Sophie Roux
Professeure, FMSS Département de médecine
FMSS Département de médecine - Service de rhumatologie
Présentation
Sujets, disciplines ou intérêts de recherche
Osteoclast biology: in vitro models, p62 and RANKL-induced signaling pathways, Unraveling Osteoclast Hyperactivation Mechanisms, Bone resorption, Autophagy, Apoptosis, Alternative Splicing, micro RNAs, Osteoclast "omics" (proteomics, RNASeq), Osteoclast phenotype in: RA, PDB, Osteoporosis
Qualifications
- Certified Specialist of the Province of Quebec (CSPQ). Research Disciplines: Rheumatology. Collège des médecins du Québec. Montreal, QC, Canada. (2002).
- Researcher. Centre de Recherche du CHUS. Université de Sherbrooke. Sherbrooke, Quebec, Canada. (2002).
- MCU-PH (Maître de Conférences des Universités-praticien Hospitalier). Research Disciplines: Rheumatology. Université Paris XI (Paris-Sud). Paris, Ile-de-France, France. (2002).
Diplômes
- (2021-2022). Certificate: Data Analysis (Statistics and R; High-dimensional data) for Life Sciences X Series; Statistics and R; High-dimensional data analysis; Case studies in functional genomics-. HarvardX. Harvard University (HarvardX). Cambridge, Massachussets, États-Unis.
- (2021). Certificate. Immuno_1X- edX Series. Ecole Polytechnique Fédérale de Lausanne. Lausanne, EPFLx on edX, Suisse.
- (2000-2002). Post-doctoral formation: Mechanisms Behind Malignant Osteolysis. Rheumatology, Faculty of Medicine. Université de Paris XI (Paris-Sud). Kremlin-Bicêtre, Ile-de-France, France.
- (1993-1997). Doctorate (PhD) - Osteo-articular Biology. INSERM. Université de Paris VII (Denis Diderot). Paris, Ile-de-France, France.
- (1987-1994). Doctorate M.D. Rheumatology. Université de Paris VI (P & M Curie). Paris, Ile-de-France, France.
- (1992-1993). Master's Thesis, Diplôme d'études approfondies (DEA). Biology, structure and function of osteo-articular tissues. Université de Paris VII (Denis Diderot). Paris, Ile-de-France, France.
- (1992-1993). Diploma of Universiy (DU). Bone Diseases. Université de Paris VII (Denis Diderot). Paris, Ile-de-France, France.
- (1990-1991). Diploma, General Immunology and Immunotechnology. Immunology. Institut Pasteur. Paris, Île-de-France, France.
- (1988-1989). Master's of Science in Biochemistry option immunology. Biochemistry. Université de Paris VII (Denis Diderot). Paris, Ile-de-France, France.
- (1986-1987). Concours Internat des Hôpitaux de Paris. DRASS. Assistance Publique – Hôpitaux de Paris. Paris, Île-de-France, France.
Expériences académiques
- Full professor. (2009-). Université de Sherbrooke. Sherbrooke, Quebec, Canada.
- Director. (2011-2020). Université de Sherbrooke. Sherbrooke, Quebec, Canada.
- Associate Professor. (2004-2009). Université de Sherbrooke. Sherbrooke, Quebec, Canada.
- Assistant Professor. (2002-2004). Université de Sherbrooke. Sherbrooke, Quebec, Canada.
- Postdoctoral Fellow or Associate. (2000-2002). Université de Paris XI (Paris-Sud). Kremlin Bicêtre, Ile de France, France.
- Chef de Clinique- Assistant. (1999-2000). Université de Paris XI (Paris-Sud). Kremlin-Bicêtre, Ile-de-France, France.
- Assistant clinician-researcher. (1998-1999). Université de Paris VII (Denis Diderot). Paris, Hôpital Lariboisière, France.
- Chef de Clinique- Assistant. (1995-1998). Université de Paris VII (Denis Diderot). Paris, Hôpital Bichat, France.
Prix et distinctions
- (2014) G. Plante's Career honorific award. Université de Sherbrooke.
- (1996) Basic research award- Procter & Gamble. Société Française de Rhumatologie.
Financement
- Subvention. New mediators in osteoclast biology. NSERC (Ottawa, Canada). Operating Grant. 220 000 $. (2025-2030).
- Subvention. Osteoclast-Related Cells as Biomarkers for Bone Homeostasis. CIHR (Ottawa, Canada). Operating Grant. 581 000 $.
Publications
Articles
- Nathalie Carrier, Javier Marrugo, Misti L Paudel, Sophie Roux, Hugues Allard-Chamard, Artur J de Brum-Fernandes, Patrick Liang, Gilles Boire. (2026). Longitudinal changes in patient characteristics as drivers of clinical outcomes in the Early Undifferentiated PolyArthritis (EUPA) cohort. Rheumatology. DOI
- Sophie Roux, Françoise Debiais, Marie-Hélène Vieillard. (2025). Tackling myeloma bone disease: From pathophysiology to cutting-edge therapies. Blood Reviews. DOI
- Zafer Akman, Gilles Boire, Nathalie Carrier, Sophie Roux, Ariel Masetto, Artur J de Brum-Fernandes, Patrick Liang, Hugues Allard-Chamard. (2025). Validation of the Coping with Health Injuries and Problems questionnaire in a longitudinal cohort with recent-onset RA. Rheumatology Advances in Practice. DOI
- Nam Nguyen, Sasha Bernatsky, Ines Colmegna, Claudie Berger, Nathalie Carrier, Hugues Allard‐Chamard, Patrick Liang, Sophie Roux, Gilles Boire, Marie Hudson. (2025). Predicting Response to Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis Using an Extended Set of Clinical Variables: An Unmet Need. International Journal of Rheumatic Diseases. DOI
- Nathalie Carrier, Sophie Roux, Ariel Masetto, Artur J. de Brum-Fernandes, Patrick Liang, Meryem Maoui, Gilles Boire. (2025). Changes at Presentation in Patients With Early Rheumatoid Arthritis: A 24-Year Study of the Early Undifferentiated Polyarthritis (EUPA) Cohort. The Journal of Rheumatology. DOI
- Sophie Roux. (2024). [Discontinuation of denosumab in tumor-related bone disease: a new challenge]. Rhumatos.
- Michèle Roy, Léopold Mbous Nguimbus, Papa Yaya Badiane, Victor Goguen-Couture, Jade Degrandmaison, Jean-Luc Parent, Marie A Brunet, Sophie Roux. (2024). Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions. Life Science Alliance. DOI
- Nguyen Hoang Dong, Lortie Audrey, Mbous Nguimbus Leopold, Marrugo Javier, Allard‐Chamard Hugues, Bouchard Luigi, Boire Gilles, Michelle S Scott, Roux Sophie. (2023). Osteoclast microRNA Profiling in Rheumatoid Arthritis to Capture the Erosive Factor. JBMR Plus. DOI
- Limoges MA, Lortie A, Demontier É, Quenum AJI, Lessard F, Drouin Z, Carrier N, Mbous Nguimbus L, Beaulieu MC, Gilles Boire, Piché A, Allard-Chamard H, Ramanathan S, Sophie Roux. (2023). SARS-Cov-2 mRNA Vaccine-Induced Immune Responses in Rheumatoid Arthritis. Journal of leukocyte biology. DOI
- Isabelle Gaboury, Patricia L Dobkin, Françoise Gendron, Pasquale Roberge, Marie-Claude Beaulieu, Nathalie Carrier, Pierre Dagenais, Sophie Roux, Gilles Boire. (2022). Mindfulness-based stress reduction to improve depression, pain and high patient global assessment in controlled rheumatoid arthritis. Rheumatology Advances in Practice. DOI
- Hoang Dong Nguyen, Martine Bisson, Michelle Scott, Gilles Boire, Luigi Bouchard, Sophie Roux. (2021). miR profile in pagetic osteoclasts: from large-scale sequencing to gene expression study. Journal of Molecular Medicine. DOI
- Michèle Roy, Elizabeth Stephens, Sophie Bouhour, Sophie Roux. (2021). RabGAP TBC1D25 is involved in human osteoclast activity. European Journal of Cell Biology. DOI
- (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. DOI
- Roy M, Roux S. (2020). Rab GTPases in Osteoclastic Bone Resorption and Autophagy. International Journal of Molecular Sciences. DOI
- Jessica Jann, Suzanne Gascon, Sophie Roux, Nathalie Faucheux. (2020). Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions. International Journal of Molecular Sciences. DOI
- Elizabeth Stephens, Michèle Roy, Martine Bisson, Hoang Dong Nguyen, Michelle S. Scott, Gilles Boire, Luigi Bouchard, Sophie Roux. (2020). Osteoclast signaling-targeting miR-146a-3p and miR-155-5p are downregulated in Paget's disease of bone. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. DOI
- Allard-Chamard H, Carrier N, Dufort P, Durand M, de Brum-Fernandes AJ, Boire G, Komarova SV, Dixon SJ, Harrison RE, Manolson MF, Roux S. (2020). Osteoclasts and their circulating precursors in rheumatoid arthritis: Relationships with disease activity and bone erosions. Bone Reports. DOI
- Carrier N, de Brum-Fernandes AJ, Liang P, Masetto A, Roux S, Biln NK, Maksymowych WP, Boire G. (2020). Impending radiographic erosive progression over the following year in a cohort of consecutive patients with inflammatory polyarthritis: prediction by serum biomarkers. RMD open. DOI
- Isabelle Gaboury, Patricia Dobkin, Pasquale Roberge, Marie-Claude Beaulieu, Pierre Dagenais, France Gervais, Sophie Roux, Gilles Boire. (2020). Mindfulness-Based Reduction Stress Reduction for Patients with Rheumatoid Arthritis and Depressive Symptoms: a Pilot Trial. International Journal of Whole Person Care. DOI
- Sophie Roux, Marie-Hélène Massicotte, Alexis Huot Daneault, Lucie Brazeau-Lamontagne, Jean Dufresne. (2019). Acute hypercalcemia and excessive bone resorption following anti-RANKL withdrawal: Case report and brief literature review. Bone. DOI
- Michèle Roy, Sophie Roux. (2018). Rab GTPases in Osteoclastic Endomembrane Systems. BioMed Research International. DOI
- S. Roux, F. Cabana, N. Carrier, M. C. Beaulieu, G. Boire. (2018). Risk of Subsequent Fragility Fractures Observed After Low-Trauma Ankle Fractures. Calcified Tissue International. DOI
- S. Roux, I. Gaboury, N. Gionet-Landry, M.-P. Garant, M.-C. Beaulieu, N. Carrier, F. Cabana, G. Boire. (2018). Using a sequential explanatory mixed method to evaluate the therapeutic window of opportunity for initiating osteoporosis treatment following fragility fractures. Osteoporosis International. DOI
- Sophie Roux. (2017). L’os du myélome multiple : physiopathologie. Revue du Rhumatisme Monographies. DOI
- Stephen McManus, Martine Bisson, Richard Chamberland, Michèle Roy, Shekeba Nazari, Sophie Roux. (2016). Autophagy and 3-Phosphoinositide-Dependent Kinase 1 (PDK1)-Related Kinome in Pagetic Osteoclasts. Journal of Bone and Mineral Research. DOI
- Beauvais S, Drevelle O, Jann J, Lauzon MA, Foruzanmehr M, Grenier G, Roux S, Faucheux N. (2016). Interactions between bone cells and biomaterials: An update. Frontiers in bioscience (Scholar edition). DOI
- Sophie Roux. (2015). [Recent advances in the pathogenesis of myeloma bone disease]. Réflexions Rhumatologiques.
- Klinck R, Laberge G, Bisson M, McManus S, Michou L, Brown JP, Roux S. (2014). Alternative splicing in osteoclasts and Paget's disease of bone. BMC medical genetics. DOI
- Roux S, Cabana F, Carrier N, Beaulieu M, April PM, Beaulieu MC, Boire G. (2014). The World Health Organization Fracture Risk Assessment Tool (FRAX) underestimates incident and recurrent fractures in consecutive patients with fragility fractures. The Journal of clinical endocrinology and metabolism. DOI
- Bissonnette L, April PM, Dumais R, Boire G, Roux S. (2013). Atypical fracture of the tibial diaphysis associated with bisphosphonate therapy: a case report. Bone. DOI
- Roux S, Beaulieu M, Beaulieu MC, Cabana F, Boire G. (2013). Priming primary care physicians to treat osteoporosis after a fragility fracture: an integrated multidisciplinary approach. The Journal of Rheumatology. DOI
- Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, Roux S. (2013). Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro. Cellular Signalling. DOI
- Chamoux E, McManus S, Laberge G, Bisson M, Roux S. (2012). Involvement of kinase PKC-zeta in the p62/p62(P392L)-driven activation of NF-κB in human osteoclasts. Biochimica et Biophysica Acta. DOI
- Yue L, Durand M, Lebeau Jacob MC, Hogan P, McManus S, Roux S, de Brum-Fernandes AJ. (2012). Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. Bone. DOI
- McManus S, Chamoux E, Bisson M, Roux S. (2012). Modulation of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors in a human osteoclast model in vitro. Apoptosis : an international journal on programmed cell death. DOI
- McManus S, Roux S. (2012). The adaptor protein p62/SQSTM1 in osteoclast signaling pathways. Journal of Molecular Signaling. DOI
- Sophie Roux. (2011). [The RANK-RANKL-OPG axis in rheumatoid arthritis]. Réflexions Rhumatologiques.
- Sophie Roux. (2011). [The RANKL-RANK pathway: an update]. Réflexions Rhumatologiques.
- Leblanc E, Trensz F, Haroun S, Drouin G, Bergeron E, Penton CM, Montanaro F, Roux S, Faucheux N, Grenier G. (2011). BMP-9-induced muscle heterotopic ossification requires changes to the skeletal muscle microenvironment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. DOI
- Estelle Chamoux, Martine Bisson, Marcel Daniel Payet, Sophie Roux. (2010). TRPV-5 Mediates a Receptor Activator of NF-κB (RANK) Ligand-induced Increase in Cytosolic Ca2+ in Human Osteoclasts and Down-regulates Bone Resorption. Journal of Biological Chemistry. DOI
- Drevelle O, Bergeron E, Senta H, Lauzon MA, Roux S, Grenier G, Faucheux N. (2010). Effect of functionalized polycaprolactone on the behaviour of murine preosteoblasts. Biomaterials. DOI
- Roux S, Mariette X. (2010). RANK and RANKL expression in giant-cell tumour of bone. The Lancet. Oncology. DOI
- Roux S. (2010). New treatment targets in osteoporosis. Joint Bone Spine. DOI
- Michou L, Chamoux E, Couture J, Morissette J, Brown JP, Roux S. (2010). Gene expression profile in osteoclasts from patients with Paget's disease of bone. Bone. DOI
- Gallant MA, Chamoux E, Bisson M, Wolsen C, Parent JL, Roux S, de Brum-Fernandes AJ. (2010). Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. The Journal of rheumatology. DOI
- E. Leblanc, F. Trensz, S. Haroun, Sophie Roux, N. Faucheux, G. Grenier. (2010). [Heterotopic Ossification after muscle damage: involvement of a new growth factor]. L’Orthopode.
- Chamoux E, Couture J, Bisson M, Morissette J, Brown JP, Roux S. (2009). The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts. Molecular Endocrinology (Baltimore, Md.). DOI
- Houde N, Chamoux E, Bisson M, Roux S. (2009). Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim. The Journal of Biological Chemistry. DOI
- Senta H, Park H, Bergeron E, Drevelle O, Fong D, Leblanc E, Cabana F, Roux S, Grenier G, Faucheux N. (2009). Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations. Cytokine & growth factor reviews. DOI
- Sophie Roux, Jacques Brown. (2009). Osteoclast Apoptosis in Rheumatic Diseases Characterized by a High Level of Bone Resorption (Osteoporosis, Rheumatoid Arthritis, Myeloma and Pagets Disease of Bone). Current Rheumatology Reviews. DOI
- Chamoux E, Houde N, L'Eriger K, Roux S. (2008). Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. Journal of cellular physiology. DOI
- Sophie Roux. (2007). [RANKL, RANK and osteoprotegerin : an update]. Rhumatos.
- Sophie Roux. (2006). [RANKL inhibitors in osteoporosis]. Médecine Clinique & Endocrinologie.
- Roux S. (2005). RANKL inhibitors: a bright future?. Joint bone spine. DOI
- Roux S, Lambert-Comeau P, Saint-Pierre C, Lépine M, Sawan B, Parent JL. (2005). Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis. Biochemical and biophysical research communications. DOI
- Sophie Roux. (2004). [Advances in osteoporosis]. Abstract-Rhumatologie.
- Roux S, Mariette X. (2004). The high rate of bone resorption in multiple myeloma is due to RANK (receptor activator of nuclear factor-kappaB) and RANK Ligand expression. Leukemia & lymphoma. DOI
- Lavie F, Miceli-Richard C, Quillard J, Roux S, Leclerc P, Mariette X. (2004). Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjögren's syndrome. The Journal of pathology. DOI
- Geoffroy V, Marty-Morieux C, Le Goupil N, Clement-Lacroix P, Terraz C, Frain M, Roux S, Rossert J, de Vernejoul MC. (2004). In vivo inhibition of osteoblastic metalloproteinases leads to increased trabecular bone mass. Journal of Bone and Mineral Research. DOI
- Roux S, Baudoin C, Boute D, Brazier M, De La Guéronniere V, De Vernejoul MC. (2004). Biological effects of drinking-water mineral composition on calcium balance and bone remodeling markers. The Journal of Nutrition, Health & Aging.
- Gottenberg JE, Roux S, Assayag P, Clerc D, Mariette X. (2004). Specific cardiomyopathy in lupus patients: report of three cases. Joint bone spine. DOI
- Sophie Roux. (2003). [New factors involved in bone resorption]. Réflexions Rhumatologiques.
- Roux S, Bergot C, Fermand JP, Frija J, Brouet JC, Mariette X. (2003). Evaluation of bone mineral density and fat-lean distribution in patients with multiple myeloma in sustained remission. Journal of Bone and Mineral Research. DOI
- X Mariette, S Roux, J Zhang, D Bengoufa, F Lavie, T Zhou, R Kimberly. (2003). The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome. Annals of the Rheumatic Diseases. DOI
- Sophie Roux. (2002). [The RANKL-RANK-OPG system in malignant osteolysis]. La Lettre du Rhumatologue.
- Roux S, Meignin V, Quillard J, Meduri G, Guiochon-Mantel A, Fermand JP, Milgrom E, Mariette X. (2002). RANK (receptor activator of nuclear factor-kappaB) and RANKL expression in multiple myeloma. British journal of haematology. DOI
- Sophie Roux. (2002). [Calcium Sensing Receptor: Pathophysiology and Therapeutic Applications]. Synoviale.
- Sophie Roux, Philippe Orcel. (2002). [Update on Osteoprotegerin]. Synpoviale.
- Roux S, Amazit L, Meduri G, Guiochon-Mantel A, Milgrom E, Mariette X. (2002). RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. American journal of clinical pathology. DOI
- Mariette X, Sibilia J, Roux S, Meignin V, Janin A. (2002). A new defensive mechanism to prevent apoptosis in salivary ductal cells from patients with Sjögren's syndrome: over-expression of p53 and p21. Rheumatology (Oxford, England). DOI
- Roux S. (2001). The genetics of osteoporosis. Joint bone spine. DOI
- Gottenberg JE, Roux S, Desmoulins F, Clerc D, Mariette X. (2001). Granulocyte colony-stimulating factor therapy resulting in a flare of systemic lupus erythematosus: comment on the article by Yang and Hamilton. Arthritis and rheumatism. DOI
- Sophie Roux. (2001). [Bone remodeling in postmenopausal osteoporosis]. Revue du Praticien- Gynécologie et Obstétrique.
- Sophie Roux. (2001). [Pathophysiology of bone remodeling and mechanisms of osteoporosis]. Gynécologie Pratique.
- Sophie Roux. (2001). [Osteoprotegerin: potential therapeutic applications in bone hyperresorption]. Abstract Rhumato.
- Lalande A, Roux S, Denne MA, Stanley ER, Schiavi P, Guez D, De Vernejoul MC. (2001). Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. DOI
- Sophie Roux. (2000). [Risedronate: recent data]. Réflexions Rhumatologiques.
- Roux S, Orcel P. (2000). Bone loss. Factors that regulate osteoclast differentiation: an update. Arthritis research. DOI
- Tubach F, Hayem G, Marchand JL, Weber M, Palazzo E, de Bandt M, Roux S, Kahn MF, Meyer O. (2000). IgG anti-beta2-glycoprotein I antibodies in adult patients with systemic lupus erythematosus: prevalence and diagnostic value for the antiphospholipid syndrome. The Journal of rheumatology.
- Sophie Roux, Philippe Orcel. (2000). [Calcium Sensing Receptor]. Revue du Rhumatisme. DOI
- Sophie Roux. (2000). [Question of the month: Bisphosphonates and corticoid-induced bone loss- Response to V. Descamps ]. Ann Dermatol Venereol.
- Roux S, Mariette X. (2000). Hematological malignancies and the bone (myeloma excluded). Joint bone spine.
- Weber M, Hayem G, DeBandt M, Palazzo E, Roux S, Kahn MF, Meyer O. (2000). The family history of patients with primary or secondary antiphospholipid syndrome (APS). Lupus. DOI
- Hayem G, Bouchaud-Chabot A, Benali K, Roux S, Palazzo E, Silbermann-Hoffman O, Kahn MF, Meyer O. (1999). SAPHO syndrome: a long-term follow-up study of 120 cases. Seminars in arthritis and rheumatism. DOI
- Weber M, Hayem G, De Bandt M, Seifert B, Palazzo E, Roux S, Kahn MF, Meyer O. (1999). Classification of an intermediate group of patients with antiphospholipid syndrome and lupus-like disease: primary or secondary antiphospholipid syndrome?. The Journal of rheumatology.
- Sophie Roux. (1999). [Calcium metabolism]. Rev Rhum Fr Ed.
- Sophie Roux. (1999). [Mechanism of action of bisphosphonates]. Réflexions Rhumatologiques.
- Sophie Roux. (1999). [Recent data on osteoporosis and its treatments]. La Lettre du Rhumatologue.
- Hayem G, De Bandt M, Palazzo E, Roux S, Combe B, Eliaou JF, Sany J, Kahn MF, Meyer O. (1999). Anti-heat shock protein 70 kDa and 90 kDa antibodies in serum of patients with rheumatoid arthritis. Annals of the rheumatic diseases. DOI
- Sophie Roux. (1999). [Giant cell tumors of bone]. Revue du Praticien Médecine Générale.
- Hayem G, Deutsch E, Roux S, Palazzo E, Grossin M, Meyer O. (1998). Spontaneous spinal epidural hematoma with spinal cord compression complicating plasma cell myeloma. A case report. Spine. DOI
- Garazi S, Roux S, Palazzo E, Meyer O. (1998). [Sarcoidosis and spondyloarthropathy. Apropos of a case]. Annales de medecine interne.
- Kettaneh A, Hayem G, Palazzo E, Debandt M, Lebail-Darné JL, Roux S, Kahn MF, Meyer O. (1998). [A case of post-partum remission of acquired dyserythropoiesis, a rare cause of anemia in disseminated lupus erythematosus]. La Revue de medecine interne. DOI
- Sophie Roux. (1998). [Bisphosphonates: uses beyond osteoporosis]. Synoviale.
- Roux S. (1998). Giant cell tumors of bone. Revue du rhumatisme (English ed.).
- Roux S, Seelig HP, Meyer O. (1998). Significance of Mi-2 autoantibodies in polymyositis and dermatomyositis. The Journal of rheumatology.
- Sophie Roux, Philippe Orcel. (1997). [Glucocorticoid-induced osteoporosis]. Synoviale.
- Roux S, Pichaud F, Quinn J, Lalande A, Morieux C, Jullienne A, de Vernejoul MC. (1997). Effects of prostaglandins on human hematopoietic osteoclast precursors. Endocrinology. DOI
- Pichaud F, Roux S, Frendo JL, Delage-Mourroux R, Maclouf J, de Vernejoul MC, Moukhtar MS, Jullienne A. (1997). 1,25-dihydroxyvitamin D3 induces NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human neonatal monocytes. Blood.
- Roux S, de Vernejoul MC, Grossin M, Bandt MD, Palazzo E, Nʼzue MK, Meyer O, Kahn MF. (1997). An unusual case of diffuse focal osteolysis with disseminated osteoclastosis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. DOI
- Pichaud F, Delage-Mourroux R, Frenkian M, Frendo JL, Roux S, de Vernejoul MC, Jullienne A. (1997). Type-I 15-hydroxyprostaglandin dehydrogenase: role in macrophage/osteoclast differentiation. Advances in experimental medicine and biology. DOI
- Roux S, Fermand JP, Brechignac S, Mariette X, Kahn MF, Brouet JC. (1996). Tumoral joint involvement in multiple myeloma and Waldenström's macroglobulinemia--report of 4 cases. The Journal of rheumatology.
- Roux S, Quinn J, Pichaud F, Orcel P, Chastre E, Jullienne A, De Vernejoul MC. (1996). Human cord blood monocytes undergo terminal osteoclast differentiation in vitro in the presence of culture medium conditioned by giant cell tumor of bone. Journal of cellular physiology. DOI
- Roux S, Grossin M, De Bandt M, Palazzo E, Vachon F, Kahn MF. (1995). Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. Journal of neurology, neurosurgery, and psychiatry. DOI
- Roux S, Kahn MF, Fermand JP. (1995). [Joint manifestations of monoclonal gammopathies]. Annales de medecine interne.
Chapitres de livre
- Sophie Roux. (2021). [Bone and joints in hematological malignancies (Myeloma excluded)]. Encycl Méd Chir, Rhumatologie-Orthopédie. France.
- Confavreux CB, Massy, E, Tingry, T, Follet, H, Sophie Roux. (2020). Malignant Bone Diseases (as they apply to Rheumatic Diseases). EULAR Textbook on Rheumatic Diseases.
- Allard-Chamard, H, Debiais, F, Sophie Roux. (2018). Malignant Bone Diseases. EULAR Textbook on Rheumatic Diseases.
- Sophie Roux. (2015). [Bone and joints in hematological malignancies (Myeloma excluded)]. Encycl Méd Chir, Rhumatologie-Orthopédie.
- Sophie Roux, Géraldine Philippin, Marie-Hélène Vieillard. (2012). Malignant Bone Diseases. Textbook on Rheumatic Diseases.
- McManus, S, Bissonnette, L, Sophie Roux. (2012). Osteoclast biology in Paget’s disease of bone. Osteoclasts: Morphology, Functions and Clinical Implications.
- Sophie Roux, Debiais, F, Brown, J. (2009). Malignant Bone Diseases (including new concepts and therapies as they apply to rheumatic diseases). EULAR Textbook on Rheumatic Diseases.
- Sophie Roux. (2008). [Myeloma bone disease: new insights in the pathophysiology and therapeutic implications]. Maladies Métaboliques Osseuses de l’Adulte.
- Sophie Roux, Estelle Chamoux. (2007). Osteoclast apoptosis. New Cell Apoptosis Research.
- Sophie Roux, Xavier Mariette. (2005). [Bone and joints in hematological malignancies (Myeloma excluded)]. Encycl Méd Chir, Rhumatologie-Orthopédie.
- Sophie Roux, Sandra Lasbleiz, Thomas Bardin. (2002). [Mechanisms and assessment of subchondral resorption in rheumatoid arthritis]. L'Actualité Rhumatologique 2002.
- Sophie Roux, Philippe Orcel. (2001). [Osteoprotegerin]. L'Actualité Rhumatologique 2001.
- Sophie Roux, Philippe Orcel. (2000). [The osteoclast revisited]. L'Actualité Rhumatologique 2000.
- Sophie Roux, François Cornelis. (1999). [Genetics of osteoporosis]. L'Actualité Rhumatologique 1999.
- Sophie Roux, François Cornelis. (1999). [Update on chondrodysplasias]. L'Actualité Rhumatologique 1999.
- Sophie Roux, Philippe Orcel. (1998). [Phosphocalcic Balance: Mechanisms of Regulation and Clinical Assessment]. Encycl Méd Chir - Endocrinologie- Nutrition.
- Sophie Roux, Philippe Orcel. (1998). [Extracellular calcium-sensing receptor and its related disorders]. L'Actualité Rhumatologique 1998.
- Sophie Roux, Marcel-Francis Kahn, Antoine Thivet, B. Benacerraf. (1997). [Localized osteoporosis of the pagetic skull]. L'Actualité Rhumatologique 1997.
- Sophie Roux, Marcel-Francis Kahn. (1996). [Anti-cytokine treatments and Rheumatoid Arthritis]. L'Actualité Rhumatologique 1996.
Ressources en ligne
- Sophie Roux, E. Massy, C. Confavreux. (2020). Joint involvement in AL amyloidosis. EULAR Online courses on Rheumatic Diseases, edited by EULAR.
- Cyrille Confavreux, Sophie Roux. (2020). Medication-Related osteonecrosis of the jaw. EULAR Online courses on Rheumatic Diseases, edited by EULAR.
- Th. Tingry, E. Massy, Sophie Roux, C. Confavreux. (2020). Rheumatic immune adverse events related to immune checkpoint inhibitors (IrAEs related to ICI). EULAR Online courses on Rheumatic Diseases, edited by EULAR.
- Sophie Roux. (2003). [Osteonews: RANKL, RANK, and Osteoprotegerin: a fundamental system in bone resorption]. Rhumato.net (Santor).
- Sophie Roux. (2003). [Osteonews: Imbalance of the RANKL-RANK-Osteoprotegerin Pathway in Multiple Myeloma]. Rhumato.net (Santor). Site Web.
Autres contributions
Cours enseignés à l'UdeS
- BCM606 - Endocrinologie moléculaire. (2026). (2CR).
Activités professionnelles
- Poste d'invité. Canadian Rheumatology Association. Rheumatology. Board of Directors. Tecumseh, Ontario, Canada. (2025-).
- Poste d'invité. Osteoporosis Canada. Scientific Advisory Council (SAC). Committee Member. Toronto, Ontario, Canada. (2024-).
- Service. Arthritis Society. Arthritis Society Canada’s Innovation Grants panel. Committee Member. Toronto, Ontario, Canada. (2024-2025).
- Service. Canadian Space Agency. Project Grant Committee. Committee Member. Longueuil, Quebec, Canada. (2023).
- Poste d'invité. Osteoporosis Canada. FLS Registry Committee. Committee Member. Toronto, Ontario, Canada. (2022-).
- Poste d'invité. Université de Sherbrooke. Rheumatology. Co-director, Biobanking executive committee. Sherbrooke, Quebec, Canada. (2022-).
- Service. International of Molecular Sciences. Guest Co-Editor, Supplement: New Insights into Osteoclasts. (2020).
- Service. Canadian Institutes of Health Research. College of Reviewers. Committee Member, Committee: Clinical Investigation CIB. Ottawa, Ontario, Canada. (2017-2024).
- Service. Joint, Bone, Spine. Editorial board. (2005-).
