Ghassan Bkaily

Prix et distinctions

• (2024) Honorary credential. International Forum on cardiovascular disease, stem cells and tissue engineering: 1st Asian IACS.
• (2015) Ken Bowman Research Achievement Award. International Academy of Cardiovascular Sciences – North American Section.
• (2015) Ramesh K. Goyal Career Award in Cardiovascular Sciences. VII International Conference on Recent Advances in Cardiovascular Sciences, India Section.
• (2004) Most outstanding Pharmacology Paper in the year 2004. The Pharmacological Society of Canada.

Financement

• Subvention. Role of the sodium/calcium exchanger in regulation of nuclear Na+ and Ca2+ homeostasis by Angiotensin II in heart cells. Natural Sciences and Engineering Research Council of Canada (ON, Canada). Discovery grant. 195 000 $. (2024-2029).
• Subvention. Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire. Canadian Institutes of Health Research (CIHR) (Ottawa, Canada). Project grant. 830 025 $. (2023-2028).
• Subvention. Regulation of nuclear calcium and ROS by Angiotensin II in heart cells. Natural Sciences and Engineering Research Council of Canada (Ottawa, Canada). Discovery grant. 125 000 $. (2016-2023).
• Subvention. Regulation of nuclear calcium and ROS by Angiotensin II in heart cells. Natural Sciences and Engineering Research Council of Canada (ON, Canada). Discovery grant. 125 000 $. (2016-2023).
• Subvention. Role of ET-1 and Ang II induced cytosolic and nuclear ROS generation in nuclear Ttubules formation in hypertrophy and ageing of human vascular smooth muscle cells. Canadian Institutes of Health Research (Ottawa, Canada). Project grant. 651 185 $.
• Subvention. Role of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy. Canadian Institutes of Health Research (Ottawa, Canada). Project grant. 663 347 $.

Publications

Articles

• Ghassan Bkaily, Danielle Jacques, Ashley Jazzar. (2025). Exogenous and endogenous antioxidants (ROS) in Physiology and Pathology of the Cardiovascular System. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Ashley Jazzar, Amira Abou-Aichi, Danielle Jacques. (2025). Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System. Biomedicines. DOI
• Ashley Jazzar, Danielle Jacques, Amira Abou-Aichi, Ghassan Bkaily. (2025). In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner. Pathophysiology. DOI
• Ghassan Bkaily, Yanick Simon, Joe Abou Abdallah, Chaimaa Ouertane, Amina Essalhi, Abdelouahed Khalil, Danielle Jacques. (2024). Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent. Nutrients. DOI
• Danielle Jacques, Ghassan Bkaily. (2024). Taurine Prevents Angiotensin II-Induced Human Endocardial Endothelium Morphological Remodeling and the Increase in Cytosolic and Nuclear Calcium and ROS. Nutrients. DOI
• Yanick Simon, Danielle Jacques, Ghassan Bkaily. (2023). High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Danielle Jacques. (2023). Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System. International Journal of Molecular Sciences. DOI
• Ghassan Bkaily, Danielle Jacques. (2023). Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases. International Journal of Molecular Sciences. DOI
• Ghassan Bkaily, Maram Ali Al-Shahrani, Moni Nader, Danielle Jacques. (2022). Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Yanick Simon, Alexandre Normand, Ashley Jazzar, Houssein Najibeddine, Abdelouahed Khalil, Danielle Jacques. (2022). Short-Communication: Short-Term Treatment with Taurine Prevents the Development of Cardiac Hypertrophy and Early Death in Hereditary Cardiomyopathy of the Hamster and Is Sex-Dependent. Nutrients. DOI
• Johny Al-Khoury, Danielle Jacques, Ghassan Bkaily. (2022). Hypotension in hereditary cardiomyopathy. Pflügers Archiv - European Journal of Physiology. DOI
• Ashley Jazzar, Danielle Jacques, Ghassan Bkaily. (2021). Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na+-Taurine Symporter. Nutrients. DOI
• Ghassan Bkaily, Yanick Simon, Ashley Jazzar, Houssein Najibeddine, Alexandre Normand, Danielle Jacques. (2021). High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells. Biomedicines. DOI
• Ghassan Bkaily, Nadia Abou Abdallah, Yanick Simon, Ashley Jazzar, Danielle Jacques. (2021). Vascular smooth muscle remodeling in health and disease. Canadian Journal of Physiology and Pharmacology. DOI
• Maxime Gagnon, Martin Savard, Jean-François Jacques, Ghassan Bkaily, Sameh Geha, Xavier Roucou, Fernand Gobeil. (2021). Potentiation of B2 receptor signaling by B2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene. Journal of Biological Chemistry. DOI
• Ghassan Bkaily, Danielle Jacques. (2020). Flaxseed as an Anticardiotoxicity Agent in Breast Cancer Therapy. The Journal of Nutrition. DOI
• Tang Zhu, Fernand Gobeil, Alejandro Vazquez-Tello, Martin Leduc, Lenka Rihakova, Michela Bossolasco, Ghassan Bkaily, Krishna Peri, Daya R. Varma, Robert Orvoine, Sylvain Chemtob. (2020). Correction: Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Ashley Jazzar, Alexandre Normand, Yanick Simon, Johny Al-Khoury, Danielle Jacques. (2020). Taurine and cardiac disease: state of the art and perspectives. Canadian Journal of Physiology and Pharmacology. DOI
• Marc Chamoun, Danielle Jacques, Ghassan Bkaily. (2019). Extracellular and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Wassim Najibeddine, Danielle Jacques. (2019). Increase of NADPH oxidase 3 in heart failure of hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology. DOI
• Danielle Jacques, Chantale Provost, Alexandre Normand, Nadia Abou Abdallah, Johny Al-Khoury, Ghassan Bkaily. (2019). Angiotensin II induces apoptosis of human right and left ventricular endocardial endothelial cells by activating the AT2 receptor. Canadian Journal of Physiology and Pharmacology. DOI
• Danielle Jacques, Ghassan Bkaily. (2019). Endocardial endothelial cell hypertrophy takes place during the development of hereditary cardiomyopathy. Molecular and Cellular Biochemistry. DOI
• Ghassan Bkaily, Yanick Simon, Istok Menkovic, Carl Bkaily, Danielle Jacques. (2018). High salt-induced hypertrophy of human vascular smooth muscle cells associated with a decrease in glycocalyx. Journal of Molecular and Cellular Cardiology. DOI
• Ghada S. Hassan, Danielle Jacques, Pedro D’Orléans-Juste, Sheldon Magder, Ghassan Bkaily. (2018). Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis. Canadian Journal of Physiology and Pharmacology. DOI
• Maud Kamal, Danielle Jacques, Ghassan Bkaily. (2017). Angiotensin II receptors’ modulation of calcium homeostasis in human vascular endothelial cells. Canadian Journal of Physiology and Pharmacology. DOI
• Danielle Jacques, Nelly Abdel-Karim Abdel-Malak, Nadia Abou Abdallah, Johny Al-Khoury, Ghassan Bkaily. (2017). Difference in the response to angiotensin II between left and right ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Danielle Jacques. (2017). Na+–H+ exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies. Canadian Journal of Physiology and Pharmacology. DOI
• Danielle Jacques, Pedro D’Orléans-Juste, Sheldon Magder, Ghassan Bkaily. (2017). Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology. DOI
• Marianne Mikhail, Pierre H. Vachon, Pedro D’Orléans-Juste, Danielle Jacques, Ghassan Bkaily. (2017). Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells. Canadian Journal of Physiology and Pharmacology. DOI
• É. Carrier, M. Houde, M. Grandbois, G. Bkaily, T.D. Warner, P. D’Orléans-Juste. (2017). Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice. Canadian Journal of Physiology and Pharmacology. DOI
• Dima Abdel-Samad, Ghassan Bkaily, Sheldon Magder, Danielle Jacques. (2016). ETA and ETB receptors contribute to neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. Neuropeptides. DOI
• Ghassan Bkaily, Mirna Chahine, Johny Al-Khoury, Levon Avedanian, Norbert Beier, Wolfgang Scholz, Danielle Jacques. (2015). Na+–H+ exchanger inhibitor prevents early death in hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology. DOI
• Farah Jules, Levon Avedanian, Johny Al-Khoury, Ramatoulaye Keita, Alexandre Normand, Ghassan Bkaily, Danielle Jacques. (2015). Nuclear Membranes ETB Receptors Mediate ET-1–induced Increase of Nuclear Calcium in Human Left Ventricular Endocardial Endothelial Cells. Journal of Cardiovascular Pharmacology. DOI
• Ghassan Bkaily, Levon Avedanian, Johny Al-Khoury, Marc Chamoun, Rana Semaan, Cynthia Jubinville-Leblanc, Pedro D’Orléans-Juste, Danielle Jacques. (2015). Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology. DOI
• Walid Semaan, Louisane Desbiens, Martin Houde, Julie Labonté, Hugo Gagnon, Daisuke Yamamoto, Shinji Takai, Tanya Laidlaw, Ghassan Bkaily, Adel Schwertani, Gunnar Pejler, Christine Levesque, Roxane Desjardins, Robert Day, Pedro D’Orléans-Juste. (2015). Chymase inhibitor-sensitive synthesis of endothelin-1 (1–31) by recombinant mouse mast cell protease 4 and human chymase. Biochemical Pharmacology. DOI
• Ghassan Bkaily, Johny Al-Khoury, Danielle Jacques. (2014). Nuclear Membranes GPCRs: Implication in Cardiovascular Health and Diseases. Current Vascular Pharmacology. DOI
• I Brochu, M Houde, L Desbiens, E Simard, F Gobeil, W Semaan, G Bkaily, P D'Orléans‐Juste. (2013). High salt‐induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722. British Journal of Pharmacology. DOI
• Lena Ahmarani, Levon Avedanian, Johny Al-Khoury, Claudine Perreault, Danielle Jacques, Ghassan Bkaily. (2013). Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial, vascular smooth muscle, and vascular endothelial cells. Canadian Journal of Physiology and Pharmacology. DOI
• Dima Abdel-Samad, Claudine Perreault, Lena Ahmarani, Levon Avedanian, Ghassan Bkaily, Sheldon Magder, Pedro D’Orléans-Juste, Danielle Jacques. (2012). Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells. Neuropeptides. DOI
• Ghassan Bkaily, Levon Avedanian, Johny Al-Khoury, Lena Ahmarani, Claudine Perreault, Danielle Jacques. (2012). Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions. Canadian Journal of Physiology and Pharmacology. DOI
• Pedro D'Orléans‐Juste, Ghassan Bkaily, Giles Alexander Rae. (2012). Endothelin and bradykinin: ‘brothers‐in‐arms’ in Chagas vasculopathies?. British Journal of Pharmacology. DOI
• Ghassan Bkaily, Levon Avedanian, Johny Al-Khoury, Chantale Provost, Moni Nader, Pedro D'Orléans-Juste, Danielle Jacques. (2011). Nuclear membrane receptors for ET-1 in cardiovascular function. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. DOI
• Levon Avedanian, Danielle Jacques, Ghassan Bkaily. (2011). Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology. DOI
• Levon Avedanian, Julie Riopel, Ghassan Bkaily, Moni Nader, Pedro D’Orleans-Juste, Danielle Jacques. (2010). ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. This article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research. Canadian Journal of Physiology and Pharmacology. DOI
• Chantale Provost, Faten Choufani, Levon Avedanian, Ghassan Bkaily, Fernand Gobeil, Danielle Jacques. (2010). Nitric oxide and reactive oxygen species in the nucleus revisitedThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Danielle Jacques. (2009). L-Type Calcium Channel Antagonists and Suppression of Expression of Plasminogen Receptors. Circulation Research. DOI
• Bruce Gottlieb, Lorraine E. Chalifour, Benjamin Mitmaker, Nathan Sheiner, Daniel Obrand, Cherrie Abraham, Melissa Meilleur, Tomoko Sugahara, Ghassan Bkaily, Morris Schweitzer. (2009). BAK1 gene variation and abdominal aortic aneurysms. Human Mutation. DOI
• Ghassan Bkaily, Levon Avedanian, Danielle Jacques. (2009). Nuclear membrane receptors and channels as targets for drug development in cardiovascular diseasesThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 1 of a 2-part Special Issue). Canadian Journal of Physiology and Pharmacology. DOI
• P. D'Orléans-Juste, M. Houde, G.A. Rae, G. Bkaily, E. Carrier, E. Simard. (2008). Endothelin-1 (1–31): From chymase-dependent synthesis to cardiovascular pathologies. Vascular Pharmacology. DOI
• Ghassan Bkaily, Sanaa Choufani, Levon Avedanian, Lena Ahmarani, Moni Nader, Danielle Jacques, Pedro D’Orléans-Juste, Johny Al Khoury. (2008). Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. This article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin. Canadian Journal of Physiology and Pharmacology. DOI
• Martin Savard, David Barbaz, Simon Bélanger, Werner Müller‐Esterl, Ghassan Bkaily, Pedro D'orléans‐Juste, Jérôme Coté, Veronica Bovenzi, Fernand Gobeil. (2008). Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation. Journal of Cellular Physiology. DOI
• Jean-Claude Honoré, Émilie Carrier, Marie-Hélène Fecteau, Carlos R. Tirapelli, Ghassan Bkaily, Pedro D’Orleans-Juste. (2008). Nonselective ETA/ETB-receptor blockade increases systemic blood pressure of Bio 14.6 cardiomyopathic hamsters. This article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Pedro D’Orleans-Juste, Danielle Jacques. (2006). A New Paradigm. Circulation Research. DOI
• Johny Al-Khoury, Ghassan Bkaily, Mirna Chahine, Danielle Jacques, Pedro D'Orléans-Juste. (2006). ETB receptor dependent alteration in aortic responses to ET-1 in the cardiomyopathic hamster. This paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference. Canadian Journal of Physiology and Pharmacology. DOI
• Hackett JA, Allard-Chamard H, Sarrazin P, de Fatima Lucena M, Gallant MA, Fortier I, Nader M, Parent JL, Bkaily G, de Brum-Fernandes AJ. (2006). Prostaglandin production by human osteoclasts in culture. The Journal of rheumatology.
• Fernand Gobeil, Tang Zhu, Sonia Brault, Antoinette Geha, Alejandro Vazquez-Tello, Audrey Fortier, David Barbaz, Daniella Checchin, Xin Hou, Moni Nader, Ghassan Bkaily, Jean-Philippe Gratton, Nikolaus Heveker, Alfredo Ribeiro-da-Silva, Krishna Peri, Harry Bard, Alzbeta Chorvatova, Pedro D'Orléans-Juste, Edward J. Goetzl, Sylvain Chemtob. (2006). Nitric Oxide Signaling via Nuclearized Endothelial Nitric-oxide Synthase Modulates Expression of the Immediate Early Genes iNOS and mPGES-1. Journal of Biological Chemistry. DOI
• Fernand Gobeil, Audrey Fortier, Tang Zhu, Michela Bossolasco, Martin Leduc, Michel Grandbois, Nikolaus Heveker, Ghassan Bkaily, Sylvain Chemtob, David Barbaz. (2006). G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigmThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Moni Nader, Levon Avedanian, Sana Choufani, Danielle Jacques, Pedro D’Orléans-Juste, Fernand Gobeil, Sylvain Chemtob, Johny Al-Khoury. (2006). G-protein-coupled receptors, channels, and Na+–H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. This paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell. Canadian Journal of Physiology and Pharmacology. DOI
• Tang Zhu, Fernand Gobeil, Alejandro Vazquez-Tello, Martin Leduc, Lenka Rihakova, Michela Bossolasco, Ghassan Bkaily, Krishna Peri, Daya R. Varma, Robert Orvoine, Sylvain Chemtob. (2006). Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. This paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell. Canadian Journal of Physiology and Pharmacology. DOI
• Carlos R. Tirapelli, Johny Al-Khoury, Ghassan Bkaily, Pedro D’Orléans-Juste, Vera L. Lanchote, Sergio A. Uyemura, Ana M. de Oliveira. (2006). Chronic Ethanol Consumption Enhances Phenylephrine-Induced Contraction in the Isolated Rat Aorta. The Journal of Pharmacology and Experimental Therapeutics. DOI
• Nicole Cauchon, Moni Nader, Ghassan Bkaily, Johan E. van Lier, Darel Hunting. (2006). Photodynamic Activity of Substituted Zinc Trisulfophthalocyanines: Role of Plasma Membrane Damage. Photochemistry and Photobiology. DOI
• Jean-Claude Honoré, Marie-Hélène Fecteau, Isabelle Brochu, Julie Labonté, Ghassan Bkaily, Pedro D’Orleans-Juste. (2005). Concomitant antagonism of endothelial and vascular smooth muscle cell ETB receptors for endothelin induces hypertension in the hamster. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• Ghassan Bkaily, Nesrine El-Bizri, Moni Nader, Khaled M. Hazzouri, Julie Riopel, Danielle Jacques, Domenico Regoli, Pedro D’Orleans-Juste, Fernand Gobeil, Levon Avedanian. (2005). Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors. Peptides. DOI
• Ghassan Bkaily, Adrian Sculptoreanu, Shimin Wang, Moni Nader, Khaled M. Hazzouri, Danielle Jacques, Domenico Regoli, Pedro D’Orleans-Juste, Levon Avedanian. (2005). Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells. Peptides. DOI
• M CHAHINE, G BKAILY, M NADER, J ALKHOURY, D JACQUES, N BEIER, W SCHOLZ. (2005). NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor. Journal of Molecular and Cellular Cardiology. DOI
• Ghassan Bkaily, Moni Nader, Levon Avedanian, Danielle Jacques, Claudine Perrault, Dima Abdel-Samad, Pedro D'Orléans-Juste, Fernand Gobeil, Khaled M Hazzouri. (2004). Immunofluorescence revealed the presence of NHE-1 in the nuclear membranes of rat cardiomyocytes and isolated nuclei of human, rabbit, and rat aortic and liver tissues. Canadian Journal of Physiology and Pharmacology. DOI
• Eric J, Bkaily G, Bkaily GB, Volkov L, Gabra BH, Sirois P. (2003). Des-Arg9-bradykinin increases intracellular Ca2+ in bronchoalveolar eosinophils from ovalbumin-sensitized and -challenged mice. European journal of pharmacology. DOI
• Ghassan Bkaily, Sanaa Choufani, Sawsan Sader, Danielle Jacques, Pedro d'Orléans-Juste, Moni Nader, Ghada Kurban, Maud Kamal. (2003). Activation of sarcolemma and nuclear membranes ET-1 receptors regulates transcellular calcium levels in heart and vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology. DOI
• G Bkaily, S Sleiman, J Stephan, C Asselin, S Choufani, M Kamal, D Jacques, F Gobeil, Jr, P D'Orléans-Juste. (2003). Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology. DOI
• Nesrine El-Bizri, Ghassan Bkaily, Shimin Wang, Danielle Jacques, Domenico Regoli, Pedro D'Orléans-Juste, Rami Sukarieh. (2003). Bradykinin induced a positive chronotropic effect via stimulation of T- and L-type calcium currents in heart cells. Canadian Journal of Physiology and Pharmacology. DOI
• M Duval, A R Beaudoin, G Bkaily, F P Gendron, P D'Orléans-Juste. (2003). Characterization of the NTPDase activities in the mesentery pre- and post-capillary circuits of the guinea pig. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Nesrine El-Bizri, Michel Bui, Rami Sukarieh, Danielle Jacques, Michael L.X Fu. (2003). Modulation of intracellular Ca2+ via L-type calcium channels in heart cells by the autoantibody directed against the second extracellular loop of the α1-adrenoceptors. Canadian Journal of Physiology and Pharmacology. DOI
• Danielle Jacques, Ghassan Bkaily, Gaétan Jasmin, Pedro D'Orléans-Juste, Mirna Chahine. (2003). Isradipine prevents the development of spontaneously occurring cardiac necrosis in cardiomyopathic hamster. Canadian Journal of Physiology and Pharmacology. DOI
• Fernand Gobeil, Jr., Alejandro Vazquez-Tello, Anne Marilise Marrache, Mosumi Bhattacharya, Daniella Checchin, Ghassan Bkaily, Pierre Lachapelle, Alfredo Ribeiro-Da-Silva, Sylvain Chemtob. (2003). Nuclear prostaglandin signaling system: biogenesis and actions via heptahelical receptors. Canadian Journal of Physiology and Pharmacology. DOI
• A. Marilise Marrache, Fernand Gobeil, Sylvie G. Bernier, Jana Stankova, Marek Rola-Pleszczynski, Sanaa Choufani, Ghassan Bkaily, Annie Bourdeau, Martin G. Sirois, Alejandro Vazquez-Tello, Li Fan, Jean-Sébastien Joyal, Janos G. Filep, Daya R. Varma, Alfredo Ribeiro-da-Silva, Sylvain Chemtob. (2002). Proinflammatory Gene Induction by Platelet-Activating Factor Mediated Via Its Cognate Nuclear Receptor. The Journal of Immunology. DOI
• D'Orléans-Juste P, Labonté J, Bkaily G, Choufani S, Plante M, Honoré JC. (2002). Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacology & therapeutics. DOI
• Isabelle BROCHU, Julie LABONTÉ, Ghassan BKAILY, Pedro D'ORLÉANS-JUSTE. (2002). Role of endothelin receptors in the hypertensive state of kinin B2 knockout mice subjected to a high-salt diet. Clinical Science. DOI
• Ghassan BKAILY, Danie MASSAAD, Sanaa CHOUFANI, Danielle JACQUES, Pedro D'ORLÉANS-JUSTE. (2002). Role of endothelin-1 receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells. Clinical Science. DOI
• Jean‐Claude Honoré, Mirco Plante, Ghassan Bkaily, Giles A Rae, Pedro D'Orléans‐Juste. (2002). Pressor and pulmonary responses to ET‐1(1–31) in guinea‐pigs. British Journal of Pharmacology. DOI
• Alcíbia M Cardozo, Pedro D'Orléans-Juste, Ghassan Bkaily, Giles A Rae. (2002). Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin. Canadian Journal of Physiology and Pharmacology. DOI
• Fernand Gobeil, Isabelle Dumont, Anne Marilise Marrache, Alejandro Vazquez-Tello, Sylvie G. Bernier, Daniel Abran, Xin Hou, Martin H. Beauchamp, Christiane Quiniou, Asmaa Bouayad, Sanaa Choufani, Mousumi Bhattacharya, Stephane Molotchnikoff, Alfredo Ribeiro-da-Silva, Daya R. Varma, Ghassan Bkaily, Sylvain Chemtob. (2002). Regulation of eNOS Expression in Brain Endothelial Cells by Perinuclear EP3 Receptors. Circulation Research. DOI
• Ondrus P, Alberty R, Pothier P, Echavé V, Poisson J, Bkaily G. (2002). Cytosolic free Ca2+ concentration in canine aortic endothelial cells lining the polyester arterial prosthesis. Physiological research. DOI
• Audrey Claing, Hadia Shbaklo, Mirco Plante, Ghassan Bkaily, Pedro D'Orléans‐Juste. (2002). Comparison of the contractile and calcium‐increasing properties of platelet‐activating factor and endothelin‐1 in the rat mesenteric artery and vein. British Journal of Pharmacology. DOI
• P. Sarrazin, G. Bkaily, R. Haché, C. Patry, R. Dumais, F.A.C. Rocha, A.J. de Brum-Fernandes. (2001). Characterization of the prostaglandin receptors in human osteoblasts in culture. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). DOI
• R Samadfam, C Teixeira, G Bkaily, P Sirois, A De Brum‐Fernandes, P D'Orleans‐Juste. (2000). Contribution of B2 receptors for bradykinin in Arthus reaction‐induced plasma extravasation in wild‐type or B2 transgenic knockout mice. British Journal of Pharmacology. DOI
• Jean-Philippe Gratton, Giles A. Rae, Ghassan Bkaily, Pedro D’Orléans-Juste. (2000). ETB Receptor Blockade Potentiates the Pressor Response to Big Endothelin-1 But Not Big Endothelin-2 in the Anesthetized Rabbit. Hypertension. DOI
• Julie Labonté, Ghassan Bkaily, Pedro DʼOrléans-Juste. (2000). Endothelin-B-Receptors-Dependent-Inhibition of Platelet Aggregation in the CD-1 Mouse. Journal of Cardiovascular Pharmacology. DOI
• Ghassan Bkaily, Hadia Shbaklo, Magda Taoudi-Benchekroun, Sawsan Sader, Martine Duval, Danielle Jacques, Pedro DʼOrléans-Juste. (2000). Nitric Oxide Relaxes the Vascular Smooth Muscle Independently of Endothelin-1- and U46619-Induced Intracellular Increase of Calcium. Journal of Cardiovascular Pharmacology. DOI
• Ghassan Bkaily, Sanaa Choufani, Ghada Hassan, Nesrine El-Bizri, Danielle Jacques, Pedro DʼOrléans-Juste. (2000). Presence of Functional Endothelin-1 Receptors in Nuclear Membranes of Human Aortic Vascular Smooth Muscle Cells. Journal of Cardiovascular Pharmacology. DOI
• G Bkaily. (1999). Cytokine-induced free radicals and their roles in myocardial dysfunctions. Cardiovascular Research. DOI
• Bkaily G, Jaalouk D, Sader S, Shbaklo H, Pothier P, Jacques D, D'Orléans-Juste P, Cragoe EJ Jr, Bose R. (1998). Taurine indirectly increases [Ca]i by inducing Ca2+ influx through the Na(+)-Ca2+ exchanger. Molecular and cellular biochemistry. DOI
• Ghassan Bkaily, Radha Naik, Doris Jaalouk, Danielle Jacques, Demetri Economos, Pédro D'Orléans-Juste, Pierre Pothier. (1998). Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein. Molecular and Cellular Biochemistry. DOI
• Jacques D, Bkaily G, Jasmin G, Ménard D, Proschek L. (1997). Early fetal like slow Na+ current in heart cells of cardiomyopathic hamster. Molecular and cellular biochemistry. DOI
• Bkaily G, Sculptoreanu A, Jacques D, Jasmin G. (1997). Increases of T-type Ca2+ current in heart cells of the cardiomyopathic hamster. Molecular and cellular biochemistry. DOI
• D'Orléans-Juste P, Sirois MG, Edelman ER, Regoli D, Pheng LH, Bkaily G, Lindsey CJ. (1997). DNA antisense strategies in the study of receptors for vasoactive peptides, and of growth and wound-healing factors. Molecular and cellular biochemistry. DOI
• Bkaily G, Pothier P, D'Orléans-Juste P, Simaan M, Jacques D, Jaalouk D, Belzile F, Hassan G, Boutin C, Haddad G, Neugebauer W. (1997). The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. Molecular and cellular biochemistry. DOI
• Bkaily G, Jaalouk D, Jacques D, Economos D, Hassan G, Simaan M, Regoli D, Pothier P. (1997). Bradykinin activates R-, T-, and L-type Ca2+ channels and induces a sustained increase of nuclear Ca2+ in aortic vascular smooth muscle cells. Canadian journal of physiology and pharmacology. DOI
• Ghassan Bkaily, Doris Jaalouk, George Haddad, Nadine Gros-Louis, May Simaan, Radha Naik, Pierre Pothier. (1997). Modulation of cytosolic and nuclear Ca2+ and Na+ transport by taurine in heart cells. Molecular and Cellular Biochemistry. DOI
• Artur J. de Brum‐Fernandes, Sophie Morisset, Ghassan Bkaily, Caroline Patry. (1996). Characterization of the PGE2 receptor subtype in bovine chondrocytes in culture. British Journal of Pharmacology. DOI
• D'Orléans-Juste P, Berthiaume N, Plante GE, Bkaily G, Claing A. (1996). Comparison of the pre- and post-capillary vascular reactivity in the rat and guinea pig perfused mesenteric bed. Canadian journal of physiology and pharmacology. DOI
• Bkaily G, Gros-Louis N, Naik R, Jaalouk D, Pothier P. (1996). Implication of the nucleus in excitation contraction coupling of heart cells. Molecular and cellular biochemistry. DOI
• Bkaily G, Wang S, Bui M, Stankova J, Rola-Pleszczynski M. (1996). Modulation of cardiac cell Ca2+ currents by PAF. Blood pressure. Supplement.
• Bkaily G, Wang S, Bui M, Ménard D. (1995). ET-1 stimulates Ca2+ currents in cardiac cells. Journal of cardiovascular pharmacology. DOI
• Bkaily G, Naik R, D'Orléans-Juste P, Wang S, Fong CN. (1995). Endothelin-1 activates the R-type Ca2+ channel in vascular smooth-muscle cells. Journal of cardiovascular pharmacology. DOI
• Benchekroun MT, Gros-Louis N, Bkaily G, D'Orleans-Juste P. (1995). R-type calcium channel involved in endothelin-1-induced contraction of rabbit aorta. Journal of cardiovascular pharmacology. DOI
• George E. Haddad, Nicholas Sperelakis, Ghassan Bkaily. (1995). Regulation of the calcium slow channel by cyclic GMP dependent protein kinase in chick heart cells. Molecular and Cellular Biochemistry. DOI
• Audrey Claing, Ghassan Bkaily, Nathalie Berthiaume, Pierre Sirois, Marek Rola‐Pleszczynski, Pedro D'Orléans‐Juste. (1994). Role of R‐type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet‐activating factor. British Journal of Pharmacology. DOI
• G. Bkaily, N. Perron, S. Wang, A. Sculptoreanu, D. Jacques, D. Ménard. (1993). Atrial Natriuretic Factor Blocks the High-threshold Ca2+ Current and Increases K+ Current in Fetal Single Ventricular Cells. Journal of Molecular and Cellular Cardiology. DOI
• Ghassan Bkaily, Pedro D'Orléans‐Juste, Radha Naik, Jacqueline Pérodin, Jana Stankova, Elias Abdulnour, Marek Rola‐Pleszczynski. (1993). PAF activation of a voltage‐gated R‐type Ca2+ channel in human and canine aortic endothelial cells. British Journal of Pharmacology. DOI
• G. Bkaily, A. Sculptoreanu, D. Jacques, D. Economos, D. Menard. (1992). Apamin, a highly potent fetal L-type Ca2+ current blocker in single heart cells. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• G. Bkaily, D. Econornos, L. Potvin, J.-L. Ardilouze, C. Marriott, J. Corcos, D. Bonneau, ChinNok Fong. (1992). Blockade of insulin sensitive steady-state R-type Ca2+ channel by PN 200-110 in heart and vascular smooth muscle. Molecular and Cellular Biochemistry. DOI
• T. Yamamoto, G. Bkaily, S. Belisle. (1991). Inwardly rectifying currents in human term placental cells. Pfl�gers Archiv European Journal of Physiology. DOI
• G Bkaily. (1991). Apamin, a highly potent blocker of the TTX- and Mn2+-insensitive fast transient Na+ current in young embryonic heart. Journal of Molecular and Cellular Cardiology. DOI
• Ghassan Bkaily, Gaétan Jasmin, Constantin Tautu, Libuse Prochek, Tatsuo Yamamoto, Adrian Sculptoreanu, Mehrzad Peyrow, Danielle Jacques. (1990). A tetrodotoxin‐ and Mn2+‐insensitive Na+ current in Duchenne muscular dystrophy. Muscle & Nerve. DOI
• Bkaily G. (1990). Bethanidine, nitroprusside and atrial natriuretic factor open a cGMP-sensitive K+ channel in aortic muscle. Progress in clinical and biological research.
• J-F Renaud, G. Bkaily, M. Benabderrazik, D. Jacques, N. Sperelakis. (1989). Bay K 8644 induce enhancement of K+ current in both single heart cell and smooth muscle cell. Molecular and Cellular Biochemistry. DOI
• G. Bkaily, M. Peyrow, T. Yamamoto, A. Sculptoreanu, D. Jacques, N. Sperelakis. (1989). Macroscopic Ca2+ -Na+ and K+ currents in single heart and aortic cells. Molecular and Cellular Biochemistry. DOI
• Rich Lomneth, Ghassan Bkaily, Nicholas Sperelakis, Boleslaw H. Liwnicz, Eric Gruenstein. (1989). Electrophysiological and biochemical characterization of a continuous human astrocytoma cell line with many properties of well-differentiated astrocytes. Brain Research. DOI
• G. Bkaily, M. Peyrow, A. Sculptoreanu, D. Jacques, M. Chahine, D. Regoli, N. Sperelakis. (1988). Angiotensin II increases Isi and blocks IK in single aortic cell of rabbit. Pflügers Archiv - European Journal of Physiology. DOI
• G. Bkaily, D. Jacques, T. Yamamoto, A. Sculptoreanu, M. D. Payet, N. Sperelakis. (1988). Three types of slow inward currents as distinguished by melittin in 3-day-old embryonic heart. Canadian Journal of Physiology and Pharmacology. DOI
• Ghassan Bkaily, Marcel D. Payet, Mourad Benabderrazik, Rémy Sauvé, Jean-François Renaud, Marvin Bacaner, Nick Sperelakis. (1988). Intracellular bretylium blocks Na+ and K+ currents in heart cells. European Journal of Pharmacology. DOI
• G. Bkaily, J.-P. Caillé, M. D. Payet, M. Peyrow, R. Sauvé, Jean-François Renaud, Nick Sperelakis. (1988). Bethanidine increases one type of potassium current and relaxes aortic muscle. Canadian Journal of Physiology and Pharmacology. DOI
• G. Bkaily, M. D. Payet, M. Benabderrazik, J.-F. Renaud, R. Sauvé, M. B. Bacaner, N. Sperelakis. (1988). Bethanidine increased Na+ and Ca2+ currents and caused a positive inotropic effect in heart cells. Canadian Journal of Physiology and Pharmacology. DOI
• G. Bkaily, P.-A. Molyvdas, J. Ousterhout, N. Sperelakis. (1986). New dihydropyridine drug, nilvadipine, blocks the calcium slow action potential in rat-cultured aortic smooth muscle cells. European Journal of Pharmacology. DOI
• Otto F. Schanne, G. Bkaily, B. Dumais, L. Boutin. (1986). Disopyramide phosphate effects on slow and depressed fast responses. Canadian Journal of Physiology and Pharmacology. DOI
• Bkaily G, Sperelakis N. (1986). Calmodulin is required for a full activation of the calcium slow channels in heart cells. Journal of cyclic nucleotide and protein phosphorylation research.
• G. Bkaily, N. Sperelakis, J. F. Renaud, M. D. Payet. (1985). Apamin, a highly specific Ca2+ blocking agent in heart muscle. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• G. Bkaily, N. Sperelakis. (1985). Injection of guanosine 5'-cyclic monophosphate into heart cells blocks calcium slow channels. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• G. Bkaily, N. Sperelakis, J. Doane. (1984). A new method for preparation of isolated single adult myocytes. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• Ghassan Bkaily, Nick Sperelakis, Moyhee Eldefrawi. (1984). Effects of the calmodulin inhibitor, trifluoperazine, on membrane potentials and slow action potentials of cultured heart cells. European Journal of Pharmacology. DOI
• G. Bkaily, N. Sperelakis. (1984). Injection of protein kinase inhibitor into cultured heart cells blocks calcium slow channels. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• G. Bkaily, N. Sperelakis, Y. Elishalom, Y. Barenholz. (1983). Effect of Na+- or Ca2+-filled liposomes on electrical activity of cultured heart cells. American Journal of Physiology-Heart and Circulatory Physiology. DOI
• Schanne OF, St-Vincent M, Bkaily G. (1983). Electrogenesis of freshly explanted spontaneously active clusters of neonatal rat ventricle cells. Revue canadienne de biologie experimentale.
• O. F. Schanne, G. Bkaily. (1981). Explanted cardiac cells: a model to study drug actions?. Canadian Journal of Physiology and Pharmacology. DOI
• M. D. Payet, G. Bkaily, O. F. Schanne, E. Ruiz-Ceretti. (1980). Influence of streptomycin on spontaneous activity of clusters of cultured cardiac cells from neonatal rats. Canadian Journal of Physiology and Pharmacology. DOI

Chapitres de livre

• Ghassan Bkaily, Johny Al-Khoury, Yanick Simon, Danielle Jacques. (2017). Intracellular Free Calcium Measurement Using Confocal Imaging. Methods in Molecular Biology. DOI
• A. Marilise Marrache, Fernand Gobeil, Sylvie G. Bernier, Jana Stankova, Marek Rola-Pleszezynski, Sanaa Choufani, Ghassan Bkaily, Annie Bourdeau, Martin G. Sirois, Alejandro Vazquez-Tello, L. Fan, Jean-Sebastien Joyal, Janos G. Filep, Daya R. Varma, Alfredo Ribeiro-da-Silva, Sylvain Chemtob. (2003). Platelet Activating Factor Receptors. Advances in Experimental Medicine and Biology. DOI
• Ghassan Bkaily, Danielle Jacques, Pierre Pothier. (1999). [8] Use of confocal microscopy to investigate cell structure and function. Methods in Enzymology. DOI
• Ghassan Bkaily, George Haddad, Doris Jaalouk, Nadine Gros-Louis, Majda Taoudi Benchekroun, Radha Naik, Pierre Pothier, Pedro D’Orléans-Juste, Michel Bui, Shimin Wang, Nicholas Sperelakis. (1996). Modulation of Ca2+ and Na+ Transport by Taurine in Heart and Vascular Smooth Muscle. Advances in Experimental Medicine and Biology. DOI
• Nicholas Sperelakis, Hiroyasu Satoh, Ghassan Bkaily. (1992). Taurine Effects on Ionic Currents in Myocardial Cells. Advances in Experimental Medicine and Biology. DOI

Autres contributions

Cours enseignés à l'UdeS

• BCL706 - Chapitres choisis de la physiopathologie membranaire. (2025). (1CR).
• BCL709 - Bioélectricité membranaire du muscle lisse. (2023-2025). (2CR).

Activités professionnelles

• European Journal of Physiology (Pfluger Archives). Associate editor. (2022-).
• Canadian Journal of Physiology and Pharmacology. Consultant Editor-in-chief. (2022).
• Nutrients. Associate editor. (2021-).
• Poste d'invité. American Heart Association. Honorary fellow. Dallas, Texas, États-Unis. (2019-).
• 4th Cardiovascular Forum for Promoting Centres of Excellence and Young Investigators-International Academy of Cardiovascular Sciences- North American Section. President, Organization committee. Sherbrooke, Quebec, Canada. (2016).
• Poste d'invité. International Academy of Cardiovascular Sciences. Honorary fellow. Wiinnipeg, Manitoba, Canada. (2016-).
• International Academy of Cardiovascular Sciences- North American Section. Executive council member. Winnipeg, Manitoba, Canada. (2015-2022).
• International Society for Heart Research. President, organizing committee of the satellite meeting of the ISHR, Montréal, Qc, Canada. Durham, North Carolina, États-Unis. (2001).