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Jean-François Lepage

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pédiatrie

Présentation

Sujets, disciplines ou intérêts de recherche

transcranial magnetic stimulation, fragile-x syndrome, neurostimulation, neurodevelopmental disorders, neuropsychology

Qualifications

  • Post-doc. Psychiatry. Stanford University. Stanford, CA, États-Unis. (2010-2012).

Diplômes

  • (2012-2015). Post-doc. Rehabilitation. Massachusetts General Hospital. Boston, Massachusetts, États-Unis.
  • (2004-2010). PhD. Psychologie. Université de Montréal. Montréal, Québec, Canada.
  • (2004-2009). M.Sc. Psychologie. Université de Montréal. Montreal, Quebec, Canada.

Expériences académiques

  • Full Professor. (2016-). University of Sherbrooke. Sherbrooke, Quebec, Canada.

Financement

  • Subvention. La stimulation magnétique transcrânienne pour les troubles anxieux et de l'humeur chez les populations pédiatriques : évaluation de l'engagement thérapeutique, développement de nouvelles interventions et mise en place de l'Initiative TMS Québec. Fonds de Recherche du Québec - Santé (Montreal, Canada). 255 574 $. (2024-2028).
    Numéro de subvention : 348433. Voir plus
  • Subvention. Brain Stimulation Platform of Université de Sherbrooke. Canada Foundation for Innovation (Ottawa, Canada). 177 050 $. (2023).
    Numéro de subvention : 44288. Voir plus
  • Subvention. Early life determinants of childhood adiposity, appetite regulation, and obesogenic dietary behaviours. Canadian Institutes of Health Research (Ottawa, Canada). 1 354 050 $. (2023-2028).
    Numéro de subvention : 202303PJT. Voir plus
  • Subvention. Towards accessible transcranial Focused Ultrasound (tFUS): Developing a portable Ultrasound-Guided (USg) system for pediatric and adult applications. Social Sciences and Humanities Research Council (Ottawa, Canada). 125 000 $. (2023-2024).
    Numéro de subvention : grant.14497783. Voir plus
  • Subvention. Développement de nouveaux outils de neurostimulation non-invasifs chez l'humain. Natural Sciences and Engineering Research Council (Ottawa, Canada). 30 000 $. (2022-2023).
    Numéro de subvention : RGPIN-2017-05510. Voir plus
  • Subvention. Empowering Next-generation Researchers in perinatal and Child Health (ENRICH). Canadian Institutes of Health Research (Ottawa, Canada). 2 400 000 $. (2022-2027).
    Numéro de subvention : 202106RT5. Voir plus
  • Subvention. Targeting the endocannabinoid system to correct GABA abnormalities in patients with Fragile-X syndrome. Canadian Institutes of Health Research (Ottawa, Canada). 531 675 $. (2021-2026).
    Numéro de subvention : 202010PJT. Voir plus
  • Subvention. Beneficial influence of acute exercise on motor learning: exploring the neurophysiological bases. Canada Foundation for Innovation (Ottawa, Canada). 255 082 $. (2020).
    Numéro de subvention : 40799. Voir plus
  • Subvention. Le système GABAergique dans les troubles neurodéveloppementaux. Fonds de Recherche du Québec - Santé (Montreal, Canada). 286 986 $. (2020-2024).
    Numéro de subvention : 283473. Voir plus
  • Subvention. Focused ultrasound stimulation for brain research. Natural Sciences and Engineering Research Council (Ottawa, Canada). 150 000 $. (2016-2017).
    Numéro de subvention : RTI-2017-00401. Voir plus
  • Subvention. La plasticité synaptique et la neurophysiologie chez les personnes présentant des anomalies des chromosomes sexuels: à la recherche d'un marqueur neurophysiologique du trouble du spectre autistique. Fonds de Recherche du Québec - Santé (Montreal, Canada). 60 000 $. (2016-2019).
    Numéro de subvention : 34604. Voir plus
  • Subvention. La plasticité synaptique et la neurophysiologie chez les personnes présentant des anomalies des chromosomes sexuels: à la recherche d'un marqueur neurophysiologique du trouble du spectre autistique. Fonds de Recherche du Québec - Santé (Montreal, Canada). 246 321 $. (2016-2020).
    Numéro de subvention : 33140. Voir plus
  • Subvention. Direct current stimulation modulation of hyperphagia in Prader-Willi syndrome. Canadian Institutes of Health Research (Ottawa, Canada). 180 000 $. (2012-2015).
    Numéro de subvention : 201102MFE. Voir plus
  • Subvention. Génétique, neurophysiologie et morphométrie de la cognition au sein du syndrome de Turner. Fonds de Recherche du Québec - Santé (Montreal, Canada). 92 122 $. (2010-2012).
    Numéro de subvention : 20890. Voir plus
  • Subvention. Empreinte genetique au sein du syndrome de turner : Neurophysiologie, neuropsychologie et anatomie de la cognition sociale. Canadian Institutes of Health Research (Ottawa, Canada). 107 500 $. (2007-2010).
    Numéro de subvention : 200610CGD. Voir plus
  • Subvention. Puissance Dys : projet-pilote préventif pré-scolaire utilisant des interventions éducatives intermodalitaires. Mitacs (Vancouver, Canada).
    Numéro de subvention : grant.13958111. Voir plus

Publications

Articles

  • Keven Lapointe, Sabrina Suffren, Maryse Lassonde, Jean-François Lepage, Johannes Frasnelli. (2025). Odor localization in structural interhemispheric deficits. Chemical Senses. DOI
  • Teddy Mohamad, Jean-François Lepage. (2024). Computing a cure for fragile-X syndrome. Brain Communications. DOI
  • Raphael Hamel, Mathilde Langlois, Jean-François Lepage. (2023). Seizure produced by 15Hz transcranial magnetic stimulation in a healthy subject following static magnetic stimulation and single pulse stimulation. Brain Stimulation. DOI
  • Haifa Akremi, Raphaël Hamel, Anne Dumas, Chantal Camden, Hélène Corriveau, Jean-Francois Lepage. (2022). Cerebellar Transcranial Direct Current Stimulation in Children with Developmental Coordination Disorder: A Randomized, Double-Blind, Sham-Controlled Pilot Study. Journal of Autism and Developmental Disorders. DOI
  • Hamel R, Lepage JF, Bernier PM. (2021). Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study. The European journal of neuroscience. DOI
  • Sussman TJ, Baker BH, Wakhloo AJ, Gillet V, Abdelouahab N, Whittingstall K, Lepage JF, St-Cyr L, Boivin A, Gagnon A, Baccarelli AA, Takser L, Posner J. (2021). The relationship between persistent organic pollutants and Attention Deficit Hyperactivity Disorder phenotypes: Evidence from task-based neural activity in an observational study of a community sample of Canadian mother-child dyads. Environmental research. DOI
  • Lafleur LP, Murray A, Desforges M, Pacheco-Barrios K, Fregni F, Tremblay S, Saint-Amour D, Lepage JF, Théoret H. (2021). No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations. Scientific reports. DOI
  • Hamel R, De La Fontaine É, Lepage JF, Bernier PM. (2021). Punishments and rewards both modestly impair visuomotor memory retention. Neurobiology of learning and memory. DOI
  • Cote S, Butler R, Michaud V, Lavallee E, Croteau E, Mendrek A, Lepage JF, Whittingstall K. (2021). The regional effect of serum hormone levels on cerebral blood flow in healthy nonpregnant women. Human brain mapping. DOI
  • Pierrieau E, Lepage JF, Bernier PM. (2021). Action Costs Rapidly and Automatically Interfere with Reward-Based Decision-Making in a Reaching Task. eNeuro. DOI
  • Lachambre C, Proteau-Lemieux M, Lepage JF, Bussières EL, Lippé S. (2021). Attentional and executive functions in children and adolescents with developmental coordination disorder and the influence of comorbid disorders: A systematic review of the literature. PloS one. DOI
  • Hall SS, Riley MJ, Weston RN, Lepage JF, Hong DS, Jo B, Hallmayer J, Reiss AL. (2021). Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome. Journal of autism and developmental disorders. DOI
  • Proteau-Lemieux M, Lacroix A, Galarneau L, Corbin F, Lepage JF, Çaku A. (2021). The safety and efficacy of metformin in fragile X syndrome: An open-label study. Progress in neuro-psychopharmacology & biological psychiatry. DOI
  • Champigny C, Morin-Parent F, Bellehumeur-Lefebvre L, Çaku A, Lepage JF, Corbin F. (2021). Combining Lovastatin and Minocycline for the Treatment of Fragile X Syndrome: Results From the LovaMiX Clinical Trial. Frontiers in psychiatry. DOI
  • Hamel R, Dallaire-Jean L, De La Fontaine É, Lepage JF, Bernier PM. (2021). Learning the same motor task twice impairs its retention in a time- and dose-dependent manner. Proceedings. Biological sciences. DOI
  • Baker BH, Lugo-Candelas C, Wu H, Laue HE, Boivin A, Gillet V, Aw N, Rahman T, Lepage JF, Whittingstall K, Bellenger JP, Posner J, Takser L, Baccarelli AA. (2020). Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity. JAMA pediatrics. DOI
  • Hamel R, De La Fontaine É, Bernier PM, Lepage JF. (2020). Response to significant influence of static magnetic stimulation applied for 30 minutes over the human M1 on corticospinal excitability. Brain stimulation. DOI
  • Hamel R, De La Fontaine É, Bernier PM, Lepage JF. (2019). Letter to the editor: No influence of static magnetic stimulation applied for 30 minutes over the human M1 on corticospinal excitability. Brain stimulation. DOI
  • Morin-Parent F, Champigny C, Lacroix A, Corbin F, Lepage JF. (2019). Hyperexcitability and impaired intracortical inhibition in patients with fragile-X syndrome. Translational psychiatry. DOI
  • Lafleur LP, Klees-Themens G, Chouinard-Leclaire C, Larochelle-Brunet F, Tremblay S, Lepage JF, Théoret H. (2019). Neurophysiological aftereffects of 10 Hz and 20 Hz transcranial alternating current stimulation over bilateral sensorimotor cortex. Brain research. DOI
  • Hamel R, Côté K, Matte A, Lepage JF, Bernier PM. (2019). Rewards interact with repetition-dependent learning to enhance long-term retention of motor memories. Annals of the New York Academy of Sciences. DOI
  • Lacroix A, Proulx-Bégin L, Hamel R, De Beaumont L, Bernier PM, Lepage JF. (2019). Static magnetic stimulation of the primary motor cortex impairs online but not offline motor sequence learning. Scientific reports. DOI
  • Trémolière B, Maheux-Caron V, Lepage JF, Blanchette I. (2018). tDCS Stimulation of the dlPFC Selectively Moderates the Detrimental Impact of Emotion on Analytical Reasoning. Frontiers in psychology. DOI
  • Morin-Parent F, de Beaumont L, Théoret H, Lepage JF. (2017). Superior non-specific motor learning in the blind. Scientific reports. DOI
  • Melissa Lortie, Léa Proulx-Bégin, Dave Saint-Amour, Dominique Cousineau, Hugo Théoret, Jean-François Lepage. (2017). Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder. Journal of Autism and Developmental Disorders. DOI
  • Beaulé V, Tremblay S, Lafleur LP, Ferland MC, Lepage JF, Théoret H. (2016). Modulation of physiological mirror activity with transcranial direct current stimulation over dorsal premotor cortex. DOI
  • Tremblay S, Larochelle-Brunet F, Lafleur LP, El Mouderrib S, Lepage JF, Théoret H. (2016). Systematic assessment of duration and intensity of anodal transcranial direct current stimulation on primary motor cortex excitability. DOI
  • Bravo GL, Poje AB, Perissinotti I, Marcondes BF, Villamar MF, Manzardo AM, Luque L, LePage JF, Stafford D, Fregni F, Butler MG. (2016). Transcranial direct current stimulation reduces food-craving and measures of hyperphagia behavior in participants with Prader-Willi syndrome. DOI
  • Bernier M, Gauvreau C, Theriault D, Madrolle S, Lepage JF, Whittingstall K. (2016). Increased BOLD activation in the left parahippocampal cortex after 1 year of medical school: an association with cumulative verbal memory learning. DOI
  • Lafleur LP, Tremblay S, Whittingstall K, Lepage JF. (2016). Assessment of Effective Connectivity and Plasticity With Dual-Coil Transcranial Magnetic Stimulation. DOI
  • Beaulé V, Tremblay S, Lafleur LP, Lassonde M, Lepage JF, Théoret H. (2015). Cortical thickness in adults with agenesis of the corpus callosum. DOI
  • Chromik LC, Quintin EM, Lepage JF, Hustyi KM, Lightbody AA, Reiss AL. (2015). The Influence of Hyperactivity, Impulsivity, and Attention Problems on Social Functioning in Adolescents and Young Adults With Fragile X Syndrome. DOI
  • Simon P. Landry, Sara Pagé, Douglas M. Shiller, Jean-François Lepage, Hugo Théoret, François Champoux. (2015). Auditory imagery forces motor action. NeuroReport. DOI
  • Jean-François Lepage, Mélissa Lortie, Cheri L. Deal, Hugo Théoret. (2014). Empathy, autistic traits, and motor resonance in adults with Turner syndrome. Social Neuroscience. DOI
  • Tremblay S, Lepage JF, Latulipe-Loiselle A, Fregni F, Pascual-Leone A, Théoret H. (2014). The uncertain outcome of prefrontal tDCS. DOI
  • (2013). Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy. DOI
  • (2013). Impact of cognitive profile on social functioning in prepubescent females with Turner syndrome. DOI
  • (2013). Skin color has no impact on motor resonance: Evidence from mu rhythm suppression and imitation. DOI
  • (2012). Occlusion of LTP-Like Plasticity in Human Primary Motor Cortex by Action Observation. DOI
  • (2011). Contribution of Executive Functions to Visuospatial Difficulties in Prepubertal Girls With Turner Syndrome. DOI
  • Jean-François Lepage, Sara Tremblay, Dang Khoa Nguyen, François Champoux, Maryse Lassonde, Hugo Théoret. (2010). Action related sounds induce early and late modulations of motor cortex activity. NeuroReport. DOI
  • (2010). Brain Connectivity: Finding a Cause. DOI
  • (2010). Early non-specific modulation of corticospinal excitability during action observation. DOI
  • (2010). Numerical Processing: Stimulating Numbers. DOI
  • (2007). The mirror neuron system: grasping others? actions from birth?. DOI
  • (2006). Autism Spectrum Disorder: Seeing Is Not Understanding. DOI
  • (2006). EEG evidence for the presence of an action observation-execution matching system in children. DOI

Autres contributions

Divers

  • François Champoux, Jean-François Lepage, Marie-Christine Désy, Mélissa Lortie, Hugo Théoret. (2008). The Neurophysiology of Early Motor Resonance. Mirror Neuron Systems.