Takser, Larissa

Professeure, Faculté de médecine et des sciences de la santé
FMSS Département de pédiatrie

Coordonnées

Courriel


819-821-8000, poste 75809

Diplômes

(2005) Postdoctorat (Postdoctorat). Université du Québec à Montréal.

(2004) Postdoctorat (Postdoctorat). Hôpital Sainte Justine.

(2003) Postdoctorat (Postdoctorat). Université du Québec à Montréal.

(2001) Doctorat (Épidémiologie, Sciences sociales et Santé publique). Université de Paris XI (Paris-Sud).

(1999) Equivalent à la maîtrise (Diplôme d'études approfondies - Maîtrise). Université de Grenoble I - Joseph Fourier.

(1996) Baccalauréat (Docteur en médecine - M.D.). Setchenov Medical Academy.

Expérience académique

(2015) Full Professor. Université de Sherbrooke.

(2003-2004) Postdoctoral Fellow. Université de Montréal.

Présentation

Sujets de recherche

Développement cognitif de l'enfant, Grossesse / Accouchement, Métabolisme des agents toxiques, Santé communautaire / santé publique, Santé environnementale.

Disciplines de recherche

Épidémiologie et biostatistique, Pédiatrie.

Mots-clés

Bio-marqueurs, environmental epidemiology, Environnement, Epidémiologie, Mere-enfant, Santé publique.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Russe

Prix et distinctions

  • (2014) New Investigator Award. Instituts de recherche en santé du Canada. (Distinction).
  • (2013) Junior 2 Scholarship. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • (2009) Junior 1 Scholarship. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • (2003) Postdoctorate Fellowship. Conseil de recherches en sciences naturelles et en génie (CRSNG).
  • Prize "Rising Star in Perinatal Research". CIHR. (Distinction).
  • Young Researcher Prize 2010. Fondation CHUS / Advanced Cyclotron Systems. (Distinction).

Financement

Subvention. (Obtenu). Chercheur principal. Effects of prenatal maternal depression and antidepressant exposures on offspring neurodevelopmental trajectories: A birth cohort study. National Institutes of Health (NIH) (USA). R01. 3321493 $ (2019-2024).

Subvention. (Obtenu). Demandeur principal. Effects of Flame Retardants on Brain Function and Attentional Déficits in School-age children - Brain Imaging, Neurobehavioral, and Gut Microbiome Studies in a Longitudinal Birth Cohort. National Institutes of Health (NIH) (USA). R01. 2000000 $ (2017-2022).

Subvention. (Obtenu). Chercheur principal. PROGRAMMING EFFECTS OF FLAME RETARDANTS ON LIPID METABOLISM IN A LONGITUDINAL BIRTH COHORT. National Institutes of Health (NIH) (USA). 275000 $ (2019-2022).

Subvention. (Obtenu). Co-chercheur. Research Advancement through Cohort Cataloguing and Harmonization (ReACH). Instituts de Recherche en Santé du Canada (IRSC). Operating grant. 1300000 $ (2016-2021).

Subvention. (Obtenu). Demandeur principal. Flame retardants, thyroid function, and psychomotor skills in children. (2015-2017).

Subvention. (Obtenu). Co-chercheur. Emerging flame retardants in pregnancy and in children and effects on thyroid hormones. (2014-2016).

(Terminé). Chercheur principal. Modès le pré-clinique de l'autisme induit par l'acide valproique. Fondation CHUS. Programme de financement interne. 15000 $ (2014-2016).

(Terminé). Co-demandeur. Les exosoms placentaires en début de grossesse normale. Fondation CHUS. Programme de financement interne. 15000 $ (2013-2015).

(Terminé). Demandeur principal. Genetic polymorphysms in one-carbon metabolism in children from Eastern Townships: an exploratory study. Foundation of Stars. regular. 15000 $ (2014-2015).

(Terminé). Co-chercheur. Home Antenatal Environment, Maternal Exposures, and Wellbeing of the Young. University of Albany. Internal Funding. 28000 $ (2014).

Subvention. (Obtenu). Co-chercheur. Flame retardants, plasma exosomal miRNAs in early pregnancy, and risk of gestational diabetes. (2013-2014).

Bourse de recherche. (Obtenu). Demandeur principal. Exposure to environmental chemicals and psychomotor development: prospective birth study of neurotoxic effects using peripheral biomarkers (GESTE study). (2009-2014).

Subvention. (Obtenu). Co-chercheur. Placental Insufficiency and Aortic isthmus Flow (PIAF). (2009-2014).

Subvention. (Obtenu). Co-chercheur. Placental Exosomes in First and Second Trimesters of Normal Pregnancies. (2013-2014).

Bourse de recherche. (Obtenu). Demandeur principal. Expositions chimiques environnementales et santé foetale: approche épidémiologique moléculaire. (2009-2013).

Subvention. (Obtenu). Co-chercheur. Infrastructure de recherche sur les ovins. (2008-2013).

Subvention. (Terminé). Chercheur principal. Exposure to environmental chemicals and psychomotor development: prospective birth study of neurotoxic effects using peripheral biomarkers. (2007-2012).

Subvention. (Terminé). Co-chercheur. Workshop «Health, Environment, Policy and emerging hazards». (2011-2012).

Subvention. (Terminé). Chercheur principal. Exposition périnatale aux faibles doses de PBDE: cible surrénalienne et effets physiologiques. (2009-2011).

Subvention. (Terminé). Co-chercheur. Thyroid Disruption at the Genomic Level in Human Development. (2010-2011).

Subvention. (Terminé). Chercheur principal. Expositions professionnelles et fonctions reproductives des hommes : état des connaissances. (2009-2010).

Subvention. (Terminé). Co-chercheur. Pregnancy disorders and impact on child development and wellbeing: Maternal, placental and fetal considerations. (2005-2010).

Subvention. (Terminé). Chercheur principal. Exposition aux PBDE, nouveau contaminants dans l'environnement: y a-t-il de nouveau un risque?. (2007-2010).

Contrat. (Terminé). Chercheur principal. Support for the redaction of 3 Notes of Scientific Topics. (2009-2010).

Subvention. (Terminé). Chercheur principal. Algues bleus et foetus : étude de l'innocuité des cyanotoxines à concentrations de référence dans un modèle développemental. (2009).

Subvention. (Terminé). Co-chercheur. Monitoring of women with preterm premature rupture of membranes (PPROM) between 27 and 33 weeks gestation with immnunochromatographic bedside test to detect IL-6, MMP-8 and TNF-alpha. (2008-2009).

Bourse de recherche. (Terminé). Demandeur principal. Expositions chimiques environnementales et santé foetale: approche épidémiologique moléculaire. (2006-2009).

Publications

Articles de revue

  • Kim J, Staedelin L, Takser L, Abdelouahab N, Zhu J. (2019). Assessment of selected chlorinated and brominated flame retardants in human plasma samples among co-residing family members. Environ Pollut, 252(Pt B), 1035-1041. DOI. (Article publié).
  • Laue HE, Brennan KJM, Gillet V, Abdelouahab N, Coull BA, Weisskopf MG, Burris HH, Zhang W, Takser L, Baccarelli AA. (2019). Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study. Environ Epidemiol., 3(1), e039. DOI. (Article publié).
  • Cassoulet R, Haroune L, Abdelouahab N, Gillet V, Baccarelli AA, Cabana H, Takser L, Bellenger JP. (2019). Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort. Environ Res, 171, 44-51. DOI. (Article publié).
  • Gillet V, Ouellet A, Stepanov Y, Rodosthenous RS, Croft EK, Brennan K, Abdelouahab N, Baccarelli A, Takser L. (2019). miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus. J Clin Endocrinol Metab., 104(11), 5157-5169. DOI. (Article publié).
  • Laue HE, Cassoulet R, Abdelouahab N, Serme-Gbedo YK, Desautels AS, Brennan KJM, Bellenger JP, Burris HH, Coull BA, Weisskopf MG, Takser L, Baccarelli AA. (2018). Association between meconium acetaminophen and childhood neurocognitive development in GESTE, a Canadian cohort study. Toxicol Sci., DOI. (Article publié).
  • Degroote S, Hunting D, Takser L. (2018). Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring. Neurotoxicol Teratol, 66, 132-138. (Article publié).
  • Takser L, Grad R. (2017). Acute psychotic symptoms following a single dose of levofloxacin. Clin Case Rep, 5(12), 2136-2137. (Article publié).
  • L Takser, N Benachour, B Husk, H Cabana, D Gris. (2016). Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: potential implications for neurodegenerative diseases. Toxicology Reports, 3, 180-9. (Article publié).
  • Degroote S, Hunting D, Takser L. (2016). Improved assessment of sensorimotor gating in animal models relevant to ASD: A data modelling approach to quantify PrePulse Inhibition of the acoustic startle reflex. J Neurosci Methods, 276, 13-22. (Article publié).
  • Degroote S, Hunting DJ, Baccarelli AA, Takser L. (2016). Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure. Prog Neuropsychopharmacol Biol Psychiatry, 71, 76-82. (Article publié).
  • Serme-Gbedo YK, Abdelouahab N, Pasquier JC, Cohen AA, Takser L. (2016). Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE. Environ Health, 15(1), 49. (Article publié).
  • Virginie Gillet, Darel Hunting, and Larissa Takser. (2016). Turing. Current Environmental Health Reports, 3, 00. (Article accepté).
  • S Degroote, D Hunting, G Sebire, L Takser. (2014). Autistic-like traits in Lewis rats exposed perinatally to a mixture of common endocrine disruptors. Endocrine Disruptors, 2(1), e976123. (Article publié).
  • Wadzinski TL, Geromini K, McKinley Brewer J, Bansal R, Abdelouahab N, Langlois MF, Takser L, Zoeller RT. (2014). Endocrine Disruption in Human Placenta: Expression of the Dioxin-Inducible Enzyme, Cyp1a1, Is Correlated With That of Thyroid Hormone-Regulated Genes. J Clin Endocrinol Metab, 9, jc20142629. (Article publié).
  • Byun HM, Benachour N, Zalko D, Frisardi MC, Colicino E, Takser L, Baccarelli AA. (2014). Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring. Toxicology, 3(328), 152-159. (Article publié).
  • Zhou SN , Siddique S , Lavoie L , Takser L , Abdelouahab N , Zhu J. (2014). Hexachloronorbornene-based flame retardants in humans: Levels in maternal serum and milk. Environment international, 66, 11-17. (Article publié).
  • Zhou SN, Buchar A, Siddique S, Takser L, Abdelouahab N, Zhu J. (2014). Measurements of selected brominated flame retardants in nursing women: implications for human exposure. Environ Sci Technol, 48(15), 8873-80. (Article publié).
  • Takser L. (2013). 'Pregnant pause': the need for an evidence-based approach for work leave in the prevention of preterm birth and low birthweight. BJOG : an international journal of obstetrics and gynaecology, 120(5), 517-20. (Article publié).
  • Abdelouahab N , Langlois MF , Lavoie L , Corbin F , Pasquier JC , Takser L. (2013). Abdelouahab et al. Respond to "Maternal PBDEs and Thyroid Hormones". American journal of epidemiology, 178(5), 720-1. (Article publié).
  • Takser L. (2013). Authors' response to: 'Pregnant pause': the need for an evidence-based approach for work leave in the prevention of preterm birth and low birthweight. BJOG : an international journal of obstetrics and gynaecology, 120(12), 1577-8. (Article publié).
  • Lapointe-Milot K , Rizcallah E , Takser L , Abdelouahab N , Duvareille C , Pasquier JC. (2013). Closure of the uterine incision with one or two layers after caesarean section: a randomized controlled study in sheep. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International So, 27(7), 671-6. (Article publié).
  • Abdelouahab N , Langlois MF , Lavoie L , Corbin F , Pasquier JC , Takser L. (2013). Maternal and Cord-Blood Thyroid Hormone Levels and Exposure to Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls During Early Pregnancy. American journal of epidemiology, 178(5), 701-7013. (Article publié).
  • da Conceição AO , de Oliveira FF , de Oliveira RA , de J da S Junior A , Takser L , Reyes-Moreno C , Lafond J. (2012). Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 1001-12. (Article publié).
  • Siddique S , Xian Q , Abdelouahab N , Takser L , Phillips SP , Feng YL , Wang B , Zhu J. (2012). Levels of dechlorane plus and polybrominated diphenylethers in human milk in two Canadian cities. Environment international, 39(1), 50-5. (Article publié).
  • Takser L. (2012). Re: "Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight". American journal of epidemiology, 175(5), 474-5. (Article publié).
  • Haché S , Takser L , LeBellego F , Weiler H , Leduc L , Forest JC , Giguère Y , Masse A , Barbeau B , Lafond J. (2011). Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta. Journal of cellular and molecular medicine, 15(3), 654-67. (Article publié).
  • (2011). Delayed Response in the Rat Frontal Lobe Transcriptome to Perinatal Exposure to the Flame Retardant BDE-47. Journal of Applied Toxicology, 31(5), 477-483.
  • Suvorov A , Bissonnette C , Takser L , Langlois MF. (2011). Does 2,2',4,4'-tetrabromodiphenyl ether interact directly with thyroid receptor?. Journal of applied toxicology : JAT, 31(2), 179-84. (Article publié).
  • da Conceição AO , Rossi MH , de Oliveira FF , Takser L , Lafond J. (2011). Genipa americana (Rubiaceae) fruit extract affects mitogen-activated protein kinase cell pathways in human trophoblast-derived BeWo cells: implications for placental development. Journal of medicinal food, 14(5), 483-94. (Article publié).
  • Abdelouahab N , Ainmelk Y , Takser L. (2011). Polybrominated diphenyl ethers and sperm quality. Reproductive toxicology (Elmsford, N.Y.), 31(4), 546-50. (Article publié).
  • Xian Q , Siddique S , Li T , Feng YL , Takser L , Zhu J. (2011). Sources and environmental behavior of dechlorane plus--a review. Environment international, 37(7), 1273-84. (Article publié).
  • da Conceição AO , Takser L , Lafond J. (2010). Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport. Journal of medicinal food, 13(4), 934-42. (Article publié).
  • Suvorov A and Takser L. (2010). Global Gene Expression Analysis in the Livers of Rat Offspring Perinatally Exposed to Low Doses of 2,2',4,4'-tetrabromodiphenyl ether. Environmental Health Perspectives, 118(1), 97-102. (Article publié).
  • Abdelouahab N , Huel G , Suvorov A , Foliguet B , Goua V , Debotte G , Sahuquillo J , Charles MA , Takser L. (2010). Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery. Neurotoxicology and teratology, 32(2), 253-61. (Article publié).
  • Suvorov A., Girard S, Lachapelle S., Abdelouahab N., Sebire G., Takser L. (2009). Perinatal Exposure to Low-Dose BDE-47, an Emergent Environmental Contaminant, Causes Hyperactivity in Rat Offspring. Neonatology, 95(3), 203-209. (Article publié).
  • Suvorov A , Battista MC , Takser L. (2009). Perinatal exposure to low-dose 2,2',4,4'-tetrabromodiphenyl ether affects growth in rat offspring: what is the role of IGF-1?. Toxicology, 260(1-3), 126-31. (Article publié).
  • Abdelouahab N, Suvorov A, Pasquier JC, Langlois MF, Praud JP, Takser L. (2009). Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs. Neonatology, 96(2), 120-4. (Article publié).
  • Waddell G , Desindes S , Takser L , Beauchemin MC , Bessette P. (2008). Cervical ripening using vaginal misoprostol before hysteroscopy: a double-blind randomized trial. Journal of minimally invasive gynecology, 15(6), 739-44. (Article publié).
  • Suvorov A , Takser L. (2008). Facing the challenge of data transfer from animal models to humans: the case of persistent organohalogens. Environmental health : a global access science source, 7, 58. (Article publié).
  • Abdelouahab N, Mergler D, Takser L, Vanier C, St-Jean M, Baldwin M, Spear PA, Chan HM. (2008). Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada). Environ Res, 107(3), 380-92. (Article publié).
  • Huel G , Sahuquillo J , Debotte G , Oury JF , Takser L. (2008). Hair mercury negatively correlates with calcium pump activity in human term newborns and their mothers at delivery. Environmental health perspectives, 116(2), 263-7. (Article publié).
  • Leduc L , Dubois E , Takser L , Rey E , David M. (2007). Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC, 29(10), 787-93. (Article publié).
  • Yazbeck C , Moreau T , Sahuquillo J , Takser L , Huel G. (2006). Effect of maternal manganese blood levels on erythrocyte calcium-pump activity in newborns. The Science of the total environment, 354(1), 28-34. (Article publié).
  • Leduc L , Takser L , Rinfret D. (2005). Persistance of adverse obstetric and neonatal outcomes in monochorionic twins after exclusion of disorders unique to monochorionic placentation. American journal of obstetrics and gynecology, 193(5), 1670-5. (Article publié).
  • Takser L , Mergler D , Baldwin M , de Grosbois S , Smargiassi A , Lafond J. (2005). Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environmental health perspectives, 113(8), 1039-45. (Article publié).
  • Takser L , Mergler D , Lafond J. (2005). Very low level environmental exposure to lead and prolactin levels during pregnancy. Neurotoxicology and teratology, 27(3), 505-8. (Article publié).
  • Takser L , Mergler D , de Grosbois S , Smargiassi A , Lafond J. (2004). Blood manganese content at birth and cord serum prolactin levels. Neurotoxicology and teratology, 26(6), 811-5. (Article publié).
  • Lafond J , Hamel A , Takser L , Vaillancourt C , Mergler D. (2004). Low environmental contamination by lead in pregnant women: effect on calcium transfer in human placental syncytiotrophoblasts. Journal of toxicology and environmental health. Part A, 67(14), 1069-79. (Article publié).
  • Takser L , Lafond J , Bouchard M , St-Amour G , Mergler D. (2004). Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population. Environmental research, 95(2), 119-25. (Article publié).
  • Morrissette J , Takser L , St-Amour G , Smargiassi A , Lafond J , Mergler D. (2004). Temporal variation of blood and hair mercury levels in pregnancy in relation to fish consumption history in a population living along the St. Lawrence River. Environmental research, 95(3), 363-74. (Article publié).
  • Takser L , Campagna D , Blot P , Huel G. (2003). Could monoamine plasma levels and erythrocyte membrane ATPase activities at birth be predictive for future hand performance?. Pediatric research, 54(3), 358-63. (Article publié).
  • Hamel A , Mergler D , Takser L , Simoneau L , Lafond J. (2003). Effects of low concentrations of organochlorine compounds in women on calcium transfer in human placental syncytiotrophoblast. Toxicological sciences : an official journal of the Society of Toxicology, 76(1), 182-9. (Article publié).
  • Takser L , Mergler D , Hellier G , Sahuquillo J , Huel G. (2003). Manganese, monoamine metabolite levels at birth, and child psychomotor development. Neurotoxicology, 24(4-5), 667-74. (Article publié).
  • Huel G , Takser L , Sahuquillo J , Girard F , Hellier G , Blot P. (2003). [Biological materials collection within population of pregnant women at delivery]. Revue d'épidémiologie et de santé publique, 51(1 Pt 2), 167-74. (Article publié).
  • Smargiassi A , Takser L , Masse A , Sergerie M , Mergler D , St-Amour G , Blot P , Hellier G , Huel G. (2002). A comparative study of manganese and lead levels in human umbilical cords and maternal blood from two urban centers exposed to different gasoline additives. The Science of the total environment, 290(1-3), 157-64. (Article publié).
  • Huel G , Fréry N , Takser L , Jouan M , Hellier G , Sahuquillo J , Giordanella JP. (2002). Evolution of blood lead levels in urban French population (1979-1995). Revue d'épidémiologie et de santé publique, 50(3), 287-95. (Article publié).
  • Takser L , Dellatolas G , Bowler R , Laplante N , Huel G. (2002). Predictive factors of manual dexterity and cognitive performance at 17 years: a 10-year longitudinal study in a rural area of France. Perceptual and motor skills, 95(1), 15-26. (Article publié).

Rapports

  • Groupe de Travail "Perturbateurs endocriniens et reprotoxiques de catégorie 3". (2011). Effet sanitaires du bisphénol A. Rapport d'expertise collective. Agence nationale de securité sanitaire (France). 383 p.

Autres contributions

Présentations

  • (2015). Expression of microRNAs in plasma exosomes collected in the first trimester of pregnancy complicated by preeclampsia, intrauterine growth restriction or gestational diabetes. International Society for Extracellular Vesicles 2015 Annual Meeting. États-Unis.
  • (2014). Common plastifyers and the developing brain: links to thyroid disruption, nutrition, attention deficit/hyperactivity and autism. First international congress: Global Environmental Contamination: challenges for the well-being of the human brain. Luxembourg.
  • (2014). Environmental contaminants and the developing brain: from population to bench and back. Seminar at Harvard School of Public Health. États-Unis.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.