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Pierre-Étienne Jacques

Professeur, Faculté des sciences

FAC. SCIENCES Biologie

Présentation

Sujet de recherche

Bioinformatique, Expression et régulation génique, Génétique du cancer, Génétique moléculaire, Génomique

Disciplines de recherche

Biologie et autres sciences connexes, Informatique

Mots-clés

Base de données, Bio-informatique, Développement d'outils, Épigénétique, Génétique, Régulation transcriptionelle, Séquençage haut-débit, Structure chromatinienne

Intérêts de recherche

Développement et utilisation d'outils bio-informatiques

Centre de recherche

Aucun

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(2010). (Post-doctorat, Post-doctorat). Institut de recherches cliniques de Montréal.

(2005). (Doctorat, Ph. D.). Université de Sherbrooke.

(1999). (Baccalauréat, B. Sc.). Université de Sherbrooke.

Publications

Articles de revue

  • Yao F , Kausalya JP , Sia YY , Teo AS , Lee WH , Ong AG , Zhang Z , Tan JH , Li G , Bertrand D , Liu X , Poh HM , Guan P , Zhu F , Pathiraja TN , Ariyaratne PN , Rao J , Woo XY , Cai S , Mulawadi FH , Poh WT , Veeravalli L , Chan CS , Lim SS , Leong ST , Neo SC , Choi PS , Chew EG , Nagarajan N , Jacques PÉ , So JB , Ruan X , Yeoh KG , Tan P , Sung WK , Hunziker W , Ruan Y , Hillmer AM. (2015). Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity. Cell reports 12 (2), 272-85. (Article publié).
  • Poulin-Laprade D , Matteau D , Jacques PÉ , Rodrigue S , Burrus V. (2015). Transfer activation of SXT/R391 integrative and conjugative elements: unraveling the SetCD regulon. Nucleic acids research 43 (4), 2045-56. (Article publié).
  • Brunelle M , Coulombe C , Poitras C , Robert MA , Markovits AN , Robert F , Jacques PÉ. (2015). Aggregate and Heatmap Representations of Genome-Wide Localization Data Using VAP, a Versatile Aggregate Profiler. Methods in molecular biology (Clifton, N.J.) 1334 273-98. (Article publié).
  • Inaki K , Menghi F , Woo XY , Wagner JP , Jacques PE , Lee YF , Shreckengast PT , Soon WW , Malhotra A , Teo AS , Hillmer AM , Khng AJ , Ruan X , Ong SH , Bertrand D , Nagarajan N , Karuturi RK , Hidalgo Miranda A , Liu ET. (2014). Systems consequences of amplicon formation in human breast cancer. Genome research (Article publié).
  • Gasmi N , Jacques PE , Klimova N , Guo X , Ricciardi A , Robert F , Turcotte B. (2014). The Switch from Fermentation to Respiration in Saccharomyces cerevisiae Is Regulated by the Ert1 Transcriptional Activator/Repressor. Genetics (Article publié).
  • Coulombe C , Poitras C , Nordell-Markovits A , Brunelle M , Lavoie MA , Robert F , Jacques PÉ. (2014). VAP: a versatile aggregate profiler for efficient genome-wide data representation and discovery. Nucleic acids research 42 (Web Server), W485-93. (Article publié).
  • Lu X , Sachs F , Ramsay L , Jacques PÉ , Göke J , Bourque G , Ng HH. (2014). The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity. Nature structural & molecular biology 21 (4), 423-5. (Article publié).
  • Trakadis YJ , Buote C , Therriault JF , Jacques PÉ , Larochelle H , Lévesque S. (2014). PhenoVar: a phenotype-driven approach in clinical genomics for the diagnosis of polymalformative syndromes. BMC medical genomics 7 22. (Article publié).
  • Lu X , Göke J , Sachs F , Jacques PÉ , Liang H , Feng B , Bourque G , Bubulya PA , Ng HH. (2013). SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nature cell biology 15 (10), 1141-52. (Article publié).
  • Jacques P-É , Jeyakani J , Bourque G. (2013). The majority of primate-specific regulatory sequences are derived from transposable elements. PLoS genetics 9 (5),
  • Nagarajan N* , Bertrand D* , Hillmer AM* , Zang ZJ* , Yao F , Jacques P-É , Teo AS , Cutcutache I , Zhang Z , Lee WH , Sia YY , Gao S , Ariyaratne PN , Ho A , Woo XY , Veeravali L , Ong CK , Deng N , Desai KV , Khor CC , Hibberd ML , Shahab A , Rao J , Wu M , Teh M , Zhu F , Chin SY , Pang B , So JB , Bourque G , Soong R , Sung WK , Teh BT , Rozen S , Ruan X , Yeoh KG , Tan PB , Ruan Y. (2012). Whole-genome reconstruction and mutational signatures in gastric cancer. Genome biology 13 (12),
  • Wollmann H , Holec S , Alden K , Clarke ND , Jacques P-É@ , Berger F@. (2012). Dynamic deposition of histone variant H3.3 accompanies developmental remodeling of the Arabidopsis transcriptome. PLoS genetics 8 (5),
  • Sansó M , Lee KM , Viladevall L , Jacques P-É , Pagé V , Nagy S , Racine A , St Amour CV , Zhang C , Shokat KM , Schwer B , Robert F , Fisher RP , Tanny JC. (2012). A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS genetics 8 (8),
  • Bataille AR* , Jeronimo C* , Jacques P-É , Laramée L , Fortin MÈ , Forest A , Bergeron M , Hanes SD , Robert F. (2012). A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes. Molecular cell 45 (2),
  • Ivanovska I , Jacques P-É , Rando OJ , Robert F , Winston F. (2011). Control of chromatin structure by spt6: different consequences in coding and regulatory regions. Molecular and cellular biology 31 (3),
  • Poschmann J , Drouin S , Jacques P-É , El Fadili K , Newmarch M , Robert F , Ramotar D. (2011). The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses. PloS one 6 (8),
  • Drouin S , Laramée L , Jacques P-É , Forest A , Bergeron M , Robert F. (2010). DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. PLoS genetics 6 (10),
  • Szilard RK* , Jacques P-É* , Laramée L , Cheng B , Galicia S , Bataille AR , Yeung M , Mendez M , Bergeron M , Robert F , Durocher D. (2010). Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nature structural & molecular biology 17 (3),
  • Hardy S* , Jacques P-É* , Gévry N , Forest A , Fortin ME , Laflamme L , Gaudreau L , Robert F. (2009). The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition. PLoS genetics 5 (10),
  • Ghazal G , Gagnon J , Jacques P-É , Landry JR , Robert F , Elela SA. (2009). Yeast RNase III triggers polyadenylation-independent transcription termination. Molecular cell 36 (1),
  • Gévry N , Hardy S , Jacques P-É , Laflamme L , Svotelis A , Robert F , Gaudreau L. (2009). Histone H2A.Z is essential for estrogen receptor signaling. Genes & development 23 (13),
  • Dubeau MP , Ghinet MG , Jacques P-É , Clermont N , Beaulieu C , Brzezinski R. (2009). Cytosine deaminase as a negative selection marker for gene disruption and replacement in the genus Streptomyces and other actinobacteria. Applied and environmental microbiology 75 (4),
  • Rufiange A* , Jacques P-É* , Bhat W , Robert F , Nourani A. (2007). Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1. Molecular cell 27 (3),
  • Rodrigue S , Brodeur J , Jacques P-É , Gervais AL , Brzezinski R , Gaudreau L. (2007). Identification of mycobacterial sigma factor binding sites by chromatin immunoprecipitation assays. Journal of bacteriology 189 (5),
  • Rodrigue S , Provvedi R , Jacques P-É , Gaudreau L , Manganelli R. (2006). The sigma factors of Mycobacterium tuberculosis. FEMS microbiology reviews 30 (6),
  • Jacques P-É , Rodrigue S , Gaudreau L , Goulet J , Brzezinski R. (2006). Detection of prokaryotic promoters from the genomic distribution of hexanucleotide pairs. BMC bioinformatics 7
  • Li H , Jacques P-É , Ghinet MG , Brzezinski R , Morosoli R. (2005). Determining the functionality of putative Tat-dependent signal peptides in Streptomyces coelicolor A3(2) by using two different reporter proteins. Microbiology (Reading, England) 151 (Pt 7),
  • Jacques P-É , Gervais AL , Cantin M , Lucier JF , Dallaire G , Drouin G , Gaudreau L , Goulet J , Brzezinski R. (2005). MtbRegList, a database dedicated to the analysis of transcriptional regulation in Mycobacterium tuberculosis. Bioinformatics (Oxford, England) 21 (10),
  • Beaucher J , Rodrigue S , Jacques P-É , Smith I , Brzezinski R , Gaudreau L. (2002). Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Molecular microbiology 45 (6),

Autres contributions

Cours enseignés

  • Introduction aux méthodes et aux données génomiques. BFT708. (2015-01-05).Université de Sherbrooke. Canada.
  • Techniques de biologie moléculaire. TSB400. (2014-01-06).Université de Sherbrooke. Canada.
  • Introduction à la bio-informatique génomique. BFT710. (2013-01-07).Université de Sherbrooke. Canada.
  • Introduction aux outils bio-informatiques. BFT402. (2012-08-28).Université de Sherbrooke. Canada.