Dory, Yves

Professeur, Faculté des sciences
FAC. SCIENCES Chimie

Coordonnées

Courriel


819-821-8000, poste 75299


Site Web

Diplômes

(1988) Design and synthesis of Valinomycins. Doctorat (Ph.D.). University of Southampton.

(1984) Maîtrise sans mémoire (Maîtrise). Université de Rennes I.

(1981) Baccalauréat (Diplôme Universitaire de Technologie). Université de Rennes I.

Présentation

Sujets de recherche

Antiviraux, Biomatériaux, Douleur, Supramolécules et autoassemblages, Thérapie cellulaire du cancer.

Disciplines de recherche

Biochimie, Chimie.

Mots-clés

calculs ab-initio, chimie médicinale, chimie organique, chimie suprmoléculaire, douleur, liens non-covalents, modelage moléculaire, nanomatériaux, nouveaux acides aminés, peptides.

Intérêts de recherche

a) L'incorporation de nanotubes dans des polymères. b) L'ajout de groupes latéraux aux propriétés variées sur les nanotubes. c) La création de nouveaux peptidomimétiques d'enképhalines pouvant traverser la barrière hémato-encéphalique et métaboliquqment stables. d) la créations de nouveaux agents anticancers peptidomimétiques e) la création de nouveaux antiviraux inhibiteurs de la furine

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Publications

Articles de revue

  • Zhang H, Marmin T*, Cuierrier É, Soldera A, Dory Y, Zhao, Y. (2015). A new comonomer design for enhancing thepH-triggered LCST shift of thermosensitive polymers. Polymer Chemistry, 6(37), 6644-6650. (Article publié).
  • Couture F, Kwiatkowska A, Dory Y L, Day R. (2015). Therapeutic uses of furin and its inhibitors: a patent review. Expert Opinion on Therapeutic Patents, 25(4), 1-18. (Article publié).
  • Kwiatkowska A , Couture F , Levesque C , Ly K , Desjardins R , Beauchemin S , Prahl A , Lammek B , Neugebauer W , Dory YL , Day R. (2014). Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. Journal of medicinal chemistry, 57(1), (Article publié).
  • Baillargeon P, Lussier T*, Dory Y L. (2014). Hydrogen Bonds between Acidic Protons from Alkynes (C–H···O) and Amides (N–H···O) and Carbonyl Oxygen Atoms as Acceptor Partners. Journal of Crystallography, 2014, 1-5. (Article publié).
  • Gagnon H , Beauchemin S , Kwiatkowska A , Couture F , D'Anjou F , Levesque C , Dufour F , Desbiens AR , Vaillancourt R , Bernard S , Desjardins R , Malouin F , Dory YL , Day R. (2014). Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin. Journal of medicinal chemistry, 57(1), (Article publié).
  • Proteau-Gagné A , Rochon K , Roy M , Albert PJ , Guérin B , Gendron L , Dory YL. (2013). Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity. Bioorganic & medicinal chemistry letters, 23(19), (Article publié).
  • Rochon K , Proteau-Gagné A , Bourassa P , Nadon JF , Côté J , Bournival V , Gobeil F , Guérin B , Dory YL , Gendron L. (2013). Preparation and Evaluation at the Delta Opioid Receptor of a Series of Linear Leu-Enkephalin Analogues Obtained by Systematic Replacement of the Amides. ACS chemical neuroscience, (Article publié).
  • Kumar S , Tong X , Dory YL , Lepage M , Zhao Y. (2013). A CO2-switchable polymer brush for reversible capture and release of proteins. Chemical communications (Cambridge, England), 49(1), (Article publié).
  • Kumar S , Allard J-F , Morris D , Dory YL , Lepage M , Zhao Y. (2012). Near-Infrared Light Sensitive Polypeptide Block Copolymer Micelles for Drug Delivery. J. Mater. Chem., 22, 7252-7257. (Article publié).
  • Levesque C , Fugère M , Kwiatkowska A , Couture F , Desjardins R , Routhier S , Moussette P , Prahl A , Lammek B , Appel JR , Houghten RA , D'Anjou F , Dory YL , Neugebauer W , Day R. (2012). The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. Journal of medicinal chemistry, 55(23), (Article publié).
  • Tong X , Bernard S , Dory YL , Zhao Y. (2011). Simultaneous chirality transfer and structured aggregation of a cyclopeptide in a liquid crystal. Langmuir : the ACS journal of surfaces and colloids, 27(7), (Article publié).
  • Proteau-Gagné A , Nadon J-F , Bernard S , Guérin B , Gendron L , Dory YD. (2011). Kinetic deconjugation: a gateway to the synthesis of Xxx-Gly (E)-alkene dipeptide isosteres. Tetrahedron Lett., 52, 6603-6605. (Article publié).
  • Zhao Y , Kumar S , Dory YD , Lepage M. (2011). Surface-Grafted Stimuli-Responsive Block Copolymer Brushes for Thermo-, Photo- and pH-Sensitive Release of Dye Molecules. Macromolecules, 44, 7385-7393. (Article publié).
  • Proteau-Gagné A , St-Jean F , Morin C , Gendron L , Rousseau É , Dory YD. (2011). Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic. Chem. Nat. Comp., 46, 841-847. (Article publié).
  • Proteau-Gagné A , Bournival V , Rochon K , Dory YL , Gendron L. (2010). Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor. ACS chemical neuroscience, 1(11), (Article publié).
  • Baillargeon P , Fortin D , Dory YD. (2010). Hierarchical self-assembly of lactams into supramolecular CO-spiked "sea urchins" then into a channelled crystal. Cryst. Growth Des., 10, 4357-4362. (Article publié).
  • Baillargeon P , Dory YD , Decken A. (2009). Crystal Structure of Hydrated Potassium Pentafluoropheno­late : Interactions between Fluorine Atoms and Metal Ions. J. Chem. Crystallogr., 39, 568-572. (Article publié).
  • Baillargeon P , Dory YL. (2009). Supramolecular Walls from Cyclic Peptides: Modulating Nature and Strength of Weak Interactions. Cryst. Growth Des., 9, 3638-3645. (Article publié).

Chapitres de livre

  • Alex Li. (2012). E and Z secondary amides in supramolecular nanotubes and nanospheres. Molecular Self-Assembly - Advances and Applications (37-75). Pan Stanford. (Article publié).

Propriétés intellectuelles

Brevets

  • Stable peptide-based PACE4 inhibitor. PCT/CA2012/050601. (Demande en cours).
  • Stable peptide-based furin inhibitor. PCT/CA2012/050603. (Demande en cours).
  • Stable peptide-based proprotein convertase inhibitors. US 61/530,478. (Terminé).

Autres contributions

Présentations

  • (2014). Conception et Synthèse d'Analogues de Ligands Peptidiques: Cas des Agonistes Opïoides. 7e Colloque Annuel du CQMF. Shawinigan.
  • (2013). Finding the way Leu-Enkephalin binds to the d Opioid Receptor. CSC 2013. Québec.
  • (2012). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Energy, Materials and Nanotechnology (EMN). Chengdu.
  • (2012). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Sichuan University). Chengdu.
  • (2012). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Tsinghua University). Beijing.
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. XIX Mendeleev Congress (IUPAC). Volgograd.
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université de Strasbourg). Strasbourg.
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université de Grenoble). Grenoble.
  • (2011). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université de Bourgogne). Dijon.
  • (2011). Synthesis and Characterization of Supramolecular Platonic Solids. Department Conference (École de Chimie de Rennes, ENSCR). Rennes.
  • (2010). Design and Synthesis of DOPr Agonists. Rencontres Sherbrooke-Montpellier 2010. Sherbrooke.
  • (2010). Design, Synthesis and Characterization of Supramolecular Tubes and Spheres. Department Conference (Université Laval). Québec.