Michel Grandbois

Financement

• Subvention. Advancing single-cell analysis: combining substrates micro-patterning techniques and surface plasmon resonance imaging to uncover cell response heterogeneity. (PI). CRSNG Canada (Ottawa, Canada). 195 000 $. (2025-2030).
• Subvention. Validation expérimentale du design, de la sélection et de l’identification par l’intelligence artificielle de peptides pour la vectorisation AAV. (Co-PI). CQDM (Montreal, Canada). 526 458 $. (2025-2027).
• Subvention salariée. Canada Research Chair in Nanopharmacology and Atomic Force Microscopy. CIHR (Ottawa, Canada). (2003-2013).

Publications

Articles

• Rebecca L. Brouillette, Frédérique Lussier, Émile Breault, Nathan Meneboo, Malihe Hassanzadeh, Victoria Tremblay, Magali Chartier, Élora Midavaine, Laurence Ulrich, Jérôme Côté, Véronique Blais, Christine E. Mona, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Martin Audet, Élie Besserer-Offroy, Philippe Sarret. (2026). A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function. Acta Pharmaceutica Sinica B. DOI
• Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret. (2025). A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor. Pharmacological Research. DOI
• Sára Ferková, Ulrike Froehlich, Marie-Édith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault. (2023). Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein–Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International Journal of Molecular Sciences. DOI
• Marion L'Exact, Christian Comeau, Alix Bourhis, Olivier Boisvert, Ulrike Fröhlich, Danny Létourneau, Éric Marsault, Pierre Lavigne, Michel Grandbois, Pierre-Luc Boudreault. (2023). Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles. Biochimica et Biophysica Acta (BBA) - Biomembranes. DOI
• Svenja C. Schüler, Yuguo Liu, Simon Dumontier, Michel Grandbois, Emmeran Le Moal, DDW Cornelison, C. Florian Bentzinger. (2022). Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche. Frontiers in Cell and Developmental Biology. DOI
• Zhor Khadir, Victor Schmidt, Kevin Chabot, Jean-François Bryche, Ulrike Froehlich, Julien Moreau, Michael Canva, Paul Charette, Michel Grandbois. (2022). Surface micropatterning for the formation of an in vitro functional endothelial model for cell-based biosensors. Biosensors and Bioelectronics. DOI
• Christian Comeau, Benjamin Ries, Thomas Stadelmann, Jacob Tremblay, Sylvain Poulet, Ulrike Fröhlich, Jérôme Côté, Pierre-Luc Boudreault, Rabeb Mouna Derbali, Philippe Sarret, Michel Grandbois, Grégoire Leclair, Sereina Riniker, Éric Marsault. (2021). Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties. Journal of Medicinal Chemistry. DOI
• Rebecca L. Brouillette, Élie Besserer-Offroy, Christine E. Mona, Magali Chartier, Sandrine Lavenus, Marc Sousbie, Karine Belleville, Jean-Michel Longpré, Éric Marsault, Michel Grandbois, Philippe Sarret. (2020). Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain. Pharmacological Research. DOI
• Fatima Awwad, Guillaume Bertrand, Michel Grandbois, Nathalie Beaudoin. (2019). Auxin protects Arabidopsis thaliana cell suspension cultures from programmed cell death induced by the cellulose biosynthesis inhibitors thaxtomin A and isoxaben. BMC Plant Biology. DOI
• Fatima Awwad, Guillaume Bertrand, Michel Grandbois, Nathalie Beaudoin. (2019). Reactive Oxygen Species Alleviate Cell Death Induced by Thaxtomin A in Arabidopsis thaliana Cell Cultures. Plants. DOI
• Frederic A. Banville, Julien Moreau, Kevin Chabot, Andrea Cattoni, Ulrike Fröhlich, Jean-François Bryche, Stéphane Collin, Paul G. Charette, Michel Grandbois, Michael Canva. (2019). Nanoplasmonics-enhanced label-free imaging of endothelial cell monolayer integrity. Biosensors and Bioelectronics. DOI
• N. Brodeur, P. Cloutier, A. D. Bass, G. Bertrand, D. J. Hunting, M. Grandbois, L. Sanche. (2018). Absolute cross section for DNA damage induced by low-energy (10 eV) electrons: Experimental refinements and sample characterization by AFM. The Journal of Chemical Physics. DOI
• Sandrine Lavenus, Élie Simard, Élie Besserer-Offroy, Ulrike Froehlich, Richard Leduc, Michel Grandbois. (2018). Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses. Pharmacological Research. DOI
• Thomas Söllradl, Frederic A. Banville, Ulrike Fröhlich, Michael Canva, Paul G. Charette, Michel Grandbois. (2018). Label-free visualization and quantification of single cell signaling activity using metal-clad waveguide (MCWG)-based microscopy. Biosensors and Bioelectronics. DOI
• Michel Grandbois. (2018). Monitoring Individual Cell-Signaling Activity Using Combined Metal-Clad Waveguide and surface-Enhanced Fluorescence Imaging. Analyst, Issue 22, 143. DOI
• Jérémy Astruc, Malladi Nagalakshmaiah, Gaétan Laroche, Michel Grandbois, Saïd Elkoun, Mathieu Robert. (2017). Isolation of cellulose-II nanospheres from flax stems and their physical and morphological properties. Carbohydrate Polymers. DOI
• É. Carrier, M. Houde, M. Grandbois, G. Bkaily, T.D. Warner, P. D’Orléans-Juste. (2017). Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice. Canadian Journal of Physiology and Pharmacology. DOI
• Élie Besserer-Offroy, Rebecca L. Brouillette, Sandrine Lavenus, Ulrike Froehlich, Andrea Brumwell, Alexandre Murza, Jean-Michel Longpré, Éric Marsault, Michel Grandbois, Philippe Sarret, Richard Leduc. (2017). The signaling signature of the neurotensin type 1 receptor with endogenous ligands. European Journal of Pharmacology. DOI
• Frederic Trensz, Fabrice Lucien, Vanessa Couture, Thomas, Sollradl, Geneviève Drouin, André-Jean Rouleau, Grandbois Michel, Gregory Lacraz, Guillaume Grenier. (2016). Increased Microenvironment Stiffness in Damaged Myofibers Promotes Myogenic Progenitor Cell Proliferation. Skeletal Muscle, Vol. 5, no. 5. DOI
• *Jean-Sébastien Maltais, Elie Simard, Ulrike Froehlich, Jean-Bernard Denault, Louis Gendron, Michel Grandbois. (2016). iRAGE as a Novel Carboxymethylated Peptide that Prevents Advanced Glycation End Product-Induced Apoptosis and Endoplasmic Reticulum Stress in Vascular Smooth Muscle Cells. Pharmacological Research, Vol. 104. DOI
• Frederik Banville, Thomas Söllradl, Pierre-Jean Zermatten, Michel Grandbois, Paul Charette. (2015). Improved Resolution in SPR and MCWG Microscopy by Combining Images Acquired with Distinct Mode Propagation Directions. Optics Letters, Vol. 40, Issue 7. DOI
• Gregory Lacraz, André-Jean Rouleau, Vanessa Couture, Thomas Sollradl, Geneviève Drouin, Grandbois Michel, Guillaume Grenier. (2015). Increase Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity. PLoS One, 11(12). DOI
• Elie Simard, Thomas Söllradl, Jean-Sébastien Maltais, Julie Boucher, Pédro d'Orléans-Juste, Michel Grandbois. (2015). Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS One, 10(8). DOI
• Julie Boucher, Elie Simard, Ulrike Froehlich, Pédro D'Orleans-Juste, Michel Grandbois. (2015). Using Carboxyfluorescein Diacetate Succinimidyl Ester to Monitor Intracellular Protein Glycation. Analytical Biochemistry, Vol. 478. DOI
• Boucher J , Simard E , Froehlich U , Grandbois M. (2014). Amplification of AngII-dependent Cell Contraction by Glyoxal: Implication of Cell Mechanical Properties and Actomyosin Activity. Integrative Biology, Issue 4. DOI
• Adrien Buissonnière, Yannick Miron, Maurice Beaudoin, O Bou Matar, Michel Grandbois, Paul Charette et Alan Renaudin. (2014). Cell Detachment and Label-Free Sorting Using Modulated Surface Acoustic Waves (SAWs) in Droplet-based Microfluidics. Lab on a Chip, Issue 18. DOI
• Bourassa P, Tudashki HB, Pineyro G, Grandbois M, Gendron L. (2014). Label-Free Monitoring of μ-Opioid Receptor-Mediated Signaling. Molecular Pharmacology, Vol. 86, Issue 2. DOI
• Chabot V , Miron Y , Charette PG , Grandbois M. (2013). Identification of the Molecular Mechanisms in Cellular Processes that Elicit a Surface Plasmon Resonance (SPR) Response Using Simultaneous Surface Plasmon-Enhanced Fluorescence (SPEF) Microscopy. Biosensors and Bioelectronics, Volume 50. DOI
• Bussonnière , Renaudin A, Miron Y, Grandbois M, Baudoin M, Charette P. (2013). Removal of Living Cells from Biosensing Surfaces in Droplet-Based Microfluidics Using Surface Acoustic Waves. Proceedings of Meetings on Acoustics (POMA), Vol. 19, Issue 1. DOI
• *Nguyen N , Biet M , Simard E , Béliveau E , Francoeur N , Guillemette G , Dumaine R , Grandbois M , Boulay G. (2013). STIM1 Participates in the Contractile Rhythmicity of HL-1 Cells by Moderating T-type Ca(2+) Channel Activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1833, Issue 6. DOI
• Simard E , Kovacs JJ , Miller WE , Kim J , Grandbois M , Lefkowitz RJ. (2013). β-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration. PloS One, 8(11). DOI
• *Maltais JS , Denault JB , Gendron L , Grandbois M. (2012). Label-Free Monitoring of Apoptosis by Surface Plasmon Resonance Detection of Morphological Changes. Apoptosis, Vol. 17. DOI
• Chabot V, Miron Y, Grandbois M, Charette P. (2012). Long Range Surface Plasmon Resonance for Increased Sensitivity in Living Cell Biosensing Through Greater Probing Depth. Sensors and Actuators B : Chemical, Vol. 174. DOI
• Graham JS , Miron Y , Grandbois M. (2011). Assembly of Collagen Fibril Meshes Using Gold Nanoparticles Functionalized with Tris(hydroxymethyl)phosphine-alanine as Multivalent Cross-Linking Agents. Journal of Molecular Recognition, Vol. 24, Issue 3. DOI
• Lamontagne CA , Plante GE , Grandbois M. (2011). Characterization of Hyaluronic Acid Interaction with Calcium Oxalate Crystals: Implication of Crystals Faces, pH and Citrate. Journal of Molecular Recognition, Vol. 24, Issue 4. DOI
• Kocun M , Grandbois M , Cuccia LA. (2011). Single Molecule Atomic Force Microscopy and Force Spectroscopy of Chitosan. Colloids and Surfaces B: Biointerfaces, Vol. 82, Issue 2. DOI
• Bovenzi V , Savard M , Morin J , Cuerrier CM , Grandbois M , Gobeil F. (2010). Bradykinin Protects Against Brain Microvascular Endothelial Cell Death Induced by Pathophysiological Stimuli. Journal of Cellular Physiology, Vol. 222, Issue 1. DOI
• *Chabot V , Cuerrier CM , Escher E , Aimez V , Grandbois M , Charette PG. (2009). Biosensing Based on Surface Plasmon Resonance and Living Cells. Biosensors and Bioelectronics, Vol. 24, Issue 6. DOI
• Cuerrier CM , Gagner A , Lebel R , Gobeil F , Grandbois M. (2009). Effect of Thrombin and Bradykinin on Endothelial Cell Mechanical Properties Monitored Through Membrane Deformation. Journal of Molecular Recognition, Vol. 22, Issue 5. DOI
• *Wieczerzak E , Hame R , Chabot V , Aimez V , Charette PG , Grandbois M , Escher E. (2009). Monitoring of Native Chemical Ligation by Surface Plasmon Resonance. Advances in Experimental Medicine and Biology, Vol. 611. DOI
• *Cuerrier CM , Benoit M , Guillemette G , Gobeil F , Grandbois M. (2009). Real-Time Monitoring of Angiotensin II-Induced Contractile Response and Cytoskeleton Remodeling in Individual Cells by Atomic Force Microscopy. Pflügers Archiv : European Journal of Physiology, Vol. 457. DOI
• Duplan V , Miron Y , Frost E , Grandbois M , Dubowski JJ. (2009). Specific Immobilization of Influenza A Virus on GaAs (001) Surface. Journal of Biomedical Optics, Vol. 14, Issue 5. DOI
• Lamontagne CA , Cuerrier CM , Grandbois M. (2008). AFM as a Tool to Probe and Manipulate Cellular Processes. Pflügers Archiv : European Journal of Physiology, Vol. 456. DOI
• *Wieczerzak E , Hamel R , Chabot V , Aimez V , Grandbois M , Charette PG , Escher E. (2008). Monitoring of Native Chemical Ligation on Solid Substrate by Surface Plasmon Resonance. Biopolymers, Vol. 90, Issue 3. DOI
• Lamontagne CA , Grandbois M. (2008). PKC-Induced Stiffening of Hyaluronan/CD44 Linkage; Local Force Measurements on Glioma Cells. Experimental Cell Research, Vol. 314, Issue 2. DOI
• Mitchell G , Lamontagne CA , Brouillette E , Grondin G , Talbot BG , Grandbois M , Malouin F. (2008). Staphylococcus aureus SigB Activity Promotes a Strong Fibronectin-Bacterium Interaction Which May Sustain Host Tissue Colonization by Small-Colony Variants Isolated From Cystic Fibrosis Patients. Molecular Microbiology, Vol. 70, Issue 6. DOI
• *Cuerrier CM , Chabot V , Vigneux S , Aimez V , Escher E , Gobeil F , Charette PG , Grandbois M. (2008). Surface Plasmon Resonance Monitoring of Cell Monolayer Integrity: Implication of Signaling Pathways Involved in Actin-Driven Morphological Remodeling. Cellular and Molecular Bioengineering, Vol. 1, Issue 4. DOI
• *Lebel R , McDuff FO , Lavigne P , Grandbois M. (2007). Direct Visualization of the Binding of c-Myc/Max Heterodimeric b-HLH-LZ to E-Box Sequences on the hTERT Promoter†. Biochemistry, Vol. 46, Issue 36. DOI
• Hosu BG , Sun M , Marga F , Grandbois M , Forgacs G. (2007). Eukaryotic membrane tethers revisited using magnetic tweezers. Physical biology.
• Cuerrier CM , Lebel R , Grandbois M. (2007). Single cell transfection using plasmid decorated AFM probes. Biochemical and biophysical research communications.
• Mitchell G , Lamontagne CA , Lebel R , Grandbois M , Malouin F. (2007). Single-molecule dynamic force spectroscopy of the fibronectin-heparin interaction. Biochemical and biophysical research communications.
• John S. Graham, Anthony N. Vomund, Charlotte L. Phillips, Michel Grandbois. (2004). Structural changes in human type I collagen fibrils investigated by force spectroscopy. Experimental Cell Research. DOI
• Philippe Desmeules, Michel Grandbois, Vladimir A. Bondarenko, Akio Yamazaki, Christian Salesse. (2002). Measurement of Membrane Binding between Recoverin, a Calcium-Myristoyl Switch Protein, and Lipid Bilayers byAFM-Based Force Spectroscopy. Biophysical Journal. DOI
• Michel Grandbois, Bernard Desbat, Christian Salesse. (2000). Monitoring of phospholipid monolayer hydrolysis by phospholipase A2 by use of polarization-modulated Fourier transform infrared spectroscopy. Biophysical Chemistry. DOI
• Wolfgang Dettmann, Michel Grandbois, Sabine André, Martin Benoit, Angelika K. Wehle, Herbert Kaltner, Hans-Joachim Gabius, Hermann E. Gaub. (2000). Differences in Zero-Force and Force-Driven Kinetics of Ligand Dissociation from β-Galactoside-Specific Proteins (Plant and Animal Lectins, Immunoglobulin G) Monitored by Plasmon Resonance and Dynamic Single Molecule Force Microscopy. Archives of Biochemistry and Biophysics. DOI
• Michel Grandbois, Wolfgang Dettmann, Martin Benoit, Hermann E. Gaub. (2000). Affinity Imaging of Red Blood Cells Using an Atomic Force Microscope. Journal of Histochemistry & Cytochemistry. DOI
• Michel Grandbois, Martin Beyer, Matthias Rief, Hauke Clausen-Schaumann, Hermann E. Gaub. (1999). How Strong Is a Covalent Bond?. Science. DOI
• Michel Grandbois, Hauke Clausen-Schaumann, Hermann Gaub. (1998). Atomic Force Microscope Imaging of Phospholipid Bilayer Degradation by Phospholipase A2. Biophysical Journal. DOI

Chapitres de livre

• Bourassa, Thomas Söllradl, Jean-Sébastien Maltais, Paul G. Charette, Louis Gendron, Michel Grandbois. (2015). Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells. Label-free Biosensor Methods in Drug Discovery. Methods in Pharmacology and Toxicology. DOI
• Cuerrier CM*, Simard E*, Lamontagne CA*, Boucher J*, Miron Y*, Grandbois,M. (2011). Label-Free Monitoring of Cell Signaling Processes Through AFM-Based Force Measurements. Life at the Nanoscale: Atomic Force Microscopy of Live Cells. Pan Stanford Publishing. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

• PHR202 - Pharmacochimie. (2024-2026). (3CR).
• PHR204 - Principes de pharmacologie II. (2024-2026). (3CR).
• PHR708 - Sujets choisis en pharmacologie. (2026). (1CR).
• PHR713 - Méthodes d'étude de cibles pharmacologiques. (2023, 2025). (2CR).
• PHR701 - Principes de pharmacologie. (2023-2024). (2CR).