Alain Frigon

Publications

Articles

• Sirine Yassine, Johannie Audet, Charly G. Lecomte, Stephen Mari, Angèle N. Merlet, Jonathan Harnie, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon. (2025). Speed-dependent locomotor adjustments following staggered thoracic lateral hemisections in adult cats. Journal of Neurophysiology. DOI
• Alain Frigon, Charly G. Lecomte. (2025). Stepping up after spinal cord injury: negotiating an obstacle during walking. Neural Regeneration Research. DOI
• Alexander N. Klishko, Jonathan Harnie, Claire E. Hanson, S. Mohammadali Rahmati, Ilya A. Rybak, Alain Frigon, Boris I. Prilutsky. (2025). Effects of spinal transection and locomotor speed on muscle synergies of the cat hindlimb. The Journal of Physiology. DOI
• Ilya A Rybak, Natalia A Shevtsova, Johannie Audet, Sirine Yassine, Sergey N Markin, Boris I Prilutsky, Alain Frigon. (2025). Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection. eLife. DOI
• Ilya A Rybak, Natalia A Shevtsova, Johannie Audet, Sirine Yassine, Sergey N Markin, Boris I Prilutsky, Alain Frigon. (2025). Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection. eLife. DOI
• Seyed Mohammadali Rahmati, Alexander N. Klishko, Ramaldo S. Martin, Nate E. Bunderson, Jeswin A. Meslie, T. Richard Nichols, Ilya A. Rybak, Alain Frigon, Thomas J. Burkholder, Boris I. Prilutsky. (2025). Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat. The Journal of Physiology. DOI
• Stephen Mari, Charly G. Lecomte, Angèle N. Merlet, Johannie Audet, Sirine Yassine, Rasha Al Arab, Jonathan Harnie, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon. (2024). Changes in intra‐ and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats. The Journal of Physiology. DOI
• Ilya A Rybak, Natalia A Shevtsova, Sergey N Markin, Boris I Prilutsky, Alain Frigon. (2024). Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback. eLife. DOI
• Ilya A Rybak, Natalia A Shevtsova, Sergey N Markin, Boris I Prilutsky, Alain Frigon. (2024). Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback. eLife. DOI
• Charly G. Lecomte, Stephen Mari, Johannie Audet, Sirine Yassine, Angèle N. Merlet, Caroline Morency, Jonathan Harnie, Claudie Beaulieu, Louis Gendron, Alain Frigon. (2023). Neuromechanical Strategies for Obstacle Negotiation during Overground Locomotion following Incomplete Spinal Cord Injury in Adult Cats. The Journal of Neuroscience. DOI
• Angèle N. Merlet, Pierre Jéhannin, Stephen Mari, Charly G. Lecomte, Johannie Audet, Jonathan Harnie, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon. (2022). Sensory Perturbations from Hindlimb Cutaneous Afferents Generate Coordinated Functional Responses in All Four Limbs during Locomotion in Intact Cats. eneuro. DOI
• Angèle N. Merlet, Jonathan Harnie, Madalina Macovei, Adam Doelman, Nathaly Gaudreault, Alain Frigon. (2021). Cutaneous inputs from perineal region facilitate spinal locomotor activity and modulate cutaneous reflexes from the foot in spinal cats. Journal of Neuroscience Research. DOI
• Jonathan Harnie, Johannie Audet, Alexander N. Klishko, Adam Doelman, Boris I. Prilutsky, Alain Frigon. (2021). The Spinal Control of Backward Locomotion. The Journal of Neuroscience. DOI
• Angèle N. Merlet, Jonathan Harnie, Madalina Macovei, Adam Doelman, Nathaly Gaudreault, Alain Frigon. (2020). Mechanically stimulating the lumbar region inhibits locomotor-like activity and increases the gain of cutaneous reflexes from the paws in spinal cats. Journal of Neurophysiology. DOI
• Jonathan Harnie, Adam Doelman, Emmanuelle de Vette, Johannie Audet, Etienne Desrochers, Nathaly Gaudreault, Alain Frigon. (2019). The recovery of standing and locomotion after spinal cord injury does not require task-specific training. eLife. DOI
• Etienne Desrochers, Jonathan Harnie, Adam Doelman, Marie‐France Hurteau, Alain Frigon. (2019). Spinal control of muscle synergies for adult mammalian locomotion. The Journal of Physiology. DOI
• Marie-France Hurteau, Alain Frigon. (2018). A Spinal Mechanism Related to Left–Right Symmetry Reduces Cutaneous Reflex Modulation Independently of Speed During Split-Belt Locomotion. The Journal of Neuroscience. DOI
• Jonathan Harnie, Célia Côté-Sarrazin, Marie-France Hurteau, Etienne Desrochers, Adam Doelman, Nawal Amhis, Alain Frigon. (2018). The modulation of locomotor speed is maintained following partial denervation of ankle extensors in spinal cats. Journal of Neurophysiology. DOI
• Marie-France Hurteau, Yann Thibaudier, Charline Dambreville, Simon M. Danner, Ilya A. Rybak, Alain Frigon. (2018). Intralimb and Interlimb Cutaneous Reflexes during Locomotion in the Intact Cat. The Journal of Neuroscience. DOI
• Victoria Kuczynski, Alessandro Telonio, Yann Thibaudier, Marie‐France Hurteau, Charline Dambreville, Etienne Desrochers, Adam Doelman, Declan Ross, Alain Frigon. (2017). Lack of adaptation during prolonged split‐belt locomotion in the intact and spinal cat. The Journal of Physiology. DOI
• Marie-France Hurteau, Yann Thibaudier, Charline Dambreville, Anass Chraibi, Etienne Desrochers, Alessandro Telonio, Alain Frigon. (2017). Nonlinear Modulation of Cutaneous Reflexes with Increasing Speed of Locomotion in Spinal Cats. The Journal of Neuroscience. DOI
• Hurteau, M.-F., Thibaudier, Y., Dambreville, C., Desaulniers, C., Frigon, A. (2015). Effect of stimulating the lumbar skin caudal to a complete spinal cord injury on hindlimb locomotion. Journal of Neurophysiology. DOI
• Frigon, A., Thibaudier, Y., Hurteau, M.-F. (2015). Modulation of forelimb and hindlimb muscle activity during quadrupedal tied-belt and split-belt locomotion in intact cats. Neuroscience. DOI
• Frigon, A. (2015). Responders and non-responders in motor control research: A framework to study physiological mechanisms of inter-individual variability. Clinical Neurophysiology. DOI
• Dambreville, C., Labarre, A., Thibaudier, Y., Hurteau, M.-F., Frigon, A. (2015). The spinal control of locomotion and step-to-step variability in left-right symmetry from slow to moderate speeds. Journal of Neurophysiology. DOI
• D’angelo, G., Thibaudier, Y., Telonio, A., Hurteau, M.-F., Kuczynski, V., Dambreville, C., Frigon, A. (2014). Modulation of phase durations, Phase variations, And temporal coordination of the four limbs during quadrupedal split-belt locomotion in intact adult cats. Journal of Neurophysiology. DOI
• Thibaudier, Y., Frigon, A. (2014). Spatiotemporal control of interlimb coordination during transverse split-belt locomotion with 1:1 or 2:1 coupling patterns in intact adult cats. Journal of Neurophysiology. DOI
• Frigon, A., D'Angelo, G., Thibaudier, Y., Hurteau, M.-F., Telonio, A., Kuczynski, V., Dambreville, C. (2014). Speed-dependent modulation of phase variations on a step-by-step basis and its impact on the consistency of interlimb coordination during quadrupedal locomotion in intact adult cats. Journal of Neurophysiology. DOI
• Thibaudier, Y., Hurteau, M.-F., Telonio, A., Frigon, A. (2013). Coordination between the fore- and hindlimbs is bidirectional, asymmetrically organized, and flexible during quadrupedal locomotion in the intact adult cat. Neuroscience. DOI
• Sirois, J., Frigon, A., Gossard, J.-P. (2013). Independent control of presynaptic inhibition by reticulospinal and sensory inputs at rest and during rhythmic activities in the cat. Journal of Neuroscience. DOI
• Frigon, A., Hurteau, M.-F., Thibaudier, Y., Leblond, H., Telonio, A., D'Angelo, G. (2013). Split-belt walking alters the relationship between locomotor phases and cycle duration across speeds in intact and chronic spinalized adult cats. Journal of Neuroscience. DOI
• Frigon, A. (2012). Central pattern generators of the mammalian spinal cord. Neuroscientist. DOI
• Sławińska, U., Rossignol, S., Bennett, D.J., Schmidt, B.J., Frigon, A., Fouad, K., Jordan, L.M. (2012). Comment on "restoring voluntary control of locomotion after paralyzing spinal cord injury". Science. DOI
• Frigon, A., Thibaudier, Y., Johnson, M.D., Heckman, C.J., Hurteau, M.-F. (2012). Cutaneous inputs from the back abolish locomotor-like activity and reduce spastic-like activity in the adult cat following complete spinal cord injury. Experimental Neurology. DOI
• Frigon, A., Johnson, M.D., Heckman, C.J. (2012). Differential modulation of crossed and uncrossed reflex pathways by clonidine in adult cats following complete spinal cord injury. Journal of Physiology. DOI
• Frigon, A., Hurteau, M.-F., Johnson, M.D., Heckman, C.J., Telonio, A., Thibaudier, Y. (2012). Synchronous and asynchronous electrically evoked motor activities during wind-up stimulation are differentially modulated following an acute spinal transection. Journal of Neurophysiology. DOI
• Frigon, A., Johnson, M.D., Heckman, C.J. (2011). Altered activation patterns by triceps surae stretch reflex pathways in acute and chronic spinal cord injury. Journal of Neurophysiology. DOI
• Frigon, A., Thompson, C.K., Johnson, M.D., Manuel, M., Hornby, T.G., Heckman, C.J. (2011). Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats. Journal of Neuroscience. DOI
• Lungu, O., Frigon, A., Piché, M., Rainville, P., Rossignol, S., Doyon, J. (2010). Changes in spinal reflex excitability associated with motor sequence learning. Journal of Neurophysiology. DOI
• Barrière, G., Frigon, A., Leblond, H., Provencher, J., Rossignol, S. (2010). Dual spinal lesion paradigm in the cat: Evolution of the kinematic locomotor pattern. Journal of Neurophysiology. DOI
• Frigon, A., Sirois, J., Gossard, J.-P. (2010). Effects of ankle and hip muscle afferent inputs on rhythm generation during fictive locomotion. Journal of Neurophysiology. DOI
• Frigon, A., Gossard, J.-P. (2010). Evidence for specialized rhythm-generating mechanisms in the adult mammalian spinal cord. Journal of Neuroscience. DOI
• Frigon, A., Barrière, G., Leblond, H., Rossignol, S. (2009). Asymmetric changes in cutaneous reflexes after a partial spinal lesion and retention following spinalization during locomotion in the cat. Journal of Neurophysiology. DOI
• Frigon, A., Gossard, J.-P. (2009). Asymmetric control of cycle period by the spinal locomotor rhythm generator in the adult cat. Journal of Physiology. DOI
• Frigon, A., Rossignol, S. (2009). Partial denervation of ankle extensors prior to spinalization in cats impacts the expression of locomotion and the phasic modulation of reflexes. Neuroscience. DOI
• Rossignol, S., Barriere, G., Alluin, O., Frigon, A. (2009). Re-expression of locomotor function after partial spinal cord injury. Physiology. DOI
• Frigon, A. (2009). Reconfiguration of the spinal interneuronal network during locomotion in vertebrates. Journal of Neurophysiology. DOI
• Frigon, A., Rossignol, S. (2008). Adaptive changes of the locomotor pattern and cutaneous reflexes during locomotion studied in the same cats before and after spinalization. Journal of Physiology. DOI
• Frigon, A., Rossignol, S. (2008). Locomotor and reflex adaptation after partial denervation of ankle extensors in chronic spinal cats. Journal of Neurophysiology. DOI
• Rossignol, S., Barrière, G., Frigon, A., Barthélemy, D., Bouyer, L., Provencher, J., Leblond, H., Bernard, G. (2008). Plasticity of locomotor sensorimotor interactions after peripheral and/or spinal lesions. Brain Research Reviews. DOI
• Frigon, A., Rossignol, S. (2008). Short-latency crossed inhibitory responses in extensor muscles during locomotion in the cat. Journal of Neurophysiology. DOI
• Frigon, A., Yakovenko, S., Gritsenko, V., Tremblay, M.-È., Barrière, G. (2008). Strengthening corticospinal connections with chronic electrical stimulation after injury. Journal of Neuroscience. DOI
• Frigon, A., Carroll, T.J., Jones, K.E., Zehr, E.P., Collins, D.F. (2007). Ankle position and voluntary contraction alter maximal M waves in soleus and tibialis anterior. Muscle and Nerve. DOI
• Frigon, A., Barrière, G., Fénélon, K., Yakovenko, S. (2007). Conceptualizing the mammalian locomotor central pattern generator with modelling. Journal of Physiology. DOI
• Frigon, A., Rossignol, S. (2007). Plasticity of reflexes from the foot during locomotion after denervating ankle extensors in intact cats. Journal of Neurophysiology. DOI
• Frigon, A., Rossignol, S. (2006). Experiments and models of sensorimotor interactions during locomotion. Biological Cybernetics. DOI
• Frigon, A., Collins, D.F., Zehr, E.P. (2004). Effect of Rhythmic Arm Movement on Reflexes in the Legs: Modulation of Soleus H-Reflexes and Somatosensory Conditioning. Journal of Neurophysiology. DOI
• Zehr, E.P., Frigon, A., Hoogenboom, N., Collins, D.F. (2004). Facilitation of soleus H-reflex amplitude evoked by cutaneous nerve stimulation at the wrist is not suppressed by rhythmic arm movement. Experimental Brain Research. DOI
• Zehr, E.P., Carroll, T.J., Chua, R., Collins, D.F., Frigon, A., Haridas, C., Hundza, S.R., Thompson, A.K. (2004). Possible contributions of CPG activity to the control of rhythmic human arm movement. Canadian Journal of Physiology and Pharmacology. DOI
• Zehr, E.P., Collins, D.F., Frigon, A., Hoogenboom, N. (2003). Neural control of rhythmic human arm movement: Phase dependence and task modulation of Hoffmann reflexes in forearm muscles. Journal of Neurophysiology. DOI

Livres

• Frigon, A. (2013). The cat model of spinal cord injury. Neuromethods. DOI
• Frigon, A. (2011). Interindividual variability and its implications for locomotor adaptation following peripheral nerve and/or spinal cord injury. Progress in Brain Research. DOI
• Rossignol, S., Frigon, A. (2011). Recovery of locomotion after spinal cord injury: Some facts and mechanisms. Annual Review of Neuroscience. DOI
• Rossignol, S., Frigon, A., Barrière, G., Martinez, M., Barthélemy, D., Bouyer, L., Bélanger, M., Provencher, J., Chau, C., Brustein, E., Barbeau, H., Giroux, N., Marcoux, J., Langlet, C., Alluin, O. (2011). Spinal plasticity in the recovery of locomotion. Progress in Brain Research. DOI
• Gossard, J.-P., Sirois, J., Noué, P., Côté, M.-P., Ménard, A., Leblond, H., Frigon, A. (2011). The spinal generation of phases and cycle duration. Progress in Brain Research. DOI
• Frigon, A., Rossignol, S. (2006). Chapter 16 Functional plasticity following spinal cord lesions. Progress in Brain Research. DOI

Autres contributions

Cours enseignés à l'UdeS

• NSC701 - Neuroanatomie et neurophysiologie fonctionnelles. (2024-2026). (2CR).
• PHS708 - Physiologie des systèmes. (2023). (2CR).