McDonald, Patrick

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de médecine

Coordonnées

Courriel


819-821-8000, poste 14849


Site Web

Diplômes

(1999) Post-doctorate (Post-doc).

(1996) Post-doctorate (Post-doc). Universita degli studi di Verona.

(1993) Doctorate (Ph.D.). Université Laval.

(1989) Bachelor's (B.Sc.). Université Laval.

Présentation

Sujets de recherche

Cell Signaling and Infectious and Immune Diseases, Gene Regulation and Expression, Immune Mediators: Cytokines and Chemokines, Leukocytes, Proteomics.

Disciplines de recherche

Immunology, Molecular Biology.

Mots-clés

Apoptosis, Chemokines, Cytokines, Granulocytes, Inflammation, Monocytes, Neutrophils, Phagocytes, Signal transduction, Transcription factors.

Intérêts de recherche

Investigation of transcriptional regulation in granulocytes, and of the upstream signaling pathways

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Allemand, Italien

Prix et distinctions

  • (2017) Guest Editorial Board member (2012-2017), in recognition of being a key organizer of the Neutrophil international meetings (chairman of Neutrophil 2014 and co-chairman of Neutrophil 2016). (Distinction).
  • paper recommended by F1000 (Ear et al, J. Immunol. 2010). (Distinction).

Publications

Articles de revue

  • Dumas L, Neagoe PE, McDonald PP, White M, Sirois MG. (2016). New insights on the pro-inflammatory activities of Ang1 on neutrophils: induction of Mip-1b synthesis and release. PLoS One, 11, e0163140. (In Press).
  • Charbonneau M, Lavoie RR, Lauzier A, Harper K, McDonald PP, Dubois CM. (2016). Platelet-Derived Growth Factor Receptor Activation Promotes the Prodestructive Invadosome-Forming Phenotype of Synoviocytes from Patients with Rheumatoid Arthritis. J. Immunol., 196(8), 3264-3275. (Published).
  • Sylvain-Prévost S, Ear T, Simard FA, Fortin CF, Dubois CM, Flamand N, McDonald PP. (2015). Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses. J. Immunol., 195, 5393-5403. (Published).
  • Simard FA, Cloutier A, Ear T, Vardhan H, and McDonald PP. (2015). MEK-independent ERK activation in human neutrophils and its impact on functional responses. J Leukoc Biol, 98, 565-573. (Published).
  • McDonald PP, Ye RD. (2014). Detection of intact transcription factors in human neutrophils. Methods Mol Biol., 1124, 485-498. (Published).
  • Poubelle PE , McDonald PP. (2013). Letter to the editor for the special issue on "The Neutrophil in Immunity". Journal of Leukocyte Biology, 94(4), 541-543. (Published).
  • Mayer TZ , Simard FA , Cloutier A , Vardhan H , Dubois CM , McDonald PP. (2013). The p38-MSK1 signaling cascade influences cytokine production through CREB and C/EBP factors in human neutrophils. Journal of Immunology, 191(8), 4299-4307. (Published).
  • Fortin CF , Mayer TZ , Cloutier A , McDonald PP. (2013). Translational control of human neutrophil responses by MNK1. Journal of Leukocyte Biology, 94(4), 693-703. (Published).
  • Guindi C , Ménard M , Cloutier A , Gaudreau S , Besin G , Larivée P , McDonald PP , Dupuis G , Amrani A. (2012). Differential role of NF-κB, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice. Cellular Immunology, 272(2), 259-268. (Published).
  • Fortin CF , Cloutier A , Ear T , Sylvain-Prévost S , Mayer TZ , Bouchelaghem R , McDonald PP. (2011). A class IA PI3K controls inflammatory cytokine production in human neutrophils. European Journal of Immunology, 41(6), 1709-1719. (Published).
  • Ear T , Fortin CF , Simard FA , McDonald PP. (2010). Constitutive association of TAK1 with the IKK complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes. Journal of Immunology, 184(7), 3897-3906. (Published).
  • Fortin CF , Sohail A , Sun Q , McDonald PP , Fridman R , Fülöp T. (2010). MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis. International Immunology, 22(8), 637-649. (Published).
  • Fortin CF , McDonald PP , Fülöp T , Lesur O. (2010). Sepsis, leukocytes, and nitric oxide (NO): An intricate affair. Shock, 33(4), 344-352. (Published).

Articles de conférence

  • O. Tatsiy and P.P. McDonald. (2016). Physiological stimuli induce ROS-independent NETosis, using PAD4 and discrete signalingpathways. Conference program, (Accepted).
  • T. Ear and P.P. McDonald. (2016). Role of casein kinase2 (CK2) in neutrophil signaling and functional responses. Conference program, (Accepted).
  • T.Z. Mayer and P.P. McDonald. (2016). STAT factors control the expression of discrete genes in human neutrophils, yet without much impact on functional responses. Conference program, (Accepted).
  • P.P. McDonald, S. Sylvain-Prévost, T. Ear, N. Flamand. (2015). Activation of TAK1 by chemoattractants and GM-CSF, and its impact on human neutrophil signaling and function. 4th European Congress of Immunology. (Published).
  • M.G. Sirois, E. Dumas, D. Chaar, S. Lavoie, P.E. Neagoe, P.P. McDonald and M. White. (2015). Angiopoietin-1 and-2: Full and differential agonists of neutrophil biological activities. 4th European Congress of Immunology. (Published).
  • O. Tatsiy, T. Ear, and P.P. McDonald. (2014). Involvement of TAK1 in cytokine production and NET formation in monosodium urate-activated human neutrophils. Neutrophil 2014 International Congress. (Published).
  • E. Dumas, K. Martel, P.E. Neagoe, P.P. McDonald, and M.G. Sirois. (2014). New insights into the pro-inflammatory activities of Ang1 on neutrophils; induction of Mip-1. Neutrophil 2014 International Congress. (Published).
  • T.Z. Mayer and P.P. McDonald. (2014). STAT factors are activated by various stimuli in human neutrophils but hardly contribute to cytokine production or delayed apoptosis. 56th Meeting of CRCQ (Club de recherches cliniques du Québec). (Published).
  • T.Z. Mayer and P.P. McDonald. (2014). STAT factors are activated by various stimuli in human neutrophils but hardly contribute to cytokine production or delayed apoptosis. Neutrophil 2014 International Congress. (Published).
  • E. Dumas, K. Martel, P.E. Neagoe, P.P. McDonald, and M.G. Sirois. (2013). New perspectives on pro-inflammatory Ang1 effects in neutrophils: Induction of Mip-1. Provincial Immunology Meeting. (Published).
  • T.Z. Mayer, F.A. Simard, A. Cloutier, H. Vardhan, and P.P. McDonald. (2013). The p38-MSK1signaling axis controls cytokine production through bZIP transcription factors in human neutrophils. International Congress of Immunology. (Published).
  • F.A. Simard and P.P. McDonald. (2012). Intricacies of the MAPK cascades in human neutrophils. Neutrophil 2012 International Symposium. (Published).
  • T.Z. Mayer, C.F.Fortin, and P.P. McDonald. (2012). Post-transcriptional control of cytokine production in human neutrophils by MNK1. Neutrophil 2012 International Symposium. (Published).
  • T.Z. Mayer, F.A. Simard, A. Cloutier, and P.P. McDonald. (2012). Role of CREB transcription factors in human neutrophil functional responses. European Congress of Immunology. (Published).
  • F.A. Simard, A. Cloutier, and P.P. McDonald. (2012). Uncoupling of the MEK/ERK signaling module in human neutrophils. 25th Meeting of the Canadian Society for Immunology. (Published).
  • T. Ear and P.P. McDonald. (2011). Differential role of TAK1 in human neutrophils stimulated with various TLR ligands. Toll2011 Meeting. (Published).
  • F.A. Simard and P.P. McDonald. (2011). Découplage du module MEK/ERK chez le neutrophile humain. 53rd Meeting of CRCQ (Club de recherches cliniques du Québec). (Published).
  • R. Bouchelaghem, C.M. Dubois, and P.P. McDonald. (2011). Modulation du facteur HIF chez le neutrophile humain et son rôle dans ses réponses fonctionnelles. ACFAS. (Accepted).
  • S. Sylvain-Prévost, T. Ear, and P.P. McDonald. (2010). Activation of TAK1 by chemoattractants and GM-CSF, and its impact on human neutrophil signaling andfunction. 43rd Meeting of the Society for Leukocyte Biology. (Published).
  • T. Ear and P.P. McDonald. (2010). Constitutive association of TAK1 with the IKK complex in human neutrophils, and its impact on downstream processes. Keystone Symposium on Innate Immunity. (Published).
  • C. Guindi, A. Cloutier, M. Ménard, C. Asselin, P.P. McDonald, and A. Amrani. (2010). Key role of C/EBPb and CREB in tolerogenic function of dendritic cells. 43rd Meeting of the Society for Leukocyte Biology. (Published).
  • C.F. Fortin and P.P. McDonald. (2010). Translational control of inflammatory chemokine production in human neutrophils. 23rd Meeting of the Canadian Society for Immunology. (Published).
  • CF Fortin and PP McDonald. (2009). Contribution of the PI 3-kinase pathway to cytokine generation by human neutrophils. 42nd Meeting of the Society for Leukocyte Biology. (Published).
  • C. Guindi, A. Cloutier, M. Ménard, P.P. McDonald, and A. Amrani. (2009). Role of C/EBPβ and CREB in IL-10 production by tolerogenic dendritic cells. 42nd Meeting of the Society for Leukocyte Biology. (Published).

Autres contributions

Présentations

  • (2016). A reliable way to assess neutrophil extracellular trap formation and its regulation. Centre de recherche en Rhumatologie et Immunologie, Université Laval. Quebec City, Canada.
  • (2015). Intracellular signaling and its impact on functional responses in human neutrophils. Dept of Microbiology & Immunology, University of Miami School of Medicine. Miami, United States.
  • (2015). New and Expanded Tales on Neutrophil Extracellular Traps. Provincial Immunology Meeting. Eastman, Canada.
  • (2015). STAT factors can be activated in human neutrophils but do not contribute to cytokine production, delayed apoptosis, or NETosis. Provincial Immunology Meeting. Eastman, Canada.
  • (2013). The p38-MSK1 signaling cascade influences cytokine production through bZIP transcription factors in human neutrophils. Provincial Immunology Meeting. Eastman, Canada.
  • (2012). Control of cytokine production in human neutrophils. Neutrophil 2012 International Meeting. Quebec City, Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.