Nicolas Gévry

Financement

• Subvention. The fertility clock: Regulation of the maintenance and depletion of the ovarian reserve. Canadian Institutes of Health Research (Ottawa, Canada). 937 125 $. (2024-2029).
  Numéro de subvention : 202309PJT. Voir plus
• Subvention. The implication of human adipocyte hypertrophy in systemic lipid metabolism and insulin resistance. Canadian Institutes of Health Research (Ottawa, Canada). 76 500 $. (2022-2024).
  Numéro de subvention : 202111FBD. Voir plus
• Subvention. Importance of estrogen receptors in adipose tissue function. Natural Sciences and Engineering Research Council (Ottawa, Canada). 36 000 $. (2021-2022).
  Numéro de subvention : RGPIN-2019-06048. Voir plus
• Subvention. Acquisition of a focused-ultrasonicator system. Natural Sciences and Engineering Research Council (Ottawa, Canada). 124 105 $. (2020-2021).
  Numéro de subvention : RTI-2021-00702. Voir plus
• Subvention. Orphan Nuclear Receptor Regulation of Fertility. Canadian Institutes of Health Research (Ottawa, Canada). 960 578 $. (2019-2024).
  Numéro de subvention : 201903PJT. Voir plus
• Subvention. Regulation of gonadotropin action by Slit/Robo signaling in the mammalian ovary. Canadian Institutes of Health Research (Ottawa, Canada). 723 817 $. (2018-2025).
  Numéro de subvention : 201803PJT. Voir plus
• Subvention. Acquisition of an Automated High-Throughput Cell Imaging System. Natural Sciences and Engineering Research Council (Ottawa, Canada). 150 000 $. (2017-2018).
  Numéro de subvention : RTI-2018-00813. Voir plus
• Subvention. Rôle physiopathologique des récepteurs nucléaires sur le contrôle de l'expression génique. Fonds de Recherche du Québec - Santé (Montreal, Canada). 255 574 $. (2017-2021).
  Numéro de subvention : 35078. Voir plus
• Subvention. Nuclear receptor regulation of ovulation. Canadian Institutes of Health Research (Ottawa, Canada). 447 233 $. (2016-2019).
  Numéro de subvention : 201603PJT. Voir plus
• Subvention. Acquisition of an in vivo imaging system. Natural Sciences and Engineering Research Council (Ottawa, Canada). 144 824 $. (2016-2017).
  Numéro de subvention : RTI-2017-00350. Voir plus
• Subvention. New mechanisms of podocyte injury in diabetic nephropathy. Canadian Institutes of Health Research (Ottawa, Canada). 100 000 $. (2015-2016).
  Numéro de subvention : 201505MOP. Voir plus
• Subvention. Étude des mécanismes de régulation épigénétique de la transcription controlée par les récepteurs nucléaires et leur implication dans le développement des cancers hormono-dépendants. Fonds de Recherche du Québec - Santé (Montreal, Canada). 148 057 $. (2015-2017).
  Numéro de subvention : 31086. Voir plus
• Subvention. Deciphering the molecular function of the estrogen receptor a in fat metabolism. Natural Sciences and Engineering Research Council (Ottawa, Canada). 130 000 $. (2014-2019).
  Numéro de subvention : RGPIN-2014-05556. Voir plus
• Subvention. Acquisition of a Fluorescence-Activated Cell Sorter (FACS). Natural Sciences and Engineering Research Council (Ottawa, Canada). 150 000 $. (2014-2015).
  Numéro de subvention : 472742-2015. Voir plus
• Subvention. Genetic hallmark of susceptible cows through macrophage profiling of MAP infected cows: Johne's-disease-associated SNPs impair macrophage function. Natural Sciences and Engineering Research Council (Ottawa, Canada). 93 540 $. (2013-2016).
  Numéro de subvention : 441719-2012. Voir plus
• Subvention. Imaging system for quantification of DNA, RNA, and proteins. Natural Sciences and Engineering Research Council (Ottawa, Canada). 136 406 $. (2013-2014).
  Numéro de subvention : 458610-2014. Voir plus
• Subvention. A web server integrated into a supercomputer for a new generation of bioinformatics tools / Serveur web intégré à un superordinateur pour une nouvelle génération d'outils bio-info. Natural Sciences and Engineering Research Council (Ottawa, Canada). 32 044 $. (2012-2013).
  Numéro de subvention : grant.2902913. Voir plus
• Subvention. Approches moléculaires et physiologiques pour comprendre les problèmes de fertilité. Fonds de Recherche du Québec – Nature et Technologies (Montreal, Canada). 212 550 $. (2012-2015).
  Numéro de subvention : 166465. Voir plus
• Subvention. Data storage unit for high-performance computation in genomics / Unité de sauvegarde de données pour calculs de haute-performance en génomique. Natural Sciences and Engineering Research Council (Ottawa, Canada). 14 744 $. (2011-2012).
  Numéro de subvention : grant.2908315. Voir plus
• Subvention. Acquisition of an ultracentrifuge / Acquisition d'une ultracentrifugeuse. Natural Sciences and Engineering Research Council (Ottawa, Canada). 149 806 $. (2010-2011).
  Numéro de subvention : grant.2891369. Voir plus
• Subvention. Chromatin Regulation of Estrogen-Mediated Transcription in Hormone-Dependent Cancer. / Role de la chromatine dans la regulation des genes dependants des recepteurs de l'oestrogene. Canadian Institutes of Health Research (Ottawa, Canada). 472 482 $. (2009-2013).
  Numéro de subvention : 200903MOP. Voir plus
• Subvention. Rôle de la chromatine dans la régulation des gènes contrôlés par les récepteurs de l'oestrogène. Fonds de Recherche du Québec - Santé (Montreal, Canada). 45 000 $. (2009-2012).
  Numéro de subvention : 20061. Voir plus
• Subvention. Rôle de la chromatine dans la régulation des gènes contrôlés par les récepteurs de l'oestrogène. Fonds de Recherche du Québec - Santé (Montreal, Canada). 246 321 $. (2009-2013).
  Numéro de subvention : 15827. Voir plus
• Subvention. Établissement d'un laboratoire d'endocrinologie moléculaire. Canada Foundation for Innovation (Ottawa, Canada). 81 604 $. (2008).
  Numéro de subvention : 17941. Voir plus
• Subvention. Role of chromatin in cellular differentiation. Natural Sciences and Engineering Research Council (Ottawa, Canada). 170 000 $. (2008-2013).
  Numéro de subvention : grant.2947684. Voir plus
• Subvention. The role of chromatin architecture and chromatin remodelling factors in the activation of estrogen-related genes. Natural Sciences and Engineering Research Council (Ottawa, Canada). 40 000 $. (2005-2006).
  Numéro de subvention : grant.2925479. Voir plus
• Subvention. The role of chromatin architecture and chromatin remodelling factors in the activation of estrogen-related genes. Natural Sciences and Engineering Research Council (Ottawa, Canada). 40 000 $. (2004-2005).
  Numéro de subvention : grant.2800977. Voir plus

Publications

Articles

• Morin, F., Hughes, C.H.K., Roussel, V., Gevry, N., Murphy, B.D. (2025). Double knockout of steroidogenic factor 1 (NR5A1) and liver receptor homolog 1 (NR5A2) in the mouse ovary results in infertility due to disruption of follicle development and ovulation. Biology of Reproduction. DOI
• St-Cyr, G., Garneau, D., Gévry, N., Blouin, R. (2025). Quantitative phosphoproteomics reveals that nestin is a downstream target of dual leucine zipper kinase during retinoic acid-induced neuronal differentiation of Neuro-2a cells. BMC Molecular and Cell Biology. DOI
• Elder, E., Lemieux, A., Legault, L.-M., Caron, M., Bertrand-Lehouillier, V., Dupas, T., Raynal, N.J.-M., Bourque, G., Sinnett, D., Gévry, N., McGraw, S. (2025). Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells. Nucleic Acids Research. DOI
• Ye, R.Z., Montastier, E., Frisch, F., Noll, C., Allard-Chamard, H., Gévry, N., Tchernof, A., Carpentier, A.C. (2024). Adipocyte hypertrophy associates with in vivo postprandial fatty acid metabolism and adipose single-cell transcriptional dynamics. Iscience. DOI
• Dos Santos, E.C., Boyer, A., St-Jean, G., Jakuc, N., Gévry, N., Price, C.A., Zamberlam, G. (2023). Is the Hippo Pathway Effector Yes-Associated Protein a Potential Key Player of Dairy Cattle Cystic Ovarian Disease Pathogenesis?. Animals. DOI
• Hughes, C.H.K., Smith, O.E., Meinsohn, M.-C., Brunelle, M., Gévry, N., Murphy, B.D. (2023). Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Ye, R.Z., Richard, G., Gévry, N., Tchernof, A., Carpentier, A.C. (2022). Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations. Endocrine Reviews. DOI
• Godin, P., Tsoi, M.F., Morin, M., Gévry, N., Boerboom, D. (2022). The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin. Cell Communication and Signaling. DOI
• Ariel, O., Gendron, D., Dudemaine, P.-L., Gévry, N., Ibeagha-Awemu, E.M., Bissonnette, N. (2020). Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes. Frontiers in Immunology. DOI
• Sahmi, F., Sahmi, M., Gévry, N., Sahadevan, P., Allen, B.G., Price, C.A. (2019). A putative protein–RNA complex regulates posttranscriptional processing of cytochrome P450 aromatase (CYP19A1) in bovine granulosa cells. Molecular Reproduction and Development. DOI
• Tsoi, M., Morin, M., Rico, C., Johnson, R.L., Paquet, M., Gévry, N., Boerboom, D. (2019). Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance. FASEB Journal. DOI
• St-Jean, G., Tsoi, M., Abedini, A., Levasseur, A., Rico, C., Morin, M., Djordjevic, B., Miinalainen, I., Kaarteenaho, R., Paquet, M., Gévry, N., Boyer, A., Vanderhyden, B., Boerboom, D. (2019). Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme. Development Cambridge. DOI
• Bianco, S., Bellefleur, A.-M., Beaulieu, É., Beauparlant, C.J., Bertolin, K., Droit, A., Schoonjans, K., Murphy, B.D., Gévry, N. (2019). The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility. Cell Reports. DOI
• Ammah, A.A., Do, D.N., Bissonnette, N., Gévry, N., Ibeagha-Awemu, E.M. (2018). Co-expression network analysis identifies miRNA–mRNA networks potentially regulating milk traits and blood metabolites. International Journal of Molecular Sciences. DOI
• Ammah, A.A., Benchaar, C., Bissonnette, N., Gévry, N., Ibeagha-Awemu, E.M. (2018). Treatment and post-treatment effects of dietary supplementation with safflower oil and linseed oil on milk components and blood metabolites of canadian holstein cows. Journal of Applied Animal Research. DOI
• Brasseur, K., Gévry, N., Asselin, E. (2017). Chemoresistance and targeted therapies in ovarian and endometrial cancers. Oncotarget. DOI
• Lizotte, F., Denhez, B., Guay, A., Gévry, N., Côté, A.M., Geraldes, P. (2016). Persistent insulin resistance in podocytes caused by epigenetic changes of SHP-1 in Diabetes. Diabetes. DOI
• Edjekouane, L., Benhadjeba, S., Jangal, M., Fleury, H., Gévry, N., Carmona, E., Tremblay, A. (2016). Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor a in breast cancer cells. Oncotarget. DOI
• Siddappa, D., Beaulieu, É., Gévry, N., Roux, P.P., Bordignon, V., Duggavathi, R. (2015). Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice. Plos One. DOI
• Bianco, S., Jangal, M., Garneau, D., Gévry, N. (2015). LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. Oncogene. DOI
• Brunelle, M., Nordell Markovits, A., Rodrigue, S., Lupien, M., Jacques, P.-E., Gévry, N. (2015). The histone variant H2A.Z is an important regulator of enhancer activity. Nucleic Acids Research. DOI
• Sanchez, R., Schuermann, Y., Gagnon-Duval, L., Baldassarre, H., Murphy, B.D., Gevry, N., Agellon, L.B., Bordignon, V., Duggavathi, R. (2014). Differential abundance of IGF1, bile acids, and the genes involved in their signaling in the dominant follicle microenvironment of lactating cows and nulliparous heifers. Theriogenology. DOI
• Bianco, S., Brunelle, M., Jangal, M., Magnani, L., Gévry, N. (2014). LRH-1 governs vital transcriptional programs in endocrine-sensitive and -resistant breast cancer cells. Cancer Research. DOI
• Jangal, M., Couture, J.-P., Bianco, S., Magnani, L., Mohammed, H., Gévry, N. (2014). The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes. Nucleic Acids Research. DOI
• Markovits, A.N., Beauparlant, C.J., Toupin, D., Wang, S., Droit, A., Gevry, N. (2013). NGS++: A library for rapid prototyping of epigenomics software tools. Bioinformatics. DOI
• Magnani, L., Brunelle, M., Gévry, N., Lupien, M. (2012). Chromatin landscape and endocrine response in breast cancer. Epigenomics. DOI
• Beshiri, M.L., Holmes, K.B., Richter, W.F., Hess, S., Islam, A.B.M.M.K., Yan, Q., Plante, L., Litovchick, L., Gévry, N., Lopez-Bigas, N., Kaelin, W.G., Benevolenskaya, E.V. (2012). Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Bianco, S., Gévry, N. (2012). Endocrine resistance in breast cancer: From cellular signaling pathways to epigenetic mechanisms. Transcription. DOI
• Brunelle, M., Gévry, N., Lupien, M. (2012). Enhancer-specific epigenetic mutations are associated with colorectal carcinogenesis,Des mutations épigénétiques spécifiques aux enhancers sont associées à la carcinogenèse colorectale. Medecine Sciences. DOI
• Couture, J.-P., Nolet, G., Beaulieu, E., Blouin, R., Gévry, N. (2012). The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes. Endocrinology. DOI
• Svotelis, A., Bianco, S., Madore, J., Huppé, G., Nordell-Markovits, A., Mes-Masson, A.-M., Gévry, N. (2011). H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency. EMBO Journal. DOI
• Svotelis, A., Gévry, N., Grondin, G., Gaudreau, L. (2010). H2A.Z overexpression promotes cellular proliferation of breast cancer cells. Cell Cycle. DOI
• Gévry, N., Hardy, S., Jacques, P.-É., Laflamme, L., Svotelis, A., Robert, F., Gaudreau, L. (2009). Histone H2A.Z is essential for estrogen receptor signaling. Genes and Development. DOI
• Svotelis, A., Gévry, N., Gaudreau, L. (2009). Regulation of gene expression and cellular proliferation by histone H2A.Z. Biochemistry and Cell Biology. DOI
• Hardy, S., Jacques, P.-É., Gévry, N., Forest, A., Fortin, M.-E., Laflamme, L., Gaudreau, L., Robert, F. (2009). The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition. Plos Genetics. DOI
• Gévry, N., Ho, M.C., Laflamme, L., Livingston, D.M., Gaudreau, L. (2007). p21 transcription is regulated by differential localization of histone H2A.Z. Genes and Development. DOI
• Lopes, F.L., Desmarais, J., Ledoux, S., Gévry, N.Y., Lefevre, P., Murphy, B.D. (2006). Transcriptional regulation of uterine vascular endothelial growth factor during early gestation in a carnivore model, Mustela vison. Journal of Biological Chemistry. DOI
• Guillemette, B., Bataille, A.R., Gévry, N., Adam, M., Blanchette, M., Robert, F., Gaudreau, L. (2005). Variant histone H2A.z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning. Plos Biology. DOI
• Gévry, N.Y., Lopes, F.L., Ledoux, S., Murphy, B.D. (2004). Aberrant intracellular cholesterol transport disrupts pituitary and ovarian function. Molecular Endocrinology. DOI
• Kim, M.Y., Mauro, S., Gévry, N., Lis, J.T., Kraus, W.L. (2004). NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell. DOI
• Ruiz-Cortés, Z.T., Martel-Kennes, Y., Gévry, N.Y., Downey, B.R., Palin, M.-F., Murphy, B.D. (2003). Biphasic effects of leptin in porcine granulosa cells. Biology of Reproduction. DOI
• Lopes, F.L., Desmarais, J., Gévry, N.Y., Ledoux, S., Murphy, B.D. (2003). Expression of vascular endothelial growth factor isoforms and receptors Flt-1 and KDR during the peri-implantation period in the mink, Mustela vison. Biology of Reproduction. DOI
• Gévry, N.Y., Lalli, E., Sassone-Corsi, P., Murphy, B.D. (2003). Regulation of Niemann-Pick C1 gene expression by the 3′5′-cyclic adenosine monophosphate pathway in steroidogenic cells. Molecular Endocrinology. DOI
• Gévry, N., Lacroix, D.A.N., Song, J.-H., Pescador, N., Dobias, M., Murphy, B.D. (2002). Porcine niemann pick-C1 protein is expressed in steroidogenic tissues and modulated by cAMP. Endocrinology. DOI
• Murphy, B.D., Gévry, N., Ruiz-Cortés, T., Coté, F., Downey, B.R., Sirois, J. (2001). Formation and early development of the corpus luteum in pigs. Reproduction Cambridge England Supplement.

Livres

• Gévry, N., Svotelis, A., Larochelle, M., Gaudreau, L. (2009). Nucleosome mapping. Methods in Molecular Biology. DOI

Chapitres de livre

• Brunelle, M., Rodrigue, S., Jacques, P.-É., Gévry, N. (2017). High-resolution genome-wide mapping of nucleosome positioning and occupancy level using paired-end sequencing technology. Methods in Molecular Biology. DOI
• Bianco, S., Rodrigue, S., Murphy, B.D., Gévry, N. (2015). Global mapping of open chromatin regulatory elements by formaldehyde-assisted isolation of regulatory elements followed by sequencing (FAIRE-seq). Methods in Molecular Biology. DOI

Articles de conférence

• Gévry, N., Schoonjans, K., Guay, F., Murphy, B.D. (2008). Cholesterol supply and SREBPs modulate transcription of the niemann-pick C-1 gene in steroidogenic tissues. Journal of Lipid Research. DOI
• Gévry, N.Y., Murphy, B.D. (2002). The role and regulation of the Niemann-Pick C1 gene in adrenal steroidogenesis. Endocrine Research. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

• ANM700 - Initiation à l’éthique et aux règlementations en sciences animales. (2026). (1CR).
• ANM701 - Éthique, règlementations et pratiques exemplaires en sciences animales. (2026). (3CR).
• BCM328 - Biochimie des cibles pharmacologiques - Travaux pratiques. (2023-2026). (4CR).
• BIM301 - Biologie moléculaire - Travaux pratiques. (2023-2026). (2CR).
• BIM631 - Initiation à la recherche en biologie moléculaire I. (2023-2026). (2CR).
• BIM633 - Initiation à la recherche en biologie moléculaire II. (2023-2026). (4CR).
• BIM635 - Initiation à la recherche en biologie moléculaire III. (2023-2026). (4CR).
• BIO625 - Initiation à la recherche en biologie. (2023-2026). (2CR).
• BIO753 - Proposition de recherche et conduite responsable en recherche. (2026). (1CR).
• OMX702 - Approches épigénomiques - protéines. (2026). (3CR).
• HTL305 - Histologie et techniques d'imagerie cellulaire. (2025). (2CR).
• TSB702 - Techniques de biologie moléculaire. (2024). (2CR).
• END506 - Éléments d'endocrinologie moléculaire. (2023). (3CR).

Divers

• Elder, E., Lemieux, A., Legault, L.-M., Caron, M., Bertrand-Lehouillier, V., Dupas, T., Raynal, N.J.-M., Bourque, G., Sinnett, D., Gévry, N., McGraw, S. (2024). Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells. Biorxiv.
• Ye, R.Z., Montastier, E., Frisch, F., Noll, C., Allard-Chamard, H., Gévry, N., Tchernof, A., Carpentier, A.C. (2022). Adipocyte Hypertrophy Associates With Differential in vivo Postprandial Fatty Acid Metabolism, Adipose Single-Cell Landscape and Transcriptional Dynamics. Ssrn.