Michel Grandbois

Financement

• Subvention. Advancing single-cell analysis: combining substrates micro-patterning techniques and surface plasmon resonance imaging to uncover cell response heterogeneity. (PI). CRSNG Canada (Ottawa, Canada). 195 000 $. (2025-2030).
• Subvention. Validation expérimentale du design, de la sélection et de l’identification par l’intelligence artificielle de peptides pour la vectorisation AAV. (Co-PI). CQDM (Montreal, Canada). 526 458 $. (2025-2027).
• Subvention salariée. Canada Research Chair in Nanopharmacology and Atomic Force Microscopy. CIHR (Ottawa, Canada). (2003-2013).

Publications

Articles

• Rebecca L. Brouillette, Frédérique Lussier, Émile Breault, Nathan Meneboo, Malihe Hassanzadeh, Victoria Tremblay, Magali Chartier, Élora Midavaine, Laurence Ulrich, Jérôme Côté, Véronique Blais, Christine E. Mona, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Martin Audet, Élie Besserer-Offroy, Philippe Sarret. (2026). A Neurotensin Receptor Type 1-Derived Pepducin Acts as a Biased Allosteric Modulator to Regulate Target Receptor Function. Acta Pharmaceutica Sinica B, Vol. 16, Issue 4. DOI
• Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret. (2025). A Lipidated Peptide Derived from the C-Terminal Tail of the Vasopressin 2 Receptor Shows Promise as a New β-Arrestin Inhibitor. Pharmacological Research, Vol. 212. DOI
• Sára Ferková, Ulrike Froehlich, Marie-Édith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault. (2023). Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein–Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International Journal of Molecular Sciences, 25(1). DOI
• Marion L'Exact, Christian Comeau, Alix Bourhis, Olivier Boisvert, Ulrike Fröhlich, Danny Létourneau, Éric Marsault, Pierre Lavigne, Michel Grandbois, Pierre-Luc Boudreault. (2023). Beyond Rule-of-Five: Permeability Assessment of Semipeptidic Macrocycles. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1865, Issue 7. DOI
• Svenja C. Schüler, Yuguo Liu, Simon Dumontier, Michel Grandbois, Emmeran Le Moal, DDW Cornelison, C. Florian Bentzinger. (2022). Extracellular Matrix: Brick and Mortar in the Skeletal Muscle Stem Cell Niche. Frontiers in Cell and Developmental Biology, Vol. 10. DOI
• Zhor Khadir, Victor Schmidt, Kevin Chabot, Jean-François Bryche, Ulrike Froehlich, Julien Moreau, Michael Canva, Paul Charette, Michel Grandbois. (2022). Surface Micropatterning for the Formation of an in vitro Functional Endothelial Model for Cell-Based Biosensors. Biosensors and Bioelectronics, Vol. 214. DOI
• Christian Comeau, Benjamin Ries, Thomas Stadelmann, Jacob Tremblay, Sylvain Poulet, Ulrike Fröhlich, Jérôme Côté, Pierre-Luc Boudreault, Rabeb Mouna Derbali, Philippe Sarret, Michel Grandbois, Grégoire Leclair, Sereina Riniker, Éric Marsault. (2021). Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties. Journal of Medicinal Chemistry, Vol. 64, Issue 9. DOI
• Rebecca L. Brouillette, Élie Besserer-Offroy, Christine E. Mona, Magali Chartier, Sandrine Lavenus, Marc Sousbie, Karine Belleville, Jean-Michel Longpré, Éric Marsault, Michel Grandbois, Philippe Sarret. (2020). Cell-Penetrating Pepducins Targeting the Neurotensin Receptor Type 1 Relieve Pain. Pharmacological Research, Vol. 155. DOI
• Fatima Awwad, Guillaume Bertrand, Michel Grandbois, Nathalie Beaudoin. (2019). Auxin Protects Arabidopsis Thaliana Cell Suspension Cultures from Programmed Cell Death Induced by the Cellulose Biosynthesis Inhibitors Thaxtomin A and Isoxaben. BMC Plant Biology, Vol. 19, Issue 512. DOI
• Fatima Awwad, Guillaume Bertrand, Michel Grandbois, Nathalie Beaudoin. (2019). Reactive Oxygen Species Alleviate Cell Death Induced by Thaxtomin A in Arabidopsis Thaliana Cell Cultures. Plants, 8(9). DOI
• Frederic A. Banville, Julien Moreau, Kevin Chabot, Andrea Cattoni, Ulrike Fröhlich, Jean-François Bryche, Stéphane Collin, Paul G. Charette, Michel Grandbois, Michael Canva. (2019). Nanoplasmonics-Enhanced Label-Free Imaging of Endothelial Cell Monolayer Integrity. Biosensors and Bioelectronics, Vol. 141. DOI
• N. Brodeur, P. Cloutier, A. D. Bass, G. Bertrand, D. J. Hunting, M. Grandbois, L. Sanche. (2018). Absolute Cross Section for DNA Damage Induced by Low-Energy (10 eV) Electrons: Experimental Refinements and Sample Characterization by AFM. The Journal of Chemical Physics, Vol. 149, Issue 16. DOI
• Sandrine Lavenus, Élie Simard, Élie Besserer-Offroy, Ulrike Froehlich, Richard Leduc, Michel Grandbois. (2018). Label-Free Cell Signaling Pathway Deconvolution of Angiotensin Type 1 Receptor Reveals Time-Resolved G-Protein Activity and Distinct AngII and AngIIIIV Responses. Pharmacological Research, Vol. 136. DOI
• Thomas Söllradl, Frederic A. Banville, Ulrike Fröhlich, Michael Canva, Paul G. Charette, Michel Grandbois. (2018). Label-Free Visualization and Quantification of Single Cell Signaling Activity Using Metal-Clad Waveguide (MCWG)-Based Microscopy. Biosensors and Bioelectronics, Vol. 100. DOI
• Michel Grandbois, Thomas Söllradl; Kevin Chabot; Ulrike Frölich, Michael Canva; Paul G. Charette. (2018). Monitoring Individual Cell-Signaling Activity Using Combined Metal-Clad Waveguide and surface-Enhanced Fluorescence Imaging. Analyst, Issue 22. DOI
• Jérémy Astruc, Malladi Nagalakshmaiah, Gaétan Laroche, Michel Grandbois, Saïd Elkoun, Mathieu Robert. (2017). Isolation of Cellulose-II Nanospheres From Flax Stems and Their Physical and Morphological Properties. Carbohydrate Polymers, Vol. 178. DOI
• É. Carrier, M. Houde, M. Grandbois, G. Bkaily, T.D. Warner, P. D’Orléans-Juste. (2017). Inhibition of Platelet Aggregation Ex Vivo is Repressed in Apolipoprotein E Deficient Mice. Canadian Journal of Physiology and Pharmacology, Vol. 95, No. 8. DOI
• Élie Besserer-Offroy, Rebecca L. Brouillette, Sandrine Lavenus, Ulrike Froehlich, Andrea Brumwell, Alexandre Murza, Jean-Michel Longpré, Éric Marsault, Michel Grandbois, Philippe Sarret, Richard Leduc. (2017). The Signaling Signature of the Neurotensin Type 1 Receptor with Endogenous Ligands. European Journal of Pharmacology, Vol. 805. DOI
• Frederic Trensz, Fabrice Lucien, Vanessa Couture, Thomas, Sollradl, Geneviève Drouin, André-Jean Rouleau, Grandbois Michel, Gregory Lacraz, Guillaume Grenier. (2016). Increased Microenvironment Stiffness in Damaged Myofibers Promotes Myogenic Progenitor Cell Proliferation. Skeletal Muscle, Vol. 5, no. 5. DOI
• *Jean-Sébastien Maltais, Elie Simard, Ulrike Froehlich, Jean-Bernard Denault, Louis Gendron, Michel Grandbois. (2016). iRAGE as a Novel Carboxymethylated Peptide that Prevents Advanced Glycation End Product-Induced Apoptosis and Endoplasmic Reticulum Stress in Vascular Smooth Muscle Cells. Pharmacological Research, Vol. 104. DOI
• Frederik Banville, Thomas Söllradl, Pierre-Jean Zermatten, Michel Grandbois, Paul Charette. (2015). Improved Resolution in SPR and MCWG Microscopy by Combining Images Acquired with Distinct Mode Propagation Directions. Optics Letters, Vol. 40, Issue 7. DOI
• Gregory Lacraz, André-Jean Rouleau, Vanessa Couture, Thomas Sollradl, Geneviève Drouin, Grandbois Michel, Guillaume Grenier. (2015). Increase Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity. PLoS One, 11(12). DOI
• Elie Simard, Thomas Söllradl, Jean-Sébastien Maltais, Julie Boucher, Pédro d'Orléans-Juste, Michel Grandbois. (2015). Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS One, 10(8). DOI
• Julie Boucher, Elie Simard, Ulrike Froehlich, Pédro D'Orleans-Juste, Michel Grandbois. (2015). Using Carboxyfluorescein Diacetate Succinimidyl Ester to Monitor Intracellular Protein Glycation. Analytical Biochemistry, Vol. 478. DOI
• Boucher J , Simard E , Froehlich U , Grandbois M. (2014). Amplification of AngII-dependent Cell Contraction by Glyoxal: Implication of Cell Mechanical Properties and Actomyosin Activity. Integrative Biology, Issue 4. DOI
• Adrien Buissonnière, Yannick Miron, Maurice Beaudoin, O Bou Matar, Michel Grandbois, Paul Charette et Alan Renaudin. (2014). Cell Detachment and Label-Free Sorting Using Modulated Surface Acoustic Waves (SAWs) in Droplet-based Microfluidics. Lab on a Chip, Issue 18. DOI
• Bourassa P, Tudashki HB, Pineyro G, Grandbois M, Gendron L. (2014). Label-Free Monitoring of μ-Opioid Receptor-Mediated Signaling. Molecular Pharmacology, Vol. 86, Issue 2. DOI
• Chabot V , Miron Y , Charette PG , Grandbois M. (2013). Identification of the Molecular Mechanisms in Cellular Processes that Elicit a Surface Plasmon Resonance (SPR) Response Using Simultaneous Surface Plasmon-Enhanced Fluorescence (SPEF) Microscopy. Biosensors and Bioelectronics, Volume 50. DOI
• Bussonnière , Renaudin A, Miron Y, Grandbois M, Baudoin M, Charette P. (2013). Removal of Living Cells from Biosensing Surfaces in Droplet-Based Microfluidics Using Surface Acoustic Waves. Proceedings of Meetings on Acoustics (POMA), Vol. 19, Issue 1. DOI
• *Nguyen N , Biet M , Simard E , Béliveau E , Francoeur N , Guillemette G , Dumaine R , Grandbois M , Boulay G. (2013). STIM1 Participates in the Contractile Rhythmicity of HL-1 Cells by Moderating T-type Ca(2+) Channel Activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1833, Issue 6. DOI
• Simard E , Kovacs JJ , Miller WE , Kim J , Grandbois M , Lefkowitz RJ. (2013). β-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration. PloS One, 8(11). DOI
• *Maltais JS , Denault JB , Gendron L , Grandbois M. (2012). Label-Free Monitoring of Apoptosis by Surface Plasmon Resonance Detection of Morphological Changes. Apoptosis, Vol. 17. DOI
• Chabot V, Miron Y, Grandbois M, Charette P. (2012). Long Range Surface Plasmon Resonance for Increased Sensitivity in Living Cell Biosensing Through Greater Probing Depth. Sensors and Actuators B : Chemical, Vol. 174. DOI
• Graham JS , Miron Y , Grandbois M. (2011). Assembly of Collagen Fibril Meshes Using Gold Nanoparticles Functionalized with Tris(hydroxymethyl)phosphine-alanine as Multivalent Cross-Linking Agents. Journal of Molecular Recognition, Vol. 24, Issue 3. DOI
• Lamontagne CA , Plante GE , Grandbois M. (2011). Characterization of Hyaluronic Acid Interaction with Calcium Oxalate Crystals: Implication of Crystals Faces, pH and Citrate. Journal of Molecular Recognition, Vol. 24, Issue 4. DOI
• Kocun M , Grandbois M , Cuccia LA. (2011). Single Molecule Atomic Force Microscopy and Force Spectroscopy of Chitosan. Colloids and Surfaces B: Biointerfaces, Vol. 82, Issue 2. DOI
• Bovenzi V , Savard M , Morin J , Cuerrier CM , Grandbois M , Gobeil F. (2010). Bradykinin Protects Against Brain Microvascular Endothelial Cell Death Induced by Pathophysiological Stimuli. Journal of Cellular Physiology, Vol. 222, Issue 1. DOI
• *Chabot V , Cuerrier CM , Escher E , Aimez V , Grandbois M , Charette PG. (2009). Biosensing Based on Surface Plasmon Resonance and Living Cells. Biosensors and Bioelectronics, Vol. 24, Issue 6. DOI
• Cuerrier CM , Gagner A , Lebel R , Gobeil F , Grandbois M. (2009). Effect of Thrombin and Bradykinin on Endothelial Cell Mechanical Properties Monitored Through Membrane Deformation. Journal of Molecular Recognition, Vol. 22, Issue 5. DOI
• *Wieczerzak E , Hame R , Chabot V , Aimez V , Charette PG , Grandbois M , Escher E. (2009). Monitoring of Native Chemical Ligation by Surface Plasmon Resonance. Advances in Experimental Medicine and Biology, Vol. 611. DOI
• *Cuerrier CM , Benoit M , Guillemette G , Gobeil F , Grandbois M. (2009). Real-Time Monitoring of Angiotensin II-Induced Contractile Response and Cytoskeleton Remodeling in Individual Cells by Atomic Force Microscopy. Pflügers Archiv : European Journal of Physiology, Vol. 457. DOI
• Duplan V , Miron Y , Frost E , Grandbois M , Dubowski JJ. (2009). Specific Immobilization of Influenza A Virus on GaAs (001) Surface. Journal of Biomedical Optics, Vol. 14, Issue 5. DOI
• Lamontagne CA , Cuerrier CM , Grandbois M. (2008). AFM as a Tool to Probe and Manipulate Cellular Processes. Pflügers Archiv : European Journal of Physiology, Vol. 456. DOI
• *Wieczerzak E , Hamel R , Chabot V , Aimez V , Grandbois M , Charette PG , Escher E. (2008). Monitoring of Native Chemical Ligation on Solid Substrate by Surface Plasmon Resonance. Biopolymers, Vol. 90, Issue 3. DOI
• Lamontagne CA , Grandbois M. (2008). PKC-Induced Stiffening of Hyaluronan/CD44 Linkage; Local Force Measurements on Glioma Cells. Experimental Cell Research, Vol. 314, Issue 2. DOI
• Mitchell G , Lamontagne CA , Brouillette E , Grondin G , Talbot BG , Grandbois M , Malouin F. (2008). Staphylococcus aureus SigB Activity Promotes a Strong Fibronectin-Bacterium Interaction Which May Sustain Host Tissue Colonization by Small-Colony Variants Isolated From Cystic Fibrosis Patients. Molecular Microbiology, Vol. 70, Issue 6. DOI
• *Cuerrier CM , Chabot V , Vigneux S , Aimez V , Escher E , Gobeil F , Charette PG , Grandbois M. (2008). Surface Plasmon Resonance Monitoring of Cell Monolayer Integrity: Implication of Signaling Pathways Involved in Actin-Driven Morphological Remodeling. Cellular and Molecular Bioengineering, Vol. 1, Issue 4. DOI
• *Lebel R , McDuff FO , Lavigne P , Grandbois M. (2007). Direct Visualization of the Binding of c-Myc/Max Heterodimeric b-HLH-LZ to E-Box Sequences on the hTERT Promoter†. Biochemistry, Vol. 46, Issue 36. DOI
• Hosu BG , Sun M , Marga F , Grandbois M , Forgacs G. (2007). Eukaryotic Membrane Tethers Revisited Using Magnetic Tweezers. Physical Biology, Vol. 4, no. 2. DOI
• Cuerrier CM , Lebel R , Grandbois M. (2007). Single Cell Transfection Using Plasmid Decorated AFM Probes. Biochemical and Biophysical Research Communications, Vol. 355, Issue 3. DOI
• Mitchell G , Lamontagne CA , Lebel R , Grandbois M , Malouin F. (2007). Single-Molecule Dynamic Force Spectroscopy of the Fibronectin-Heparin Interaction. Biochemical and Biophysical Research Communications, Vol. 364, Issue 3. DOI
• John S. Graham, Anthony N. Vomund, Charlotte L. Phillips, Michel Grandbois. (2004). Structural Changes in Human Type I Collagen Fibrils Investigated by Force Spectroscopy. Experimental Cell Research, Vol. 299, Issue 2. DOI
• Philippe Desmeules, Michel Grandbois, Vladimir A. Bondarenko, Akio Yamazaki, Christian Salesse. (2002). Measurement of Membrane Binding between Recoverin, a Calcium-Myristoyl Switch Protein, and Lipid Bilayers byAFM-Based Force Spectroscopy. Biophysical Journal, Vol. 82, Issue 6. DOI
• Michel Grandbois, Bernard Desbat, Christian Salesse. (2000). Monitoring of phospholipid monolayer hydrolysis by phospholipase A2 by use of polarization-modulated Fourier transform infrared spectroscopy. Biophysical Chemistry, Vol. 88, Issues 1-3. DOI
• Wolfgang Dettmann, Michel Grandbois, Sabine André, Martin Benoit, Angelika K. Wehle, Herbert Kaltner, Hans-Joachim Gabius, Hermann E. Gaub. (2000). Differences in Zero-Force and Force-Driven Kinetics of Ligand Dissociation from β-Galactoside-Specific Proteins (Plant and Animal Lectins, Immunoglobulin G) Monitored by Plasmon Resonance and Dynamic Single Molecule Force Microscopy. Archives of Biochemistry and Biophysics, Vol. 383, Issue 2. DOI
• Michel Grandbois, Wolfgang Dettmann, Martin Benoit, Hermann E. Gaub. (2000). Affinity Imaging of Red Blood Cells Using an Atomic Force Microscope. Journal of Histochemistry and Cytochemistry, Vol. 48, Issue 5. DOI
• Michel Grandbois, Martin Beyer, Matthias Rief, Hauke Clausen-Schaumann, Hermann E. Gaub. (1999). How Strong Is a Covalent Bond?. Science, Vol. 283, Issue 5408. DOI
• Michel Grandbois, Hauke Clausen-Schaumann, Hermann Gaub. (1998). Atomic Force Microscope Imaging of Phospholipid Bilayer Degradation by Phospholipase A2. Biophysical Journal, Vol. 74, Issue 5. DOI

Chapitres de livre

• Bourassa, Thomas Söllradl, Jean-Sébastien Maltais, Paul G. Charette, Louis Gendron, Michel Grandbois. (2015). Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells. Label-free Biosensor Methods in Drug Discovery. Methods in Pharmacology and Toxicology. DOI
• Cuerrier CM*, Simard E*, Lamontagne CA*, Boucher J*, Miron Y*, Grandbois,M. (2011). Label-Free Monitoring of Cell Signaling Processes Through AFM-Based Force Measurements. Life at the Nanoscale: Atomic Force Microscopy of Live Cells. Pan Stanford Publishing. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

• PHR202 - Pharmacochimie. (2024-2026). (3CR).
• PHR204 - Principes de pharmacologie II. (2024-2026). (3CR).
• PHR708 - Sujets choisis en pharmacologie. (2026). (1CR).
• PHR713 - Méthodes d'étude de cibles pharmacologiques. (2023, 2025). (2CR).
• PHR701 - Principes de pharmacologie. (2023-2024). (2CR).