Brigitte Guérin

Prix et distinctions

• (2023) Prix d’excellence 2023-2024 du CIUSSS de l’Estrie – CHUS dans la catégorie Mission universitaire et rayonnement. Centre intégré universitaire de santé et des services sociaux de l'Estrie (CIUSSE)-CHUS.
• (2023) Prix Hippocrate pour l’innovation interdisciplinaire en matière de qualité et de sa gestion / Hippocrate Prize for interdisciplinary innovation in quality and its management. MSSS.
• (2022) Innovation Prize. Université de Sherbrooke.
• (2022) Prix Éric-Marsault. Université de Sherbrooke.
• (2022) chercheuse de l’année au CRCHUS/Researcher of the year at the CRCHUS. CRCHUS.
• (2018) 2018 Clara Benson Award Winner. Chemical Institute of Canada/Canadian Society for Chemistry.
• (2017) First Winner- Category Quality of Care and Services: 68Ga-DOTA-TATE-. Centre intégré universitaire de santé et des services sociaux de l'Estrie (CIUSSE)-CHUS.
• (2016) Titulaire de la Chaire de recherche Jeanne et Jean-Louis Lévesque en radiobiologie. Fondation de l'Université de Sherbrooke.
• (2011) Prix du Doyen au Gala du Mérite Dean's Award Production of Tc-99m by cyclotron. Université de Sherbrooke.
• (2010) Prix d'excellence de groupe, catégorie Rayonnement for a national effort to develop an alternative production method for Tc-99m using cyclotron. Centre Hospitalier Universitaire de Sherbrooke.

Financement

• Subvention. Chaire Jeanne et Jean-Louis Lévesque de radiobiologie. Université de Sherbrooke (Sherbrooke, Canada). La Fondation de l’Université de Sherbrooke. 870 000 $. (2026-2030).
• Subvention. Development of radiotheranostics. Fondation Jean-Louis Lévesque (QC, Canada). Fondation J.-Louis Lévesque. 100 000 $. (2026-2027).
• Subvention. Novel treatment of Alzheimer’s disease by early targeting and visualizing soluble amyloid beta oligomers using cyclic azapeptides. Canadian Institutes of Health Research (Ottawa, Canada). 1 086 300 $. (2025-2030).
  Numéro de subvention : 203726.
• Subvention. Brain-Penetrating Apelin Receptor Radioligands for Glioblastoma Therapy. Canadian Institutes of Health Research (Ottawa, Canada). 1 032 750 $. (2025-2030).
• Subvention. Concomitant radioligand/immunotherapy to conquer immune-desert head and neck cancers. Société Recherche sur le Cancer (Montréal, Canada). 135 000 $. (2025-2027).
• Subvention. A Translational Platform in CNS Drug Development. Brain Canada Foundation (Montreal, Canada). 4 290 000 $. (2025-2028).
• Subvention. Development of novel terpyridine platinum-based chemo-radiotheranostic agents. Natural Sciences and Engineering Research Council of Canada (ON, Canada). 180 000 $. (2025-2030).
  Numéro de subvention : RGPIN-2025-05324.
• Subvention. Alzheimer’s disease PET imaging of nonfibrillar amyloid beta aggregates using azapeptide (AZP) tracer. Cure Alzheimer’s Fund (Wellesley, États-Unis). 350 000 USD. (2024-2026).
• Subvention. Imaging T2D. Fondation canadienne pour l'innovation (Ottawa, Canada). 16 000 000 $. (2024-2026).
• Subvention. Cross-disciplinary program in intelligent and responsible drug discovery. ENGAGE, Natural Sciences and Engineering Research Council of Canada (Ottawa, Canada). 1 650 000 $. (2023-2029).
• Subvention. Étude des interactions supramoléculaires de feuillets bêta de l’amyloïde modulée par les azapeptides pour mieux comprendre la base structurelle des maladies amyloïdes et faciliter leur détection précoce. Fonds Québécois de la Recherche sur la Nature et les Technologies (QC, Canada). 190 500 $. (2023-2026).
• Subvention. Rare Isotopes to Transform Cancer Therapy. New Frontiers in Research Fund (Ottawa, Canada). 23 796 774 $. (2023-2029).
  Numéro de subvention : NFRFT-2022-00269.
• Subvention. Établir un corridor de service en imagerie par tomographie d’émission de positrons au 68Ga-DOTA-TATE afin d’assurer le maintien d’un service diagnostique clé pour les cancers exprimant les récepteurs de la somatostatine. MEDTEQ+ (QC, Canada). 240 000 $. (2022-2026).
• Subvention. Imaging the contribution of early cerebrovascular inflammation in Alzheimer's disease. Canadian Institutes of Health Research (ON, Canada). 1 002 150 $. (2022-2027).

Publications

Articles

• Gandy SE, Castranio EL, Varghese M, Argyrousi EK, Tripathi K, Söderberg L, Bresnahan E, Lerner D, Garretti F, Zhang H, de Loo JV, Teunissen B, Talty R, Levy E, Wang M, Zhang B, Lannfelt L, Glabe CG, Lubell WD, ... Ehrlich ME. (2025). Alzheimer's Imaging Consortium. Alzheimer's & dementia : the journal of the Alzheimer's Association. DOI
• Hoda Talebian, Samia Ait-Mohand, Prenitha Mercy Ignatius Arokia Doss, Léon Sanche, Brigitte Guérin. (2025). Development and In Vitro Evaluation of [⁶⁴Cu]Cu-NOTA-TP-PSMA, a Novel Radiotheranostic Agent Against Prostate Cancer. International Journal of Molecular Sciences. DOI
• Sadaf Ghanaatgar Kasbi, Martin Savard, Céléna Dubuc, Yves Dory, Brigitte Guérin, Fernand Gobeil. (2025). Preclinical Theranostic Profiling of [⁶⁴Cu]Cu-Acetate in Prostate Cancer. Molecules. DOI
• Sadaf Ghanaatgar Kasbi, Martin Savard, Frédéric Couture, Céléna Dubuc, Véronique Dumulon-Perreault, Marie-Edith Nepveu-Traversy, Samia Ait-Mohand, Robert Sabbagh, Sameh Geha, Brigitte Guérin, Yves Dory, Fernand Gobeil. (2025). Theranostic Potential of a New ⁶⁴Cu-Labeled NOTA-R954 Peptide Conjugate for Kinin B1R Expressing Prostate Cancer. Pharmaceutics. DOI
• Alireza Mirzaei, Samia Ait-Mohand, Prenitha Mercy Ignatius Arokia Doss, Étienne Rousseau, Brigitte Guérin. (2025). A Targeted Radiotheranostic Agent for Glioblastoma: [⁶⁴Cu]Cu-NOTA-TP-c(RGDfK). Brain Sciences. DOI
• Dumont L, Richard G, Espagnet R, Frisch F, Fortin M, Samson A, Bouchard J, Fontaine R, Croteau E, Phoenix S, Dubreuil S, Guérin B, Turcotte ÉE, Carpentier AC, Blondin DP. (2025). Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women. Cell metabolism. DOI
• Zamanian A, Rousseau É, Buteau FA, Arsenault F, Beaulieu A, April G, Juneau D, Plouznikoff N, Turcotte ÉE, Allard C, Richard PO, Saad F, Guérin B, Pouliot F, Beauregard JM. (2025). The tumour sink effect on <sup>68</sup>Ga-PSMA-PET/CT in metastatic castration-resistant prostate cancer and its implications for PSMA-RPT: a sub-analysis of the 3TMPO study. Cancer imaging : the official publication of the International Cancer Imaging Society. DOI
• Granger Joly de Boissel P, Nehmé R, Fortier M, Létourneau M, Guérin B, Dumulon-Perreault V, Ait-Mohand S, Sarrhini O, Fuselier C, Dumoulin A, Chatenet D, Doucet N, St-Pierre Y. (2025). Development and Use of a Galectin-1-Specific Nanobody for Tumor Imaging and Elucidating the Role of Galectin‑1 in Cancer. ACS pharmacology & translational science. DOI
• Déry L, Charest G, Guérin B, Fortin D. (2025). Detailed characterization of partial tumor resection in the Syngeneic Fischer/F98 Glioma Model. Journal of neuroscience methods. DOI
• Nehmé R, Fortier M, Létourneau M, Fuselier C, Granger Joly de Boissel P, Dumoulin A, Guérin B, Dumulon-Perreault V, Ait-Mohand S, Sarrhini O, Larda ST, Castellanos Villamizar Y, Bernier M, Porębska N, Opaliński Ł, Chatenet D, Doucet N, St-Pierre Y. (2025). Development of Galectin-7-Specific Nanobodies: Implications for Immunotherapy and Molecular Imaging in Cancer. Journal of medicinal chemistry. DOI
• Montastier É, Ye RZ, Noll C, Amrani M, Frisch F, Fortin M, Bouffard L, Phoenix S, Sarrhini O, Cunnane SC, Guérin B, Turcotte EE, Carpentier AC. (2025). Nicotinic acid increases adipose tissue dietary fatty acid trapping and reduces postprandial hepatic and cardiac fatty acid uptake in prediabetes. European journal of pharmacology. DOI
• Croteau E, Richard G, Prud'Homme P, Rousseau E, Cunnane SC, Dumulon-Perreault V, Sarrhini O, Phoenix S, Tremblay S, Guérin B, Lecomte R. (2025). Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model. EJNMMI research. DOI
• Tremblay D, Joly-Mischlich T, Dufour A, Battista MC, Berbiche D, Côté J, Décelles M, Forget C, Guérin B, Larivière M, Lemay F, Lemonde M, Maillet É, Moreau N, Pavic M, Soldera S, Wilhelmy C. (2025). Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study. JMIR research protocols. DOI
• Rousseau JA, Maier M, Ait-Mohand S, Dumulon-Perreault V, Sarrhini O, Tremblay S, Rousseau E, Salzmann M, Guérin B. (2025). Antibody-Based PET Imaging of Misfolded Superoxide Dismutase 1 in an Amyotrophic Lateral Sclerosis Mouse Model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Pouliot F, Saad F, Rousseau E, Richard PO, Zamanian A, Probst S, Lévesque É, Castonguay V, Marcoux N, Lodde M, Juneau D, Hamilou Z, Lattouf JB, Buteau FA, Pavic M, Castilloux JF, Neveu B, Bouvet GF, Allard C, ... 3TMPO Investigators. (2024). Intrapatient Intermetastatic Heterogeneity Determined by Triple-Tracer PET Imaging in mCRPC Patients and Correlation to Survival: The 3TMPO Cohort Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Dumont L, Caron A, Richard G, Croteau E, Fortin M, Frisch F, Phoenix S, Dubreuil S, Guérin B, Turcotte ÉE, Carpentier AC, Blondin DP. (2024). The effects of the β<sub>1</sub>-adrenergic receptor antagonist bisoprolol administration on mirabegron-stimulated human brown adipose tissue thermogenesis. Acta physiologica (Oxford, England). DOI
• Huwaidi A, Robert G, Kumari B, Bass AD, Cloutier P, Guérin B, Sanche L, Wagner JR. (2024). Electron-Induced Damage by UV Photolysis of DNA Attached to Gold Nanoparticles. Chemical research in toxicology. DOI
• Ouyang L, Lin H, Zhuang P, Shao Y, Khosravifarsani M, Guérin B, Zheng Y, Sanche L. (2023). DNA radiosensitization by terpyridine-platinum: damage induced by 5 and 10 eV transient anions. Nanoscale. DOI
• Habashi M, Chauhan PS, Vutla S, Senapati S, Diachkov M, El-Husseini A, Guérin B, Lubell WD, Rahimipour S. (2023). Aza-Residue Modulation of Cyclic d,l-α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity. Journal of medicinal chemistry. DOI
• Milot MC, Bélissant-Benesty O, Dumulon-Perreault V, Ait-Mohand S, Geha S, Richard PO, Rousseau É, Guérin B. (2023). Theranostic ⁶⁴Cu-DOTHA₂-PSMA allows low toxicity radioligand therapy in mice prostate cancer model. Frontiers in oncology. DOI
• Habashi M, Vutla S, Tripathi K, Senapati S, Chauhan PS, Haviv-Chesner A, Richman M, Mohand SA, Dumulon-Perreault V, Mulamreddy R, Okun E, Chill JH, Guérin B, Lubell WD, Rahimipour S. (2022). Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Khosravifarsani M, Ait-Mohand S, Paquette B, Sanche L, Guérin B. (2022). <i>In vivo</i> behavior of [⁶⁴Cu]NOTA-terpyridine platinum, a novel chemo-radio-theranostic agent for imaging, and therapy of colorectal cancer. Frontiers in medicine. DOI
• Richard G, Blondin DP, Syed SA, Rossi L, Fontes ME, Fortin M, Phoenix S, Frisch F, Dubreuil S, Guérin B, Turcotte ÉE, Lepage M, Surette MG, Schertzer JD, Steinberg GR, Morrison KM, Carpentier AC. (2022). High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome. Cell reports. Medicine. DOI
• Ye RZ, Montastier É, Noll C, Frisch F, Fortin M, Bouffard L, Phoenix S, Guérin B, Turcotte ÉE, Carpentier AC. (2022). Total Postprandial Hepatic Nonesterified and Dietary Fatty Acid Uptake Is Increased and Insufficiently Curbed by Adipose Tissue Fatty Acid Trapping in Prediabetes With Overweight. Diabetes. DOI
• Milot MC, Benesty OB, Dumulon-Perreault V, Ait-Mohand S, Richard PO, Rousseau É, Guérin B. (2022). ⁶⁴Cu-DOTHA₂-PSMA, a Novel PSMA PET Radiotracer for Prostate Cancer with a Long Imaging Time Window. Pharmaceuticals (Basel, Switzerland). DOI
• Tremblay S, Beaudoin JF, Bélissant Benesty O, Ait-Mohand S, Dumulon-Perreault V, Rousseau É, Turcotte ÉE, Guérin B. (2022). ⁶⁸Ga-DOTATATE Prepared from Cyclotron-Produced ⁶⁸Ga: An Integrated Solution from Cyclotron Vault to Safety Assessment and Diagnostic Efficacy in Neuroendocrine Cancer Patients. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Tippayamontri T, Betancourt-Santander E, Guérin B, Lecomte R, Paquette B, Sanche L. (2022). Estimation of the Internal Dose Imparted by ¹⁸F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography. Frontiers in nuclear medicine. DOI
• Hasrat Ali, Brigitte Guérin, Johan E. van Lier. (2022). Pd-catalyzed synthesis of C-C (Sonogashira, Suzuki, Heck, Stille), C-P and C-S linked products using <i>gem</i> -dibromovinyl BODIPY. Journal of Porphyrins and Phthalocyanines. DOI
• Pouliot F, Beauregard JM, Saad F, Trudel D, Richard PO, Turcotte É, Rousseau É, Probst S, Kassouf W, Anidjar M, Camirand Lemyre F, Bouvet GF, Neveu B, Tétu A, Guérin B. (2021). The Triple-Tracer strategy against Metastatic PrOstate cancer (3TMPO) study protocol. BJU international. DOI
• Laurence Déry, Gabriel Charest, Brigitte Guérin, Mohsen Akbari, David Fortin. (2021). Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors. International Journal of Molecular Sciences. DOI
• Kahn Ali S, Ait-Mohand S, Dumulon-Perreault V, Guérin B. (2021). [⁶⁸Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation. EJNMMI research. DOI
• Huwaidi A, Kumari B, Robert G, Guérin B, Sanche L, Wagner JR. (2021). Profiling DNA Damage Induced by the Irradiation of DNA with Gold Nanoparticles. The journal of physical chemistry letters. DOI
• Paquette M, Espinosa-Bentancourt E, Lavallée É, Phoenix S, Lapointe-Milot K, Bessette P, Guérin B, Turcotte ÉE. (2021). ¹⁸F-4FMFES and ¹⁸F-FDG PET/CT in Estrogen Receptor-Positive Endometrial Carcinomas: Preliminary Report. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Meysam Khosravifarsani, Samia Ait-Mohand, Benoit Paquette, Léon Sanche, Brigitte Guérin. (2021). Design, Synthesis, and Cytotoxicity Assessment of [⁶⁴Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker. Nanomaterials. DOI
• Hasrat Ali, Brigitte Guérin, Johan E. van Lier. (2021). Front Cover: Pd‐Catalyzed Sonogashira Cross‐Coupling Reactions of <i>gem</i>‐Dibromovinyl BODIPY Derivatives (22/2021). European Journal of Organic Chemistry. DOI
• Khosravifarsani M, Ait-Mohand S, Paquette B, Sanche L, Guérin B. (2021). High Cytotoxic Effect by Combining Copper-64 with a NOTA-Terpyridine Platinum Conjugate. Journal of medicinal chemistry. DOI
• Montastier É, Ye RZ, Noll C, Bouffard L, Fortin M, Frisch F, Phoenix S, Guérin B, Turcotte ÉE, Lewis GF, Carpentier AC. (2021). Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping. American journal of physiology. Endocrinology and metabolism. DOI
• Jalilian AR, Osso JA Jr, Vera-Araujo J, Kumar V, Harris MJ, Gutfilen B, Guérin B, Li H, Zhuravlev F, Chakravarty R, Alirezapour B, Ávila-Rodríguez MA, Khan IU, Aljammaz I, Assaad T, Luurtsema G, Smith J, Duatti A. (2020). IAEA contribution to the development of 64Cu radiopharmaceuticals for theranostic applications. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of. DOI
• Richard G, Noll C, Archambault M, Lebel R, Tremblay L, Ait-Mohand S, Guérin B, Blondin DP, Carpentier AC, Lepage M. (2020). Contribution of perfusion to the ¹¹ C-acetate signal in brown adipose tissue assessed by DCE-MRI and ⁶⁸ Ga-DOTA PET in a rat model. Magnetic resonance in medicine. DOI
• Blondin DP, Nielsen S, Kuipers EN, Severinsen MC, Jensen VH, Miard S, Jespersen NZ, Kooijman S, Boon MR, Fortin M, Phoenix S, Frisch F, Guérin B, Turcotte ÉE, Haman F, Richard D, Picard F, Rensen PCN, Scheele C, Carpentier AC. (2020). Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation. Cell metabolism. DOI
• Hasrat Ali, Brigitte Guérin, Johan E. van Lier. (2020). Synthesis, spectral and crystal structures of gem-dibromovinyl boron dipyrrins. Dyes and Pigments. DOI
• Paquette M, Phoenix S, Lavallée É, Rousseau JA, Guérin B, Turcotte ÉE, Lecomte R. (2020). Cross-Species Physiological Assessment of Brain Estrogen Receptor Expression Using ¹⁸F-FES and ¹⁸F-4FMFES PET Imaging. Molecular imaging and biology. DOI
• Paquette M, Phoenix S, Lawson C, Guérin B, Lecomte R, Tai LH, Turcotte ÉE, Leyton JV. (2020). A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts. EJNMMI research. DOI
• Alnahwi AH, Ait-Mohand S, Dumulon-Perreault V, Dory YL, Guérin B. (2020). Promising Performance of 4HMS, a New Zirconium-89 Octadendate Chelator. ACS omega. DOI
• Carreau AM, Noll C, Blondin DP, Frisch F, Nadeau M, Pelletier M, Phoenix S, Cunnane SC, Guérin B, Turcotte EE, Lebel S, Biertho L, Tchernof A, Carpentier AC. (2020). Bariatric Surgery Rapidly Decreases Cardiac Dietary Fatty Acid Partitioning and Hepatic Insulin Resistance Through Increased Intra-abdominal Adipose Tissue Storage and Reduced Spillover in Type 2 Diabetes. Diabetes. DOI
• Noll C, Montastier É, Amrani M, Kunach M, Frisch F, Fortin M, Bouffard L, Dubreuil S, Phoenix S, Cunnane SC, Guérin B, Turcotte EE, Laville M, Carpentier AC. (2019). Seven-day overfeeding enhances adipose tissue dietary fatty acid storage and decreases myocardial and skeletal muscle dietary fatty acid partitioning in healthy subjects. American journal of physiology. Endocrinology and metabolism. DOI
• Alnahwi AH, Tremblay S, Ait-Mohand S, Beaudoin JF, Guérin B. (2019). Automated radiosynthesis of ⁶⁸Ga for large-scale routine production using ⁶⁸Zn pressed target. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. DOI
• Ali H, Guérin B, van Lier JE. (2019). gem-Dibromovinyl boron dipyrrins: synthesis, spectral properties and crystal structures. Dalton transactions (Cambridge, England : 2003). DOI
• Tippayamontri T, Guérin B, Ouellet R, Sarrhini O, Rousseau J, Lecomte R, Paquette B, Sanche L. (2019). Intratumoral ¹⁸F-FLT infusion in metabolic targeted radiotherapy. EJNMMI research. DOI
• Kwiatkowska A, Couture F, Ait-Mohand S, Desjardins R, Dory YL, Guérin B, Day R. (2019). Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug. Scientific reports. DOI
• Beaudeau JL, Blais V, Holleran BJ, Bergeron A, Piñeyro G, Guérin B, Gendron L, Dory YL. (2019). N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties. ACS chemical neuroscience. DOI
• Aiman H. Alnahwi, Sébastien Tremblay, Brigitte Guérin. (2018). Comparative Study with ⁸⁹Y-foil and ⁸⁹Y-pressed Targets for the Production of ⁸⁹Zr <xref rid="fn1-applsci-351091" ref-type="fn">†</xref>. Applied Sciences. DOI
• Beaudoin S, Paquette M, Fafard-Couture L, Tremblay MA, Lecomte R, Guérin B, Leyton JV. (2018). Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting. Journal of visualized experiments : JoVE. DOI
• Paquette M, Beaudoin S, Tremblay MA, Jean S, Lopez AF, Lecomte R, Guérin B, Bentourkia M, Sabbagh R, Leyton JV. (2018). NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model. Bioconjugate chemistry. DOI
• Mansour N, Paquette M, Ait-Mohand S, Dumulon-Perreault V, Guérin B. (2017). Evaluation of a novel GRPR antagonist for prostate cancer PET imaging: [⁶⁴Cu]-DOTHA₂-PEG-RM26. Nuclear medicine and biology. DOI
• Paquette M, Lavallée É, Phoenix S, Ouellet R, Senta H, van Lier JE, Guérin B, Lecomte R, Turcotte ÉE. (2017). Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer ¹⁸F-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Paquette M, Vilera-Perez LG, Beaudoin S, Ekindi-Ndongo N, Boudreaut PL, Bonin MA, Battista MC, Bentourkia M, Lopez AF, Lecomte R, Marsault E, Guérin B, Sabbagh R, Leyton JV. (2017). Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. Oncoimmunology. DOI
• Osati S, Ali H, Guerin B, van Lier JE. (2017). Synthesis and spectral properties of estrogen- and androgen-BODIPY conjugates. Steroids. DOI
• Pirisedigh A, Blais V, Ait-Mohand S, Abdallah K, Holleran BJ, Leduc R, Dory YL, Gendron L, Guérin B. (2017). Synthesis and Evaluation of a ⁶⁴Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Organic letters. DOI
• Panet F, Couture F, Kwiatkowska A, Desjardins R, Guérin B, Day R. (2017). PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. European journal of cell biology. DOI
• Mansour N, Dumulon-Perreault V, Ait-Mohand S, Paquette M, Lecomte R, Guérin B. (2017). Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [⁶⁴ Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists. Journal of labelled compounds & radiopharmaceuticals. DOI
• Blondin DP, Tingelstad HC, Noll C, Frisch F, Phoenix S, Guérin B, Turcotte ÉE, Richard D, Haman F, Carpentier AC. (2017). Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men. Nature communications. DOI
• Blondin DP, Frisch F, Phoenix S, Guérin B, Turcotte ÉE, Haman F, Richard D, Carpentier AC. (2017). Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans. Cell metabolism. DOI
• Osati S, Ali H, Marques F, Paquette M, Beaudoin S, Guerin B, Leyton JV, van Lier JE. (2016). BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities. Bioorganic & medicinal chemistry letters. DOI
• Nadon JF, Rochon K, Grastilleur S, Langlois G, Dao TT, Blais V, Guérin B, Gendron L, Dory YL. (2016). Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic. ACS chemical neuroscience. DOI
• Selivanova SV, Lavallée É, Senta H, Caouette L, McEwan AJB, Guérin B, Lecomte R, Turcotte É. (2016). Clinical Trial with Sodium ^99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Shi M, Paquette B, Thippayamontri T, Gendron L, Guérin B, Sanche L. (2016). Increased radiosensitivity of colorectal tumors with intra-tumoral injection of low dose of gold nanoparticles. International journal of nanomedicine. DOI
• Zhang C, Pan J, Lin KS, Dude I, Lau J, Zeisler J, Merkens H, Jenni S, Guérin B, Bénard F. (2016). Targeting the Neuropeptide Y1 Receptor for Cancer Imaging by Positron Emission Tomography Using Novel Truncated Peptides. Molecular pharmaceutics. DOI
• Noll C, Kunach M, Frisch F, Bouffard L, Dubreuil S, Jean-Denis F, Phoenix S, Cunnane SC, Guérin B, Turcotte EE, Carpentier AC. (2015). Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects. Diabetes. DOI
• Selivanova SV, Lavallée É, Senta H, Caouette L, Sader JA, van Lier EJ, Zyuzin A, van Lier JE, Guérin B, Turcotte É, Lecomte R. (2015). Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. DOI
• Couture F, Ly K, Levesque C, Kwiatkowska A, Ait-Mohand S, Desjardins R, Guérin B, Day R. (2015). Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. BioMed research international. DOI
• Blondin DP, Labbé SM, Noll C, Kunach M, Phoenix S, Guérin B, Turcotte ÉE, Haman F, Richard D, Carpentier AC. (2015). Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes. Diabetes. DOI
• Levesque C, Couture F, Kwiatkowska A, Desjardins R, Guérin B, Neugebauer WA, Day R. (2015). PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation. Oncotarget. DOI
• Blondin DP, Labbé SM, Phoenix S, Guérin B, Turcotte ÉE, Richard D, Carpentier AC, Haman F. (2014). Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men. The Journal of physiology. DOI
• Kunach M, Noll C, Phoenix S, Guérin B, Baillargeon JP, Turcotte EE, Carpentier AC. (2014). Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans. Diabetes. DOI
• Ait-Mohand S, Denis C, Tremblay G, Paquette M, Guérin B. (2014). Development of bifunctional chelates bearing hydroxamate arms for highly efficient (64)Cu radiolabeling. Organic letters. DOI
• Couture F, Levesque C, Dumulon-Perreault V, Ait-Mohand S, D'Anjou F, Day R, Guérin B. (2014). PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor. Neoplasia (New York, N.Y.). DOI
• Labbé SM, Noll C, Grenier-Larouche T, Kunach M, Bouffard L, Phoenix S, Guérin B, Baillargeon JP, Langlois MF, Turcotte EE, Carpentier AC. (2014). Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance. American journal of physiology. Endocrinology and metabolism. DOI
• Blondin DP, Labbé SM, Tingelstad HC, Noll C, Kunach M, Phoenix S, Guérin B, Turcotte EE, Carpentier AC, Richard D, Haman F. (2014). Increased brown adipose tissue oxidative capacity in cold-acclimated humans. The Journal of clinical endocrinology and metabolism. DOI
• Beaudoin J, Ekici S, Daldal F, Ait-Mohand S, Guérin B, Labbé S. (2013). Copper transport and regulation in Schizosaccharomyces pombe. Biochemical Society transactions. DOI
• Ranyuk E, Lebel R, Bérubé-Lauzière Y, Klarskov K, Lecomte R, van Lier JE, Guérin B. (2013). (68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine conjugates as fluorescent/PET bimodal imaging probes. Bioconjugate chemistry. DOI
• Proteau-Gagné A, Rochon K, Roy M, Albert PJ, Guérin B, Gendron L, Dory YL. (2013). Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity. Bioorganic & medicinal chemistry letters. DOI
• Rochon K, Proteau-Gagné A, Bourassa P, Nadon JF, Côté J, Bournival V, Gobeil F Jr, Guérin B, Dory YL, Gendron L. (2013). Preparation and evaluation at the delta opioid receptor of a series of linear leu-enkephalin analogues obtained by systematic replacement of the amides. ACS chemical neuroscience. DOI
• Inkster J, Lin KS, Ait-Mohand S, Gosselin S, Bénard F, Guérin B, Pourghiasian M, Ruth T, Schaffer P, Storr T. (2013). 2-Fluoropyridine prosthetic compounds for the 18F labeling of bombesin analogues. Bioorganic & medicinal chemistry letters. DOI
• Ranyuk E, Cauchon N, Klarskov K, Guérin B, van Lier JE. (2013). Phthalocyanine-peptide conjugates: receptor-targeting bifunctional agents for imaging and photodynamic therapy. Journal of medicinal chemistry. DOI
• Labbé SM, Grenier-Larouche T, Noll C, Phoenix S, Guérin B, Turcotte EE, Carpentier AC. (2012). Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans. Diabetes. DOI
• Fournier P, Dumulon-Perreault V, Ait-Mohand S, Tremblay S, Bénard F, Lecomte R, Guérin B. (2012). Novel radiolabeled peptides for breast and prostate tumor PET imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),βAla(11),Thi(13),Nle(14)]BBN(6-14). Bioconjugate chemistry. DOI
• Inkster JA, Liu K, Ait-Mohand S, Schaffer P, Guérin B, Ruth TJ, Storr T. (2012). Sulfonyl fluoride-based prosthetic compounds as potential 18F labelling agents. Chemistry (Weinheim an der Bergstrasse, Germany). DOI
• Bessi VL, Labbé SM, Huynh DN, Ménard L, Jossart C, Febbraio M, Guérin B, Bentourkia M, Lecomte R, Carpentier AC, Ong H, Marleau S. (2012). EP 80317, a selective CD36 ligand, shows cardioprotective effects against post-ischaemic myocardial damage in mice. Cardiovascular research. DOI
• Fournier P, Dumulon-Perreault V, Ait-Mohand S, Langlois R, Bénard F, Lecomte R, Guérin B. (2012). Comparative study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging. EJNMMI research. DOI
• Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin B, Haman F, Turcotte EE, Richard D, Carpentier AC. (2012). Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. The Journal of clinical investigation. DOI
• Ranyuk ER, Cauchon N, Ali H, Lecomte R, Guérin B, van Lier JE. (2011). PET imaging using 64Cu-labeled sulfophthalocyanines: synthesis and biodistribution. Bioorganic & medicinal chemistry letters. DOI
• Beaudoin J, Ioannoni R, López-Maury L, Bähler J, Ait-Mohand S, Guérin B, Dodani SC, Chang CJ, Labbé S. (2011). Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells. The Journal of biological chemistry. DOI
• Ait-Mohand S, Fournier P, Dumulon-Perreault V, Kiefer GE, Jurek P, Ferreira CL, Bénard F, Guérin B. (2011). Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates. Bioconjugate chemistry. DOI
• Ali H, Ait-Mohand S, Gosselin S, van Lier JE, Guérin B. (2011). Phthalocyanine-peptide conjugates via palladium-catalyzed cross-coupling reactions. The Journal of organic chemistry. DOI
• Labbé SM, Croteau E, Grenier-Larouche T, Frisch F, Ouellet R, Langlois R, Guérin B, Turcotte EE, Carpentier AC. (2011). Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes. Diabetes. DOI
• Labbé SM, Grenier-Larouche T, Croteau E, Normand-Lauzière F, Frisch F, Ouellet R, Guérin B, Turcotte EE, Carpentier AC. (2010). Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography. American journal of physiology. Endocrinology and metabolism. DOI
• Guérin B, Tremblay S, Rodrigue S, Rousseau JA, Dumulon-Perreault V, Lecomte R, van Lier JE, Zyuzin A, van Lier EJ. (2010). Cyclotron production of 99mTc: an approach to the medical isotope crisis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
• Guérin B, Ait-Mohand S, Tremblay MC, Dumulon-Perreault V, Fournier P, Bénard F. (2010). Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging. Organic letters. DOI
• Guérin B, Dumulon-Perreault V, Tremblay MC, Ait-Mohand S, Fournier P, Dubuc C, Authier S, Bénard F. (2009). [Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging. Bioorganic & medicinal chemistry letters. DOI
• Jastrzebska B, Lebel R, Therriault H, McIntyre JO, Escher E, Guérin B, Paquette B, Neugebauer WA, Lepage M. (2009). New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging. Journal of medicinal chemistry. DOI
• Cardinal-David B, Guérin B, Guindon Y. (2005). Synthesis of tertiary and quaternary stereogenic centers: a diastereoselective tandem reaction sequence combining Mukaiyama and free radical-based allylation. The Journal of organic chemistry. DOI
• Lawson SR, Gabra BH, Guérin B, Neugebauer W, Nantel F, Battistini B, Sirois P. (2005). Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist. Regulatory peptides. DOI
• Guindon Y, Prévost M, Mochirian P, Guérin B. (2002). Synthesis of 2,3-anti-3,4-anti and 2,3-anti-3,4-syn propionate motifs: a diastereoselective tandem sequence of Mukaiyama and free-radical-based hydrogen transfer reactions. Organic letters. DOI
• Guindon Y, Gagnon M, Thumin I, Chapdelaine D, Jung G, Guérin B. (2002). Synthesis of N-glycosides. An alternative approach based on diastereoselective base coupling and S(N)2 cyclization. Organic letters. DOI

Autres contributions

Cours enseignés à l'UdeS

• RBL501 - Études pharmacologiques en imagerie biomédicale et radiothérapie. (2024, 2026). (2CR).
• PHR202 - Pharmacochimie. (2024-2025). (3CR).
• RBL718 - Synthèse et propriétés des produits radiopharmaceutiques. (2024). (1CR).

Activités professionnelles

• Poste d'invité. Institut de recherche sur le cancer de l'Université de Sherbrooke (IRCUS). Dépistage précoce, diagnostic et pronostic. Chercheuse et membre du Comité exécutif. Sherbrooke, Québec, Canada. (2021-).
• Poste d'invité. CRCHUS. Axe imagerie médicale. Directrice. Sherbrooke, Québec, Canada. (2018-2025).
• Poste d'invité. Université de Sherbrooke. Centre d'excellence en imagerie médicale. Directrice. Sherbrooke, Quebec, Canada. (2018-2025).
• Poste d'invité. Université de Sherbrooke. Institut de Pharmacologie. Chercheuse. Sherbrooke, Quebec, Canada. (2007-).
• Poste d'invité. Université de Sherbrooke. Département de Chimie. Membre affiliée. Sherbrooke, Quebec, Canada. (2007-).
• Poste d'invité. CRCHUS. Laboratoire de radiochimie-R&D. Directrice. Sherbrooke, Québec, Canada. (2006-).
• Poste d'invité. CRCHUS. Axe imagerie médicale. Chercheuse. Sherbrooke, Québec, Canada.