Denis Gris
Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie
Présentation
Sujets, disciplines ou intérêts de recherche
Neuroimmunology, Machine Learning, Innate immune response, behavioral analysis, Multiple Sclerosis
Expériences académiques
- Professor (Physiology Pharmacology). (2011-). Universite de Sherbrooke Faculté de Médecine et des Sciences de la Santé. Sherbrooke, QC, Canada.
Publications
Articles
- Puregmaa Khongorzul, Farhan Ullah Khan, Daphnée Levasseur, Denis Gris, Abdelaziz Amrani. (2026). Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8<sup>+</sup> T Cells in Autoimmune Diabetes. International Journal of Molecular Sciences. DOI
- (2026). Effects of the Antiretroviral Raltegravir on Amyloid-Beta1-42-Induced Neuroinflammation. JOURNAL OF IMMUNOLOGY. DOI
- Haroun R, Rutihinda C, Diallo AH, Ordonez JP, Nassri S, Shams A, Pacheco MFM, Saidi NE, Bouchard L, Turgeon GA, Gris D, Tai LH, Oweida AJ. (2025). Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy. Cancer biology & therapy. DOI
- Hardy I, Gagnon A, Croft EK, Tremblay L, Lebel R, Roy-Lacroix MÈ, Takser L, Ouellet A, Gris D. (2025). Neurodevelopmental impacts of betamethasone administered in the late preterm period: An experimental study in CD-1 mice. Neurotoxicology and teratology. DOI
- Khan FU, Khongorzul P, Gris D, Amrani A. (2025). Role of USP7 in the regulation of tolerogenic dendritic cell function in type 1 diabetes. Cellular & molecular biology letters. DOI
- (2025). Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ<sub>1-42</sub>-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease. JOURNAL OF ALZHEIMERS DISEASE. DOI
- (2025). Real-time behavioral monitoring of C57BL/6J mice during reproductive cycle. FRONTIERS IN NEUROSCIENCE. DOI
- (2024). A convenient analytic method for gel quantification using ImageJ paired with Python or R. PLOS ONE. DOI
- (2024). Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes. INTERNATIONAL IMMUNOPHARMACOLOGY. DOI
- (2023). Inhibition of PI3K/C/EBP? axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development. TRANSLATIONAL RESEARCH. DOI
- (2023). Neurodevelopmental impacts of betamethasone in the late preterm period: a randomized controlled trial in mice. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY.
- (2022). Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. DOI
- (2021). Machine Learning in Modeling of Mouse Behavior. FRONTIERS IN NEUROSCIENCE. DOI
- (2020). Elucidating the Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. DOI
- (2020). Volumetric MRI Demonstrates Atrophy of the Olfactory Cortex in AD. CURRENT ALZHEIMER RESEARCH. DOI
- (2019). Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release. CELLS. DOI
- (2019). Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease (Publication with Expression of Concern). PLOS GENETICS. DOI
- (2019). Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
- (2019). NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes. CELLS. DOI
- (2019). NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. PLOS BIOLOGY. DOI
- (2019). The Mitochondrial Innate Immune Sensor, NLRX1, Inhibits Early Stages of CNS Inflammation and Prevents the Onset of Progressive EAE. MULTIPLE SCLEROSIS JOURNAL.
- (2019). The Mitochondrial Innate Immune Sensor, NLRX1, Inhibits Early Stages of CNS Inflammation and Prevents the Onset of Progressive EAE. MULTIPLE SCLEROSIS JOURNAL.
- (2018). Exhaustive Multi-Parametric Assessment of the Behavioral Array of Daily Activities of Mice Using Cluster and Factor Analysis. FRONTIERS IN BEHAVIORAL NEUROSCIENCE. DOI
- (2018). Exhaustive behavioral profile assay to detect genotype differences between wild-type, inflammasome-deficient, and Nlrp12 knock-out mice. AIMS MEDICAL SCIENCE. DOI
- (2018). NLR-Dependent Regulation of inflammation in Multiple Sclerosis-Dependent Regulation of inflammation in Multiple Sclerosis. FRONTIERS IN IMMUNOLOGY. DOI
- (2018). Nlrx1 Prevents the Development of Spontaneous Experimental Autoimmune Encephalomyelitis in Mice. MULTIPLE SCLEROSIS JOURNAL.
- (2018). Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells. CELLS. DOI
- (2018). The Dual Immunoregulatory function of <i>Nlrp12</i> in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis. CELLS. DOI
- (2017). Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. JOURNAL OF AUTOIMMUNITY. DOI
- (2017). Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury. JOURNAL OF IMMUNOLOGY. DOI
- (2017). Supervised and Unsupervised Learning Technology in the Study of Rodent Behavior. FRONTIERS IN BEHAVIORAL NEUROSCIENCE. DOI
- (2017). The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to -amyloid peptide. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI
- (2016). Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: Potential implications for neurodegenerative diseases. TOXICOLOGY REPORTS. DOI
- (2016). Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. MEDIATORS OF INFLAMMATION. DOI
- (2016). Threading Granules in Freiburg 2nd International Symposium on "One Mitochondrion, Many Diseases - Biological and Molecular Perspectives", a FRIAS Junior Researcher Conference, Freiburg im Breisgau, Germany, March 9th/10th, 2016. MICROBIAL CELL. DOI
- (2015). Struggling for breath in Sherbrooke. MICROBIAL CELL. DOI
- (2015). The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis. JOURNAL OF NEUROINFLAMMATION. DOI
- (2014). Nlrx1 regulates neuronal cell death. MOLECULAR BRAIN. DOI
- (2014). The Nucleotide-binding Leucine-rich Repeat (NLR) Family Member NLRX1 Mediates Protection against Experimental Autoimmune Encephalomyelitis and Represses Macrophage/Microglia-induced Inflammation. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI
- (2013). Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy. JOURNAL OF NEUROINFLAMMATION. DOI
- (2011). Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. NATURE IMMUNOLOGY. DOI
- (2011). NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways. IMMUNITY. DOI
- (2011). Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. JOURNAL OF NEURAL TRANSMISSION. DOI
- (2011). The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI
- (2010). A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. MOLECULAR PAIN. DOI
- (2010). Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity. JOURNAL OF IMMUNOLOGY. DOI
- (2010). Deletion of <i>ripA</i> Alleviates Suppression of the Inflammasome and MAPK by <i>Francisella tularensis</i>. JOURNAL OF IMMUNOLOGY. DOI
- (2010). NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses. JOURNAL OF IMMUNOLOGY. DOI
- (2010). The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18. JOURNAL OF NEUROSCIENCE. DOI
- (2009). <i>Staphylococcus aureus</i> α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells. PLOS ONE. DOI
- (2008). The systemic inflammatory response after spinal cord injury damages lungs and kidneys. EXPERIMENTAL NEUROLOGY. DOI
Documents de travail
- Elucidating Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b. DOI