Philippe Sarret

Prix et distinctions

• (2016) Prix du doyen. Université de Sherbrooke.
• (2015) Best publication of the year. Université de Sherbrooke.
• (2013) Young investigator. Université de Sherbrooke.
• (2013) Prix Relève à la recherche médicale. Foundation of Sherbrooke University Health Center.
• (2009) Best publication of the year. Université de Sherbrooke.
• (2006) Young investigator. Université de Sherbrooke.
• (2006) Early Career Award. Canadian Pain Society.

Publications

Articles

• Lounes Haroune, Sabrina Saibi, Jean-Philippe Bellenger, Matthieu Vincenot, Guillaume Léonard, Louis Gendron, Philippe Sarret. (2025). Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis. ACS Omega. DOI
• Émile Breault, Rebecca L. Brouillette, Terence E. Hébert, Philippe Sarret, Élie Besserer-Offroy. (2025). Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail. CNS Drugs. DOI
• Dany Dion, Christophe Noll, Mélanie Fortin, Lounès Haroune, Sabrina Saibi, Philippe Sarret, André C Carpentier. (2025). Plasma Endocannabinoids Are Independently Associated With the Metabolic Function of White Adipose Tissue. The Journal of Clinical Endocrinology & Metabolism. DOI
• Juan Antonio Contreras Vite, Alexandria Tiffinger, Léa Théroux, Nathalie Morin, Mannix Auger-Messier, Pierre-Luc Boudreault, Philippe Sarret, Olivier Lesur, Robert Dumaine. (2025). A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome. International Journal of Molecular Sciences. DOI
• Michael Desgagné, Magali Chartier, Camille Lagard, Sára Ferková, Mathieu Choquette, Jean‐Michel Longpré, Jérôme Côté, Pierre‐Luc Boudreault, Philippe Sarret. (2024). Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid‐Free Analgesics. Angewandte Chemie. DOI
• Michael Desgagné, Magali Chartier, Camille Lagard, Sára Ferková, Mathieu Choquette, Jean‐Michel Longpré, Jérôme Côté, Pierre‐Luc Boudreault, Philippe Sarret. (2024). Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid‐Free Analgesics. Angewandte Chemie International Edition. DOI
• Sára Ferková, Ulrike Froehlich, Marie-Édith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault. (2023). Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein–Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International Journal of Molecular Sciences. DOI
• Santo Previti, Michael Desgagné, Dirk Tourwé, Florine Cavelier, Philippe Sarret, Steven Ballet. (2023). Opening the amino acid toolbox for peptide‐based NTS2‐selective ligands as promising lead compounds for pain management. Journal of Peptide Science. DOI
• Tran, K., Sainsily, X., Côté, J., Coquerel, D., Couvineau, P., Saibi, S., Haroune, L., Besserer-Offroy, E., Flynn-Robitaille, J., Resua Rojas, M., Murza, A., Longpré, J.-M., Auger-Messier, M., Lesur, O., Bouvier, M., Marsault, E., Boudreault, P.-L., Sarret, P. (2022). Size-Reduced Macrocyclic Analogues of [Pyr¹]-apelin-13 Showing Negative Gα₁₂Bias Still Produce Prolonged Cardiac Effects. Journal of Medicinal Chemistry. DOI
• Marc-André Dansereau, Élora Midavaine, Valérie Bégin-Lavallée, Mounir Belkouch, Nicolas Beaudet, Jean-Michel Longpré, Stéphane Mélik-Parsadaniantz, Philippe Sarret. (2021). Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity. Journal of Neuroinflammation. DOI
• Maxime Fougère, Cornelis Immanuel van der Zouwen, Joël Boutin, Kloé Neszvecsko, Philippe Sarret, Dimitri Ryczko. (2021). Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease. Proceedings of the National Academy of Sciences. DOI
• Christian Comeau, Benjamin Ries, Thomas Stadelmann, Jacob Tremblay, Sylvain Poulet, Ulrike Fröhlich, Jérôme Côté, Pierre-Luc Boudreault, Rabeb Mouna Derbali, Philippe Sarret, Michel Grandbois, Grégoire Leclair, Sereina Riniker, Éric Marsault. (2021). Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties. Journal of Medicinal Chemistry. DOI
• Magali Chartier, Michael Desgagné, Marc Sousbie, Jérôme Côté, Jean-Michel Longpré, Eric Marsault, Philippe Sarret. (2021). Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic. Journal of Medicinal Chemistry. DOI
• Coquerel, D., Lamoureux, J., Chagnon, F., Trân, K., Sage, M., Fortin-Pellerin, E., Delile, E., Sainsily, X., Fournier, J., Dumont, A.-A., Auger-Messier, M., Sarret, P., Marsault, E., Praud, J.-P., Fülöp, T., Lesur, O. (2021). Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients. Scientific Reports. DOI
• Trân, K., Van Den Hauwe, R., Sainsily, X., Couvineau, P., Côté, J., Simard, L., Echevarria, M., Murza, A., Serre, A., Théroux, L., Saibi, S., Haroune, L., Longpré, J.-M., Lesur, O., Auger-Messier, M., Spino, C., Bouvier, M., Sarret, P., Ballet, S., Marsault, É. (2021). Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. Journal of Medicinal Chemistry. DOI
• Sainsily, X., Coquerel, D., Giguère, H., Dumont, L., Tran, K., Noll, C., Ionescu, A.L., Côté, J., Longpré, J.-M., Carpentier, A., Marsault, É., Lesur, O., Sarret, P., Auger-Messier, M. (2021). Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake. Frontiers in Pharmacology. DOI
• Coquerel, D., Delile, E., Dumont, L., Chagnon, F.E., Murza, A., Sainsily, X., Salvail, D., Sarret, P., Marsault, E., Auger-Messier, M., Lesur, O. (2021). Gai-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats. American Journal of Physiology - Heart and Circulatory Physiology. DOI
• Midavaine, É., Côté, J., Marchand, S., Sarret, P. (2021). Glial and neuroimmune cell choreography in sexually dimorphic pain signaling. Neuroscience and Biobehavioral Reviews. DOI
• Chartier, M., Desgagné, M., Sousbie, M., Rumsby, C., Chevillard, L., Théroux, L., Haroune, L., Côté, J., Longpré, J.-M., Boudreault, P.-L., Marsault, É., Sarret, P. (2021). Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog. Biomedicine and Pharmacotherapy. DOI
• Michaelian, N., Sadybekov, A., Besserer-Offroy, É., Han, G.W., Krishnamurthy, H., Zamlynny, B.A., Fradera, X., Siliphaivanh, P., Presland, J., Spencer, K.B., Soisson, S.M., Popov, P., Sarret, P., Katritch, V., Cherezov, V. (2021). Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Nature Communications. DOI
• Trân, K., Murza, A., Sainsily, X., Delile, E., Couvineau, P., Côté, J., Coquerel, D., Peloquin, M., Auger-Messier, M., Bouvier, M., Lesur, O., Sarret, P., Marsault, É. (2021). Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor. Journal of Medicinal Chemistry. DOI
• Dassieu, L., Paul-Savoie, E., Develay, É., Villela Guilhon, A.C., Lacasse, A., Guénette, L., Perreault, K., Beaudry, H., Dupuis, L., Bérubé, M., Blaise, G., Boulanger, A., Cogan, J., Décary, S., Ferland, C.E., Gélinas, C., Gendron, L., Hudon, A., Huni, G., Lafrenaye, S., Lavigne, G., Lemay, S., Lussier, D., Pagé, M.G., Pageaux, B., Pineyro, G., Rainville, P., Sarret, P., Shir, Y., Troncy, E., Williamson, D. (2021). Swallowing the pill of adverse effects: A qualitative study of patients' and pharmacists' experiences and decision-making regarding the adverse effects of chronic pain medications. Health Expectations. DOI
• Midavaine, É., Côté, J., Sarret, P. (2021). The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers. Cancer and Metastasis Reviews. DOI
• Biet, M., Dansereau, M.-A., Sarret, P., Dumaine, R. (2021). The neuronal potassium current I_A is a potential target for pain during chronic inflammation. Physiological Reports. DOI
• Sarret, P. (2021). Éric Marsault (1971-2021): A Legacy through the Prism of Relationship Chemistry. Journal of Medicinal Chemistry. DOI
• Mélissa Girard, Steve Dagenais Bellefeuille, Émilie Eiselt, Rebecca Brouillette, Morgane Placet, Guillaume Arguin, Jean‐Michel Longpré, Philippe Sarret, Fernand‐Pierre Gendron. (2020). The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration. Journal of Cellular Physiology. DOI
• Émilie Eiselt, Valérie Otis, Karine Belleville, Gaoqiang Yang, Alain Larocque, Anthony Régina, Michel Demeule, Philippe Sarret, Louis Gendron. (2020). Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain. The Journal of Pharmacology and Experimental Therapeutics. DOI
• Constanzo, J., Midavaine, É., Fouquet, J., Lepage, M., Descoteaux, M., Kirby, K., Tremblay, L., Masson-Côté, L., Geha, S., Longpré, J.-M., Paquette, B., Sarret, P. (2020). Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner. Progress in Neuro-Psychopharmacology and Biological Psychiatry. DOI
• Besserer-Offroy, É., Tétreault, P., Brouillette, R.L., René, A., Murza, A., Fanelli, R., Kirby, K., Parent, A., Dubuc, I., Beaudet, N., Côté, J., Longpré, J.-M., Martinez, J., Cavelier, F., Sarret, P. (2020). Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8–13) analog. Data in Brief. DOI
• Previti, S., Vivancos, M., Rémond, E., Beaulieu, S., Longpré, J.-M., Ballet, S., Sarret, P., Cavelier, F. (2020). Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia. Frontiers in Chemistry. DOI
• Gonzalez, S., Dumitrascuta, M., Eiselt, E., Louis, S., Kunze, L., Blasiol, A., Vivancos, M., Previti, S., Dewolf, E., Martin, C., Tourwé, D., Cavelier, F., Gendron, L., Sarret, P., Spetea, M., Ballet, S. (2020). Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies. Journal of Medicinal Chemistry. DOI
• Barrière, D.A., Boumezbeur, F., Dalmann, R., Cadeddu, R., Richard, D., Pinguet, J., Daulhac, L., Sarret, P., Whittingstall, K., Keller, M., Mériaux, S., Eschalier, A., Mallet, C. (2020). Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey. British Journal of Pharmacology. DOI
• Barrière, D.A., Midavaine, É., Doré-Savard, L., Kirby, K., Tremblay, L., Beaudoin, J.-F., Beaudet, N., Longpré, J.-M., Lecomte, R., Lepage, M., Sarret, P. (2020). Publisher Correction: Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management (Scientific Reports, (2019), 9, 1, (20155), 10.1038/s41598-019-56622-5). Scientific Reports. DOI
• Sadybekov, A.A., Brouillette, R.L., Marin, E., Sadybekov, A.V., Luginina, A., Gusach, A., Mishin, A., Besserer-Offroy, É., Longpré, J.-M., Borshchevskiy, V., Cherezov, V., Sarret, P., Katritch, V. (2020). Structure-based virtual screening of ultra-large library yields potent antagonists for a lipid gpcr. Biomolecules. DOI
• Boulkeroua, C., Ayari, H., Khalfaoui, T., Lafrance, M., Besserer-Offroy, É., Ekindi, N., Sabbagh, R., Dumaine, R., Lesur, O., Sarret, P., Chraibi, A. (2019). Apelin-13 regulates vasopressin-induced aquaporin-2 expression and trafficking in kidney collecting duct cells. Cellular Physiology and Biochemistry. DOI
• Murza, A., Trân, K., Bruneau-Cossette, L., Lesur, O., Auger-Messier, M., Lavigne, P., Sarret, P., Marsault, É. (2019). Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond. Peptide Science. DOI
• André Barrière, D., Midavaine, É., Doré-Savard, L., Kirby, K., Tremblay, L., Beaudoin, J.-F., Beaudet, N., Longpré, J.-M., Lecomte, R., Lepage, M., Sarret, P. (2019). Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management. Scientific Reports. DOI
• Claff, T., Yu, J., Blais, V., Patel, N., Martin, C., Wu, L., Han, G.W., Holleran, B.J., Van der Poorten, O., White, K.L., Hanson, M.A., Sarret, P., Gendron, L., Cherezov, V., Katritch, V., Ballet, S., Liu, Z.-J., Müller, C.E., Stevens, R.C. (2019). Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. Science advances. DOI
• Eiselt, E., Gonzalez, S., Martin, C., Chartier, M., Betti, C., Longpré, J.-M., Cavelier, F., Tourwé, D., Gendron, L., Ballet, S., Sarret, P. (2019). Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chemical Neuroscience. DOI
• Besserer-Offroy, E., Sarret, P. (2019). Sending out biased signals: An appropriate proposition for pain?. Douleur et Analgesie. DOI
• Gusach, A., Luginina, A., Marin, E., Brouillette, R.L., Besserer-Offroy, É., Longpré, J.-M., Ishchenko, A., Popov, P., Patel, N., Fujimoto, T., Maruyama, T., Stauch, B., Ergasheva, M., Romanovskaia, D., Stepko, A., Kovalev, K., Shevtsov, M., Gordeliy, V., Han, G.W., Katritch, V., Borshchevskiy, V., Sarret, P., Mishin, A., Cherezov, V. (2019). Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nature Communications. DOI
• Luginina, A., Gusach, A., Marin, E., Mishin, A., Brouillette, R., Popov, P., Shiriaeva, A., Besserer-Offroy, É., Longpré, J.-M., Lyapina, E., Ishchenko, A., Patel, N., Polovinkin, V., Safronova, N., Bogorodskiy, A., Edelweiss, E., Hu, H., Weierstall, U., Liu, W., Batyuk, A., Gordeliy, V., Han, G.W., Sarret, P., Katritch, V., Borshchevskiy, V., Cherezov, V. (2019). Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Science Advances. DOI
• Eiselt, E., Côté, J., Longpré, J.-M., Blais, V., Sarret, P., Gendron, L. (2019). The combination of opioid and neurotensin receptor agonists improves their analgesic/adverse effect ratio. European Journal of Pharmacology. DOI
• (2018). A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects. Journal of medicinal chemistry. DOI
• (2018). Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications. Scientific reports. DOI
• Willemse, T., Eiselt, E., Hollanders, K., Schepens, W., van Vlijmen, H.W.T., Chung, N.N., Blais, V., Holleran, B., Longpré, J.-M., Schiller, P.W., Maes, B.U.W., Sarret, P., Gendron, L., Ballet, S. (2018). Chemical space screening around Phe³ in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings. Bioorganic and Medicinal Chemistry Letters. DOI
• Willemse, T., Eiselt, E., Hollanders, K., Schepens, W., van Vlijmen, H.W.T., Chung, N.N., Blais, V., Holleran, B., Longpré, J.-M., Schiller, P.W., Maes, B.U.W., Sarret, P., Gendron, L., Ballet, S. (2018). Corrigendum to “Chemical space screening around Phe ³ in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings” [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320–2323](S0960894X18304049)(10.1016/j.bmcl.2018.05.015). Bioorganic and Medicinal Chemistry Letters. DOI
• Constanzo, J., Dumont, M., Lebel, R., Tremblay, L., Whittingstall, K., Masson-Côté, L., Geha, S., Sarret, P., Lepage, M., Paquette, B., Descoteaux, M. (2018). Diffusion MRI monitoring of specific structures in the irradiated rat brain. Magnetic Resonance in Medicine. DOI
• Sousbie, M., Besserer-Offroy, E., Brouillette, R.L., Longpré, J.-M., Leduc, R., Sarret, P., Marsault, E. (2018). In Search of the Optimal Macrocyclization Site for Neurotensin. ACS Medicinal Chemistry Letters. DOI
• Normandeau, C.P., Torruella Suárez, M.L., Sarret, P., McElligott, Z.A., Dumont, E.C. (2018). Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice. Neuropharmacology. DOI
• Sousbie, M., Vivancos, M., Brouillette, R.L., Besserer-Offroy, É., Longpré, J.-M., Leduc, R., Sarret, P., Marsault, É. (2018). Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13). Journal of Medicinal Chemistry. DOI
• Maurice-Gélinas, C., Deslauriers, J., Monpays, C., Sarret, P., Grignon, S. (2018). The 5α-reductase inhibitor finasteride increases suicide-related aggressive behaviors and blocks clozapine-induced beneficial effects in an animal model of schizophrenia. Physiology and Behavior. DOI
• Coquerel, D., Sainsily, X., Dumont, L., Sarret, P., Marsault, Auger-Messier, M., Lesur, O. (2018). The apelinergic system as an alternative to catecholamines in low-output septic shock. Critical Care. DOI
• Chagnon, F., Coquerel, D., Salvail, D., Marsault, E., Dumaine, R., Auger-Messier, M., Sarret, P., Lesur, O. (2017). Apelin Compared with Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction∗. Critical Care Medicine. DOI
• Choinière, M., Ware, M.A., Pagé, M.G., Lacasse, A., Lanctôt, H., Beaudet, N., Boulanger, A., Bourgault, P., Cloutier, C., Coupal, L., De Koninck, Y., Dion, D., Dolbec, P., Germain, L., Martin, V., Sarret, P., Shir, Y., Taillefer, M.-C., Tousignant, B., Trépanier, A., Truchon, R. (2017). Development and implementation of a registry of patients attending multidisciplinary pain treatment clinics: The Quebec pain registry. Pain Research and Management. DOI
• Coquerel, D., Chagnon, F., Sainsily, X., Dumont, L., Murza, A., Côté, J., Dumaine, R., Sarret, P., Marsault, É., Salvail, D., Auger-Messier, M., Lesur, O. (2017). ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock. Critical care medicine. DOI
• Ferland, C.E., Parent, A.J., Saran, N., Ingelmo, P.M., Lacasse, A., Marchand, S., Sarret, P., Ouellet, J.A. (2017). Preoperative Norepinephrine Levels in Cerebrospinal Fluid and Plasma Correlate With Pain Intensity After Pediatric Spine Surgery. Spine Deformity. DOI
• Murza, A., Sainsily, X., Côté, J., Bruneau-Cossette, L., Besserer-Offroy, Élie., Longpré, J.-M., Leduc, R., Dumaine, R., Lesur, O., Auger-Messier, M., Sarret, P., Marsault, É. (2017). Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Organic and Biomolecular Chemistry. DOI
• Constanzo, J., Masson-Côté, L., Tremblay, L., Fouquet, J.P., Sarret, P., Geha, S., Whittingstall, K., Paquette, B., Lepage, M. (2017). Understanding the continuum of radionecrosis and vascular disorders in the brain following gamma knife irradiation: An MRI study. Magnetic Resonance in Medicine. DOI
• Fanelli, R., Floquet, N., Besserer-Offroy, E., Delort, B., Vivancos, M., Longpré, J.-M., Renault, P., Martinez, J., Sarret, P., Cavelier, F. (2017). Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. Journal of Medicinal Chemistry. DOI
• Van Der Poorten, O., Van Den Hauwe, R., Eiselt, E., Betti, C., Guillemyn, K., Chung, N.N., Hallé, F., Bihel, F., Schiller, P.W., Tourwé, D., Sarret, P., Gendron, L., Ballet, S. (2017). χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds. ACS Medicinal Chemistry Letters. DOI
• (2016). Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development. Molecular pain. DOI
• Deslauriers, J., Belleville, K., Beaudet, N., Sarret, P., Grignon, S. (2016). A two-hit model of suicide-trait-related behaviors in the context of a schizophrenia-like phenotype: Distinct effects of lithium chloride and clozapine. Physiology and Behavior. DOI
• Otis, C., Gervais, J., Guillot, M., Gervais, J.-A., Gauvin, D., Péthel, C., Authier, S., Dansereau, M.-A., Sarret, P., Martel-Pelletier, J., Pelletier, J.-P., Beaudry, F., Troncy, E. (2016). Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model. Arthritis Research and Therapy. DOI
• Parent, A.J., Tétreault, P., Roux, M., Belleville, K., Longpré, J.-M., Beaudet, N., Goffaux, P., Sarret, P. (2016). Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain. Neuroscience. DOI
• Murza, A., Sainsily, X., Coquerel, D., Côté, J., Marx, P., Besserer-Offroy, E., Longpré, J.-M., Lainé, J., Reversade, B., Salvail, D., Leduc, R., Dumaine, R., Lesur, O., Auger-Messier, M., Sarret, P., Marsault, E. (2016). Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. Journal of Medicinal Chemistry. DOI
• Thomas, J.B., Vivancos, M., Giddings, A.M., Wiethe, R.W., Warner, K.R., Murza, A., Besserer-Offroy, E., Longpré, J.-M., Runyon, S.P., Decker, A.M., Gilmour, B.P., Sarret, P. (2016). Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chemical Neuroscience. DOI
• Souissi, H., Fréchette, Y., Murza, A., Masse, M.-H., Marsault, É., Sarret, P., D’Aragon, F., Parent, A.J., Sansoucy, Y. (2016). Intracuff 160 mg alkalinized lidocaine reduces cough upon emergence from N₂O-free general anesthesia: a randomized controlled trial,Une solution de 160 mg de lidocaïne alcalinisée dans le ballonnet réduit la toux à l’émergence d’une anesthésie générale sans N₂O: une étude randomisée contrôlée. Canadian Journal of Anesthesia. DOI
• Monpays, C., Deslauriers, J., Sarret, P., Grignon, S. (2016). Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model. Journal of Molecular Neuroscience. DOI
• Hapəu, D., Rémond, E., Fanelli, R., Vivancos, M., René, A., Côté, J., Besserer-Offroy, É., Longpré, J.-M., Martinez, J., Zaharia, V., Sarret, P., Cavelier, F. (2016). Stereoselective Synthesis of β-(5-Arylthiazolyl) α-Amino Acids and Use in Neurotensin Analogues. European Journal of Organic Chemistry. DOI
• Quaegebeur, N., Masson, P., Beaudet, N., Sarret, P. (2016). Touchscreen Surface Based on Interaction of Ultrasonic Guided Waves with a Contact Impedance. IEEE Sensors Journal. DOI
• Murza, A., Besserer-Offroy, E., Côté, J., Bérubé, P., Longpré, J.-M., Dumaine, R., Lesur, O., Auger-Messier, M., Leduc, R., Sarret, P., Marsault, E. (2015). C-terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. Journal of Medicinal Chemistry. DOI
• Brial, F., Lussier, C.R., Belleville, K., Sarret, P., Boudreau, F. (2015). Ghrelin inhibition restores glucose homeostasis in hepatocyte nuclear factor-1a (MODY3)-deficient mice. Diabetes. DOI
• Thomas, J.B., Giddings, A.M., Olepu, S., Wiethe, R.W., Harris, D.L., Narayanan, S., Warner, K.R., Sarret, P., Longpre, J.-M., Runyon, S.P., Gilmour, B.P. (2015). Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorganic and Medicinal Chemistry Letters. DOI
• Parent, A.J., Beaudet, N., Daigle, K., Sabbagh, R., Sansoucy, Y., Marchand, S., Sarret, P., Goffaux, P. (2015). Relationship between blood- and cerebrospinal fluid-bound neurotransmitter concentrations and conditioned pain modulation in pain-free and chronic pain subjects. Journal of Pain. DOI
• Fanelli, R., Besserer-Offroy, E., René, A., Côté, J., Tétreault, P., Collerette-Tremblay, J., Longpré, J.-M., Leduc, R., Martinez, J., Sarret, P., Cavelier, F. (2015). Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. Journal of Medicinal Chemistry. DOI
• Thomas, J.B., Giddings, A.M., Olepu, S., Wiethe, R.W., Warner, K.R., Sarret, P., Longpre, J.-M., Runyon, S.P., Gilmour, B.P. (2015). The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2. Bioorganic and Medicinal Chemistry Letters. DOI
• Demeule, M., Beaudet, N., Régina, A., Besserer-Offroy, E., Murza, A., Tétreault, P., Belleville, K., Ché, C., Larocque, A., Thiot, C., Béliveau, R., Longpré, J.-M., Marsault, E., Leduc, R., Lachowicz, J.E., Gonias, S.L., Castaigne, J.-P., Sarret, P. (2014). Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. Journal of Clinical Investigation. DOI
• Belkouch, M., Dansereau, M.-A., Tétreault, P., Biet, M., Beaudet, N., Dumaine, R., Chraibi, A., Mélik-Parsadaniantz, S., Sarret, P. (2014). Functional up-regulation of Na_v1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation. Journal of Neuroinflammation. DOI
• Thomas, J.B., Giddings, A.M., Wiethe, R.W., Olepu, S., Warner, K.R., Sarret, P., Gendron, L., Longpre, J.-M., Zhang, Y., Runyon, S.P., Gilmour, B.P. (2014). Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3- yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. Journal of Medicinal Chemistry. DOI
• Thomas, J.B., Giddings, A.M., Wiethe, R.W., Olepu, S., Warner, K.R., Sarret, P., Gendron, L., Longpre, J.-M., Zhang, Y., Runyon, S.P., Gilmour, B.P. (2014). Identification of N -[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1 H -indol-1-yl)acetyl]- l -leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. Journal of Medicinal Chemistry. DOI
• Deslauriers, J., Desmarais, C., Sarret, P., Grignon, S. (2014). Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells. Journal of Molecular Neuroscience. DOI
• Beaudet, N., Courteau, J., Sarret, P., Vanasse, A. (2014). Improving the selection of true incident cases of low back pain by screening retrospective administrative data. European Journal of Pain (United Kingdom). DOI
• Deslauriers, J., Racine, W., Sarret, P., Grignon, S. (2014). Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia. Neuroscience. DOI
• Murza, A., Belleville, K., Longpré, J.-M., Sarret, P., Marsault, É. (2014). Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid. Biopolymers - Peptide Science Section. DOI
• (2013). Mammary cancer bone metastasis follow-up using multimodal small-animal MR and PET imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Doré-Savard, L., Beaudet, N., Tremblay, L., Xiao, Y., Lepage, M., Sarret, P. (2013). A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model. Clinical and Experimental Metastasis. DOI
• Deslauriers, J., Larouche, A., Sarret, P., Grignon, S. (2013). Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers. Progress in Neuro-Psychopharmacology and Biological Psychiatry. DOI
• Beaudet, N., Courteau, J., Sarret, P., Vanasse, A. (2013). Prevalence of claims-based recurrent low back pain in a Canadian population: A secondary analysis of an administrative database. BMC Musculoskeletal Disorders. DOI
• Tétreault, P., Beaudet, N., Perron, A., Belleville, K., René, A., Cavelier, F., Martinez, J., Stroh, T., Jacobi, A.M., Rose, S.D., Behlke, M.A., Sarret, P. (2013). Spinal NTS2 receptor activation reverses signs of neuropathic pain. FASEB Journal. DOI
• Deslauriers, J., Desmarais, C., Sarret, P., Grignon, S. (2013). α-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3β signaling pathway induced by antipsychotics: Potential relevance for the treatment of schizophrenia. Journal of Molecular Neuroscience. DOI
• Murza, A., Parent, A., Besserer-Offroy, E., Tremblay, H., Karadereye, F., Beaudet, N., Leduc, R., Sarret, P., Marsault, E. (2012). Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability. ChemMedChem. DOI
• Parent, A.J., Beaudet, N., Beaudry, H., Bergeron, J., Bérubé, P., Drolet, G., Sarret, P., Gendron, L. (2012). Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. Behavioural Brain Research. DOI
• Guillemette, A., Dansereau, M.A., Beaudet, N., Richelson, E., Sarret, P. (2012). Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. European journal of pain (London, England). DOI
• Girard, S., Sébire, H., Brochu, M.-E., Briota, S., Sarret, P., Sébire, G. (2012). Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries. Brain, Behavior, and Immunity. DOI
• Chen, A., Goling, E.K., Witkowski, L., Bhindi, A., Bauch, C., Roussy, G., Sarret, P., Kreienkamp, H.-J., Stroh, T. (2012). Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system. Journal of Comparative Neurology. DOI
• Deslauriers, J., Lefrançois, M., Larouche, A., Sarret, P., Grignon, S. (2011). Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y Neuroblastoma cells. Synapse. DOI
• van Steenwinckel, J., Goazigo, A.R.-L., Pommier, B., Mauborgne, A., Dansereau, M.-A., Kitabgi, P., Sarret, P., Pohl, M., Parsadaniantz, S.M. (2011). CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. Journal of Neuroscience. DOI
• Maloum, F., Allaire, J.M., Gagné-Sansfaçon, J., Roy, E., Belleville, K., Sarret, P., Morisset, J., Carrier, J.C., Mishina, Y., Kaestner, K.H., Perreault, N. (2011). Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. American Journal of Physiology - Gastrointestinal and Liver Physiology. DOI
• Benoit, C.-E., Rowe, W.B., Menard, C., Sarret, P., Quirion, R. (2011). Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory. Trends in Pharmacological Sciences. DOI
• Rostène, W., Dansereau, M.-A., Godefroy, D., Van Steenwinckel, J., Goazigo, A.R.-L., Mélik-Parsadaniantz, S., Apartis, E., Hunot, S., Beaudet, N., Sarret, P. (2011). Neurochemokines: A menage a trois providing new insights on the functions of chemokines in the central nervous system. Journal of Neurochemistry. DOI
• Otis, V., Sarret, P., Gendron, L. (2011). Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience. DOI
• Belkouch, M., Dansereau, M., Goazigo, A.R.-L., van Steenwinckel, J., Beaudet, N., Chraibi, A., Melik-Parsadaniantz, S., Sarret, P. (2011). The chemokine CCL2 increases Na _v1.8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism. Journal of Neuroscience. DOI
• Tétreault, P., Dansereau, M.-A., Doré-Savard, L., Beaudet, N., Sarret, P. (2011). Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats. Physiology and Behavior. DOI
• (2010). Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain. PloS one. DOI
• Roussy, G., Beaudry, H., Lafrance, M., Belleville, K., Beaudet, N., Wada, K., Gendron, L., Sarret, P. (2010). Altered morphine-induced analgesia in neurotensin type 1 receptor null mice. Neuroscience. DOI
• Sarret, P., Doré-Savard, L., Beaudet, N. (2010). Direct application of siRNA for in vivo pain research. Methods in molecular biology (Clifton, N.J.). DOI
• Hwang, J.R., Baek, M.W., Sim, J., Choi, H.-S., Han, J.M., Kim, Y.L., Hwang, J.-I., Kwon, H.B., Beaudet, N., Sarret, P., Seong, J.Y. (2010). Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. Biochemical and Biophysical Research Communications. DOI
• Lafrance, M., Roussy, G., Belleville, K., Maeno, H., Beaudet, N., Wada, K., Sarret, P. (2010). Involvement of NTS2 receptors in stress-induced analgesia. Neuroscience. DOI
• Benoit, C.-E., Bastianetto, S., Brouillette, J., Tse, Y., Boutin, J.A., Delagrange, P., Wong, T., Sarret, P., Quirion, R. (2010). Loss of quinone reductase 2 function selectively facilitates learning behaviors. Journal of Neuroscience. DOI
• Chamberland, C., Barajas-Martinez, H., Haufe, V., Fecteau, M.-H., Delabre, J.-F., Burashnikov, A., Antzelevitch, C., Lesur, O., Chraibi, A., Sarret, P., Dumaine, R. (2010). Modulation of canine cardiac sodium current by Apelin. Journal of Molecular and Cellular Cardiology. DOI
• Lesur, O., Roussy, J.-F., Chagnon, F., Gallo-Payet, N., Dumaine, R., Sarret, P., Chraibi, A., Chouinard, L., Hogue, B. (2010). Proven infection-related sepsis induces a differential stress response early after ICU admission. Critical Care. DOI
• Girard, S., Kadhim, H., Beaudet, N., Sarret, P., Sébire, G. (2009). Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: A novel animal model for cerebral palsy in very premature infants. Neuroscience. DOI
• Roussy, G., Dansereau, M.-A., Baudisson, S., Ezzoubaa, F., Belleville, K., Beaudet, N., Martinez, J., Richelson, E., Sarret, P. (2009). Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity. Molecular Pain. DOI
• Doré-Savard, L., Roussy, G., Dansereau, M.-A., Collingwood, M.A., Lennox, K.A., Rose, S.D., Beaudet, N., Behlke, M.A., Sarret, P. (2008). Central delivery of dicer-substrate siRNA: A direct application for pain research. Molecular Therapy. DOI
• Gosselin, R.D., Dansereau, M.A., Pohl, M., Kitabgi, P., Beaudet, N., Sarret, P., Parsadaniantz, S.M. (2008). Chemokine network in the nervous system: A new target for pain relief. Current Medicinal Chemistry. DOI
• Dansereau, M.-A., Gosselin, R.-D., Pohl, M., Pommierjt, B., Mechighel, P., Mauborgne, A., Rostene, J.W., Kitabgi, P., Beaudet, N., Sarret, P., Melik-Parsadaniantzt, S. (2008). Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Journal of Neurochemistry. DOI
• Roussy, G., Dansereau, M.-A., Doré-Savard, L., Belleville, K., Beaudet, N., Richelson, E., Sarret, P. (2008). Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. Journal of Neurochemistry. DOI
• Larouche, A., Berube, P., Sarret, P., Grignon, S. (2008). Subacute H₂O₂, but not poly(IC), upregulates dopamine D2 receptors in retinoic acid differentiated SH-SY5Y neuroblastoma. Synapse. DOI
• Sharif, N., Gendron, L., Wowchuk, J., Sarret, P., Mazella, J., Beaudet, A., Stroh, T. (2007). Coexpression of somatostatin receptor subtype 5 affects internalization and trafficking of somatostatin receptor subtype 2. Endocrinology. DOI
• Sarret, P., Beaudet, N., Roussy, G. (2007). Le récepteur nts2 : Un frein á la douleur. Medecine/Sciences. DOI
• Perron, A., Sharif, N., Sarret, P., Stroh, T., Beaudet, A. (2007). NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization. Biochemical and Biophysical Research Communications. DOI
• Stroh, T., Sarret, P., Tannenbaum, G.S., Beaudet, A. (2006). Immunohistochemical distribution and subcellular localization of the somatostatin receptor subtype 1 (sst1) in the rat hypothalamus. Neurochemical Research. DOI
• Perron, A., Sarret, P., Gendron, L., Stroh, T., Beaudet, A. (2005). Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system. Journal of Biological Chemistry. DOI
• Sarret, P., Esdaile, M.J., Perron, A., Martinez, J., Stroh, T., Beaudet, A. (2005). Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors. Journal of Neuroscience. DOI
• Gendron, L., Perron, A., Payet, M.D., Gallo-Payet, N., Sarret, P., Beaudet, A. (2004). Low-affinity neurotensin receptor (NTS2) signaling: Internalization- dependent activation of extracellular signal-regulated kinases 1/2. Molecular Pharmacology. DOI
• Sarret, P., Esdaile, M.J., McPherson, P.S., Schonbrunn, A., Kreienkamp, H.-J., Beaudet, A. (2004). Role of Amphiphysin II in Somatostatin Receptor Trafficking in Neuroendocrine Cells. Journal of Biological Chemistry. DOI
• Sarret, P., Krzywkowski, P., Segal, L., Nielsen, M.S., Petersen, C.M., Mazella, J., Stroh, T., Beaudet, A. (2003). Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system. Journal of Comparative Neurology. DOI
• Sarret, P., Perron, A., Stroh, T., Beaudet, A. (2003). Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system. Journal of Comparative Neurology. DOI
• Sarret, P., Gendron, L., Kilian, P., Gallo-Payet, N., Payet, M.-D., Beaudet, A. (2002). Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells. Journal of Biological Chemistry. DOI
• Dal Farra, C., Sarret, P., Navarro, V., Botto, J.-M., Mazella, J., Vincent, J.-P. (2001). Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines. International Journal of Cancer. DOI
• Navarro, V., Martin, S., Sarret, P., Nielsen, M.S., Petersen, C.M., Vincent, J.-P., Mazella, J. (2001). Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. FEBS Letters. DOI
• Stroh, T., Jackson, A.C., Sarret, P., Dal Farra, C., Vincent, J.-P., Kreienkamp, H.-J., Mazella, J., Beaudet, A. (2000). Intracellular dynamics of sst₅ receptors in transfected COS-7 cells: Maintenance of cell surface receptors during ligand-induced endocytosis. Endocrinology. DOI
• Boudin, H., Sarret, P., Mazella, J., Schonbrunn, A., Beaudet, A. (2000). Somatostatin-induced regulation of SST(2A) receptor expression and cell surface availability in central neurons: Role of receptor internalization. Journal of Neuroscience. DOI
• Dubuc, I., Sarret, P., Labbé-Jullié, C., Botto, J.-M., Honoré, E., Bourdel, E., Martinez, J., Costentin, J., Vincent, J.-P., Kitabgi, P., Mazella, J. (1999). Identification of the receptor subtype involved in the analgesic effect of neurotensin. Journal of Neuroscience. DOI
• Nouel, D., Sarret, P., Vincent, J.-P., Mazella, J., Beaudet, A. (1999). Pharmacological, molecular and functional characterization of glial neurotensin receptors. Neuroscience. DOI
• Sarret, P., Nouel, D., Dal Farra, C., Vincent, J.-P., Beaudet, A., Mazella, J. (1999). Receptor-mediated internalization is critical for the inhibition of the expression of growth hormone by somatostatin in the pituitary cell line AtT- 20. Journal of Biological Chemistry. DOI
• Sarret, P., Botto, J.-M., Vincent, J.-P., Mazella, J., Beaudet, A. (1998). Preferential expression of sst2A over sst2B somatostatin receptor splice variant in rat brain and pituitary. Neuroendocrinology. DOI
• Sarret, P., Beaudet, A., Vincent, J.-P., Mazella, J. (1998). Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brain. Journal of Comparative Neurology. DOI
• Botto, J.-M., Chabry, J., Sarret, P., Vincent, J.-P., Mazella, J. (1998). Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: Binding properties, photoaffinity labeling, and internalization mechanism. Biochemical and Biophysical Research Communications. DOI
• Botto, J.-M., Sarret, P., Vincent, J.-P., Mazella, J. (1997). Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system. FEBS Letters. DOI
• Mazella, J., Botto, J.-M., Guillemare, E., Coppola, T., Sarret, P., Vincent, J.-P. (1996). Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. Journal of Neuroscience. DOI

Livres

• Sarret, P., Cavelier, F. (2016). Neurotensin and its receptors. The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. DOI
• Sarret, P., Doré-Savard, L., Tétreault, P., Bégin-Lavallée, V., Dansereau, M.-A., Beaudet, N. (2011). Using RNA interference to downregulate G protein-coupled receptors. Neuromethods. DOI
• Parsadaniantz, S.M., Banisadr, G., Sarret, P., Rostène, W. (2010). Chemokines and chemokine receptors in the brain. Chemokine Receptors and NeuroAIDS: Beyond Co-Receptor Function and Links to Other Neuropathologies. DOI
• Sarret, P., Beaudet, A. (2002). Chapter VI Neurotensin receptors in the central nervous system. Handbook of Chemical Neuroanatomy. DOI

Articles de conférence

• Quaegebeur, N., Masson, P., Beaudet, N., Sarret, P. (2013). Pressure mapping system based on guided waves reflection. Proceedings of Meetings on Acoustics. DOI

Propriétés intellectuelles

Brevets

• TRAN, K., MURZA, A., CÔTÉ, J., LONGPRÉ, JM., MARSAULT, É., BOUDREAULT, PL., SARRET, P. Apelinergic macrocycles and uses thereof. PCT/CA2022/051838. Canada. (2022).
• MARSAULT, É., DESGAGNÉ M., SOUSBIE, M., CHARTIER M., LONGPRÉ, JM., SARRET, P. Neurotensinergic agonists and method of using same preventing or treating pain. PCT/CA2020/50176. Canada. (2020).
• SARRET, P., MARSAULT, É., BOUDREAULT P.L., TRABOULSI H., NEPVEU-TRAVERSY M.E., GAUDREAU S., LEDUC F., LARRIVÉE J.F., ARCAND M. Antibodies specific for NTSR1 and uses thereof. WO 2020/041896 A1. Canada. (2017).
• MARSAULT, É., SOUSBIE, M., LEDUC, R., LONGPRÉ, JM., BESSERER-OFFROY, E., BROUILETTE, R., SARRET, P. Macrocyclic compounds and methods of preventing or treating pain. 2018/0362582 A1. Canada. (2017).
• MASSON P., QUAEGEBEUR N., LANGLOIS DEMERS D., ELKOUN S., OSTIGUY P-C., BEAUDET, N., SARRET, P. Active Acoustic Pressure Mapping System. US 61/679,232. États-Unis.
• TRAN, K., MURZA, THEROUX, L., LONGPRÉ, JM., MARSAULT, É., BOUDREAULT, PL., SARRET, P. Aminobenzamido Derivatives as Apelin Receptor Ligands and Uses Thereof. États-Unis.
• SARRET, P., MÉLIK-PARSADANIANTZ, S., BEAUDET, N. Chemokines : a novel therapeutics approach for the treatment of pain (en instance). États-Unis.
• TRAN, K., MURZA, A., MARSAULT, É., BOUDREAULT, PL., SARRET, P., AUGER-MESSIER, M., BENTZINGER, F. Method of treating skeletal muscle stem cell pathologic dysfunction (en instance). 63/368,535. Canada.
• LAVIGNE, P., MONTAGNE, M., ROY, V., LONGPRÉ, JM., SARRET, P. New Max design proteins as a delivery carrier of nucleic acids in cells (en instance). Canada.
• SARRET, P., BEHLKE, M., MÉLIK-PARSADANIANTZ, S., BEAUDET, N. Utilisation des Dicer Duplex siRNA dans le traitement central de la douleur chronique (en instance). États-Unis.

Autres contributions

Cours enseignés à l'UdeS

• PHR500 - Pharmacologie du système nerveux. (2023-2025). (3CR).

Activités professionnelles

• Service. Fonds de Recherche du Québec - Santé. Quebec Pain Research Network. Director. QC, QC, Canada. (2014-2019).
• Service. Institut de Pharmacologie de Sherbrooke. Director. Sherbrooke, Canada. (2013-).
• Service. Fonds de Recherche du Québec - Santé. Quebec Pain Research Network. Co-Director. QC, QC, Canada. (2010-2014).
• Service. Sherbrooke Neuroscience Center. Director. Sherbrooke, Canada. (2006-).

Divers

• Offroy, É.B.-O., Brouillette, R.L., Lavenus, S., Froehlich, U., Brumwell, A., Murza, A., Longpré, J.-M., Marsault, É., Grandbois, M., Sarret, P., Leduc, R. (2018). The signaling signature of the neurotensin type 1 receptor with endogenous ligands. arXiv.
• Fougère, M., van der Zouwen, C.I., Boutin, J., Neszvecsko, K., Sarret, P., Ryczko, D. (2021). ptogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotor movements in a mouse model of Parkinson’s disease. bioRxiv.
• Philippe Sarret, Florine Cavelier. (2017). Neurotensin and Its Receptors ☆. Reference Module in Neuroscience and Biobehavioral Psychology.
• Brouillette, R.L., Besserer-Offroy, E., Mona, C.E., Chartier, M., Lavenus, S., Sousbie, M., Belleville, K., Longpré, J.-M., Marsault, E., Grandbois, M., Sarret, P. (2020). Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. arXiv.
• P. Sarret, P. Kitabgi. (2009). Neurotensin and Receptors. Encyclopedia of Neuroscience.
• Vivancos, M., Fanelli, R., Besserer-Offroy, É., Beaulieu, S., Chartier, M., Resua-Rojas, M., Mona, C.E., Previti, S., Rémond, E., Longpré, J.-M., Cavelier, F., Sarret, P. (2021). Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia without Hypothermia. arXiv.
• Tétreault, P., Besserer-Offroy, É., Brouillette, R.L., René, A., Murza, A., Fanelli, R., Kirby, K., Parent, A.J., Dubuc, I., Beaudet, N., Côté, J., Longpré, J.-M., Martinez, J., Cavelier, F., Sarret, P. (2020). Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog. arXiv.
• Besserer-Offroy, É., Bérubé, P., Côté, J., Murza, A., Longpré, J.-M., Dumaine, R., Lesur, O., Auger-Messier, M., Leduc, R., Marsault, É., Sarret, P. (2018). The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment. arXiv.
• van der Zouwen, C.I., Boutin, J., Fougère, M., Flaive, A., Vivancos, M., Santuz, A., Akay, T., Sarret, P., Ryczko, D. (2020). Freely behaving mice can brake and turn during optogenetic stimulation of the mesencephalic locomotor region. bioRxiv.
• Alain Beaudet, Pierre Villeneuve, Philippe Sarret. (2002). Neurotensin. Wiley Encyclopedia of Molecular Medicine.
• Normandeau, C.P., Torruella Suárez, M.L., Sarret, P., McElligott, Z.A., Dumont, E.C. (2018). Neurotensin and dynorphin bi-directionally modulates CeA inhibition of oval BNST neurons in male mice. bioRxiv.