Sherif Abou Elela

Publications

Articles

• Danny Bergeron, Hermes Paraqindes, Étienne Fafard-Couture, Gabrielle Deschamps-Francoeur, Laurence Faucher-Giguère, Philia Bouchard-Bourelle, Sherif Abou Elela, Frédéric Catez, Virginie Marcel, Michelle S Scott. (2023). snoDB 2.0: an enhanced interactive database, specializing in human snoRNAs. Nucleic Acids Research. DOI
• Kyra Kerkhofs, Jyoti Garg, Étienne Fafard-Couture, Sherif Abou Elela, Michelle S. Scott, Ronald E. Pearlman, Mark A. Bayfield. (2022). Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila. Nature Communications. DOI
• Mustafa Malik Ghulam, Mathieu Catala, Gaspard Reulet, Michelle S. Scott, Sherif Abou Elela. (2022). Duplicated ribosomal protein paralogs promote alternative translation and drug resistance. Nature Communications. DOI
• Gabrielle Deschamps-Francoeur, Sonia Couture, Sherif Abou-Elela, Michelle S Scott. (2022). The snoGloBe interaction predictor reveals a broad spectrum of C/D snoRNA RNA targets. Nucleic Acids Research. DOI
• Laurence Faucher-Giguère, Audrey Roy, Gabrielle Deschamps-Francoeur, Sonia Couture, Ryan M Nottingham, Alan M Lambowitz, Michelle S Scott, Sherif Abou Elela. (2022). High-grade ovarian cancer associated H/ACA snoRNAs promote cancer cell proliferation and survival. NAR Cancer. DOI
• Delong Zhou, Sonia Couture, Michelle S Scott, Sherif Abou Elela. (2021). RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners. Nucleic Acids Research. DOI
• Cyrielle Petibon, Mustafa Malik Ghulam, Mathieu Catala, Sherif Abou Elela. (2021). Regulation of ribosomal protein genes: An ordered anarchy. WIREs RNA. DOI
• Julie Parenteau, Sherif Abou Elela. (2019). Introns: Good Day Junk Is Bad Day Treasure. Trends in Genetics. DOI
• Vincent Boivin, Laurence Faucher‐Giguère, Michelle Scott, Sherif Abou‐Elela. (2019). The cellular landscape of mid‐size noncoding RNA. WIREs RNA. DOI
• Mathieu Catala, Sherif Abou Elela. (2019). Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression. Communications Biology. DOI
• Sherif Abou Elela, Xinhua Ji. (2019). Structure and function of Rnt1p: An alternative to RNAi for targeted RNA degradation. WIREs RNA. DOI
• Parenteau J, Maignon L, Berthoumieux M, Catala M, Gagnon V, Abou Elela S. (2019). Introns are mediators of cell response to starvation. Nature. DOI
• Boivin, V., Deschamps-Francoeur, G., Couture, S., Nottingham, R.M., Bouchard-Bourelle, P., Lambowitz, A.M., Scott, M.S., Abou-Elela, S. (2018). Simultaneous sequencing of coding and noncoding RNA reveals a human transcriptome dominated by a small number of highly expressed noncoding genes. RNA. DOI
• Petibon, C., Parenteau, J., Catala, M., Elela, S.A. (2016). Introns regulate the production of ribosomal proteins by modulating splicing of duplicated ribosomal protein genes. Nucleic Acids Research. DOI
• Comeau, M.-A., Lafontaine, D.A., Abou Elela, S. (2016). The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate. Nucleic Acids Research. DOI
• Madgwick, A., Fort, P., Hanson, P.S., Thibault, P., Gaudreau, M.-C., Lutfalla, G., Möröy, T., Elela, S.A., Chaudhry, B., Elliott, D.J., Morris, C.M., Venables, J.P. (2015). Neural differentiation modulates the vertebrate brain specific splicing program. PLoS ONE. DOI
• Parenteau, J., Lavoie, M., Catala, M., Malik-Ghulam, M., Gagnon, J., Abou Elela, S. (2015). Preservation of Gene Duplication Increases the Regulatory Spectrum of Ribosomal Protein Genes and Enhances Growth under Stress. Cell Reports. DOI
• Gagnon, J., Lavoie, M., Catala, M., Malenfant, F., Elela, S.A. (2015). Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals. PLoS Genetics. DOI
• Deschamps-Francoeur, G., Garneau, D., Dupuis-Sandoval, F., Roy, A., Frappier, M., Catala, M., Couture, S., Barbe-Marcoux, M., Abou-Elela, S., Scott, M.S. (2014). Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency. Nucleic Acids Research. DOI
• Brosseau, J.-P., Lucier, J.-F., Lamarche, A.-A., Shkreta, L., Gendron, D., Lapointe, E., Thibault, P., Paquet, E., Perreault, J.-P., Elela, S.A., Chabot, B. (2014). Redirecting splicing with bifunctional oligonucleotides. Nucleic Acids Research. DOI
• Liang, Y.-H., Lavoie, M., Comeau, M.-A., Elela, S.A., Ji, X. (2014). Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection. Molecular Cell. DOI
• Brosseau, J.-P., Lucier, J.-F., Nwilati, H., Thibault, P., Garneau, D., Gendron, D., Durand, M., Couture, S., Lapointe, E., Prinos, P., Klinck, R., Perreault, J.-P., Chabot, B., Abou-Elela, S. (2014). Tumor microenvironment-associated modifications of alternative splicing. RNA. DOI
• Dionne, I., Larose, S., Dandjinou, A.T., Elela, S.A., Wellinger, R.J. (2013). Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA. RNA. DOI
• Venables, J.P., Lapasset, L., Gadea, G., Fort, P., Klinck, R., Irimia, M., Vignal, E., Thibault, P., Prinos, P., Chabot, B., Abou Elela, S., Roux, P., Lemaitre, J.-M., Tazi, J. (2013). MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nature Communications. DOI
• Venables, J.P., Brosseau, J.-P., Gadea, G., Klinck, R., Prinos, P., Beaulieu, J.-F., Lapointe, E., Durand, M., Thibault, P., Tremblay, K., Rousset, F., Tazi, J., Elela, S.A., Chabot, B. (2013). RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Molecular and Cellular Biology. DOI
• Abo-Elmatty DM, Badawy EA, Hussein JS, Elela SA, Megahed HA. (2012). Role of Heme Oxygenase, Leptin, Coenzyme Q10 and Trace Elements in Pre-eclamptic Women. Indian journal of clinical biochemistry : IJCB. DOI
• Noël, J.-F., Larose, S., Elela, S.A., Wellinger, R.J. (2012). Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway. Nucleic Acids Research. DOI
• Lund, N., Milev, M.P., Wong, R., Sanmuganantham, T., Woolaway, K., Chabot, B., Abou Elela, S., Mouland, A.J., Cochrane, A. (2012). Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression. Nucleic Acids Research. DOI
• Michelle, L., Cloutier, A., Toutant, J., Shkreta, L., Thibault, P., Durand, M., Garneau, D., Gendron, D., Lapointe, L., Couture, S., Le Hir, H., Klinck, R., Elela, S.A., Prinos, P., Chabot, B. (2012). Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Molecular and Cellular Biology. DOI
• Catala, M., Aksouh, L., Elela, S.A. (2012). RNA-dependent regulation of the cell wall Stress response. Nucleic Acids Research. DOI
• Lavoie, M., Ge, D., Abou Elela, S. (2012). Regulation of conditional gene expression by coupled transcription repression and RNA degradation. Nucleic Acids Research. DOI
• Prinos, P., Garneau, D., Lucier, J.-F., Gendron, D., Couture, S., Boivin, M., Brosseau, J.-P., Lapointe, E., Thibault, P., Durand, M., Tremblay, K., Gervais-Bird, J., Nwilati, H., Klinck, R., Chabot, B., Perreault, J.-P., Wellinger, R.J., Elela, S.A. (2011). Alternative splicing of SYK regulates mitosis and cell survival. Nature Structural and Molecular Biology. DOI
• Parenteau, J., Durand, M., Morin, G., Gagnon, J., Lucier, J.-F., Wellinger, R.J., Chabot, B., Elela, S.A. (2011). Introns within ribosomal protein genes regulate the production and function of yeast ribosomes. Cell. DOI
• Tanackovic, G., Ransijn, A., Thibault, P., Elela, S.A., Klinck, R., Berson, E.L., Chabot, B., Rivolta, C. (2011). PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Human Molecular Genetics. DOI
• Meaux, S., Lavoie, M., Gagnon, J., Elela, S.A., Van Hoof, A. (2011). Reporter mRNAs cleaved by Rnt1p are exported and degraded in the cytoplasm. Nucleic Acids Research. DOI
• Brosseau, J.-P., Lucier, J.-F., Lapointe, E., Durand, M., Gendron, D., Gervais-Bird, J., Tremblay, K., Perreault, J.-P., Elela, S.A. (2010). High-throughput quantification of splicing isoforms. RNA. DOI
• Bergeron Jr., L., Perreault, J.-P., Elela, S.A. (2010). Short RNA duplexes guide sequence-dependent cleavage by human Dicer. RNA. DOI
• Venables, J.P., Klinck, R., Koh, C., Gervais-Bird, J., Bramard, A., Inkel, L., Durand, M., Couture, S., Froehlich, U., Lapointe, E., Lucier, J.-F., Thibault, P., Rancourt, C., Tremblay, K., Prinos, P., Chabot, B., Elela, S.A. (2009). Cancer-associated regulation of alternative splicing. Nature Structural and Molecular Biology. DOI
• Alló, M., Buggiano, V., Fededa, J.P., Petrillo, E., Schor, I., De La Mata, M., Agirre, E., Plass, M., Eyras, E., Elela, S.A., Klinck, R., Chabot, B., Kornblihtt, A.R. (2009). Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nature Structural and Molecular Biology. DOI
• Ghazal, G., Gagnon, J., Jacques, P.-E., Landry, J.-R., Robert, F., Abou Elela, S. (2009). Yeast RNase III Triggers Polyadenylation-Independent Transcription Termination. Molecular Cell. DOI
• Hai, Y., Cao, W., Liu, G., Hong, S.-P., Elela, S.A., Klinck, R., Chu, J., Xie, J. (2008). A G-tract element in apoptotic agents-induced alternative splicing. Nucleic Acids Research. DOI
• Shkreta, L., Froehlich, U., Paquet, É.R., Toutant, J., Elela, S.A., Chabot, B. (2008). Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes. Molecular Cancer Therapeutics. DOI
• Chabot, B., Elela, S.A., Zhuo, D. (2008). Comment on "when good transcripts go bad: Artifactual RT-PCR 'splicing' and genome analysis". BioEssays. DOI
• Catala, M., Tremblay, M., Samson, É., Conconi, A., Elela, S.A. (2008). Deletion of Rnt1p alters the proportion of open versus closed rRNA gene repeats in yeast. Molecular and Cellular Biology. DOI
• Parenteau, J., Durand, M., Véronneau, S., Lacombe, A.-A., Morin, G., Guérin, V., Cecez, B., Gervais-Bird, J., Koh, C.-S., Brunelle, D., Wellinger, R.J., Chabot, B., Abou Elela, S. (2008). Deletion of many yeast introns reveals a minority of genes that require splicing for function. Molecular Biology of the Cell. DOI
• Venables, J.P., Klinck, R., Bramard, A., Inkel, L., Dufresne-Martin, G., Koh, C., Gervais-Bird, J., Lapointe, E., Froehlich, U., Durand, M., Gendron, D., Brosseau, J.-P., Thibault, P., Lucier, J.-F., Tremblay, K., Prinos, P., Wellinger, R.J., Chabot, B., Rancourt, C., Elela, S.A. (2008). Identification of alternative splicing markers for breast cancer. Cancer Research. DOI
• Klinck, R., Bramard, A., Inkel, L., Dufresne-Martin, G., Gervais-Bird, J., Madden, R., Paquet, É.R., Koh, C., Venables, J.P., Prinos, P., Jilaveanu-Pelmus, M., Wellinger, R., Rancourt, C., Chabot, B., Elela, S.A. (2008). Multiple alternative splicing markers for ovarian cancer. Cancer Research. DOI
• Venables, J.P., Koh, C.-S., Froehlich, U., Lapointe, E., Couture, S., Inkel, L., Bramard, A., Paquet, É.R., Watier, V., Durand, M., Lucier, J.-F., Gervais-Bird, J., Tremblay, K., Prinos, P., Klinck, R., Elela, S.A., Chabot, B. (2008). Multiple and specific mRNA processing targets for the major human hnRNP proteins. Molecular and Cellular Biology. DOI
• Lavoie, M., Abou Elela, S. (2008). Yeast ribonuclease III uses a network of multiple hydrogen bonds for RNA binding and cleavage. Biochemistry. DOI
• Zhuo, D., Madden, R., Elela, S.A., Chabot, B. (2007). Modern origin of numerous alternatively spliced human introns from tandem arrays. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Larose, S., Laterreur, N., Ghazal, G., Gagnon, J., Wellinger, R.J., Elela, S.A. (2007). RNase III-dependent regulation of yeast telomerase. Journal of Biological Chemistry. DOI
• Lamontagne, B., Elela, S.A. (2007). Short RNA guides cleavage by eukaryotic RNase III. PLoS ONE. DOI
• Toussaint, M., Levasseur, G., Gervais-Bird, J., Wellinger, R.J., Elela, S.A., Conconi, A. (2006). A high-throughput method to measure the sensitivity of yeast cells to genotoxic agents in liquid cultures. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. DOI
• Ghazal, G., Elela, S.A. (2006). Characterization of the Reactivity Determinants of a Novel Hairpin Substrate of Yeast RNase III. Journal of Molecular Biology. DOI
• Gendron, D., Carriero, S., Garneau, D., Villemaire, J., Klinck, R., Elela, S.A., Damha, M.J., Chabot, B. (2006). Modulation of 5′ splice site selection using tailed oligonucleotides carrying splicing signals. BMC Biotechnology. DOI
• Lucier, J.-F., Bergeron, L.J., Brière, F.P., Ouellette, R., Elela, S.A., Perreault, J.-P. (2006). RiboSubstrates: A web application addressing the cleavage specificities of ribozymes in designated genomes. BMC Bioinformatics. DOI
• Gaudin, C., Ghazal, G., Yoshizawa, S., Elela, S.A., Fourmy, D. (2006). Structure of an AAGU Tetraloop and its Contribution to Substrate Selection by yeast RNase III. Journal of Molecular Biology. DOI

Livres

• Shkreta, L., Bell, B., Revil, T., Venables, J.P., Prinos, P., Elela, S.A., Chabot, B. (2013). Cancer-associated perturbations in alternative pre-messenger RNA splicing. Cancer Treatment and Research. DOI
• Ghazal, G., Gagnon, J., Elela, S.A. (2012). Detection and characterization of transcription termination. Methods in Molecular Biology. DOI
• Klinck, R., Chabot, B., Elela, S.A. (2012). High-Throughput Analysis of Alternative Splicing by RT-PCR. Alternative pre-mRNA Splicing: Theory and Protocols. DOI

Autres contributions

Divers

• Mustafa Malik-Ghulam, Mathieu Catala, Michelle S. Scott, Sherif Abou Elela. (2021). Post translational modification of duplicated ribosomal protein paralogs promotes alternative translation and drug resistance.
• Laurence Faucher-Giguère, Audrey Roy, Gabrielle Deschamps-Francoeur, Sonia Couture, Ryan M. Nottingham, Alan M. Lambowitz, Michelle S. Scott, Sherif Abou Elela. (2021). High-grade Ovarian Cancer Associated H/ACA snoRNAs Promote Cancer Cell Proliferation and Survival.
• Deschamps-Francoeur G, Boivin V, Abou Elela S, Scott MS. (2018). CoCo: RNA-seq Read Assignment Correction for Nested Genes and Multimapped Reads.