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Michel Grandbois

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie


Sujet de recherche

Maladies cardiovasculaires, Mécanismes biologiques et biochimiques

Disciplines de recherche

Biochimie, Biologie cellulaire


Biomécanique moléculaire, Glycation, Mécanique cellulaire, Microscopie force atomiqu, résonance des plasmons de surface, Single molécule exp., Spectroscopie de force

Centre de recherche


Centre de recherche du CHUS

Langues parlées et écrites

Allemand, Anglais, Français


(1999). (Post-doctorat, ès sciences). Ludwig-Maximilians Universität München.

(1997). (Doctorat, ès sciences). Université du Québec à Trois-Rivières.

(1992). (Baccalauréat, ès sciences). Université du Québec à Trois-Rivières.

Prix et distinctions

  • (2013) Chaire de Recherche du Canada Tier II. (Distinction).


Articles de revue

  • Adrien Buissonnière, Yannick Miron, Maurice Beaudoin, O Bou Matar, Michel Grandbois, Paul Charette et Alan Renaudin. (2015). Cell detachment and label-free sorting using modulated surface acoustic waves (SAWS) in droplet-based microfluidics. Lab on a Chip 14 (18), 3556-3563. (Article publié).
  • *Jean-Sébastien Maltais, Elie Simard, Ulrike Froehlich, Jean-Bernard Denault, Louis Gendron, Michel Grandbois. (2015). iRAGE as a novel carboxymethylated peptide that prevents advanced glycation end product-induced apoptosis and endoplasmic reticulum stress in vascular smooth muscle cells. Pharmacological Research (Article accepté).
  • Gregory Lacraz, André-Jean Rouleau, Vanessa Couture, Thomas Sollradl, Geneviève Drouin, Grandbois Michel and Guillaume Grenier. (2015). Increase Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity. PLoS One 10 (8), e0136217. (Article publié).
  • Elie Simard, Thomas Söllradl, Jean-Sébastien Maltais, Julie Boucher, Pédro d'Orléans-Juste and Michel Grandbois. (2015). Receptor for Advanced Glycation End-products Signaling interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS One 10 (8), e0128881. (Article publié).
  • Frederik Banville, Thomas Söllradl, Pierre-Jean Zermatten, Michel Grandbois and Paul Charette. (2015). Improved Resolution in SPR and MCWG microscopy by combining images acquired with distinct mode propagation directions. Optics Letters 40 (7), 1165-1168. (Article publié).
  • Frederic Trensz, Fabrice Lucien, Vanessa Couture, Thomas, Sollradl, Geneviève Drouin, André-Jean Rouleau, Grandbois Michel, Gregory Lacraz and Guillaume Grenier. (2015). Increased Microenvironment Stiffness in Damaged Myofibers Promotes Myogenic Progenitor Cell Proliferation. Skeletal Muscle 17 (5), 1-16. (Article publié).
  • Julie Boucher, Elie Simard, Ulrike Froehlich, Pédro D'Orleans-Juste, Michel Grandbois. (2015). Using carboxyfluorescein diacetate succinimidyl ester to monitor the glycation of proteins involved in cell contraction. Analytical Biochemistry 478 73-81. (Article publié).
  • Bourassa P, Tudashki HB, Pineyro G, Grandbois M, Gendron L. (2014). Label-free monitoring of μ-opioid receptor-mediated signaling. Mol Pharmacol. 86 (2), 138-149. (Article publié).
  • Boucher J , Simard E , Froehlich U , Grandbois M. (2014). Amplification of AngII-dependent cell contraction by glyoxal: implication of cell mechanical properties and actomyosin activity. Integrative Biology (Camb) 6 (4), 411-421. (Article publié).
  • Chabot V , Miron Y , Charette PG , Grandbois M. (2013). Identification of the molecular mechanisms in cellular processes that elicit a surface plasmon resonance (SPR) response using simultaneous surface plasmon-enhanced fluorescence (SPEF) microscopy. Biosensors & bioelectronics 50 125-131. (Article publié).
  • *Nguyen N , Biet M , Simard E , Béliveau E , Francoeur N , Guillemette G , Dumaine R , Grandbois M , Boulay G. (2013). STIM1 participates in the contractile rhythmicity of HL-1 cells by moderating T-type Ca(2+) channel activity. Biochimica et Biophysica acta 1833 (6), 1294-1303. (Article publié).
  • Bussonnière , Renaudin A, Miron Y, Grandbois M, Baudoin M, Charette P. (2013). Removal of living cells from biosensing surfaces in droplet-based microfluidics using surface acoustic waves. J Acoust Soc Am. 133 (2), (Article publié).
  • Simard E , Kovacs JJ , Miller WE , Kim J , Grandbois M , Lefkowitz RJ. (2013). β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. PloS one 8 (11), e80532. (Article publié).
  • Chabot V, Miron Y, Grandbois M, Charette P. (2012). Long range surface plasmon resonance for increased sensitivity in living cell biosensing through greater probing depth. Sensors and Actuators B : Chemical 174 94-101. (Article publié).
  • *Maltais JS , Denault JB , Gendron L , Grandbois M. (2012). Label-free monitoring of apoptosis by surface plasmon resonance detection of morphological changes. Apoptosis 17 (8), 916-925. (Article publié).
  • Graham JS , Miron Y , Grandbois M. (2011). Assembly of collagen fibril meshes using gold nanoparticles functionalized with tris(hydroxymethyl)phosphine-alanine as multivalent cross-linking agents. Journal of molecular recognition : JMR 24 (3), 477-482. (Article publié).
  • Lamontagne CA , Plante GE , Grandbois M. (2011). Characterization of hyaluronic acid interaction with calcium oxalate crystals: implication of crystals faces, pH and citrate. Journal of molecular recognition : JMR 24 (4), 733-740. (Article publié).
  • Kocun M , Grandbois M , Cuccia LA. (2011). Single molecule atomic force microscopy and force spectroscopy of chitosan. Colloids and surfaces. B, Biointerfaces 82 (2), 470-476. (Article publié).
  • Bovenzi V , Savard M , Morin J , Cuerrier CM , Grandbois M , Gobeil F. (2010). Bradykinin protects against brain microvascular endothelial cell death induced by pathophysiological stimuli. Journal of cellular physiology 222 (1), 168-176. (Article publié).
  • Duplan V , Miron Y , Frost E , Grandbois M , Dubowski JJ. (2009). Specific immobilization of influenza A virus on GaAs (001) surface. Journal of biomedical optics 14 (5), 054042. (Article publié).
  • Cuerrier CM , Gagner A , Lebel R , Gobeil F , Grandbois M. (2009). Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformation. Journal of molecular recognition : JMR 22 (5), 389-396. (Article publié).
  • *Chabot V , Cuerrier CM , Escher E , Aimez V , Grandbois M , Charette PG. (2009). Biosensing based on surface plasmon resonance and living cells. Biosensors & bioelectronics 24 (6), 1667-1673. (Article publié).
  • *Cuerrier CM , Benoit M , Guillemette G , Gobeil F , Grandbois M. (2009). Real-time monitoring of angiotensin II-induced contractile response and cytoskeleton remodeling in individual cells by atomic force microscopy. Pflügers Archiv : European journal of physiology 457 (6), 1361-1372. (Article publié).
  • *Wieczerzak E , Hame R , Chabot V , Aimez V , Charette PG , Grandbois M , Escher E. (2009). Monitoring of native chemical ligation by surface plasmon resonance. Advances in experimental medicine and biology 611 (Article publié).
  • Mitchell G , Lamontagne CA , Brouillette E , Grondin G , Talbot BG , Grandbois M , Malouin F. (2008). Staphylococcus aureus SigB activity promotes a strong fibronectin-bacterium interaction which may sustain host tissue colonization by small-colony variants isolated from cystic fibrosis patients. Molecular microbiology 70 (6),
  • *Cuerrier CM , Chabot V , Vigneux S , Aimez V , Escher E , Gobeil F , Charette PG , Grandbois M. (2008). Surface Plasmon Resonance Monitoring of Cell Monolayer Integrity: Implication of Signaling Pathways Involved in Actin-Driven Morphological Remodeling. Cellular and molecular bioengineering 1 (4),
  • Lamontagne CA , Cuerrier CM , Grandbois M. (2008). AFM as a tool to probe and manipulate cellular processes. Pflügers Archiv : European journal of physiology 456 (1),
  • *Wieczerzak E , Hamel R , Chabot V , Aimez V , Grandbois M , Charette PG , Escher E. (2008). Monitoring of native chemical ligation on solid substrate by surface plasmon resonance. Biopolymers 90 (3),
  • Lamontagne CA , Grandbois M. (2008). PKC-induced stiffening of hyaluronan/CD44 linkage; local force measurements on glioma cells. Experimental cell research 314 (2),
  • Mitchell G , Lamontagne CA , Lebel R , Grandbois M , Malouin F. (2007). Single-molecule dynamic force spectroscopy of the fibronectin-heparin interaction. Biochemical and biophysical research communications 364 (3),
  • *Lebel R , McDuff FO , Lavigne P , Grandbois M. (2007). Direct visualization of the binding of c-Myc/Max heterodimeric b-HLH-LZ to E-box sequences on the hTERT promoter. Biochemistry 46 (36),
  • Hosu BG , Sun M , Marga F , Grandbois M , Forgacs G. (2007). Eukaryotic membrane tethers revisited using magnetic tweezers. Physical biology 4 (2),
  • Cuerrier CM , Lebel R , Grandbois M. (2007). Single cell transfection using plasmid decorated AFM probes. Biochemical and biophysical research communications 355 (3),

Chapitres de livre

  • Bourassa, Thomas Söllradl, Jean-Sébastien Maltais, Paul G. Charette, Louis Gendron and Michel Grandbois. (2015). Surface Plasmon Resonance to study cell signaling and GPCR functional selectivity in live cells Label-free biosensor methods in drug discovery. Label-free biosensor methods in drug discovery Springer "Methods in Pharmacology and Toxicology" series (Article publié).
  • Cuerrier CM*, Simard E*, Lamontagne CA*, Boucher J*, Miron Y*, Grandbois,M. (2011). Label-free monitoring of cell signaling processes through AFM-based force measurements. Life at the Nanoscale : Atomic Force Microscopy of live Cells (353-373). Pan Stanford Publishing. (Article publié).

Autres contributions

Activités de collaboration internationale

  • Research collaboration.


  • (2015). Investigation of intracellular signalling in single cells by SPR. CSC symposium on Surface Plasmon Resonance for Biological Applications. Ottawa
  • (2014). Le Nanomonde ou l'espace invisible. De l'infiniment grand à l'infiniment petit. Colloque du 50e anniversaire du FRQS. Montreal
  • (2012). Monitoring of AT1-R dependent contraction in individual cells. Ludwig-Maximilians-Universität München Walther-Straub-Institut für Pharmakologie und Toxikologie. Munich
  • (2012). AFM-based force sensing on individual cells; applications in pharmacology. Dept. of Biochemistry and Molecular Biology, University Dalhousie, Halifax. Halifax
  • (2012). AFM-based force sensing on individual cells; applications in pharmacology. Annual meeting of the Canadian Society of Pharmacology and Therapeutics. University of Toronto. Totonto
  • (2010). Force spectroscopy as a label-free readout of receptor activation in individual cells. NanoBio Views. NanoBio Views. Berlin