021).
Grant. (Awarded). Co-investigator. Developing gastrointestinal tumor organoid microenvironment models for testing oncolytic viruses.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projet Structurant. 75000 $ (2019-2021).
Grant. (Awarded). Co-investigator. The Sherbrooke Personalized Cancer Avatar Model Initiative: A Feasibility Study of Treatment Guided by the Combination of DNA Profiling and Next-Generation Medical Avatars in Patients with Advanced Kidney Cancer.. MEDTEQ Consortium. Medteq. 703760 $ (2018-2021).
Grant. (Awarded). Co-investigator. Flipping the paradigm on organ transplants: a scientific multidisciplinary strategy combined with a patient-oriented approach study. Canadian Institutes of Health Research (CIHR). New Frontiers in Research Funds. 250000 $ (2019-2021).
Grant. (Awarded). Co-applicant. Montreal Immunology Meetings, Annual Meeting 2019. Canadian Institutes of Health Research (CIHR). Planning and dissemination grant. 10000 $ (2019-2020).
Grant. (Awarded). Co-applicant. Chronic Inflammation, Immunity and Cancer 2019. Canadian Institutes of Health Research (CIHR). Planning and dissemination grant. 15000 $ (2019-2020).
Grant. (Awarded). Principal Applicant. FRQS Chercheurs Boursiers, Junior 1. Fonds de recherche du Québec - Santé (FRQS). Chercheur Boursier, Junior 1. 246321 $ (2016-2020).
Grant. (Completed). Co-investigator. Effects of catecholamine therapy on the immune system: unsuspected consequences of routine medical interventions and opportunities for individualized care - the OVATION study.. Merck Sharp & Dohme Research Laboratory. Universite de Sherbrooke. 67000 $ (2017-2019).
Grant. (Awarded). Principal Investigator. FRQS Chercheurs Boursiers Junior 1, Fonds d'Etablissement. Fonds de recherche du Québec - Santé (FRQS). Fonds d'Etablissement. 60000 $ (2016-2019).
Grant. (Completed). Co-investigator. Epi-STORM, translational and multicentre study on the epigenetic regulation of the cytokine storm in organ donors on organ transplantation success.. CRCHUS. Projet Structurant. 75000 $ (2018-2019).
Grant. (Completed). Principal Investigator. Oncolytic vesicular stomatitis virus for the treatment of non-muscle invasive bladder cancer in humanized mice. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projet Structurant. 75000 $ (2017-2019).
Grant. (Completed). Principal Investigator. Preventing postoperative cancer metastasis through regulation of NKG2D/NKG2DL axis in natural killer cells. CRCHUS. PAFI Institutional grant. 25000 $ (2018-2019).
Grant. (Completed). Principal Investigator. Harnessing CRISPR/Cas9 technology for fundamental and translational cancer studies.. Universite de Sherbrooke, CRIODUS (Centre of Excellence). Technology development grant. 18000 $ (2018-2019).
Grant. (Completed). Co-investigator. Generation of an orthotopic murine model to study the role of genetic and microenvironmental factors in carcinogenesis of pancreatic cancer.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projet Structurant. 75000 $ (2016-2018).
Grant. (Completed). Co-investigator. Phase Ib trial of perioperative sildenafil and influenza vaccination in cancer patients undergoing laparotomy for surgical resection of a primary abdominal malignancy. CureAccelerator. Project Grant. 100000 $ (2016-2018).
Grant. (Completed). Co-investigator. The Sherbrooke personalized colorectal cancer avatar models initiative (COLOR project): a feasibility study of treatment guided by the combination of a living organoids biobank and personalized avatars in patients with advanced. Merck Sharp & Dohme Research Laboratory. Universite de Sherbrooke. 250000 $ (2016-2018).
Grant. (Completed). Principal Investigator. Preventing metastatic disease by boosting postoperative natural killer cell activity. Cancer Research Society (The). Scholarship for the Next Generation of Scientists. 160000 $ (2015-2018).
Grant. (Completed). Principal Investigator. Adjuvant immunogenic cancer vaccine to treat metastatic solid tumors.. Merck Sharp & Dohme Research Laboratory. Universite de Sherbrooke. 67000 $ (2017-2018).
Grant. (Completed). Co-investigator. Autotiss one semi-automatic tissue microarrayer. Centre de recherche du CHUS. Perc Internal Grant. 20000 $ (2017-2018).
Grant. (Completed). Principal Investigator. Preventing postoperative cancer metastasis through regulation of immune cell metabolism. Canada Foundation for Innovation (CFI). John R. Evans Leaders Fund. 750000 $ (2017-2018).
Grant. (Completed). Co-applicant. Combining oncolytic viruses with surgery and immune modulation to prevent postoperative cancer recurrence and metastases.. Canadian Cancer Society Research Institute (CCSRI). Innovation to Impact Grant. 450000 $ (2015-2018).
Grant. (Completed). Co-investigator. Optimizing antibody-drug conjugate therapy by enhancing cellular accumulation – formulation development. Merck Sharp & Dohme Research Laboratory. Universite de Sherbrooke. 50000 $ (2016-2017).
Grant. (Completed). Co-applicant. A personalized oncolytic vaccine: using oncolytic viruses to exploit neo-antigens derived from the tumour mutanome. Canadian Institutes of Health Research (CIHR). Terry Fox New Investigator Award. 450000 $ (2012-2015).
Fellowship. (Completed). Principal Investigator. CIHR Fellowship. Canadian Institutes of Health Research (CIHR). Fellowship. 110000 $ (2013-2015).
Grant. (Completed). Co-investigator. Adjuvant melatonin in the prevention of recurrence and mortality following lung cancer resection (AMPLCaRe): A phase II substudy of a randomized placebo controlled clinical trial. Gateway for Cancer Research (The). Cancer Research. 230576 $ (2012-2015).
Grant. (Completed). Co-investigator. Prophylactic vaccines to reduce cancer metastases: a pilot study to assess natural killer cell activation. Ottawa Hospital (The). Department of Surgery Research Award. 25000 $ (2012-2013).
Fellowship. (Completed). Principal Investigator. FRQS Fellowship. Fonds de recherche du Québec - Santé (FRQS). Fellowship. 135000 $ (2010-2013).
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