Subburaj Ilangumaran

Publications

Articles

• Akhil Shukla, Anny Armas Cayarga, Jean‐François Lucier, Madanraj Appiya Santharam, Akouavi Julite Irmine Quenum, Awais Ullah Ihsan, Dominique Lévesque, François‐Michel Boisvert, Sheela Ramanathan, Subburaj Ilangumaran. (2025). Essential Role of NLRC5 in Cancer Immune Surveillance and Cancer Immunoediting. Scandinavian Journal of Immunology. DOI
• Akhil Shukla, Md Gulam Musawwir Khan, Anny Armas Cayarga, Mozhdeh Namvarpour, Mohammad Mobarak H. Chowdhury, Dominique Levesque, Jean-François Lucier, François-Michel Boisvert, Sheela Ramanathan, Subburaj Ilangumaran. (2024). The Tumor Suppressor SOCS1 Diminishes Tolerance to Oxidative Stress in Hepatocellular Carcinoma. Cancers. DOI
• Rajani Kandhi, Alfredo Menendez, Sheela Ramanathan, Subburaj Ilangumaran. (2024). Regulation of High-fat Diet-induced Liver Fibrosis by SOCS1 Expression in Hepatic Stellate Cells. Journal of Clinical and Experimental Hepatology. DOI
• Rajani Kandhi, Bhavesh Variya, Sheela Ramanathan, Subburaj Ilangumaran. (2023). An improved method for isolation and flow cytometric characterization of intrahepatic leukocytes from fatty and fibrotic liver tissues. The Anatomical Record. DOI
• Madanraj Appiya Santharam, Akhil Shukla, Dominique Levesque, Thomas A. Kufer, François-Michel Boisvert, Sheela Ramanathan, Subburaj Ilangumaran. (2023). NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity. International Journal of Molecular Sciences. DOI
• Madhuparna Nandi, Amit Ghosh, Sara Ali Akbari, Diwakar Bobbala, Marie-Josée Boucher, Alfredo Menendez, Trang Hoang, Subburaj Ilangumaran, Sheela Ramanathan. (2023). IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation. Cancers. DOI
• Md Gulam Musawwir Khan, Nadia Boufaied, Mehdi Yeganeh, Rajani Kandhi, Stephanie Petkiewicz, Ankur Sharma, Akihiko Yoshimura, Gerardo Ferbeyre, David P. Labbé, Sheela Ramanathan, Subburaj Ilangumaran. (2023). SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation. Cancers. DOI
• Akouavi Julite Irmine Quenum, Madanraj Appiya Santharam, Sheela Ramanathan, Subburaj Ilangumaran. (2022). Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8+ T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation. International Journal of Molecular Sciences. DOI
• Madanraj Appiya Santharam, Akhil Shukla, Awais Ullah Ihsan, Maryse Cloutier, Dominique Levesque, Sheela Ramanathan, François-Michel Boisvert, Subburaj Ilangumaran. (2021). SILAC proteomics implicates SOCS1 in modulating cellular macromolecular complexes and the ubiquitin conjugating enzyme UBE2D involved in MET receptor tyrosine kinase downregulation. Biochimie. DOI
• Akhil Shukla, Maryse Cloutier, Madanraj Appiya Santharam, Sheela Ramanathan, Subburaj Ilangumaran. (2021). The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy. International Journal of Molecular Sciences. DOI
• Nandi, M., Moyo, M.M., Orkhis, S., Mobulakani, J.M.F., Limoges, M.-A., Rexhepi, F., Mayhue, M., Cayarga, A.A., Marrero, G.C., Ilangumaran, S., Menendez, A., Ramanathan, S. (2021). IL-15Rα-Independent IL-15 Signaling in Non-NK Cell-Derived IFNγ Driven Control of Listeria monocytogenes. Frontiers in Immunology. DOI
• Quenum, A.J.I., Shukla, A., Rexhepi, F., Cloutier, M., Ghosh, A., Kufer, T.A., Ramanathan, S., Ilangumaran, S. (2021). NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis. Frontiers in Immunology. DOI
• Limoges, M.-A., Cloutier, M., Nandi, M., Ilangumaran, S., Ramanathan, S. (2021). The GIMAP Family Proteins: An Incomplete Puzzle. Frontiers in Immunology. DOI
• Maryse Cloutier, Madhuparna Nandi, Awais Ullah Ihsan, Hugues Allard Chamard, Subburaj Ilangumaran, Sheela Ramanathan. (2020). ADE and hyperinflammation in SARS-CoV2 infection- comparison with dengue hemorrhagic fever and feline infectious peritonitis. Cytokine. DOI
• Hugues Allard-Chamard, Hemant K. Mishra, Madhuparna Nandi, Marian Mayhue, Alfredo Menendez, Subburaj Ilangumaran, Sheela Ramanathan. (2020). Interleukin-15 in autoimmunity. Cytokine. DOI
• Md Gulam Musawwir Khan, Amit Ghosh, Bhavesh Variya, Madanraj Appiya Santharam, Awais Ullah Ihsan, Sheela Ramanathan, Subburaj Ilangumaran. (2020). Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma. BMC Cancer. DOI
• Euphrasie Kawila Mafanda, Rajani Kandhi, Diwakar Bobbala, Md Gulam Musawwir Khan, Madhuparna Nandi, Alfredo Menendez, Sheela Ramanathan, Subburaj Ilangumaran. (2019). Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. Cytokine. DOI
• Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis Gendron, Carles Vilariño-Güell, A. Dessa Sadovnick, Jenny P. Ting, Peter A. Calabresi, Abdelaziz Amrani, Denis Gris. (2019). NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. PLOS Biology. DOI
• Khan MGM, Ghosh A, Variya B, Santharam MA, Kandhi R, Ramanathan S, Ilangumaran S. (2019). Hepatocyte growth control by SOCS1 and SOCS3. Cytokine. DOI
• Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G. (2019). Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis. Cancer research. DOI
• Ilangumaran S, Moriggl R, Kalvakolanu DV. (2018). Editorial: Cytokines in liver diseases. Cytokine. DOI
• Volatiana Rakotoarivelo, Bhavesh Variya, Subburaj Ilangumaran, Marie-France Langlois, Sheela Ramanathan. (2018). Inflammation in human adipose tissues–Shades of gray, rather than white and brown. Cytokine & Growth Factor Reviews. DOI
• Rakotoarivelo V, Lacraz G, Mayhue M, Brown C, Rottembourg D, Fradette J, Ilangumaran S, Menendez A, Langlois MF, Ramanathan S. (2018). Corrigendum to "Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes" EBioMedicine 30C (2018) 237-247. EBioMedicine. DOI
• Subburaj Ilangumaran, Bryan R.G. Williams, Dhan V. Kalvakolanu. (2018). Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer. Cytokine. DOI
• Rakotoarivelo V, Lacraz G, Mayhue M, Brown C, Rottembourg D, Fradette J, Ilangumaran S, Menendez A, Langlois MF, Ramanathan S. (2018). Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes. EBioMedicine. DOI
• Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, Md Gulam Musawwir Khan, Sheela Ramanathan, Caroline Saucier, Gerardo Ferbeyre, Sameh Geha, Subburaj Ilangumaran. (2017). Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. BMC Cancer. DOI
• Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G. (2017). SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. Aging. DOI
• Gui Y, Khan MGM, Bobbala D, Dubois C, Ramanathan S, Saucier C, Ilangumaran S. (2017). Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. World journal of gastroenterology. DOI
• Antoine Couture-Cossette, Alex Carignan, Subburaj Ilangumaran, Louis Valiquette. (2017). Bezlotoxumab for the prevention of Clostridium difficile recurrence. Expert Opinion on Biological Therapy. DOI
• Tremblay S, Côté NML, Grenier G, Duclos-Lasnier G, Fortier LC, Ilangumaran S, Menendez A. (2017). Ileal antimicrobial peptide expression is dysregulated in old age. Immunity & ageing : I & A. DOI
• Serrano D, Ghobadi F, Boulay G, Ilangumaran S, Lavoie C, Ramanathan S. (2017). GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Frontiers in immunology. DOI
• Ilangumaran S, Bobbala D, Ramanathan S. (2017). SOCS1: Regulator of T Cells in Autoimmunity and Cancer. Current topics in microbiology and immunology. DOI
• Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Ramanathan S. (2016). Correction: Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PloS one. DOI
• Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Gros P. (2016). Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature immunology. DOI
• Villalobos-Hernandez A, Bobbala D, Kandhi R, Khan MG, Mayhue M, Dubois CM, Ferbeyre G, Saucier C, Ramanathan S, Ilangumaran S. (2016). SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma. Prostate cancer and prostatic diseases. DOI
• Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Gros P. (2016). USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature immunology. DOI
• Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Ramanathan S. (2016). Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PloS one. DOI
• Diwakar Bobbala, Sakina Orkhis, Rajani Kandhi, Sheela Ramanathan, Subburaj Ilangumaran. (2016). Interleukin-21-dependent modulation of T cell antigen receptor reactivity towards low affinity peptide ligands in autoreactive CD8+ T lymphocytes. Cytokine. DOI
• Subburaj Ilangumaran, Gerardo Ferbeyre. (2016). Editorial: Cytokines in inflammation, aging, cancer and obesity. Cytokine. DOI
• Rajani Kandhi, Diwakar Bobbala, Mehdi Yeganeh, Marian Mayhue, Alfredo Menendez, Subburaj Ilangumaran. (2016). Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1. Cytokine. DOI
• Subburaj Ilangumaran, Alberto Villalobos-Hernandez, Diwakar Bobbala, Sheela Ramanathan. (2016). The hepatocyte growth factor (HGF)–MET receptor tyrosine kinase signaling pathway: Diverse roles in modulating immune cell functions. Cytokine. DOI
• Rodriguez GM, Bobbala D, Serrano D, Mayhue M, Champagne A, Saucier C, Steimle V, Kufer TA, Menendez A, Ramanathan S, Ilangumaran S. (2016). NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes. Oncoimmunology. DOI
• Chen XL, Serrano D, Ghobadi F, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S. (2016). TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5). PloS one. DOI
• Bobbala D, Kandhi R, Chen X, Mayhue M, Bouchard E, Yan J, Knecht H, Barabé F, Ramanathan S, Ilangumaran S. (2016). Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency. Leukemia. DOI
• Cepero-Donates Y, Lacraz G, Ghobadi F, Rakotoarivelo V, Orkhis S, Mayhue M, Chen YG, Rola-Pleszczynski M, Menendez A, Ilangumaran S, Ramanathan S. (2016). Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. Cytokine. DOI
• Bobbala D, Mayhue M, Menendez A, Ilangumaran S, Ramanathan S. (2016). Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes. Cellular & molecular immunology. DOI
• Yeganeh M, Gui Y, Kandhi R, Bobbala D, Tobelaim WS, Saucier C, Yoshimura A, Ferbeyre G, Ramanathan S, Ilangumaran S. (2016). Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver. Oncogene. DOI
• Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S. (2015). GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes. PloS one. DOI
• Gharagozloo M, Mahvelati TM, Imbeault E, Gris P, Zerif E, Bobbala D, Ilangumaran S, Amrani A, Gris D. (2015). The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis. Journal of neuroinflammation. DOI
• Tobelaim WS, Beaurivage C, Champagne A, Pomerleau V, Simoneau A, Chababi W, Yeganeh M, Thibault P, Klinck R, Carrier JC, Ferbeyre G, Ilangumaran S, Saucier C. (2015). Tumour-promoting role of SOCS1 in colorectal cancer cells. Scientific reports. DOI
• Gui Y, Yeganeh M, Donates YC, Tobelaim WS, Chababi W, Mayhue M, Yoshimura A, Ramanathan S, Saucier C, Ilangumaran S. (2015). Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma. Oncogene. DOI
• Chen XL, Bobbala D, Cepero Donates Y, Mayhue M, Ilangumaran S, Ramanathan S. (2014). IL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes. Cellular & molecular immunology. DOI
• Gui Y, Yeganeh M, Cepero-Donates Y, Ramanathan S, Saucier C, Ilangumaran S. (2014). Regulation of MET receptor signaling by SOCS1 and its implications for hepatocellular carcinoma. Current pharmaceutical design. DOI
• Chen XL, Bobbala D, Rodriguez GM, Mayhue M, Chen YG, Ilangumaran S, Ramanathan S. (2013). Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells. Clinical and experimental immunology. DOI
• Rodriguez GM, D'Urbano D, Bobbala D, Chen XL, Yeganeh M, Ramanathan S, Ilangumaran S. (2013). SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions. The Journal of investigative dermatology. DOI
• Chen XL, Serrano D, Mayhue M, Wieden HJ, Stankova J, Boulay G, Ilangumaran S, Ramanathan S. (2013). GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation. The Biochemical journal. DOI
• Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S. (2012). Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia. DOI
• Bobbala, D., Chen, X.-L., Leblanc, C., Mayhue, M., Stankova, J., Tanaka, T., Chen, Y.-G., Ilangumaran, S., Ramanathan, S. (2012). Erratum: Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse (Diabetologia DOI: 10.1007/s00125-012-2675- 1). Diabetologia. DOI
• Gui Y, Yeganeh M, Ramanathan S, Leblanc C, Pomerleau V, Ferbeyre G, Saucier C, Ilangumaran S. (2011). SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. Journal of hepatology. DOI
• Ramanathan S, Dubois S, Chen XL, Leblanc C, Ohashi PS, Ilangumaran S. (2011). Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950). DOI
• Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G. (2010). SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging. DOI
• Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S. (2010). Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. Journal of immunology (Baltimore, Md. : 1950). DOI
• Ilangumaran S, Gagnon J, Leblanc C, Poussier P, Ramanathan S. (2010). Increased generation of CD8 single positive cells in SOCS1-deficient thymus does not proportionately increase their export. Immunology letters. DOI
• Gagnon J, Chen XL, Forand-Boulerice M, Leblanc C, Raman C, Ramanathan S, Ilangumaran S. (2010). Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression. Immunology and cell biology. DOI
• Calabrese V, Mallette FA, Deschênes-Simard X, Ramanathan S, Gagnon J, Moores A, Ilangumaran S, Ferbeyre G. (2009). SOCS1 links cytokine signaling to p53 and senescence. Molecular cell. DOI
• Ramanathan S, Gagnon J, Dubois S, Forand-Boulerice M, Richter MV, Ilangumaran S. (2009). Cytokine synergy in antigen-independent activation and priming of naive CD8+ T lymphocytes. Critical reviews in immunology. DOI
• Ilangumaran S, Forand-Boulerice M, Bousquet SM, Savard A, Rocheleau P, Chen XL, Dupuis G, Poussier P, Boulay G, Ramanathan S. (2008). Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes. Molecular immunology. DOI
• Ramanathan S, Gagnon J, Ilangumaran S. (2008). Antigen-nonspecific activation of CD8+ T lymphocytes by cytokines: relevance to immunity, autoimmunity, and cancer. Archivum immunologiae et therapiae experimentalis. DOI
• Gagnon J, Ramanathan S, Leblanc C, Cloutier A, McDonald PP, Ilangumaran S. (2008). IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). DOI
• Chen G, Dimitriou ID, La Rose J, Ilangumaran S, Yeh WC, Doody G, Turner M, Gommerman J, Rottapel R. (2007). The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Molecular and cellular biology. DOI
• Gagnon J, Ramanathan S, Leblanc C, Ilangumaran S. (2006). Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes. Cellular signalling. DOI
• Ramanathan, S., Gagnon, J., Leblanc, C., Rottapel, R., Ilangumaran, S. (2006). Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. Journal of Immunology. DOI
• Shabaana AK, Kulangara K, Semac I, Parel Y, Ilangumaran S, Dharmalingam K, Chizzolini C, Hoessli DC. (2005). Mycobacterial lipoarabinomannans modulate cytokine production in human T helper cells by interfering with raft/microdomain signalling. Cellular and molecular life sciences : CMLS. DOI
• Ilangumaran, S., Rottapel, R. (2005). Regulation of IFNγ-induced MHC class-II expression by suppressor of cytokine signaling 1 (SOCS1). Modern Aspects of Immunobiology.
• Ilangumaran S, Ramanathan S, Rottapel R. (2004). Regulation of the immune system by SOCS family adaptor proteins. Seminars in immunology. DOI
• Ilangumaran S, Ramanathan S, La Rose J, Poussier P, Rottapel R. (2003). Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). DOI
• Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P, Rottapel R. (2003). Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood. DOI
• Ilangumaran S, Finan D, Raine J, Rottapel R. (2003). Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease. The Journal of biological chemistry. DOI
• Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. (2003). Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Molecular and cellular biology. DOI
• Ilangumaran S, Rottapel R. (2003). Regulation of cytokine receptor signaling by SOCS1. Immunological reviews. DOI
• Hoessli DC, Poincelet M, Gupta R, Ilangumaran S, Nasir-ud-Din. (2003). Plasmodium falciparum merozoite surface protein 1. European journal of biochemistry. DOI
• Ilangumaran, S., Finan, D., Rottapel, R. (2003). Flow cytometric analysis of cytokine receptor signal transduction. Journal of Immunological Methods. DOI
• Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P. (2002). The tumor suppressor activity of SOCS-1. Oncogene. DOI
• Ilangumaran, S., Finan, D., La Rose, J., Raine, J., Silverstein, A., De Sepulveda, P., Rottapel, R. (2002). A positive regulatory role for suppressor of cytokine signaling 1 in IFN-γ-induced MHC class II expression in fibroblasts. Journal of Immunology. DOI
• Narayan NP, Ramu G, Ilangumaran S, Desikan KV, Muthukaruppan VR. (2001). Poor correlation of systemic immunological parameters with clinical features in macular leprosy. Indian journal of leprosy.
• Shanker Narayan, N.P., Ramu, G., Ilangumaran, S., Desikan, K.V., Muthukaruppan, V.R. (2001). Poor correlation of systemic immunological parameters with clinical features in macular leprosy. Indian Journal of Leprosy.
• De Sepulveda P, Ilangumaran S, Rottapel R. (2000). Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. The Journal of biological chemistry. DOI
• Hoessli DC, Ilangumaran S, Soltermann A, Robinson PJ, Borisch B, Nasir-Ud-Din. (2000). Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform. Glycoconjugate journal. DOI
• Ilangumaran S, He HT, Hoessli DC. (2000). Microdomains in lymphocyte signalling: beyond GPI-anchored proteins. Immunology today. DOI
• Ilangumaran S, Borisch B, Hoessli DC. (1999). Signal transduction via CD44: role of plasma membrane microdomains. Leukemia & lymphoma. DOI
• Ilangumaran S, Arni S, van Echten-Deckert G, Borisch B, Hoessli DC. (1999). Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes. Molecular biology of the cell. DOI
• Ilangumaran S, Hoessli DC. (1998). Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. The Biochemical journal. DOI
• Ilangumaran S, Briol A, Hoessli DC. (1998). CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes. Blood.
• Ilangumaran S, Briol A, Hoessli DC. (1997). Distinct interactions among GPI-anchored, transmembrane and membrane associated intracellular proteins, and sphingolipids in lymphocyte and endothelial cell plasma membranes. Biochimica et biophysica acta. DOI
• Arni S, Ilangumaran S, van Echten-Deckert G, Sandhoff K, Poincelet M, Briol A, Rungger-Brändle E, Hoessli DC. (1996). Differential regulation of Src-family protein tyrosine kinases in GPI domains of T lymphocyte plasma membranes. Biochemical and biophysical research communications. DOI
• Ilangumaran S, Robinson PJ, Hoessli DC. (1996). Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes. Trends in cell biology. DOI
• Ilangumaran S, Arni S, Chicheportiche Y, Briol A, Hoessli DC. (1996). Evaluation by dot-immunoassay of the differential distribution of cell surface and intracellular proteins in glycosylphosphatidylinositol-rich plasma membrane domains. Analytical biochemistry. DOI
• Ilangumaran S, Ramanathan S, Shankernarayan N, Ramu G, Muthukkarauppan V. (1996). Immunological profiles of leprosy patients and healthy family contacts toward M. leprae antigens. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
• Ilangumaran, S., Ramanathan, S., Shankernarayan, N., Ramu, G., Muthukkarauppan, V. (1996). Immunological Profiles of Leprosy Patients and Healthy Family Contacts Toward M. leprae Antigens. International Journal of Leprosy and Other Mycobacterial Diseases.
• Ilangumaran S, Arni S, Poincelet M, Theler JM, Brennan PJ, Nasir-ud-Din, Hoessli DC. (1995). Integration of mycobacterial lipoarabinomannans into glycosylphosphatidylinositol-rich domains of lymphomonocytic cell plasma membranes. Journal of immunology (Baltimore, Md. : 1950).
• Ilangumaran, S., Arni, S., Poincelet, M., Theler, J.-M., Brennan, P.J., Nasir-ud- Din, Hoessli, D.C. (1995). Integration of mycobacterial lipoarabinomannans into glycosylphosphatidylinositol-rich domains of lymphomonocytic cell plasma membranes. Journal of Immunology.
• Ilangumaran S, Shankernarayan N, Ramu G, Muthukkaruppan V. (1994). Antibody response to recombinant 65-kDa, 70-kDa and 18-kDa mycobacterial antigens in leprosy patients and healthy contacts in a leprosy-endemic population. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
• Ilangumaran S, Shanker Narayan NP, Ramu G, Muthukkaruppan VR. (1994). Cellular and humoral immune responses to recombinant 65-kD antigen of Mycobacterium leprae in leprosy patients and healthy controls. Clinical and experimental immunology. DOI
• Ilangumaran S, Robinson P, Shankernarayan NP, Ramu G, Mahadevan PR, Muthukkaruppan VR. (1994). T lymphocyte reactivity of leprosy patients and healthy contacts from a leprosy-endemic population to delipidified cell components of Mycobacterium leprae. Leprosy review. DOI
• Ilangumaran, S., Shankernarayan, N., Ramu, G., Muthukkaruppan, V. (1994). Antibody response to recombinant 65-kDa, 70-kDa and 18-kDa mycobacterial antigens in leprosy patients and healthy contacts in a leprosy-endemic population. International Journal of Leprosy.
• Sheela R, Ilangumaran S, Muthukkaruppan VR. (1991). Flow cytometric analysis of CD2 modulation on human peripheral blood T lymphocytes by Dharmendra preparation of Mycobacterium leprae. Scandinavian journal of immunology. DOI

Autres contributions

Cours enseignés à l'UdeS

• IML600 - Immunologie moléculaire. (2025). (2CR).
• IML701 - Cytokines. (2023-2024). (2CR).

Divers

• Khan, M.G.M., Boufaied, N., Yeganeh, M., Ghosh, A., Kandhi, R., Bagheri, R., Petkiewicz, S., Sharma, A., Yoshimura, A., Ferbeyre, G., Labbé, D.P., Ramanathan, S., Ilangumaran, S. (2021). SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma. bioRxiv.