Rona Graham

Prix et distinctions

• Canada research Chair. Canada Research Chairs.
• FRQS salary award. FRQS.

Financement

• Subvention. Validation and characterization of the caspase-6 interactome. Natural Sciences and Engineering Research Council (Ottawa, Canada). 28 000 $. (2021-2022).
  Numéro de subvention : RGPIN-2019-05290. Voir plus
• Subvention. Validation and characterization of the caspase-6 interactome. Natural Sciences and Engineering Research Council (Ottawa, Canada). 12 500 $. (2019-2020).
  Numéro de subvention : DGECR-2019-00164. Voir plus
• Subvention. Canada Research Chair in Neurodegenerative Diseases. Canadian Institutes of Health Research (Ottawa, Canada). 500 000 $. (2012-2017).
  Numéro de subvention : 201104CRC. Voir plus
• Subvention. To define the role of caspases and caspase cleavage of htt in the pathogenesis of HD. Michael Smith Health Research BC (Vancouver, Canada). 78 000 $. (2007-2008).
  Numéro de subvention : RT-2006-5145. Voir plus
• Subvention. Truncation of huntingtin and its relationship to the pathogenesis of Huntington's Disease. Michael Smith Health Research BC (Vancouver, Canada). 22 040 $. (2003).
  Numéro de subvention : RT-2002-4583. Voir plus
• Subvention. Truncation of Huntington and its relationship to the pathogenesis of Huntington's disease. Canadian Institutes of Health Research (Ottawa, Canada). 63 083 $. (2002-2005).
  Numéro de subvention : 200110MDR. Voir plus
• Subvention. Truncation of Huntingtin and its relationship to the Pathogenesis of Huntington's Disease. Michael Smith Health Research BC (Vancouver, Canada). 25 707 $. (2001).
  Numéro de subvention : RT-2001-4430. Voir plus

Publications

Articles

• Majed M. Alotaibi, Matteo De Marco, Rona Graham, Annalena Venneri. (2025). Alterations in Olfactory Cortex Volume in Mild Cognitive Impairment and Mild Alzheimer’s Disease Dementia: A Study of Sex-Related Differences. Brain Sciences. DOI
• Alotaibi, M., Lessard-Beaudoin, M., Busch, K., Loudghi, A., Gaudreau, P., Graham, R.K. (2024). Olfactory Dysfunction Associated with Cognitive Decline in an Elderly Population. Experimental Aging Research. DOI
• González, L.M., Bourissai, A., Lessard-Beaudoin, M., Lebel, R., Tremblay, L., Lepage, M., Graham, R.K. (2023). Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment. Molecular Neurobiology. DOI
• Camara, G., Alotaibi, M., Lessard-Beaudoin, M., Busch, K., Gendron, L., Graham, R.K. (2023). Specific olfactory deficit patterns observed in seniors and associated with cognitive decline. Progress in Neuro Psychopharmacology and Biological Psychiatry. DOI
• Lessard-Beaudoin, M., M. Gonzalez, L., AlOtaibi, M., Chouinard-Watkins, R., Plourde, M., Calon, F., Graham, R.K. (2021). Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice. European Journal of Neuroscience. DOI
• Laroche, M., Lessard-Beaudoin, M., Garcia-Miralles, M., Kreidy, C., Peachey, E., Leavitt, B.R., Pouladi, M.A., Graham, R.K. (2020). Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model. Human Molecular Genetics. DOI
• Al-Otaibi, M., Lessard-Beaudoin, M., Castellano, C.-A., Gris, D., Cunnane, S.C., Graham, R.K. (2020). Volumetric mri demonstrates atrophy of the olfactory cortex in AD. Current Alzheimer Research. DOI
• Lessard-Beaudoin, M., Yu-Taeger, L., Laroche, M., Singer, E., Riess, O., Nguyen, H.H.P., Graham, R.K. (2019). Olfactory bulb atrophy and caspase activation observed in the BACHD rat models of Huntington disease. Neurobiology of Disease. DOI
• Girling, K.D., Demers, M.-J., Laine, J., Zhang, S., Wang, Y.T., Graham, R.K. (2018). Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor–mediated excitotoxicity. Journal of Neuroscience Research. DOI
• Lessard-Beaudoin, M., Laroche, M., Demers, M.-J., Duclos, C., Denault, J.-B., Grenier, G., Riechers, S.-P., Wanker, E.E., Graham, R.K. (2016). Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice. Biogerontology. DOI
• Riechers, S.-P., Butland, S., Deng, Y., Skotte, N., Ehrnhoefer, D.E., Russ, J., Laine, J., Laroche, M., Pouladi, M.A., Wanker, E.E., Hayden, M.R., Graham, R.K. (2016). Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD. Human Molecular Genetics. DOI
• Lessard-Beaudoin, M., Laroche, M., Loudghi, A., Demers, M.-J., Denault, J.-B., Grenier, G., Riechers, S.-P., Wanker, E.E., Graham, R.K. (2016). Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process. Neurobiology of Aging. DOI
• Lessard-Beaudoin, M., Laroche, M., Demers, M.-J., Grenier, G., Graham, R.K. (2015). Characterization of age-associated changes in peripheral organ and brain region weights in C57BL/6 mice. Experimental Gerontology. DOI
• Wong, B.K.Y., Ehrnhoefer, D.E., Graham, R.K., Martin, D.D.O., Ladha, S., Uribe, V., Stanek, L.M., Franciosi, S., Qiu, X., Deng, Y., Kovalik, V., Zhang, W., Pouladi, M.A., Shihabuddin, L.S., Hayden, M.R. (2015). Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. Neurobiology of Disease. DOI
• Biet, M., Morin, N., Lessard-Beaudoin, M., Graham, R.K., Duss, S., Gagné, J., Sanon, N.T., Carmant, L., Dumaine, R. (2015). Prolongation of Action Potential Duration and QT Interval during Epilepsy Linked to Increased Contribution of Neuronal Sodium Channels to Cardiac Late Na + Current. Circulation Arrhythmia and Electrophysiology. DOI
• Stroedicke, M., Bounab, Y., Strempel, N., Klockmeier, K., Yigit, S., Friedrich, R.P., Chaurasia, G., Li, S., Hesse, F., Riechers, S.-P., Russ, J., Nicoletti, C., Boeddrich, A., Wiglenda, T., Haenig, C., Schnoegl, S., Fournier, D., Graham, R.K., Hayden, M.R., ... Wanker, E.E. (2015). Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Genome Research. DOI
• Butland, S.L., Sanders, S.S., Schmidt, M.E., Riechers, S.-P., Lin, D.T.S., Martin, D.D.O., Vaid, K., Graham, R.K., Singaraja, R.R., Wanker, E.E., Conibear, E., Hayden, M.R. (2014). The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: Implications for a role in the pathogenesis of Huntington's disease. Human Molecular Genetics. DOI
• Marco, S., Giralt, A., Petrovic, M.M., Pouladi, M.A., Martínez-Turrillas, R., Martínez-Hernández, J., Kaltenbach, L.S., Torres-Peraza, J., Graham, R.K., Watanabe, M., Luján, R., Nakanishi, N., Lipton, S.A., Lo, D.C., Hayden, M.R., Alberch, J., Wesseling, J.F., Pérez-Otaño, I. (2013). Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nature Medicine. DOI
• Graham, R.K., Deng, Y., Pouladi, M.A., Vaid, K., Ehrnhoefer, D., Southwell, A.L., Bissada, N., Franciosi, S., Hayden, M.R. (2012). Caspase-6-resistant mutant huntingtin does not rescue the toxic effects of caspase-cleavable mutant huntingtin in vivo. Journal of Huntington S Disease. DOI
• Pouladi, M.A., Brillaud, E., Xie, Y., Conforti, P., Graham, R.K., Ehrnhoefer, D.E., Franciosi, S., Zhang, W., Poucheret, P., Compte, E., Maurel, J.-C., Zuccato, C., Cattaneo, E., Néri, C., Hayden, M.R. (2012). NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease. Neurobiology of Disease. DOI
• Uribe, V., Wong, B.K.Y., Graham, R.K., Cusack, C.L., Skotte, N.H., Pouladi, M.A., Xie, Y., Feinberg, K., Ou, Y., Ouyang, Y., Deng, Y., Franciosi, S., Bissada, N., Spreeuw, A., Zhang, W., Ehrnhoefer, D.E., Vaid, K., Miller, F.D., Deshmukh, M., ... Hayden, M.R. (2012). Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. Human Molecular Genetics. DOI
• Waldron-Roby, E., Ratovitski, T., Wang, X., Jiang, M., Watkin, E., Arbez, N., Graham, R.K., Hayden, M.R., Hou, Z., Mori, S., Swing, D., Pletnikov, M., Duan, W., Tessarollo, L., Ross, C.A. (2012). Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin. Journal of Neuroscience. DOI
• Graham, R.K., Ehrnhoefer, D.E., Hayden, M.R. (2011). Caspase-6 and neurodegeneration. Trends in Neurosciences. DOI
• Carroll, J.B., Southwell, A.L., Graham, R.K., Lerch, J.P., Ehrnhoefer, D.E., Cao, L.-P., Zhang, W.-N., Deng, Y., Bissada, N., Henkelman, R., Hayden, M.R. (2011). Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease. Molecular Neurodegeneration. DOI
• Graham, R.K., Deng, Y., Carroll, J., Vaid, K., Cowan, C., Pouladi, M.A., Metzler, M., Bissada, N., Wang, L., Faull, R.L.M., Gray, M., Yang, X.W., Raymond, L.A., Hayden, M.R. (2010). Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. Journal of Neuroscience. DOI
• Milnerwood, A.J., Gladding, C.M., Pouladi, M.A., Kaufman, A.M., Hines, R.M., Boyd, J.D., Ko, R.W.Y., Vasuta, O.C., Graham, R.K., Hayden, M.R., Murphy, T.H., Raymond, L.A. (2010). Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice. Neuron. DOI
• Milnerwood, A.J., Gladding, C.M., Pouladi, M.A., Kaufman, A.M., Hines, R.M., Boyd, J.D., Ko, R.W.Y., Vasuta, O.C., Graham, R.K., Hayden, M.R., Murphy, T.H., Raymond, L.A. (2010). Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice (DOI:10.1016/j.neuron.2010.01.008). Neuron. DOI
• Pouladi, M.A., Xie, Y., Skotte, N.H., Ehrnhoefer, D.E., Graham, R.K., Kim, J.E., Bissada, N., Yang, X.W., Paganetti, P., Friedlander, R.M., Leavitt, B.R., Hayden, M.R. (2010). Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression. Human Molecular Genetics. DOI
• Metzler, M., Gan, L., Mazarei, G., Graham, R.K., Liu, L., Bissada, N., Lu, G., Leavitt, B.R., Hayden, M.R. (2010). Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A. Journal of Neuroscience. DOI
• Okamoto, S.-I., Pouladi, M.A., Talantova, M., Yao, D., Xia, P., Ehrnhoefer, D.E., Zaidi, R., Clemente, A., Kaul, M., Graham, R.K., Zhang, D., Vincent Chen, H.-S., Tong, G., Hayden, M.R., Lipton, S.A. (2009). Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nature Medicine. DOI
• Graham, R.K., Pouladi, M.A., Joshi, P., Lu, G., Deng, Y., Wu, N.-P., Figueroa, B.E., Metzler, M., André, V.M., Slow, E.J., Raymond, L., Friedlander, R., Levine, M.S., Leavitt, B.R., Hayden, M.R. (2009). Differential susceptibility to excitotoxic stress in YAC128 mouse models of huntington disease between initiation and progression of disease. Journal of Neuroscience. DOI
• Ratovitski, T., Gucek, M., Jiang, H., Chighladze, E., Waldron, E., D'Ambola, J., Zhipeng, H., Yideng, L., Poirier, M.A., Hirschhorn, R.R., Graham, R., Hayden, M.R., Cole, R.N., Ross, C.A. (2009). Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells. Journal of Biological Chemistry. DOI
• Warby, S.C., Doty, C.N., Graham, R.K., Shively, J., Singaraja, R.R., Hayden, M.R. (2009). Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments. Molecular and Cellular Neuroscience. DOI
• Pouladi, M.A., Graham, R.K., Karasinska, J.M., Xie, Y., Santos, R.D., Petersn, Â., Hayden, M.R. (2009). Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin. Brain. DOI
• Wang, C.-E., Tydlacka, S., Orr, A.L., Yang, S.-H., Graham, R.K., Hayden, M.R., Li, S., Chan, A.W.S., Li, X.-J. (2008). Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human Molecular Genetics. DOI
• Warby, S.C., Doty, C.N., Graham, R.K., Carroll, J.B., Yang, Y.-Z., Singaraja, R.R., Overall, C.M., Hayden, M.R. (2008). Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus. Human Molecular Genetics. DOI
• Zhang, H., Li, Q., Graham, R.K., Slow, E., Hayden, M.R., Bezprozvanny, I. (2008). Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiology of Disease. DOI
• Cowan, C.M., Fan, M.M.Y., Fan, J., Shehadeh, J., Zhang, L.Y.J., Graham, R.K., Hayden, M.R., Raymond, L.A. (2008). Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: Impact on NMDA receptor function and toxicity. Journal of Neuroscience. DOI
• Benn, C.L., Slow, E.J., Farrell, L.A., Graham, R., Deng, Y., Hayden, M.R., Cha, J.-H.J. (2007). Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease. Neuroscience. DOI
• Ratovitski, T., Nakamura, M., D'Ambola, J., Chighladze, E., Liang, Y., Wang, W., Graham, R., Hayden, M.R., Borchelt, D.R., Hirschhorn, R.R., Ross, C.A. (2007). N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle. DOI
• Van Raamsdonk, J.M., Metzler, M., Slow, E., Pearson, J., Schwab, C., Carroll, J., Graham, R.K., Leavitt, B.R., Hayden, M.R. (2007). Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiology of Disease. DOI
• Graham, R.K., Deng, Y., Slow, E.J., Haigh, B., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Bertram, L., Murphy, Z., Warby, S.C., Doty, C.N., Roy, S., Wellington, C.L., Leavitt, B.R., Raymond, L.A., Nicholson, D.W., Hayden, M.R. (2006). Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin. Cell. DOI
• Guidetti, P., Bates, G.P., Graham, R.K., Hayden, M.R., Leavitt, B.R., MacDonald, M.E., Slow, E.J., Wheeler, V.C., Woodman, B., Schwarcz, R. (2006). Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiology of Disease. DOI
• Graham, R.K., Slow, E.J., Deng, Y., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Leavitt, B.R., Raymond, L.A., Hayden, M.R. (2006). Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models. Neurobiology of Disease. DOI
• Shehadeh, J., Fernandes, H.B., Zeron Mullins, M.M., Graham, R.K., Leavitt, B.R., Hayden, M.R., Raymond, L.A. (2006). Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiology of Disease. DOI
• Slow, E.J., Graham, R.K., Hayden, M.R. (2006). To be or not to be toxic: aggregations in Huntington and Alzheimer disease. Trends in Genetics. DOI
• Leavitt, B.R., Van Raamsdonk, J.M., Shehadeh, J., Fernandes, H., Murphy, Z., Graham, R.K., Wellington, C.L., Raymond, L.A., Hayden, M.R. (2006). Wild-type huntingtin protects neurons from excitotoxicity. Journal of Neurochemistry. DOI
• Slow, E.J., Graham, R.K., Osmand, A.P., Devon, R.S., Lu, G., Deng, Y., Pearson, J., Vaid, K., Bissada, N., Wetzel, R., Leavitt, B.R., Hayden, M.R. (2005). Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Saleh, M., Vaillancourt, J.P., Graham, R.K., Huyck, M., Srinivasula, S.M., Alnemri, E.S., Steinberg, M.H., Holan, V., Baldwin, C.T., Hotchkiss, R.S., Buchman, T.G., Zehnbauer, B.A., Hayden, M.R., Farrer, L.A., Roy, S., Nicholson, D.W. (2004). Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. DOI
• Slow, E.J., van Raamsdonk, J., Rogers, D., Coleman, S.H., Graham, R.K., Deng, Y., Oh, R., Bissada, N., Hossain, S.M., Yang, Y.-Z., Li, X.-J., Simpson, E.M., Gutekunst, C.-A., Leavitt, B.R., Hayden, M.R. (2003). Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Human Molecular Genetics. DOI
• Wellington, C.L., Ellerby, L.M., Gutekunst, C.-A., Rogers, D., Warby, S., Graham, R.K., Loubser, O., Van Raamsdonk, J., Singaraja, R., Yang, Y.-Z., Gafni, J., Bredesen, D., Hersch, S.M., Leavitt, B.R., Roy, S., Nicholson, D.W., Hayden, M.R. (2002). Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. Journal of Neuroscience. DOI
• Metzler, M., Chen, N., Helgason, C.D., Graham, R.K., Nichol, K., McCutcheon, K., Nasir, J., Humphries, R.K., Raymond, L.A., Hayden, M.R. (1999). Life without Huntington: Normal differentiation into functional neurons. Journal of Neurochemistry. DOI
• Kalchman, M.A., Koide, H.B., McCutcheon, K., Graham, R.K., Nichol, K., Nishiyama, K., Kazemi-Esfarjani, P., Lynn, F.C., Wellington, C., Metzler, M., Goldberg, Y.P., Kanazawa, I., Gietz, R.D., Hayden, M.R. (1997). HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane- associated huntingtin in the brain. Nature Genetics. DOI
• Goldberg, Y.P., Kalchman, M.A., Metzler, M., Nasir, J., Zeisler, J., Graham, R., Koide, H.B., O'Kusky, J., Sharp, A.H., Ross, C.A., Jirik, F., Hayden, M.R. (1996). Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript. Human Molecular Genetics. DOI
• Goldberg, Y.P., Nicholson, D.W., Rasper, D.M., Kalchman, M.A., Koide, H.B., Graham, R.K., Bromm, M., Kazemi-Esfarjani, P., Thornberry, N.A., Vaillancourt, J.P., Hayden, M.R. (1996). Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genetics. DOI
• Kalchman, M.A., Graham, R.K., Xia, G., Brook Koide, H., Graeme Hodgson, J., Graham, K.C., Paul Goldberg, Y., Dan Gietz, R., Pickart, C.M., Hayden, M.R. (1996). Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme. Journal of Biological Chemistry. DOI
• Lin, B., Nasir, J., McDonald, H., Graham, R., Rommens, J.M., Goldberg, Y.P., Hayden, M.R. (1995). Genomic organization of the human α-adducin gene and its alternately spliced isoforms. Genomics. DOI
• Riess, O., Thies, U., Siedlaczck, I., Potisek, S., Graham, R., Theilmann, J., Grimm, T., Epplen, J.T., Hayden, M.R. (1994). Precise mapping of the brain α2-Adrenergic receptor gene within chromosome 4p16. Genomics. DOI
• Lin, B., Nasir, J., Macdonald, H., Hutchinson, G., Graham, R.K., Rommens, J.M., Hayden, M.R. (1994). Sequence of the murine huntington disease gene: Evidence for conservation, alternate splicing and polymorphism in a triplet (ccg) repeat. Human Molecular Genetics. DOI
• Lin, B., Nasir, J., Macdonald, H., Hutchinson, G., Graham, R.K., Rommesns, J.M., Hayden, M.R. (1994). Sequence of the murine huntington dusease gene: Evidence for conservation, and polymorphism in a triplet (CCG) repeat alternate splicing. Human Molecular Genetics. DOI
• Weber, B., Riess, O., Daneshvar, H., Graham, R., Hayden, M.R. (1993). (ca)n-dinucleotide repeat at the PDEB locus in 4p16.3. Human Molecular Genetics. DOI
• Rommens, J.M., Lin, B., Hutchinson, G.B., Andrew, S.E., Goldberg, Y.P., Glaves, M.L., Graham, R., Lal, V., Mcarthur, J., Nasir, J., Theilmann, J., Mcdonald, H., Kalchman, M., Clarke, L.A., Schappert, K., Hayden, M.R. (1993). A transcription map of the region containing the huntington disease gene. Human Molecular Genetics. DOI
• Hutchinson, G.B., Andrew, S.E., Mcdonald, H., Goldberg, Y.P., Graham, R., Rommens, J.M., Hayden, M.R. (1993). An Alu element retroposition in two families with huntington disease defines a new active alu subfamily. Nucleic Acids Research. DOI
• Lin, B., Rommens, J.M., Graham, R.K., Kalchman, M., Macdonald, H., Nasir, J., Delaney, A., Goldberg, Y.P., Hayden, M.R. (1993). Differential 3' polyadenylation of the huntington disease gene results in two mRNA species with variable tissue expression. Human Molecular Genetics. DOI
• Rommens, J.M., Lin, B., Hutchinson, G.B., Andrew, S.E., Goldberg, Y.P., Glaves, M.L., Graham, R., Lai, V., McArthur, J., Nasir, J., Theilmann, J., McDonald, H., Kalchman, M., Clarke, L.A., Schappert, K., Hayden, M.R. (1993). Erratum: A transcription map of the region containing the Huntington disease gene (Human molecular genetics (1993) 2 (901-907)). Human Molecular Genetics.
• Goldberg, Y.P., Rommens, J.M., Andrew, S.E., Hutchinson, G.B., Lin, B., Theilmann, J., Graham, R., Glaves, M.L., Starr, E., McDonald, H., Nasir, J., Schappert, K., Kalchman, M.A., Clarke, L.A., Hayden, M.R. (1993). Identification of an Alu retrotransposition event in close proximity to a strong candidate gene for Huntington's disease. Nature. DOI
• Goldberg, Y.P., Kremer, B., Andrew, S.E., Theilmann, J., Graham, R.K., Squitieri, F., Telenius, H., Adam, S., Sajoo, A., Starr, E., Heiberg, A., Wolff, G., Hayden, M.R. (1993). Molecular analysis of new mutations for Huntington's disease: Intermediate alleles and sex of origin effects. Nature Genetics. DOI
• Andrew, S.E., Goldberg, Y.P., Kremer, B., Telenius, H., Theilmann, J., Adam, S., Starr, E., Squitieri, F., Lin, B., Kalchman, M.A., Graham, R.K., Hayden, M.R. (1993). The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nature Genetics. DOI
• Goldberg, Y.P., Lin, B.-Y., Andrew, S.E., Nasir, J., Graham, R., Glaves, M.L., Hutchinson, G., Theilmann, J., Ginzinger, D.G., Schappert, K., Clarke, L., Rommens, J.M., Hayden, M.R. (1992). Cloning and mapping of the α-adducin gene close to D4S95 and assessment of its relationship to huntington disease. Human Molecular Genetics. DOI
• Weber, B., Riess, O., Wolff, G., Andrew, S., Collins, C., Graham, R., Theilmann, J., Hayden, M.R. (1992). Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington’s disease. Nature Genetics. DOI