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Pedro D'Orléans-Juste

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie


Sujet de recherche

Cardiovascular System, Heart Failure, Hypertension, Prostheses and Vascular Substitutes

Disciplines de recherche



cyclooxygenases, endothelin, endothelin receptors, platelets, real-time PCR, telemetry

Intérêts de recherche

We will pursue the study of endothelial function in the cardiovascular apparatus. This study will include pharmacological, molecular and biochemical approaches, particularly in the fields of endothelins, kinins, nucleotides, EDRF and eicosanoids.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Haïtien (créole haïtien), Portuguais, Espagnol (castillan)


(1987). (Doctorate, Ph.D.). Université de Sherbrooke.

(1983). (Master's Thesis, MSc). Université de Sherbrooke.

(1980). (Bachelor's, Bachelor). Bishop's University.

Titres de compétence

(2015) Directeur.

Prix et distinctions

  • (2030) Fellow of the British Pharmacological Society. British Pharmacological Society. (Distinction).
  • (2023) Joseph Edwards Cardiovascular Research Chair. JC Ewdards Foundation. (Prize / Award).
  • (2023) Editor In Chief. Canadian Journal of Physiology and Pharmacology. (Honor).
  • (2012) Prix Rayonnement. Conseil d'Administration du Centre Hospitalier Universitaire de Sherbrooke. (Distinction).
  • Among the 100 most cited pharmacologists worldwide (1992-2002). Institute for Scientific Information Survey. (Distinction).
  • F1000 Prime for the manuscript by Houde et al.,'Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1., The Journal of Pharmacology and Experimental Therapeutics, 2013 (DOI: 10.3410/f.718003609.793475. Faculty of 1000. (Distinction).
  • Prix Coeur Québec 2008. Fondation des Maladies du Coeur du Québec. (Distinction).


  • Contract. (Awarded). Principal Applicant. PRE-CLINICAL PROJECT (Title non disclosable due to institutional/industry agreement). Bayer AG. Preclinical program. 218 000 $. (2020-2023)
  • Grant. (Awarded). Principal Applicant. ANTI-THROMBOTIC PROPERTIES OF SERINE PROTEASES INHIBITORS. Fonds Institutionnel de Recherche de l'Université de Sherbrooke. Projets innovants de l'Institut de Pharmacologie de Sherbrooke. 30 000 $. (2019-2021)
  • Grant. (Awarded). Principal Applicant. NEW PHARMACOLOGICAL APPROACHES AGAINST DEEP VEIN THROMBOSIS WITHOUT BLEEDING SIDE EFFECTS. FRQS. Cibles Thérapeutiques. 36 000 $. (2019-2020)
  • Grant. (Completed). Co-applicant. Modulation du tubule-T nucléaire dans l'hyperthophie et le vieillissement du muscle lisse vasculaire. Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT). Programme de Recherche en Équipe. 180 000 $. (2014-2017)


Articles de revue

  • Catherine Lapointe, Laurence Vincent, Hugo Giguère, Mannix Auger‐Messier, Adel Schwertani, Denan Jin, Shinji Takai, Gunnar Pejler, Martin G. Sirois, Hanna Tinel, Stefan Heitmeier and Pedro D'Orléans‐Juste. (2023). Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model. JAHA 12 (4), 1-13. DOI. (Published).
  • Sarrhini, O, D’Orléans-Juste , P. Rousseau, T. Beaudoin, J-F. and Lecomte, R. (2023). Enhanced Extraction of Blood and Tissue Time-activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization. International Journal of Biomedical Imaging N/A 1-14. (Accepted).
  • Desbiens L*, Touil, H*, Weir G, Mauban J, Annabi MS, Clavel MA, Pibarot P, Auger-Messier M, Giguère* H, Gobeil H, Bkaily G, D’Orléans-Juste P. (2021). Endothelin-1 and other vasoactive agents prompt hemodynamic responses at subfentomole doses in conscious unrestrained mice. HYPERTENSION N/A 1-18. (Revision Requested).
  • Laurence Vincent, Catherine Lapointe, Modou Lo, Hugo Gagnon, Gunnar Pejler, Shinji Takai, Robert Day, and Pedro D'Orleans-Juste. (2021). Mast cell degranulation increases mouse Mast Cell Protease 4-dependent vasopressor responses to big endothelin-1 but not Angiotensin I. Journal of Pharmacology and Experimental Therapeutics 376 213-221. (Published).
  • Pedro D'Orléans-Juste and Catherine Lapointe. (2020). The Fifth Tomoh Masaki Award. Canadian Journal of Physiology and Pharmacology 89 (9), 12-16. DOI. (Published).
  • Pedro D'Orléans-Juste, Anthony Davenport. Theophile Godfraind, Robert R. Ruffolo , Janet J Maguire, Eliott Ohlstein. (2019). Endothelin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology 2019 (4), 1-8. (Published).
  • D’Orleans-Juste, P., Ndunge, OBA, Desbiens, N*., Tanowitz, H., Desruisseaux, M. (2019). Endothelins in inflammatory neurological diseases. Pharmacology & Therapeutics 194 145-160. DOI. (Published).
  • Desbiens, L*., Lapointe, C*., Gendron, L. Gharagozloo, M., Vincent, L*., Pejler, G., Gris, D., D’Orléans-Juste, P. (2019). Experimental autoimmune encephalomyelitis potentiates mouse mast cell protease 4-dependent pressor responses to centrally or systemically administered big-endothelin-1. Journal of Pharmacology and Experimental Therapeutics. 2019 Jun 27. pii: jpet.118.256016. doi: 10.1124/jpet.118.256016 370 (3), 437-446. (Published).
  • Houde, M*., Schwertani, A., Touil, H*., Desbiens, L*., Sarrhini, O., Lecompte, R., Lepage, M., Gagnon, H., Takai, S., Pejler, G., Jacques, D., Gobeil, F., Day, R. and D'Orleans-Juste, P. (2018). MOUSE MAST CELL PROTEASE 4 DELETION PROTECTS HEART FUNCTION AND SURVIVAL AFTER ACUTE MYOCARDIAL INFARCTION. Frontiers in Pharmacology 9 1-15. (Published).
  • Hassan GS, Jacques D, D'Orléans-Juste P, Magder S, Bkaily G. (2018). Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis. Canadian Journal of Physiology and Pharmacology 96 655-661. (Published).
  • Pierre Sirois, Pedro D'Orléans-Juste. (2018). The Aspirin miracle: From Antiquity to the 3rd Millenium. Landmark papers in Pain ISBN: 9780198737490 1-15. (In Press).
  • Carrier, E*,, Houde, M*., Grandbois, M., Bkaily, G., Warner, TD,, D'Orleans-Juste, P. (2017). INHIBITION OF PLATELET AGGREGATION EX VIVO IS REPRESSED IN APOLIPOPROTEIN E DEFICIENT MICE. Canadian Journal of Physiology and Pharmacology 95 954-960. DOI. (Published).
  • Jacques D, D'Orleans-Juste P, Magder S, Bkaily G. (2017). Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology 95 1224-1229. DOI. (Published).
  • Mikhail M, Vachon PH, D'Orleans-Juste P, Jacques D, Bkaily G. (2017). ROLE OF ENDOTHELIN-1 AND ITS RECEPTORS ETA AND ETB IN THE SURVIVAL OF HUMAN VASCULAR ENDOTHELIAL CELLS. Canadian Journal of Physiology and Pharmacology 95 (10), 1298-1305. DOI. (Published).
  • Martin Houde*, Louisane Desbiens* and Pedro D’Orléans-Juste. (2016). Endothelin-1 biosynthesis, signalling and vasoreactivity. Advances in Pharmacology 77 143-75. DOI. (Published).
  • Martin Houde*, Louisane Desbiens*, Adel Schwertani, Gunnar Pejler, Marc Iglarz, Pedro D’Orléans-Juste. (2016). Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice. Life Sciences 159 71-75. DOI. (Published).
  • Desbiens L*, Lapointe C*, Gharagozloo M, Mahmoud S, Pejler G, Gris D, D'Orléans-Juste P. (2016). Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation 2016 1-10. DOI. (Published).
  • Elie Simard , Thomas Söllradl , Jean-Sébastien Maltais , Julie Boucher , Pédro D’Orléans-Juste and Michel Grandbois. (2015). Activation of receptor for advanced glycation end-products interfere with the expression of the vascular smooth muscle cell contractile phenotype. PLOS One 10 73-81. (Published).
  • Janaina A. Simplicio, Leonardo B. Resstel, Daniela P.C. Tirapelli, Pedro D’Orléans-Juste, Carlos R. Tirapelli. (2015). Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vascular Pharmacology 73 124-37. (Published).
  • Ghassan Bkaily, Levon Avedanian, Johny Al-Khoury, Marc Chamoun, Rana Semaan, Cynthia Jubinville-Leblanc, Pedro D'Orleans-Juste, Danielle Jacques. (2015). Nuclear membranes R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology 93 ((4)), 291-7. (Accepted).
  • Julie Boucher, Élie Simard; Ulrike Froehlich; Pedro D'Orléans-Juste ; Michel Grandbois. (2015). USING CARBOXYFLUORESCEIN DIACETATESUCCINIMIDYL ESTER TO MONITOR THE GLYCATION OF PROTEINS INVOLVED IN CELLCONTRACTION. Analytical Biochemistry: Methods in the Biological Sciences 478 73-81. (Published).
  • Walid Semaan*, Louisane Desbiens*, Martin Houde*, Julie Labonté*, Hugo Gagnon, Daisuke Yamamoto, Shinji Takai, Tanya Laidlaw, Ghassan Bkaily, Adel Schwertani, Gunnar Pejler, Christine Levesque, Roxane Desjardins, Robert Day, Pedro D'Orléans-Juste. (2014). CHYMASE INHIBITOR-SENSITIVE SYNTHESIS OF ENDOTHELIN-1 (1-31) BY RECOMBINANT MOUSE MAST CELL PROTEASE 4 OR HUMAN CHYMASE. Biochemical Pharmacology 94 ((2)), 91-100. (Published).
  • Alexa N. Bramall, Michael J. Szego1, Laura R. Pacione, Inik Chang, Eduardo Diez, Pedro D’Orleans-Juste, Duncan J. Stewart, William W. Hauswirth, Masashi Yanagisawa, Roderick R. McInnes. (2014). Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration. PLOS-1 8 1-14. DOI. (Published).
  • Joanna Lecka, Irina Gillerman, Michel Fausther, Mabrouka Salem, Mercedes N. Munkonda, Jean-Philippe Brosseau, Christine Cadot, Mireia Martín-Satué1, Pedro d'Orléans-Juste, Éric Rousseau, Donald Poirier, Beat Künzli, Bilha Fischer and Jean Sévigny. (2013). 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. British Journal of Pharmacology 169 179-196. (Published).
  • D'Orléans-Juste P , Houde M , Semaan W. (2013). Are Sildenafil Derivatives Useful Even in Unborn Males?. Hypertension 62 685-6. (Published).
  • Savard M, Labonté J, Dubuc C, Neugebauer W, D'Orléans-Juste P, Gobeil F. (2013). Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist. Biological Chemistry 394 (3), 353-360. (Published).
  • Martin Houde, Walid Semaan, Giles Rae, Pedro D’Orléans-Juste. (2013). GPCR models of pain in cardiovascular diseases: Contributions of kinins and endothelins. Drug Discovery Today: Disease Models 9 (3), e137-e142. (Published).
  • Houde M* , Jamain MD* , Labonte J* , Desbiens L* , Pejler G , Gurish M , Takai S , D'Orleans-Juste P. (2013). PIVOTAL ROLE OF MOUSE MAST CELL PROTEASE 4 IN THE CONVERSION AND PRESSOR PROPERTIES OF BIG-ENDOTHELIN-1. The Journal of pharmacology and experimental therapeutics 349 31-37. (Published).
  • Brochu I*, Houde M* , Desbiens L* , Simard E , Gobeil F , Semaan W* , Bkaily G , D'Orléans-Juste P. (2013). high salt induced hypertension in B2 knockout mice is corrected by the ETA ANTAGONIST, a127722. British journal of pharmacology 170 266-277. (Published).
  • Abdel-Samad D, Perreault C, Ahmarani L, Avedanian L, Bkaily G, Magder S, D'Orléans-Juste P, Jacques D. (2012). Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells. Neuropeptides 46 (6), 373-382. (Published).
  • D'Orléans-Juste P , Bkaily G , Rae GA. (2012). Endothelin and bradykinin: 'brothers-in-arms' in Chagas vasculopathies?. British journal of pharmacology 165 (5), 1-4. (Published).
  • You Z , Genest J , Barrette PO , Hafiane A , Behm DJ , D'Orleans-Juste P , Schwertani AG. (2012). Genetic and Pharmacological Manipulation of Urotensin II Ameliorate the Metabolic and Atherosclerosis Sequalae in Mice. Arteriosclerosis, thrombosis, and vascular biology 32 1809-1816. (Published).
  • Bkaily G , Avedanian L , Al-Khoury J , Provost C , Nader M , D'Orléans-Juste P , Jacques D. (2011). Nuclear membrane receptors for ET-1 in cardiovascular function. American journal of physiology. Regulatory, integrative and comparative physiology 300 (2), R251-263. (Published).
  • Houde, M , Labonté J , D'Orléans-Juste P. (2011). Peptide and non-peptide antagonists targeting endothelin receptors in physiology and pathology. Current pharmaceutical design 17 (25), 2613-2625. (Published).
  • Avedanian L , Riopel J , Bkaily G , Nader M , D'Orleans-Juste P , Jacques D. (2010). ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. Canadian journal of physiology and pharmacology 88 (8), (Published).
  • D'Orléans-Juste P , Benigni A , Davenport AP , Pollock DM. (2010). Introduction. The 11th International conference on Endothelin. Canadian journal of physiology and pharmacology 88 (6), (Published).
  • Kauffenstein G , Fürstenau CR , D'Orléans-Juste P , Sévigny J. (2010). The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation. British journal of pharmacology 159 (3), (Published).
  • Bkaily G , Nader M , Avedanian L , Choufani S , Jacques D , D'Orléans-Juste P , Gobeil F , Chemtob S , Al-Khoury J. (2006). G-protein-coupled receptors, channels, and Na+-H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. Canadian journal of physiology and pharmacology 84 (3-4), (Published).
  • Teixeira CF, Jancar S, Lima WT, D'Orléans-Juste P, Sirois P. (2004). Association of endothelin with lung hemorrhage induced by immune complexes in rats. Inflammation 23 253-61. DOI. (Published).
  • Bkaily G , Nader M , Avedanian L , Jacques D , Perrault C , Abdel-Samad D , D'Orléans-Juste P , Gobeil F , Hazzouri KM. (2004). Immunofluorescence revealed the presence of NHE-1 in the nuclear membranes of rat cardiomyocytes and isolated nuclei of human, rabbit, and rat aortic and liver tissues. Canadian journal of physiology and pharmacology 82 (8-9), 805-811. (Published).

Chapitres de livre

  • Pierre Sirois, Pedro D'Orléans-Juste. (2016). The Aspirin miracle: From Antiquity to the 3rd Millenium. Patrick du Souich. Landmark papers in Pain - commentary United Kingdom : Oxford University Press. (In Press).

Articles de conférence

  • Louisane Desbiens, Catherine Lapointe et Pedro D'Orléans-Juste. (2017). Unmasking the functionality of super sensitive ETB receptors innon-anesthetized mice. The Fifteenth International Conference on Endothelin (ET-15). (Published).
  • L. Desbiens, C. Lapointe, D. Gris, and P. D'Orléans-Juste. (2015). Is there a role for mast cells dependent synthesis of Endothelin 1 in neuro-degenerative diseases?. 2015 APS/ET-14: International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics. (Published).
  • Louisane Desbiens, Robert Day, Martin Houde, Walid Semaan, Shinji Takai, Mizuo Miyazaki, Gunnar Pejler, Pedro D’Orléans-Juste. (2013). Mastocytes derived or recombinant mouse mast cell protease 4 (mMCP-4) converts Big-ET-1 to ET-1 (1-31). Proceedings of the 13th International Conference on Endothelin-1, (Accepted).
  • Martin Houde, Walid Semaan, Louisane Desbiens, Zhipeng You, Adel G. Schwertani, Gunnar Pejler, Shinji Takai, Pedro D’Orléans-Juste. (2013). Mouse mast cell protease-4-dependent production of ET-1 (1-31) and of plaque progression in a apolipoprotein E knock-out mouse model of spontaneous atherosclerosis. Proceedings of the 13th International Conference on Endothelin-1, (Accepted).
  • Martin Houde, Julie Labonté, Louisane Desbiens, Marc Jamain, Gunnar Pejler, Michael Gurish, Shinji Takai, Pedro D'Orléans-Juste. (2013). The Mouse Mast Mell Protease 4 is Involved in the Generation of Endothelin-1 In Vitro and In Vivo. American Heart Association Scientific Session 2012. (Submitted).

Propriétés intellectuelles


  • (2005). Discovery and development of specific R-type calcium channel blockers (European patent delivered in 2005; US patent delivered in 2006). 217088, 1997 Canada/USA. Canada. (Granted/Issued).

Autres contributions


  • (2019). The Tomoh Masaki Award. International Conference on Endothelins. Japan
  • (2017). Surprenante réponse cardiovasculaire aux agents vasoactifs chez la souris consciente et non restreinte. Institut de Cardiologie de Montréal. Montréal, Canada
  • (2016). New indications for endothelin antagonists in cardiovascular diseases. 4TH CARDIOVASCULAR FORUM FOR PROMOTING CENTERS OF EXCELLENCE AND YOUNG INVESTIGATORS. Sherbrooke, Canada
  • (2016). Role of chymases in cardiovascular diseases. Cuban Cardiology Society. Havanna, Cuba
  • (2016). Roles of chymases in mouse models of heart failure and atherosclerosis. Invited speakers series Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre University of Manitoba. Sherbrooke, Canada
  • (2015). Endothelins in cardiovascular diseases: established and emerging targets. Annual Meeting of the International Academy of Cardiovascular Sciences (IACS): North American Section. Omaha, United States of America
  • (2015). Is there a role for mast cells dependent synthesis of Endothelin 1 in neurodegenerative diseases?. 5th International Society for Neurovascular Disease (ISNVD) Meeting. Naples, Italy
  • (2015). Is there a role for mast cells dependent synthesis of Endothelin 1 in neurodegenerative diseases?. 5th International Society for Neurovascular Disease (ISNVD) Meeting. Naples, Italy
  • (2014). Chymase: the other Endothelin Converting Enzyme?. Lady Davis Research Institute, McGill University. Montréal, Canada
  • (2014). Roles of chymases in mouse models of heart failure and atherosclerosis. Institute of Cardiovascular Sciences Annual Conferences. Winnipeg, Canada