Benoît Chabot

Prix et distinctions

• (2025) Fellow. Royal Society of Canada.
• (2023) RNA Society Lifetime Service Award. RNA Society.
• (2018) JIOMICS and Proteomass Scientific Society Research Award. JIOMICS.
• (2015) Chaire Pierre C. Fournier en génomique fonctionnelle (CRMUS/UdeS) (2015-2020). Université de Sherbrooke.
• (2013) NRC Research Press Senior Investigator Award. Canadian Society for Molecular Biosciences.
• (2007) Fellow. Canadian Academy of Health Sciences.
• (2001) Canada Research Chair in Functional Genomics (2001-2015). Canada Research Chairs.

Publications

Articles

• Behrang Salahshournia, Ali Noroozi, Daniel Fortin, Lulzim Shkreta, Benoit Chabot, Armand Soldera, Hubert Cabana, Pierre D. Harvey. (2025). A Porphyrin-Based Metal–Organic Framework as a Photosensitizer for Singlet Oxygen Generation and Photocatalytic Water Treatment. ACS Applied Optical Materials. DOI
• Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoit Chabot, Martha Brown, Mario Huesca, Alan Cochrane. (2024). Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals. Viruses. DOI
• Shkreta L, Delannoy A, Toutant J, Chabot B. (2024). Regulatory interplay between SR proteins governs <i>CLK1</i> kinase splice variants production. RNA (New York, N.Y.). DOI
• Pastor F, Charles E, Di Vona C, Chapelle M, Rivoire M, Passot G, Chabot B, de la Luna S, Lucifora J, Durantel D, Salvetti A. (2024). The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA. PloS one. DOI
• Deschênes M, Durand M, Olivier MA, Pellerin-Viger A, Rodier F, Chabot B. (2024). A defective splicing machinery promotes senescence through MDM4 alternative splicing. Aging cell. DOI
• Chang C, Li L, Su L, Yang F, Zha Q, Sun M, Tao L, Wang M, Song K, Jiang L, Gao H, Liang Y, Xu C, Yong C, Huang J, Liu J, Jin W, Lv W, Dong H, Li Q, Bu F, Yan S, Qi H, Zhao S, Zhu Y, Wang Y, Shi J, Qiao Y, Xu J, Chabot B, Chen J. (2024). Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany). DOI
• Shkreta L, Toutant J, Delannoy A, Durantel D, Salvetti A, Ehresmann S, Sauvageau M, Delbrouck JA, Gravel-Trudeau A, Comeau C, Huard C, Coulombe-Huntington J, Tyers M, Grierson D, Boudreault PL, Chabot B. (2024). The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response. Oncotarget. DOI
• Morin C, Simard É, See W, Sage M, Imane R, Nadeau C, Samson N, Lavoie PM, Chabot B, Marouan S, Tremblay S, Praud JP, Micheau P, Fortin-Pellerin É. (2023). Total liquid ventilation in an ovine model of extreme prematurity: a randomized study. Pediatric research. DOI
• Dahal S, Clayton K, Cabral T, Cheng R, Jahanshahi S, Ahmed C, Koirala A, Villasmil Ocando A, Malty R, Been T, Hernandez J, Mangos M, Shen D, Babu M, Calarco J, Chabot B, Attisano L, Houry WA, Cochrane A. (2023). On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine. Journal of virology. DOI
• Lemaitre F, Chakrama F, O'Grady T, Peulen O, Rademaker G, Deward A, Chabot B, Piette J, Colige A, Lambert C, Dequiedt F, Habraken Y. (2022). The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress. Nucleic acids research. DOI
• Dahal S, Clayton K, Been T, Fernet-Brochu R, Ocando AV, Balachandran A, Poirier M, Maldonado RK, Shkreta L, Boligan KF, Guvenc F, Rahman F, Branch D, Bell B, Chabot B, Gray-Owen SD, Parent LJ, Cochrane A. (2022). Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency. Retrovirology. DOI
• Chang C, Rajasekaran M, Qiao Y, Dong H, Wang Y, Xia H, Deivasigamani A, Wu M, Sekar K, Gao H, Sun M, Niu Y, Li Q, Tao L, Yan Z, Wang M, Chen S, Zhao S, Chen D, Li L, Yang F, Chen B, Su L, Xu L, Chen Y, Seshachalam VP, Chen G, Gunaratne J, Hong W, Shi J, Grierson DS, Chabot B, Xie T, Hui KM, Chen J. (2022). The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma. Nature communications. DOI
• Dahal S, Cheng R, Cheung PK, Been T, Malty R, Geng M, Manianis S, Shkreta L, Jahanshahi S, Toutant J, Chan R, Park S, Brockman MA, Babu M, Mubareka S, Mossman K, Banerjee A, Gray-Owen S, Brown M, Houry WA, Chabot B, Grierson D, Cochrane A. (2021). The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation. Viruses. DOI
• Zamiri M, Cheung PK, Brockman MA, Brumme ZL, Chabot B, Cochrane A, Grierson DS. (2021). 2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing. ACS medicinal chemistry letters. DOI
• Shkreta L, Delannoy A, Salvetti A, Chabot B. (2021). SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication. RNA (New York, N.Y.). DOI
• Sohail M, Shkreta L, Toutant J, Rabea S, Babeu JP, Huard C, Coulombe-Huntington J, Delannoy A, Placet M, Geha S, Gendron FP, Boudreau F, Tyers M, Grierson DS, Chabot B. (2021). A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. NAR cancer. DOI
• Pastor F, Shkreta L, Chabot B, Durantel D, Salvetti A. (2021). Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond. Frontiers in microbiology. DOI
• Chabrolles H, Auclair H, Vegna S, Lahlali T, Pons C, Michelet M, Couté Y, Belmudes L, Chadeuf G, Kim Y, Di Bernardo A, Jalaguier P, Cosset FL, Fusil F, Rivoire M, Arnold LD, Lopatin U, Combet C, Zoulim F, Grierson D, Chabot B, Lucifora J, Durantel D, Salvetti A. (2020). Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production. PLoS pathogens. DOI
• Sage, M., See, W., Nault, S., Morin, C., Michalski, C., Chabot, B., Marouan, S., Lavoie, P.M., Micheau, P., Praud, J.-P., Fortin-Pellerin, É. (2020). Effect of Low Versus High Tidal-Volume Total Liquid Ventilation on Pulmonary Inflammation. Frontiers in Physiology. DOI
• Nourreddine, S., Lavoie, G., Paradis, J., Ben El Kadhi, K., Méant, A., Aubert, L., Grondin, B., Gendron, P., Chabot, B., Bouvier, M., Carreno, S., Roux, P.P. (2020). NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. Cell Reports. DOI
• Capelo-Martinez, J.-L., Chabot, B., Espiño, C.L., dos Santos, H.M.B.C. (2019). Editorial – splicing and alternative splicing. International Journal of Biochemistry and Cell Biology. DOI
• Cloutier, A., Shkreta, L., Toutant, J., Durand, M., Thibault, P., Chabot, B. (2018). HnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage. Scientific Reports. DOI
• Tétreault, M., Deshaies, J.-E., Semmler, S., Sidibé, H., Shkreta, L., Volkening, K., Soreq, H., Strong, M.J., Chabot, B., Vande Velde, C. (2018). Reply: TDP-43 mutations increase HNRNP A1-7B through gain of splicing function. Brain : a journal of neurology. DOI
• Deshaies, J.-E., Shkreta, L., Moszczynski, A.J., Sidibé, H., Semmler, S., Fouillen, A., Bennett, E.R., Bekenstein, U., Destroismaisons, L., Toutant, J., Delmotte, Q., Volkening, K., Stabile, S., Aulas, A., Khalfallah, Y., Soreq, H., Nanci, A., Strong, M.J., Chabot, B., Vande Velde, C. (2018). TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis. Brain. DOI
• Shkreta, L., Blanchette, M., Toutant, J., Wilhelm, E., Bell, B., Story, B.A., Balachandran, A., Cochrane, A., Cheung, P.K., Harrigan, P.R., Grierson, D.S., Chabot, B. (2017). Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication. Nucleic Acids Research. DOI
• Cloutier, P., Poitras, C., Durand, M., Hekmat, O., Fiola-Masson, É., Bouchard, A., Faubert, D., Chabot, B., Coulombe, B. (2017). R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Nature Communications. DOI
• Bondy-Chorney, E., Baldwin, R.M., Didillon, A., Chabot, B., Jasmin, B.J., Côté, J. (2017). RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells. International Journal of Biochemistry and Cell Biology. DOI
• Sutherland, L.C., Thibault, P., Durand, M., Lapointe, E., Knee, J.M., Beauvais, A., Kalatskaya, I., Hunt, S.C., Loiselle, J.J., Roy, J.G., Tessier, S.J., Ybazeta, G., Stein, L., Kothary, R., Klinck, R., Chabot, B. (2017). Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA. BMC Molecular Biology. DOI
• Deschênes, M., Chabot, B. (2017). The emerging role of alternative splicing in senescence and aging. Aging Cell. DOI
• Cheung, P.K., Horhant, D., Bandy, L.E., Zamiri, M., Rabea, S.M., Karagiosov, S.K., Matloobi, M., McArthur, S., Harrigan, P.R., Chabot, B., Grierson, D.S. (2016). A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV-1 Pre-mRNA Alternative Splicing. Journal of Medicinal Chemistry. DOI
• Chabot, B., Shkreta, L. (2016). Defective control of pre-messenger RNA splicing in human disease. Journal of Cell Biology. DOI
• Shkreta, L., Toutant, J., Durand, M., Manley, J.L., Chabot, B. (2016). SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors. Cell Reports. DOI
• Bondy-Chorney, E., Crawford Parks, T.E., Ravel-Chapuis, A., Klinck, R., Rocheleau, L., Pelchat, M., Chabot, B., Jasmin, B.J., Côté, J. (2016). Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. PLoS Genetics. DOI
• Lemieux, B., Blanchette, M., Monette, A., Mouland, A.J., Wellinger, R.J., Chabot, B. (2015). A function for the hnRNP A1/A2 proteins in transcription elongation. PLoS ONE. DOI
• Mauger, O., Klinck, R., Chabot, B., Muchardt, C., Allemand, E., Batsché, E. (2015). Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions. Nucleic Acids Research. DOI
• Chabot, B. (2015). Finding the rules of splicing, and using them ... alternatively. RNA. DOI
• Chabot, B. (2015). My road to alternative splicing control: From simple paths to loops and interconnections. Biochemistry and Cell Biology. DOI
• Bergeron, D., Pal, G., Beaulieu, Y.B., Chabot, B., Bachand, F. (2015). Regulated intron retention and nuclear pre-mRNA decay contribute to PABPN1 autoregulation. Molecular and Cellular Biology. DOI
• Gabriel, M., Delforge, Y., Deward, A., Habraken, Y., Hennuy, B., Piette, J., Klinck, R., Chabot, B., Colige, A., Lambert, C. (2015). Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis. BMC Cancer. DOI
• Shkreta, L., Chabot, B. (2015). The RNA splicing response to DNA damage. Biomolecules. DOI
• Best, A., James, K., Dalgliesh, C., Hong, E., Kheirolahi-Kouhestani, M., Curk, T., Xu, Y., Danilenko, M., Hussain, R., Keavney, B., Wipat, A., Klinck, R., Cowell, I.G., Cheong Lee, K., Austin, C.A., Venables, J.P., Chabot, B., Santibanez Koref, M., Tyson-Capper, A., Elliott, D.J. (2014). Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Nature Communications. DOI
• Klinck, R., Fourrier, A., Thibault, P., Toutant, J., Durand, M., Lapointe, E., Caillet-Boudin, M.-L., Sergeant, N., Gourdon, G., Meola, G., Furling, D., Puymirat, J., Chabot, B. (2014). RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1. PLoS ONE. DOI
• Brosseau, J.-P., Lucier, J.-F., Lamarche, A.-A., Shkreta, L., Gendron, D., Lapointe, E., Thibault, P., Paquet, E., Perreault, J.-P., Elela, S.A., Chabot, B. (2014). Redirecting splicing with bifunctional oligonucleotides. Nucleic Acids Research. DOI
• Brosseau, J.-P., Lucier, J.-F., Nwilati, H., Thibault, P., Garneau, D., Gendron, D., Durand, M., Couture, S., Lapointe, E., Prinos, P., Klinck, R., Perreault, J.-P., Chabot, B., Abou-Elela, S. (2014). Tumor microenvironment-associated modifications of alternative splicing. RNA. DOI
• Venables, J.P., Lapasset, L., Gadea, G., Fort, P., Klinck, R., Irimia, M., Vignal, E., Thibault, P., Prinos, P., Chabot, B., Abou Elela, S., Roux, P., Lemaitre, J.-M., Tazi, J. (2013). MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nature Communications. DOI
• Diaz, Z., Aguilar-Mahecha, A., Paquet, E.R., Basik, M., Orain, M., Camlioglu, E., Constantin, A., Benlimame, N., Bachvarov, D., Jannot, G., Simard, M.J., Chabot, B., Gologan, A., Klinck, R., Gagnon-Kugler, T., Lespérance, B., Samson, B., Kavan, P., Alcindor, T., Dalfen, R., Lan, C., Chabot, C., Buchanan, M., Przybytkowrski, E., Qureshi, S., Rousseau, C., Spatz, A., Têtu, B., Batist, G. (2013). Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine. Modern Pathology. DOI
• Venables, J.P., Brosseau, J.-P., Gadea, G., Klinck, R., Prinos, P., Beaulieu, J.-F., Lapointe, E., Durand, M., Thibault, P., Tremblay, K., Rousset, F., Tazi, J., Elela, S.A., Chabot, B. (2013). RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Molecular and Cellular Biology. DOI
• Lund, N., Milev, M.P., Wong, R., Sanmuganantham, T., Woolaway, K., Chabot, B., Abou Elela, S., Mouland, A.J., Cochrane, A. (2012). Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression. Nucleic Acids Research. DOI
• Michelle, L., Cloutier, A., Toutant, J., Shkreta, L., Thibault, P., Durand, M., Garneau, D., Gendron, D., Lapointe, L., Couture, S., Le Hir, H., Klinck, R., Elela, S.A., Prinos, P., Chabot, B. (2012). Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Molecular and Cellular Biology. DOI
• Montes, M., Cloutier, A., Sánchez-Hernández, N., Michelle, L., Lemieux, B., Blanchette, M., Hernández-Munain, C., Chabot, B., Suñé, C. (2012). TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription. Molecular and Cellular Biology. DOI
• Prinos, P., Garneau, D., Lucier, J.-F., Gendron, D., Couture, S., Boivin, M., Brosseau, J.-P., Lapointe, E., Thibault, P., Durand, M., Tremblay, K., Gervais-Bird, J., Nwilati, H., Klinck, R., Chabot, B., Perreault, J.-P., Wellinger, R.J., Elela, S.A. (2011). Alternative splicing of SYK regulates mitosis and cell survival. Nature Structural and Molecular Biology. DOI
• Parenteau, J., Durand, M., Morin, G., Gagnon, J., Lucier, J.-F., Wellinger, R.J., Chabot, B., Elela, S.A. (2011). Introns within ribosomal protein genes regulate the production and function of yeast ribosomes. Cell. DOI
• Tanackovic, G., Ransijn, A., Thibault, P., Elela, S.A., Klinck, R., Berson, E.L., Chabot, B., Rivolta, C. (2011). PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Human Molecular Genetics. DOI
• Shkreta, L., Michelle, L., Toutant, J., Tremblay, M.L., Chabot, B. (2011). The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. Journal of Biological Chemistry. DOI
• Dominguez, C., Fisette, J.-F., Chabot, B., Allain, F.H.-T. (2010). Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nature Structural and Molecular Biology. DOI
• Fisette, J.-F., Toutant, J., Dugré-Brisson, S., Desgroseillers, L., Chabot, B. (2010). hnRNP A1 and hnRNP H can collaborate to modulate 5′ splice site selection. RNA. DOI
• Venables, J.P., Klinck, R., Koh, C., Gervais-Bird, J., Bramard, A., Inkel, L., Durand, M., Couture, S., Froehlich, U., Lapointe, E., Lucier, J.-F., Thibault, P., Rancourt, C., Tremblay, K., Prinos, P., Chabot, B., Elela, S.A. (2009). Cancer-associated regulation of alternative splicing. Nature Structural and Molecular Biology. DOI
• Alló, M., Buggiano, V., Fededa, J.P., Petrillo, E., Schor, I., De La Mata, M., Agirre, E., Plass, M., Eyras, E., Elela, S.A., Klinck, R., Chabot, B., Kornblihtt, A.R. (2009). Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nature Structural and Molecular Biology. DOI
• Fisette, J.-F., Michelle, L., Revil, T., Chabot, B. (2009). Guiding and integrating to control and diversify splicing,Guider et intégrer pour un épissage diversifié. Medecine/Sciences. DOI
• Revil, T., Pelletier, J., Toutant, J., Cloutier, A., Chabot, B. (2009). Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-x<inf>S</inf> splice isoform. Journal of Biological Chemistry. DOI
• Scott William Roy, Manuel Irimia. (2008). In response to letter from Benoit Chabot. BioEssays. DOI
• Cloutier, P., Toutant, J., Shkreta, L., Goekjian, S., Revil, T., Chabot, B. (2008). Antagonistic effects of the SRp30c protein and cryptic 5′ splice sites on the alternative splicing of the apoptotic regulator Bcl-x. Journal of Biological Chemistry. DOI
• Shkreta, L., Froehlich, U., Paquet, É.R., Toutant, J., Elela, S.A., Chabot, B. (2008). Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes. Molecular Cancer Therapeutics. DOI
• Chabot, B., Elela, S.A., Zhuo, D. (2008). Comment on "when good transcripts go bad: Artifactual RT-PCR 'splicing' and genome analysis". BioEssays. DOI
• Parenteau, J., Durand, M., Véronneau, S., Lacombe, A.-A., Morin, G., Guérin, V., Cecez, B., Gervais-Bird, J., Koh, C.-S., Brunelle, D., Wellinger, R.J., Chabot, B., Abou Elela, S. (2008). Deletion of many yeast introns reveals a minority of genes that require splicing for function. Molecular Biology of the Cell. DOI
• Venables, J.P., Klinck, R., Bramard, A., Inkel, L., Dufresne-Martin, G., Koh, C., Gervais-Bird, J., Lapointe, E., Froehlich, U., Durand, M., Gendron, D., Brosseau, J.-P., Thibault, P., Lucier, J.-F., Tremblay, K., Prinos, P., Wellinger, R.J., Chabot, B., Rancourt, C., Elela, S.A. (2008). Identification of alternative splicing markers for breast cancer. Cancer Research. DOI
• Klinck, R., Bramard, A., Inkel, L., Dufresne-Martin, G., Gervais-Bird, J., Madden, R., Paquet, É.R., Koh, C., Venables, J.P., Prinos, P., Jilaveanu-Pelmus, M., Wellinger, R., Rancourt, C., Chabot, B., Elela, S.A. (2008). Multiple alternative splicing markers for ovarian cancer. Cancer Research. DOI
• Venables, J.P., Koh, C.-S., Froehlich, U., Lapointe, E., Couture, S., Inkel, L., Bramard, A., Paquet, É.R., Watier, V., Durand, M., Lucier, J.-F., Gervais-Bird, J., Tremblay, K., Prinos, P., Klinck, R., Elela, S.A., Chabot, B. (2008). Multiple and specific mRNA processing targets for the major human hnRNP proteins. Molecular and Cellular Biology. DOI
• Zhuo, D., Madden, R., Elela, S.A., Chabot, B. (2007). Modern origin of numerous alternatively spliced human introns from tandem arrays. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Revil, T., Toutant, J., Shkreta, L., Garneau, D., Cloutier, P., Chabot, B. (2007). Protein kinase C-dependent control of Bcl-x alternative splicing. Molecular and Cellular Biology. DOI
• Bakkour, N., Lin, Y.-L., Maire, S., Ayadi, L., Mahuteau-Betzer, F., Chi, H.N., Mettling, C., Portales, P., Grierson, D., Chabot, B., Jeanteur, P., Branlant, C., Corbeau, P., Tazi, J. (2007). Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance. PLoS Pathogens. DOI
• Jeronimo, C., Forget, D., Bouchard, A., Li, Q., Chua, G., Poitras, C., Thérien, C., Bergeron, D., Bourassa, S., Greenblatt, J., Chabot, B., Poirier, G.G., Hughes, T.R., Blanchette, M., Price, D.H., Coulombe, B. (2007). Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme. Molecular Cell. DOI
• Paradis, C., Cloutier, P., Shkreta, L., Toutant, J., Klarskov, K., Chabot, B. (2007). hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. RNA. DOI
• Martinez-Contreras, R., Fisette, J.-F., Nasim, F.-U.H., Madden, R., Cordeau, M., Chabot, B. (2006). Intronic binding sites for hnRNP A/B and hnRNP F/H proteins stimulate pre-mRNA splicing. PLoS Biology. DOI
• Gendron, D., Carriero, S., Garneau, D., Villemaire, J., Klinck, R., Elela, S.A., Damha, M.J., Chabot, B. (2006). Modulation of 5′ splice site selection using tailed oligonucleotides carrying splicing signals. BMC Biotechnology. DOI
• Revil, T., Shkreta, L., Chabot, B. (2006). Pre-mRNA alternative splicing in cancer: Functional impact, molecular mechanisms and therapeutic perspectives,Épissage alternatif des ARN prémessagers dans le cancer: Impact fonctionnel, mécanismes moléculaires et espoirs thérapeutiques. Bulletin du Cancer.
• Garneau, D., Revil, T., Fisette, J.-F., Chabot, B. (2005). Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x. Journal of Biological Chemistry. DOI
• Naud, J.-F., McDuff, F.-O., Sauvé, S., Montagne, M., Webb, B.A., Smith, S.P., Chabot, B., Lavigne, P. (2005). Structural and thermodynamical characterization of the complete p21 gene product of Max. Biochemistry. DOI
• Bériault, V., Clément, J.-F., Lévesque, K., Lebel, C., Yong, X., Chabot, B., Cohen, É.A., Cochrane, A.W., Rigby, W.F.C., Mouland, A.J. (2004). A late role for the association of hnRNP A2 with the HIV-1 hnRNP A2 response elements in genomic RNA, Gag, and Vpr localization. Journal of Biological Chemistry. DOI
• Patry, C., Lemieux, B., Wellinger, R.J., Chabot, B. (2004). Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines. Molecular Cancer Therapeutics.
• Gagné, J.-P., Hunter, J.M., Labrecque, B., Chabot, B., Poirier, G.G. (2003). A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins. Biochemical Journal. DOI
• Jean-François, N., Frédéric, G., Raymund, W., Benoit, C., Lavigne, P. (2003). Improving the thermodynamic stability of the leucine zipper of Max increases the stability of its b-HLH-LZ:E-box complex. Journal of Molecular Biology. DOI
• Villemaire, J., Dion, I., Elela, S.A., Chabot, B. (2003). Reprogramming Alternative Pre-messenger RNA Splicing through the Use of Protein-binding Antisense Oligonucleotides. Journal of Biological Chemistry. DOI
• Patry, C., Bouchard, L., Labrecque, P., Gendron, D., Lemieux, B., Toutant, J., Lapointe, E., Wellinger, R., Chabot, B. (2003). Small Interfering RNA-Mediated Reduction in Heterogeneous Nuclear Ribonucleoparticule A1/A2 Proteins Induces Apoptosis in Human Cancer Cells but not in Normal Mortal Cell Lines. Cancer Research.
• Robert, F., Blanchette, M., Maes, O., Chabot, B., Coulombe, B. (2002). A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly. Journal of Biological Chemistry. DOI
• Hutchison, S., LeBel, C., Blanchette, M., Chabot, B. (2002). Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor. The Journal of biological chemistry. DOI
• Nasim, F.-U.H., Hutchison, S., Cordeau, M., Chabot, B. (2002). High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5′ splice site selection in support of a common looping out and repression mechanism. RNA. DOI
• Simard, M.J., Chabot, B. (2002). SRp30c is a repressor of 3′ splice site utilization. Molecular and Cellular Biology. DOI
• Fang, L.J., Simard, M.J., Vidaud, D., Assouline, B., Lemieux, B., Vidaud, M., Chabot, B., Thirion, J.-P. (2001). A novel mutation in the neurofibromatosis type 1 (NF1) gene promotes skipping of two exons by preventing exon definition. Journal of Molecular Biology. DOI
• Bolduc, L., Labrecque, B., Cordeau, M., Blanchette, M., Chabot, B. (2001). Dimethyl Sulfoxide Affects the Selection of Splice Sites. Journal of Biological Chemistry. DOI
• Fiset, S., Chabot, B. (2001). hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro. Nucleic Acids Research. DOI
• Simard, M.J., Chabot, B. (2000). Control of hnRNP A1 alternative splicing: An intron element represses use of the common 3' splice site. Molecular and Cellular Biology. DOI
• Dallaire, F., Dupuis, S., Fiset, S., Chabot, B. (2000). Heterogeneous nuclear ribonucleoprotein A1 and UP1 protect mammalian telomeric repeats and modulate telomere replication in vitro. Journal of Biological Chemistry. DOI
• Côté, J., Simard, M.J., Chabot, B. (1999). An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection. Nucleic Acids Research. DOI
• Blanchette, M., Chabot, B. (1999). Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization. EMBO Journal. DOI
• LaBranche, H., Dupuis, S., Ben-David, Y., Bani, M.-R., Wellinger, R.J., Chabot, B. (1998). Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nature Genetics. DOI
• Blanchette, M., Chabot, B. (1997). A highly stable duplex structure sequesters the 5′ splice site region of hnRNP A1 alternative exon 7B. RNA.
• Chabot, B., Blanchette, M., Lapierre, I., Branche, H.L. (1997). An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1. Molecular and Cellular Biology. DOI
• Côté, J., Chabot, B. (1997). Natural base-pairing interactions between 5′ splice site and branch site sequences affect mammalian 5′ splice site selection. RNA.
• Granger, D., Tremblay, A., Boulanger, C., Chabot, B., Ménard, H.-A., Boire, G. (1996). Autoantigenic Epitopes on hY5 Ro RNA Are Distinct from Regions Bound by the 60-kDa Ro and la Proteins. Journal of Immunology.
• Chabot, B. (1996). Directing alternative splicing: Cast and scenarios. Trends in Genetics. DOI
• Granger, D., Gendron, M., Tremblay, A., Chabot, B., Ménard, H.A., Boire, G. (1996). RNA-labelled Ro and La ribonucleoprotein complexes reassembled in vitro; characterization by gel shift analysis. Clinical and Experimental Immunology. DOI
• Vincent, M., Lauriault, P., Dubois, M.-F., Lavoie, S., Bensaude, O., Chabot, B. (1996). The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes. Nucleic Acids Research. DOI
• Boulanger, C., Chabot, B., Menard, H.A., Boire, G. (1995). Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clinical and Experimental Immunology. DOI
• Cote, J., Beaudoin, J., Tacke, R., Chabot, B. (1995). The U1 small nuclear ribonucleoprotein/5' splice site interaction affects U2AF⁶⁵ binding to the downstream 3' splice site. Journal of Biological Chemistry. DOI
• Chabot, B., Bisoltto, S., Vincent, M. (1995). The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/Y6.U5]tri-snRNP particle. Nucleic Acids Research. DOI
• Yang, X., Bani, M.-R., Lu, S.-J., Rowan, S., Ben-David, Y., Chabot, B. (1994). The A1 and A1(B) proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Lavigueur, A., La Branche, H., Kornblihtt, A.R., Chabot, B. (1993). A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes and Development. DOI
• Chabot, B., Frappier, D., Branche, H.L. (1992). Differential ASF/SF2 activity in extracts from normal WI38 and transformed WI38VA13 cells. Nucleic Acids Research. DOI
• Ben-David, Y., Bani, M.R., Chabot, B., De Koven, A., Bernstein, A. (1992). Retroviral Insertions Downstream of the Heterogeneous Nuclear Ribonucleoprotein A1 Gene in Erythroleukemia Cells: Evidence that A1 Is Not Essential for Cell Growth. Molecular and Cellular Biology. DOI
• La Branche, H., Frappier, D., Chabot, B. (1991). Proteolysis of splicing factors during rat and monkey cell fractionation. Nucleic Acids Research. DOI
• Bernstein, A., Chabot, B., Dubreuil, P., Reith, A., Nocka, K., Majumder, S., Ray, P., Besmer, P. (1990). The mouse W/c-kit locus. Ciba Foundation symposium.
• Nocka, K., Majumder, S., Chabot, B., Ray, P., Cervone, M., Bernstein, A., Besmer, P. (1989). Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. Genes &amp; development. DOI
• Chabot, B., Stephenson, D.A., Chapman, V.M., Besmer, P., Bernstein, A. (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. DOI
• Chabot, B., Steitz, J.A. (1987). Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Molecular and Cellular Biology. DOI
• Chabot, B., Steitz, J.A. (1987). Recognition of mutant and cryptic 5' splice sites by the U1 small nuclear ribonucleoprotein in vitro. Molecular and Cellular Biology. DOI
• Chabot, B., Black, D.L., LeMaster, D.M., Steitz, J.A. (1985). The 3′ splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Science. DOI
• Black, D.L., Chabot, B., Steitz, J.A. (1985). U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell. DOI

Livres

• Shkreta, L., Bell, B., Revil, T., Venables, J.P., Prinos, P., Elela, S.A., Chabot, B. (2013). Cancer-associated perturbations in alternative pre-messenger RNA splicing. Cancer Treatment and Research. DOI

Chapitres de livre

• Klinck, R., Chabot, B., Elela, S.A. (2012). High-Throughput Analysis of Alternative Splicing by RT-PCR. Alternative pre-mRNA Splicing: Theory and Protocols. DOI