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Abdelaziz Amrani

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pédiatrie

Présentation

Sujet de recherche

Système immunitaire, Maladies du système immunitaire, Immunothérapie

Disciplines de recherche

Immunologie, Biologie cellulaire

Mots-clés

Autoimmunité, Cellules dendritiques, Cytométrie de flux, Diabète de type 1, Lymphocytes T, Lymphocytes T régulateurs, RT-PCR, ELISA, Souris transgéniques, Test de cytotoxicité, tests de prolifération

Intérêts de recherche

Étude des mécanismes cellulaires et moléculaires par lesquels les cellules dendritiques induisent la tolérance des lymphocytes T dans les maladies autoimmunes.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Arabe, Français

Diplômes

(2001). (Postdoctorat, ). The University of Calgary.

(1996). (Postdoctorat, ). The University of Calgary.

(1995). (Doctorat, ). Université de Paris VI (P & M Curie).

(1992). (Maîtrise avec mémoire, ). Université de Paris VI (P & M Curie).

Financement

  • Subvention. (En cours d’évaluation). Chercheur principal. Molecular mechanisms of dendritic cell tolerogenic function. Discovery Grants. 375 415 $. (2023-2028)
  • Subvention. (En cours d’évaluation). Candidat principal. Molecular mechanisms underlying prevention of autoimmune pathogenesis.. Instituts de Recherche en Santé du Canada (IRSC). project grant. 1 065 000 $. (2023-2028)
  • Subvention. (Obtenu). Chercheur principal. Role of tolerogenic dendritic cells in the prevention of arthritis. Ignite Innovation Grant. 100 000 $. (2023-2025)
  • Subvention. (Refusé). Candidat principal. Molecular mechanisms underlying type 1 diabetes prevention by regulatory T cells. Diabète Canada. Operating Grant - End Diabetes 2022. 300 000 $. (2022-2025)
  • Subvention. (Terminé). Candidat principal. Molecular signaling in the regulation of dendritic cell function. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Discovery Grant. 150 000 $. (2015-2020)
  • Subvention. (Terminé). Chercheur principal. Role of STAT5B in the protection against diabetes. (2013-2018)

Publications

Articles de revue

  • Farhan Ullah Khan*, Puregmaa Khongorzul*, Ahmed Aziz Raki*, Ashwini Rajasekaran*, Denis Gris and Abdelaziz Amrani*. (2022). Dendritic cells and their immunotherapeutic potential for treating type 1 diabetes. International Journal of Molecular Sciences 23 (4885), 1-22. (Article accepté).
  • Simon Gaudreau*, Farhan Ullah Khan*, Chantal Guindi*, Alexandre Cloutier, Ahmed Aziz Raki* and Abdelaziz Amrani. (2022). GM-CSF-induced Tr1 cells contribute to diabetes protection in NOD mice by regulating tolerogenic preventing dendritic cell functions. Cells NA (NA), 1-32. (Article soumis).
  • Chantal Guindi*, Farhan Ullah Khan*, Alexandre Cloutier*, Ahmed Aziz Raki*, Simon Gaudreau*, Patrick P McDonald, Denis Gris and Abdelaziz Amrani. (2022). Inhibition of PI3KC/C/EBPβ axis in tolerogenic bone marrow derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development. Translational Research DOI: 10.1016/j.trsl. (NA), 1-39. (Article accepté).
  • Marjan Gharagozloo, Abdelaziz Amrani, Kevin Whittingstall, Andrew Hamilton-Wright and Denis Gris. (2021). Machine Learning in Modelling of Mouse Behaviour. Front. Neurosci. 15 (August), 1 - 11. (Article publié).
  • Zerif E* , Khan FU*, Raki AA*, Lullier V*, Gris D, Dupuis G and Amrani A. (2020). Elucidating the role of Ezh2 in tolerogenic function in NOD bone marrow-derived dendritic cells expressing constitutively active Stat5b. International Journal of molecular Biology 21 (18), 6453. (Article publié).
  • Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Amrani , and Gris D. (2019). PLos Biology 17 (9), 1 - 30. DOI. (Article publié).
  • Marjan Gharagozloo, Katsiaryna V. Gris, Tara Mahvelati, Abdelaziz Amrani, John R. Lukens and Denis Gris. (2018). NLR-Dependent Regulation of inflammation in Multiple Sclerosis. Frontiers in Immunology 8 (January), 1-18. (Article publié).
  • Gharagozloo M, Mahmoud S, Mahvelati TM , Amrani A, and Denis Gris. (2018). Nlrp12The dual immunoregulatory function of in T Cell-mediated Immune Response. :Lessons from Experimental Autoimmune Encephalomyelitis. Cells 7 (9), 1-19. (Article publié).
  • Chantal Guindi *, Alexandre Cloutier, Simon Gaudreau *, Echarki Zerif *, Patrick McDonald, Claude Asselin, Gilles Dupuis, Denis Gris And Abdelaziz Amrani. (2018). Role of CREB/C/EBPbeta axis in the Regulation of the Phenotype and IL-10/IL-12 Production in Tolerogenic Bone Marrow-Derived Dendritic cells. Cells ?? (??), 1 - 30. (Article soumis).
  • Guindi C* , Cloutier A, Gaudreau S* , Zerif E *, McDonald PP, Tatsiy O, Asselin C, Dupuis G, Dris D' AND Amrani A. (2018). Role of the p38MAPK/C/EBP? Pathway in the regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic cells. Cells 7 (12), 256. (Article publié).
  • Zerif Echarki *, Aida Maalem *, Simon Gaudreau *, Chantal Guindi *, Muhammad Ramzan*, Steeve Véroneau, Denis Gris, Jana Stankova, Marek Rola-Pleszczynski, Walid Mourad, Gilles Dupuis and Abdelaziz Amrani. (2017). Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. Journal of Autoimmunity 76 (6), 63-74. (Article publié).
  • Chabot, Sylvie; Alvarez, Fernando; Amrani, Abdelaziz and Idriss, Djilali-Saiah. (2016). Novel model of double transgenic mouse results in autoimmune diabetes in males. Autoimmunity 49 (6), 397 - 404. (Article publié).

Articles de conférence

  • Farhan Khan*, Puregmaa Khongorzul* and Abdelaziz Amrani. (2022). Inhibition of PI3KC/CEBPbeta axis in tolerogenic bone marrow derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development. Journée Scientifique de Pédiatrie, FMSS. (Article accepté).
  • Ahmed Aziz Raki*, Farhan Ullah Khan* and Abdelaziz Amrani. (2021). Role of Methytransferase EZh2 in tolerogenic function of bone marrow derived dendritic cells in type 1 diabetes in NOD mice. 33rd Annual CSI Virtual Conference May 31 - June 2, 2021. (Article accepté).

Autres contributions

Présentations

  • Guindi C*, Khan F*, Cloutier, Gaudreau S*, and A Amrani. (2022). Dendritic Cells Use PI3K to control Treg/Th17 balance in type 1 diabetes. American Diabetes Association, 82 th scientific sessions. New Orleans, États-Unis d'Amérique
  • Farhan Khan, Puregmaa Khongorzul and Abdelaziz Amrani. (2022). Inhibition of PI3K/C/EBPbeta axis in tolerogenic bone marrow dendritic cells of NOD mice promotes Th17 differentiation and diabetes development. Journée scientifique du département de Pédiatrie. Sherbrooke, Canada
  • Ahmed-Aziz Raki*, Frahan Allah Kan*, Puregmaa Khongorzul and abdelaziz Amrani. (2022). Role of Stat5b-expressing dendritic cells in the development of intestinal inflammation in DSS-induced colitis. Scientific Meeting of the Diabetes, obesity and cardiovascular complications. Sherbrooke, Canada
  • Ahmed Raki, Farhan Ullah Khan, Puregmaa Khongorzul and Abdelaziz Amrani. (2022). Role of Stat54 expressing dendritic cells in the development of intestinal inflammation in DSS-induced colitis. 10th scientific Meeting of The Diabetes, obesity and cardiovascular complications. (DOCC) axis. Sherbrooke, Canada
  • A. Raki*, F Khan* and A. Amrani. (2021). Eluciding role of methyl transferase Ezh2 in tolerogenic function of bone marrow dendritic cells in type 1 diabetes in NOD mice. Canadian Society for Immunology 2021. Vancouver, Canada
  • Farhan Ullah Khan*, Echarki Zerif* and Abdelaziz Amrani. (2020). Role of Ezh2 in bone marrow derived tolerogenic DC function in NOD mice. Federation of Clinical Immunology Societies (FOCIS). États-Unis d'Amérique
  • Pooja Sainarayan, Echarki Zerif, Abdelaziz Amrani. (2019). Mechanisms of regulatory T cell suppression in autoimmune diabetes. Scientific Meeting of The Diabetes, obesity and cardiovascular complications. (DOCC) axis. Sherbrooke, Canada
  • (2018). Induction of Immune tolerance in autoimmune diabetes. 3rd World Congress and Expo on Immunology" (Immunology Congress-2018). Pays-Bas