Fernand Pierre Gendron
Professeur, Faculté de médecine et des sciences de la santé
FMSS Département d’immunologie et de biologie cellulaire
Présentation
Qualifications
- Post doctoral fellow. Anatomie et Biologie Cellulaire. Université de Sherbrooke. Sherbrooke, Quebec, Canada. (2003-2005).
- Post-doctoral fellow. Biochemistry. University of Missouri–Columbia. Columbia, Missouri, États-Unis. (2000-2002).
Diplômes
- (1995-2000). Ph.D. Biologie. Université de Sherbrooke. Sherbrooke, Quebec, Canada.
- (1992-1995). B.Sc. Biochimie. Université de Sherbrooke. Sherbrooke, Quebec, Canada.
Expériences académiques
- Professeures/Professor. (2005-). Université de Sherbrooke. Sherbrooke, Quebec, Canada.
Publications
Articles
- Girard M, Bellefeuille SD, Eiselt É, Arguin G, Longpré JM, Sarret P, Gendron FP. (2023). Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor. Biochimica et biophysica acta. Molecular cell research. DOI
- Morgane Placet, Caroline M. Molle, Guillaume Arguin, Sameh Geha, Fernand‐Pierre Gendron. (2021). The expression of P2Y6 receptor promotes the quality of mucus in colitic mice. The FEBS Journal. DOI
- Sohail M, Shkreta L, Toutant J, Rabea S, Babeu JP, Huard C, Coulombe-Huntington J, Delannoy A, Placet M, Geha S, Gendron FP, Boudreau F, Tyers M, Grierson DS, Chabot B. (2021). A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. NAR cancer. DOI
- Leticia Scussel Bergamin, Letizia Penolazzi, Elisabetta Lambertini, Simonetta Falzoni, Alba Clara Sarti, Caroline M. Molle, Fernand‐Pierre Gendron, Pasquale De Bonis, Francesco Di Virgilio, Roberta Piva. (2021). Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor. Journal of Cellular Physiology. DOI
- Mélissa Girard, Steve Dagenais Bellefeuille, Émilie Eiselt, Rebecca Brouillette, Morgane Placet, Guillaume Arguin, Jean‐Michel Longpré, Philippe Sarret, Fernand‐Pierre Gendron. (2020). The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration. Journal of Cellular Physiology. DOI
- Caroline M. Molle, Guillaume Arguin, Charlotte Jemfer, Morgane Placet, Steve Dagenais Bellefeuille, Fernand-Pierre Gendron. (2020). The expression of the P2Y6 receptor is regulated at the transcriptional level by p53. Biochemical and Biophysical Research Communications. DOI
- Steve Dagenais Bellefeuille, Caroline M. Molle, Fernand-Pierre Gendron. (2019). Reviewing the role of P2Y receptors in specific gastrointestinal cancers. Purinergic Signalling. DOI
- Nassir M, Pelletier J, Arad U, Arguin G, Khazanov N, Gendron FP, Sévigny J, Senderowitz H, Fischer B. (2019). Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold. European journal of medicinal chemistry. DOI
- Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B. (2018). Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-P<sub>α,α</sub>-Dithiophosphate Analogues. Journal of medicinal chemistry. DOI
- Placet M, Arguin G, Molle CM, Babeu JP, Jones C, Carrier JC, Robaye B, Geha S, Boudreau F, Gendron FP. (2018). The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis. Biochimica et biophysica acta. Molecular basis of disease. DOI
- Arguin G, Bourzac JF, Placet M, Molle CM, Paquette M, Beaudoin JF, Rousseau JA, Lecomte R, Plourde M, Gendron FP. (2017). The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Scientific reports. DOI
- Placet M, Arguin G. (2017). P2Y2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer. Advances in experimental medicine and biology. DOI
- Lepage D, Bélanger É, Jones C, Tremblay S, Allaire JM, Bruneau J, Asselin C, Perreault N, Menendez A, Gendron FP, Boudreau F. (2016). Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Scientific reports. DOI
- Vinette V, Placet M, Arguin G, Gendron FP. (2015). Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5'-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs. PloS one. DOI
- Meltzer D, Ethan O, Arguin G, Nadel Y, Danino O, Lecka J, Sévigny J, Gendron FP, Fischer B. (2015). Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists. Bioorganic & medicinal chemistry. DOI
- Bilodeau MS, Arguin G, Gendron FP. (2014). C/EBPβ regulates P2X7 receptor expression in response to glucose challenge in intestinal epithelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. DOI
- Asselin C, Gendron FP. (2014). Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis. FEBS letters. DOI
- Turgeon N, Gagné JM, Blais M, Gendron FP, Boudreau F, Asselin C. (2014). The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis. American journal of physiology. Gastrointestinal and liver physiology. DOI
- Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. (2013). The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. PloS one. DOI
- Bourzac JF, L'Ériger K, Larrivée JF, Arguin G, Bilodeau MS, Stankova J, Gendron FP. (2013). Glucose transporter 2 expression is down regulated following P2X7 activation in enterocytes. Journal of cellular physiology. DOI
- Degagné E, Degrandmaison J, Grbic DM, Vinette V, Arguin G, Gendron FP. (2013). P2Y2 receptor promotes intestinal microtubule stabilization and mucosal re-epithelization in experimental colitis. Journal of cellular physiology. DOI
- Ginsburg-Shmuel T, Haas M, Grbic D, Arguin G, Nadel Y, Gendron FP, Reiser G, Fischer B. (2012). UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorganic & medicinal chemistry. DOI
- Degagné E, Turgeon N, Moore-Gagné J, Asselin C, Gendron FP. (2012). P2Y2 receptor expression is regulated by C/EBPβ during inflammation in intestinal epithelial cells. The FEBS journal. DOI
- Grbic DM, Degagné É, Larrivée JF, Bilodeau MS, Vinette V, Arguin G, Stankova J, Gendron FP. (2011). P2Y6 receptor contributes to neutrophil recruitment to inflamed intestinal mucosa by increasing CXC chemokine ligand 8 expression in an AP-1-dependent manner in epithelial cells. Inflammatory bowel diseases. DOI
- Darsigny M, Babeu JP, Seidman EG, Gendron FP, Levy E, Carrier J, Perreault N, Boudreau F. (2010). Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer research. DOI
- Darsigny M, Babeu JP, Dupuis AA, Furth EE, Seidman EG, Lévy E, Verdu EF, Gendron FP, Boudreau F. (2009). Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PloS one. DOI
- Langlois C, Gendron FP. (2009). Promoting MPhi transepithelial migration by stimulating the epithelial cell P2Y(2) receptor. European journal of immunology. DOI
- Degagné E, Grbic DM, Dupuis AA, Lavoie EG, Langlois C, Jain N, Weisman GA, Sévigny J, Gendron FP. (2009). P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells. Journal of immunology (Baltimore, Md. : 1950). DOI
- Grbic DM, Degagné E, Langlois C, Dupuis AA, Gendron FP. (2008). Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. Journal of immunology (Baltimore, Md. : 1950). DOI
- Boudreau F, Rivard N, Gendron FP, Beaulieu JF. (2007). [CDX2: a transcription factor with multiple tasks for epithelial cells of the digestive tract]. Medecine sciences : M/S. DOI
- Gendron FP, Mongrain S, Laprise P, McMahon S, Dubois CM, Blais M, Asselin C, Rivard N. (2005). The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation. American journal of physiology. Gastrointestinal and liver physiology. DOI
- Gendron FP, Chalimoniuk M, Strosznajder J, Shen S, González FA, Weisman GA, Sun GY. (2003). P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells. Journal of neurochemistry. DOI
- Duval M, Beaudoin AR, Bkaily G, Gendron FP, D' Orléans-Juste P. (2003). Characterization of the NTPDase activities in the mesentery pre- and post-capillary circuits of the guinea pig. Canadian journal of physiology and pharmacology. DOI
- Gendron FP, Neary JT, Theiss PM, Sun GY, Gonzalez FA, Weisman GA. (2003). Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells. American journal of physiology. Cell physiology. DOI
- Gendron FP, Benrezzak O, Krugh BW, Kong Q, Weisman GA, Beaudoin AR. (2002). Purine signaling and potential new therapeutic approach: possible outcomes of NTPDase inhibition. Current drug targets. DOI
- Gendron FP, Latour JG, Gravel D, Wang Y, Beaudoin AR. (2000). Ca(2+)-channel blockers and nucleoside triphosphate diphosphohydrolase (NTPDase) influence of diltiazem, nifedipine, and verapamil. Biochemical pharmacology. DOI
- Fischer B, Shahar L, Chulkin A, Boyer JL, Harden KT, Gendron FP, Beaudoin AR, Chapal J, Hillaire-Buys D, Petit P. (2000). 2-Thioether-5'-O-(1-thiotriphosphate)-adenosine derivatives: new insulin secretagogues acting through P2Y-receptors. The Israel Medical Association journal : IMAJ.
- Gendron FP, Halbfinger E, Fischer B, Duval M, D'Orléans-Juste P, Beaudoin AR. (2000). Novel inhibitors of nucleoside triphosphate diphosphohydrolases: chemical synthesis and biochemical and pharmacological characterizations. Journal of medicinal chemistry. DOI
- Leclerc MC, Grondin G, Gendron FP, Sévigny J, Beaudoin AR. (2000). Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver. Archives of biochemistry and biophysics. DOI
- Fischer B, Kabha E, Gendron FP, Beaudoin AR. (2000). Synthesis, mechanism and fluorescence properties of 8-(aryl)-3-beta-D-ribofuranosylimidazo[2,1-i]purine 5'-phosphate derivatives. Nucleosides, nucleotides & nucleic acids. DOI
- Gendron FP, Halbfinger E, Fischer B, Beaudoin AR. (2000). Inhibitors of NTPDase: key players in the metabolism of extracellular purines. Advances in experimental medicine and biology. DOI
- Benrezzak O, Grondin G, Sévigny J, Gendron FP, Rousseau E, D'Orléans-Juste P, Beaudoin AR. (1999). Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system. Archives of biochemistry and biophysics. DOI
- Fischer B, Chulkin A, Boyer JL, Harden KT, Gendron FP, Beaudoin AR, Chapal J, Hillaire-Buys D, Petit P. (1999). 2-thioether 5'-O-(1-thiotriphosphate)adenosine derivatives as new insulin secretagogues acting through P2Y-Receptors. Journal of medicinal chemistry. DOI
- Beaudoin AR, Grondin G, Gendron FP. (1999). Immunolocalization of ATP diphosphohydrolase in pig and mouse brains, and sensory organs of the mouse. Progress in brain research. DOI
- Sévigny J, Grondin G, Gendron FP, Roy J, Beaudoin AR. (1998). Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system. The American journal of physiology. DOI