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Pedro D'Orléans-Juste

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Présentation

Diplômes

(1987-1989). Fellow postdoctoral. Pharmacologie. William Harvey Research Institute. London, England, Royaume-Uni.
(1983-1987). Doctorat. Pharmacologie. Université de Sherbrooke. Sherbrooke, Quebec, Canada.
(1980-1983). Maîtrise. Pharmacologie. Université de Sherbrooke. Sherbrooke, Quebec, Canada.

Expériences académiques

Professeur Titulaire. (1990-). Université de Sherbrooke. Sherbrooke, Quebec, Canada.

Publications

Articles

(2025). Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood. FRONTIERS IN IMMUNOLOGY. DOI
(2024). Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution. JOURNAL OF MEDICINAL CHEMISTRY. DOI
(2023). Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model. JOURNAL OF THE AMERICAN HEART ASSOCIATION. DOI
(2023). Enhanced Extraction of Blood and Tissue Time-Activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization. INTERNATIONAL JOURNAL OF BIOMEDICAL IMAGING. DOI
(2021). Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2020). The Fifth Tomoh Masaki Award (2019) INTRODUCTION. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2019). ALTERED INHIBITION OF PLATELET AGGREGATION IN HYPERCHOLEROLEMIA IN MICE AND HUMANS. ATHEROSCLEROSIS. DOI
(2019). Endothelins in inflammatory neurological diseases. PHARMACOLOGY & THERAPEUTICS. DOI
(2019). Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2018). Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction. FRONTIERS IN PHARMACOLOGY. DOI
(2018). Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2017). Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2017). Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2017). Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2016). Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice. LIFE SCIENCES. DOI
(2016). Endothelin-1: Biosynthesis, Signaling and Vasoreactivity. ENDOTHELIUM. DOI
(2016). Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. MEDIATORS OF INFLAMMATION. DOI
(2015). Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase. BIOCHEMICAL PHARMACOLOGY. DOI
(2015). Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. VASCULAR PHARMACOLOGY. DOI
(2015). Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2015). Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLOS ONE. DOI
(2015). Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation. ANALYTICAL BIOCHEMISTRY. DOI
(2013). 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2013). Are Sildenafil Derivatives Useful Even in Unborn Males?. HYPERTENSION. DOI
(2013). Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration. PLOS ONE. DOI
(2013). Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist. BIOLOGICAL CHEMISTRY. DOI
(2013). High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2013). Pivotal Role of Mouse Mast Cell Protease 4 in the Conversion and Pressor Properties of Big-Endothelin-1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2012). 'Endothelin and bradykinin: brothers-in-arms' in Chagas vasculopathies?. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2012). Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells. NEUROPEPTIDES. DOI
(2012). Disruption of Proprotein Convertase 1/3 (PC1/3) Expression in Mice Causes Innate Immune Defects and Uncontrolled Cytokine Secretion. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI
(2012). Genetic and Pharmacological Manipulation of Urotensin II Ameliorate the Metabolic and Atherosclerosis Sequalae in Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. DOI
(2012). Heterofunctional dimer of endothelin ETA antagonist and ETB agonist "clicked" N-terminally on resin with second peptide component in solution. JOURNAL OF PEPTIDE SCIENCE.
(2012). Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death. MOLECULAR AND CELLULAR BIOLOGY. DOI
(2012). The Mouse Mast Cell Protease 4 is Involved in the Generation of Endothelin-1 in vitro and in vivo. CIRCULATION.
(2011). Nuclear membrane receptors for ET-1 in cardiovascular function. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. DOI
(2011). Peptide and Non-peptide Antagonists Targeting Endothelin Receptors in Physiology and Pathology. CURRENT PHARMACEUTICAL DESIGN. DOI
(2010). 20 Years of Endothelin Research - Part 1 - Introduction. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.
(2010). Contribution of Kinin B1 Receptor (B1R) in Diabetic Complications under Septic Shock. DIABETES.
(2010). ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2010). NTPDase1 (CD39) controls nucleotide dependent vasomotion in mouse. PURINERGIC SIGNALLING.
(2010). NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse. CARDIOVASCULAR RESEARCH. DOI
(2010). Potential Role of Endothelin-1 in Pulmonary Fibrosis From the Bench to the Clinic. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. DOI
(2010). The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2010). Tissue-Engineered Vascular Substitutes: New Models Toward Successful Small Diameter Grafts. ADVANCES IN VASCULAR MEDICINE. DOI
(2009). Chymase-Dependent Conversion of Big Endothelin-1 in the Mouse in Vivo. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2009). Design, Synthesis and Pharmacological Characterization of Fluorescein-Derived Endothelin Antagonists Bq-123 And Bq-788. PEPTIDES FOR YOUTH. DOI
(2009). Roles of endothelin ETA and ETB receptors in nociception and chemical, thermal and mechanical hyperalgesia induced by endothelin-1 in the rat hindpaw. PEPTIDES. DOI
(2009). Urotensin II Receptor Knockout Mice on an ApoE Knockout Background Fed a High-Fat Diet Exhibit an Enhanced Hyperlipidemic and Atherosclerotic Phenotype. CIRCULATION RESEARCH. DOI
(2008). Nonselective ETA/ETB-receptor blockade increases systemic blood pressure of Bio 14.6 cardiomyopathic hamsters. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2008). Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2008). Distinct modulation of the endothelin-1 pathway in iNOS-/- and eNOS-/- mice. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2008). Endothelin-1 (1-31):: From chymase-dependent synthesis to cardiovascular pathologies. VASCULAR PHARMACOLOGY. DOI
(2008). Forefronts in endothelin. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2008). Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2007). Characterization of the non-adrenergic/noncholinergic response to perivascular nerve stimulation in the double-perfused mesenteric bed of the mouse. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2007). Design, synthesis and pharmacological characterization of FITC-derived endothelin antagonists BQ-123 and BQ788. BIOPOLYMERS.
(2007). The inducible nitric-oxide synthase modulates endothelin-1-dependent release of prostacyclin and inhibition of platelet aggregation ex vivo in the mouse. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2006). A new paradigm - Calcium independent and caveolae internalization dependent release of nitric oxide by the endothelial nitric oxide synthase. CIRCULATION RESEARCH. DOI
(2006). Adventitia contribution in vascular tone:: insights from adventitia-derived cells in a tissue-engineered human blood vessel. FASEB JOURNAL. DOI
(2006). Central endothelin ETB receptors mediate IL-1-dependent fever induced by preformed pyrogenic factor and corticotropin-releasing factor in the rat. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. DOI
(2006). Chronic ethanol consumption enhances phenylephrine-induced contraction in the isolated rat aorta. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2006). ETB receptor dependent alteration in aortic responses to ET-1 in the cardiomyopathic hamster. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2006). Effect of erythropoietin on the vascular ET-1/ETB receptor system in rodents. JOURNAL OF HYPERTENSION.
(2006). Endothelin-1 causes pruritus in mice. EXPERIMENTAL BIOLOGY AND MEDICINE.
(2006). Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2006). Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. DOI
(2006). G-protein-coupled receptors, channels, and Na+-H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2006). Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. JOURNAL OF BIOLOGICAL CHEMISTRY. DOI
(2006). Tissue-engineered human vascular media produced in vitro by the self-assembly approach present functional properties similar to those of their native blood vessels. TISSUE ENGINEERING. DOI
(2005). Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. NATURE MEDICINE. DOI
(2005). A new strategy towards a high yield synthesis of the ETB receptor antagonist BQ-788. Peptides 2004, Proceedings.
(2005). Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors. PEPTIDES. DOI
(2005). Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells. PEPTIDES. DOI
(2005). Concomitant antagonism of endothelial and vascular smooth muscle cell ETB receptors for endothelin induces hypertension in the hamster. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. DOI
(2005). Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues. PEPTIDES. DOI
(2005). Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo. HYPERTENSION. DOI
(2005). Endothelin-1 as a central mediator of LPS-induced fever in rats. BRAIN RESEARCH. DOI
(2005). Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2005). Hypertensive effect of erythropoietin in the mouse with heterozygous knock-out of endothelin B receptors. HYPERTENSION.
(2005). Tissue-engineered human vascular media with a functional endothelin system. CIRCULATION. DOI
(2005). Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats. PEPTIDES. DOI
(2004). A NEW STRATEGY TOWARDS A HIGH YIELD SYNTHESIS OF THE ETB RECEPTOR ANTAGONIST BQ-788. JOURNAL OF PEPTIDE SCIENCE.
(2004). Association of endothelin with lung hemorrhage induced by immune complexes in rats. INFLAMMATION. DOI
(2004). Contractile responses of aortae from WKY and SHR to vasoconstrictors. CLINICAL AND EXPERIMENTAL HYPERTENSION. DOI
(2004). Effects of selective and non-selective endothelin receptor blockade on ET-1-induced pressor response in the hamster. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(2004). Endothelin ETB receptors inhibit articular nociception and priming induced by carrageenan in the rat knee-joint. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(2004). Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2004). Enhanced or repressed pressor responses to endothelin-1 or IRL-1620, respectively, in eNOS knockout mice. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(2004). Human urotensin-II enhances plasma extravasation in specific vascular districts in Wistar rats. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2004). Immunofluorescence revealed the presence of NHE-1 in the nuclear membranes of rat cardiomyocytes and isolated nuclei of human, rabbit, and rat aortic and liver tissues. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2004). Role of endothelins in thermal hyperalgesia to cold stimuli induced by chronic infraorbital nerve constriction in rats. FUNDAMENTAL & CLINICAL PHARMACOLOGY.
(2003). Activation of sarcolemma and nuclear membranes ET-1 receptors regulates transcellular calcium levels in heart and vascular smooth muscle cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2003). Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2003). Bradykinin induced a positive chronotropic effect via stimulation of T- and L-type calcium currents in heart cells. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2003). Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease (vol 32(12), pg 1497, 2002). INTERNATIONAL JOURNAL FOR PARASITOLOGY. DOI
(2003). Cardiovascular diseases:: new insights from knockout mice. CURRENT OPINION IN PHARMACOLOGY. DOI
(2003). Characterization of the NTPDase activities in the mesentery pre- and post-capillary circuits of the guinea pig. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2003). Isradipine prevents the development of spontaneously occurring cardiac necrosis in cardiomyopathic hamster. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2003). Synthesis and degradation of endothelin-1. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2002). Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. INTERNATIONAL JOURNAL FOR PARASITOLOGY. DOI
(2002). Comparison of the contractile and calcium-increasing properties of platelet-activating factor and endothelin-1 in the rat mesenteric artery and vein. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2002). Endothelin B receptors located on the endothelium provide cardiovascular protection in the hamster. CLINICAL SCIENCE. DOI
(2002). Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ETB receptors in the guinea pig perfused lung. CLINICAL SCIENCE. DOI
(2002). Function of the endothelinB receptor in cardiovascular physiology and pathophysiology. PHARMACOLOGY & THERAPEUTICS. DOI
(2002). Influence of indomethacin on effects of endothelin-1 on guinea pig isolated rings of common bile duct and sphincter of Oddi. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(2002). Phosphoramidon treatment improves the consequences of chagasic heart disease in mice. CLINICAL SCIENCE. DOI
(2002). Pressor and pulmonary responses to ET-1(1-31) in guinea-pigs. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2002). Role of endothelin receptors in the hypertensive state of kinin B2 knockout mice subjected to a high-salt diet. CLINICAL SCIENCE. DOI
(2002). Role of endothelin-1 receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells. CLINICAL SCIENCE. DOI
(2002). Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(2001). Role of ETB and B2 receptors in the ex vivo platelet inhibitory properties of endothelin and bradykinin in the mouse. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2000). A synopsis of ET-6 in Montreal - Preface. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(2000). Characterization and immunohistochemical localization of nucleoside triphosphate diphosphohydrolase (NTPDase) in pig adrenal glands (presence of a non-sedimentable isoform). BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. DOI
(2000). Contribution of B2 receptors for bradykinin in Arthus reaction-induced plasma extravasation in wild-type or B2 transgenic knockout mice. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2000). Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (±) knockout mice. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(2000). ETB receptor blockade potentiates the pressor response to big endothelin-1 but not big endothelin-2 in the anesthetized rabbit. HYPERTENSION. DOI
(2000). Endothelin-1 induces an endothelin-A-receptor-dependent and L-NAME-sensitive vasoconstriction in the isolated perfused guinea-pig kidney. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(2000). Endothelin-1 regulates cytosolic and nuclear Ca2+ in human endocardial endothelium. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(2000). Endothelin-1-induced ETA receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ETB receptor activation. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(2000). Endothelin-B-receptors-dependent-inhibition of platelet aggregation in the CD-1 mouse. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(2000). Heterozygous knock-out of ETB receptors induces BQ-123-sensitive hypertension in the mouse. HYPERTENSION. DOI
(2000). Influences of indomethacin on contractions induced by endothelins in guinea pig isolated gallbladder. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(2000). Nitric oxide relaxes the vascular smooth muscle independently of endothelin-1-and U46619-induced intracellular increase of calcium. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(2000). Novel inhibitors of nucleoside triphosphate diphosphohydrolases: Chemical synthesis and biochemical and pharmacological characterizations. JOURNAL OF MEDICINAL CHEMISTRY. DOI
(2000). Presence of functional endothelin-1 receptors in nuclear membranes of human aortic vascular smooth muscle cells. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(2000). Receptors mediating endothelin-1-induced contractions of rabbit gallbladder. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1999). Cytokine-induced free radicals and their roles in myocardial dysfunctions. CARDIOVASCULAR RESEARCH. DOI
(1999). Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. DOI
(1999). Nitric oxide limits the eicosanoid-dependent bronchoconstriction and hypotension induced by endothelin-1 in the guinea-pig. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1998). Articular nociception induced by endothelin-1, carrageenan and LPS in naive and previously inflamed knee-joints in the rat: inhibition by endothelin receptor antagonists. PAIN. DOI
(1998). Effects of endothelin-1 on capsaicin-induced nociception in mice. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1998). Effects of endothelin-1 on inflammatory incapacitation of the rat knee joint. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1998). Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein. MOLECULAR AND CELLULAR BIOCHEMISTRY. DOI
(1998). Endothelin-1 selectively potentiates the purinergic component of sympathetic neurotransmission in rat seminal vesicle. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1998). Endothelin-B receptor-dependent modulation of the pressor and prostacyclin-releasing properties of dynamically converted big endothelin-1 in the anesthetized rabbit. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1998). Essential role for endothelin ETB receptors in fever induced by LPS (E-coli) in rats. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1998). Essential role for endothelin ETB receptors in fever induced by LPS (E-coli) in rats. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.
(1998). L-NAME potentiates endothelin-stimulated thromboxane release from guinea pig lung. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1998). Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1998). Role for endothelins in articular nociception caused by LPS in the previously inflamed knee-joint of rats. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.
(1998). Taurine indirectly increases [Ca]i by inducing Ca2+ influx through the Na+-Ca2+ exchanger. MOLECULAR AND CELLULAR BIOCHEMISTRY. DOI
(1997). DNA antisense strategies in the study of receptors for vasoactive peptides, and of growth and wound-healing factors. MOLECULAR AND CELLULAR BIOCHEMISTRY. DOI
(1997). Drug development, new compounds, clinical applications and perspectives on peptide receptors. DRUG NEWS & PERSPECTIVES.
(1997). ETB receptor and nitric oxide synthase blockade induce BQ-123-sensitive pressor effects in the rabbit. HYPERTENSION. DOI
(1997). Effect of neuropeptide Y on bradykinin-induced release of prostacyclin and thromboxane from guinea pig perfused lung. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1997). Endothelins potentiate formalin-induced nociception and paw edema in mice. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1997). Influence of endothelin ETA and ETB receptor antagonists on endothelin-induced contractions of the guinea pig isolated gall bladder. REGULATORY PEPTIDES. DOI
(1997). Modulation of endothelin production and metabolism in guinea-pig tracheal epithelial cells by peptidase inhibitors. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. DOI
(1997). Nuclear membrane receptors and channels:: Potential therapeutical targets for drug action. DRUG DEVELOPMENT RESEARCH. DOI
(1997). Pharmacology of kinins in the arterial and venous mesenteric bed of normal and B-2 knockout transgenic mice. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1997). Pharmacology of two novel mixed ET(A)/ET(B) receptor antagonists, BQ-928 and 238, in the carotid and pulmonary arteries and the perfused kidney of the rabbit. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1997). Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo. EUROPEAN JOURNAL OF BIOCHEMISTRY. DOI
(1997). Role of neutral endopeptidases in diabetic-mediated capillary dysfunctions in the rat. THERAPIE.
(1997). The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. MOLECULAR AND CELLULAR BIOCHEMISTRY. DOI
(1996). Characterization of endothelin receptors in the human umbilical artery and vein. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1996). Comparison of the pre- and post-capillary vascular reactivity in the rat and guinea pig perfused mesenteric bed. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1996). ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells: Synergistic effect of IL-1. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. DOI
(1996). Endothelial and smooth muscle pharmacology of pre- and post capillary microcirculation: Correlation with plasma extravasation. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. DOI
(1996). Endothelin cardiovascular pharmacology and pathophysiology. M S-MEDECINE SCIENCES. DOI
(1996). Endothelin cardiovascular pharmacology and pathophysiology (vol 12, pg 567, 1996). M S-MEDECINE SCIENCES.
(1996). Guinea pig Clara cells secrete endothelin 1 through a phosphoramidon-sensitive pathway. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. DOI
(1996). Hydrolysis of P-2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase. BIOCHEMICAL PHARMACOLOGY. DOI
(1996). Modulation of Ca2+ and Na+ transport by taurine in heart and vascular smooth muscle. TAURINE 2.
(1996). Pharmacology of endothelins: Vascular preparations for studying ET(A) and ET(B) receptors. MOLECULAR AND CELLULAR BIOCHEMISTRY.
(1996). Receptor and mechanism that mediate endothelin- and big endothelin-1-induced phosphoinositide hydrolysis in the rat spinal cord. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1996). Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1995). CHARACTERIZATION OF ENDOTHELIN RECEPTORS AND ENDOTHELIN-CONVERTING ENZYME-ACTIVITY IN THE RABBIT LUNG. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). CHARACTERIZATION OF RECEPTORS FOR ENDOTHELINS IN THE GUINEA-PIG MESENTERIC VASCULATURE. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). CHARACTERIZATION OF RECEPTORS FOR KININS AND NEUROKININS IN THE ARTERIAL AND VENOUS MESENTERIC VASCULATURES OF THE GUINEA-PIG. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1995). CHARACTERIZATION OF THE ENDOTHELIN-CONVERTING ENZYME IN GUINEA-PIG UPPER BRONCHUS. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). DEXAMETHASONE AND PHOSPHORAMIDON INHIBIT ENDOTHELIN RELEASE BY CULTURED NONCILIATED BRONCHIOLAR EPITHELIAL (CLARA) CELLS. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). DIFFERENT PRESSOR AND BRONCHOCONSTRICTOR PROPERTIES OF HUMAN BIG-ENDOTHELIN-1, BIG-ENDOTHELIN-2(1-38) AND BIG-ENDOTHELIN-3 IN KETAMINE XYLAZINE-ANESTHETIZED GUINEA-PIGS. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1995). EFFECTS AND MECHANISMS OF ACTION OF ENDOTHELINS ON NONVASCULAR SMOOTH-MUSCLE OF THE RESPIRATORY, GASTROINTESTINAL AND UROGENITAL TRACTS. REGULATORY PEPTIDES. DOI
(1995). ENDOTHELIN-1 ACTIVATES THE R-TYPE CA2+ CHANNEL IN VASCULAR SMOOTH-MUSCLE CELLS. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). ENDOTHELIN-1 AND THROMBIN SYNERGISTICALLY STIMULATE IL-6 MESSENGER-RNA EXPRESSION AND PROTEIN-PRODUCTION IN HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). ENDOTHELIN-1 CONTRACTS AND INCREASES MOTOR-RESPONSES TO ATP IN RAT SEMINAL-VESICLE. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). ENDOTHELINS STIMULATE PHOSPHOINOSITIDE BREAKDOWN IN THE RAT SPINAL-CORD THROUGH ET(A) RECEPTORS. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). ET(A) RECEPTOR ANTAGONISTS INHIBIT ALLERGIC INFLAMMATION IN THE MOUSE. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). EVIDENCE FOR ATYPICAL ENDOTHELIN RECEPTORS AND FOR PRESENCE OF ENDOTHELIN-CONVERTING ENZYME-ACTIVITY IN THE MOUSE ISOLATED VAS-DEFERENS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1995). FUNCTION AND INHIBITION OF DISTINCT PULMONARY AND RENAL ENDOTHELIN-CONVERTING ENZYMES. HYPERTENSION.
(1995). HYPERRESPONSIVENESS TO ET-1 AFTER TREATMENT WITH A MIXTURE OF ET(A) AND ET(B) RECEPTOR ANTAGONISTS IN THE RABBIT IN-VIVO AND IN-VITRO. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). INHIBITION OF CONVERTASE-RELATED PROCESSING OF PROENDOTHELIN-1. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). NEUTRAL ENDOPEPTIDASE INHIBITION, A NEW APPROACH IN THE EXPLORATION OF DIABETIC VASCULOPATHY IN RATS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1995). PHARMACOLOGICAL PROPERTIES OF ENDOTHELINS AND BIG ENDOTHELINS IN KETAMINE XYLAZINE OR URETHANE-ANESTHETIZED RATS. AMERICAN JOURNAL OF HYPERTENSION. DOI
(1995). PROCESSING OF PROENDOTHELIN-1 BY HUMAN FURIN CONVERTASE. FEBS LETTERS. DOI
(1995). R-TYPE CALCIUM-CHANNEL INVOLVED IN ENDOTHELIN-1-INDUCED CONTRACTION OF RABBIT AORTA. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1995). RAT ADRENOMEDULLIN INDUCES A SELECTIVE ARTERIAL VASODILATION VIA CGRP(1) RECEPTORS IN THE DOUBLE-PERFUSED MESENTERIC BED OF THE RAT. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1995). [PHE(22)]-BIG ENDOTHELIN-1[19-37] - A NEW AND POTENT INHIBITOR OF THE ENDOTHELIN-CONVERTING ENZYME. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1994). BLOCK OF ENDOTHELIN-1-INDUCED RELEASE OF THROMBOXANE A(2) FROM THE GUINEA-PIG LUNG AND NITRIC-OXIDE FROM THE RABBIT KIDNEY BY A SELECTIVE ET(B) RECEPTOR ANTAGONIST, BQ-788. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1994). CARDIOVASCULAR EFFECTS OF INTRATHECALLY ADMINISTERED ENDOTHELINS AND BIG ENDOTHELIN-1 IN CONSCIOUS RATS - RECEPTOR CHARACTERIZATION AND MECHANISM OF ACTION. BRAIN RESEARCH. DOI
(1994). NEUTRAL ENDOPEPTIDASE INHIBITORS AND DIABETIC VASCULOPATHY. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY.
(1994). ROLE OF R-TYPE CALCIUM CHANNELS IN THE RESPONSE OF THE PERFUSED ARTERIAL AND VENOUS MESENTERIC VASCULATURE OF THE RAT TO PLATELET-ACTIVATING-FACTOR. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1993). A NOVEL TYPE OF ANGIOTENSIN-II RECEPTOR MEDIATING INHIBITION OF PHOSPHOLIPASE-C IN BOVINE AORTIC ENDOTHELIAL-CELLS. FASEB JOURNAL.
(1993). A POTENT AND LONG-ACTING NK-1 SELECTIVE AGONIST. LIFE SCIENCES. DOI
(1993). BIG-ENDOTHELIN-1 CONTRACTS RAT ISOLATED UTERUS VIA A PHOSPHORAMIDON-SENSITIVE ENDOTHELIN-ET(A) RECEPTOR-MEDIATED MECHANISM. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1993). CHARACTERIZATION OF RECEPTORS FOR ENDOTHELINS IN THE PERFUSED ARTERIAL AND VENOUS MESENTERIC VASCULATURES OF THE RAT. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1993). CONVERSION OF BIG ENDOTHELIN-1 IN RAT UTERUS CAUSES CONTRACTION MEDIATED BY ETA RECEPTORS. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1993). ENDOTHELIN-1 INDUCES VASOCONSTRICTION AND PROSTACYCLIN RELEASE VIA THE ACTIVATION OF ENDOTHELIN ET(A) RECEPTORS IN THE PERFUSED RABBIT KIDNEY. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1993). ENDOTHELINS - CIRCULATING PLASMA-LEVELS AND PRESENCE IN OTHER BIOLOGIC FLUIDS. LABORATORY INVESTIGATION.
(1993). ET(A)-DEPENDENT PRESSOR EFFECTS AND RELEASE OF PROSTACYCLIN INDUCED BY ENDOTHELINS IN PULMONARY AND RENAL VASCULATURE. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1993). GROWTH REGULATORY PROPERTIES OF ENDOTHELINS. PEPTIDES. DOI
(1993). INCREASED PLASMA-LEVELS OF ENDOTHELIN DURING ANAPHYLACTIC SHOCK IN THE GUINEA-PIG. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1993). PAF ACTIVATION OF A VOLTAGE-GATED R-TYPE CA(2+) CHANNEL IN HUMAN AND CANINE AORTIC ENDOTHELIAL-CELLS. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1993). PHARMACOLOGICAL EVIDENCE FOR THE SPECIFICITY OF THE PHOSPHORAMIDON-SENSITIVE ENDOTHELIN-CONVERTING ENZYME FOR BIG ENDOTHELIN-1. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1993). PRESENCE OF FURIN MESSENGER-RNA IN CULTURED BOVINE ENDOTHELIAL-CELLS AND POSSIBLE INVOLVEMENT OF FURIN IN THE PROCESSING OF THE ENDOTHELIN PRECURSOR. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1993). SUBSTANCE-P (NK-1 RECEPTOR) ANTAGONISTS - INVIVO AND INVITRO ACTIVITIES IN RATS AND GUINEA-PIGS. LIFE SCIENCES. DOI
(1993). VASOACTIVE PEPTIDES AND CHARACTERIZATION OF THEIR RECEPTORS. REGULATORY PEPTIDES. DOI
(1993). VASOACTIVE PEPTIDES AND CHARACTERIZATION OF THEIR RECEPTORS (VOL 45, PG 323, 1993). REGULATORY PEPTIDES.
(1992). CHARACTERIZATION OF ENDOTHELIN-CONVERTING ENZYME FROM ENDOTHELIAL-CELLS AND RAT-BRAIN - DETECTION OF THE FORMATION OF BIOLOGICALLY-ACTIVE ENDOTHELIN-1 BY RAPID BIOASSAY. MOLECULAR PHARMACOLOGY.
(1992). COMPARISON OF THE RELEASE OF VASOACTIVE FACTORS FROM VENOUS AND ARTERIAL BOVINE CULTURED ENDOTHELIAL-CELLS. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1992). ENDOTHELINS AND THE LUNG. M S-MEDECINE SCIENCES. DOI
(1992). HUMAN BIG-ENDOTHELIN-1 AND ENDOTHELIN-1 RELEASE PROSTACYCLIN VIA THE ACTIVATION OF ET1 RECEPTORS IN THE RAT PERFUSED LUNG. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1992). NONADRENERGIC AND NONCHOLINERGIC ARTERIAL DILATATION AND VENOCONSTRICTION ARE MEDIATED BY CALCITONIN GENE-RELATED PEPTIDE(1) AND NEUROKININ-1 RECEPTORS, RESPECTIVELY, IN THE MESENTERIC VASCULATURE OF THE RAT AFTER PERIVASCULAR NERVE-STIMULATION. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.
(1992). PHOSPHORAMIDON BLOCKS BIG-ENDOTHELIN-1 BUT NOT ENDOTHELIN-1 ENHANCEMENT OF VASCULAR-PERMEABILITY IN THE RAT. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1992). PHOSPHORAMIDON-SENSITIVE EFFECTS OF BIG ENDOTHELINS IN THE PERFUSED RABBIT KIDNEY. HYPERTENSION. DOI
(1992). PHOSPHORAMIDON-SENSITIVE EFFECTS OF HUMAN BIG-ENDOTHELIN-1 ON PLASMA EXTRAVASATION IN CONSCIOUS RATS. BRITISH JOURNAL OF PHARMACOLOGY.
(1991). DIFFERENT PHARMACOLOGICAL PROFILES OF BIG-ENDOTHELIN-3 AND BIG-ENDOTHELIN-1 INVIVO AND INVITRO. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1991). DUP-753 IS A SPECIFIC ANTAGONIST FOR THE ANGIOTENSIN RECEPTOR. HYPERTENSION. DOI
(1991). ENDOTHELIN-1 AND BIG ENDOTHELIN CAUSE SUBARACHNOID HEMORRHAGE IN THE ANESTHETIZED RABBIT. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY.
(1991). HUMAN BIG ENDOTHELIN RELEASES PROSTACYCLIN INVIVO AND INVITRO THROUGH A PHOSPHORAMIDON-SENSITIVE CONVERSION TO ENDOTHELIN-1. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1991). NEUROKININ AGONISTS AND ANTAGONISTS. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. DOI
(1991). NEUROKININS PRODUCE SELECTIVE VENOCONSTRICTION VIA NK-3 RECEPTORS IN THE RAT MESENTERIC VASCULAR BED. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1991). PRESENCE OF A PHOSPHORAMIDON-SENSITIVE ENDOTHELIN-CONVERTING ENZYME WHICH CONVERTS BIG-ENDOTHELIN-1, BUT NOT BIG-ENDOTHELIN-3, IN THE RAT VAS-DEFERENS. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.
(1990). ENDOTHELIN-1 AND U46619 POTENTIATE SELECTIVELY THE VENOUS RESPONSES TO NERVE-STIMULATION WITHIN THE PERFUSED SUPERIOR MESENTERIC VASCULAR BED OF THE RAT. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. DOI
(1990). EXOGENOUS HUMAN BIG-ENDOTHELIN IS CONVERTED TO ENDOTHELIN-1 IN THE RABBIT INVIVO. BRITISH JOURNAL OF PHARMACOLOGY.
(1990). VASOACTIVE PEPTIDES AND THEIR RECEPTORS. BLOOD VESSELS.
(1989). ENDOTHELIN-1 CONTRACTS ISOLATED VESSELS INDEPENDENTLY OF DIHYDROPYRIDINE-SENSITIVE CA-2+ CHANNEL ACTIVATION. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1989). KININS ACT ON B1 OR B2 RECEPTORS TO RELEASE CONJOINTLY ENDOTHELIUM-DERIVED RELAXING FACTOR AND PROSTACYCLIN FROM BOVINE AORTIC ENDOTHELIAL-CELLS. BRITISH JOURNAL OF PHARMACOLOGY. DOI
(1989). PHARMACOLOGY OF ENDOTHELIN-1 IN ISOLATED VESSELS - EFFECT OF NICARDIPINE, METHYLENE-BLUE, HEMOGLOBIN, AND GOSSYPOL. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. DOI
(1989). RECEPTORS FOR SUBSTANCE-P AND RELATED NEUROKININS. PHARMACOLOGY. DOI
(1989). SELECTIVE AGONISTS FOR RECEPTORS OF SUBSTANCE-P AND RELATED NEUROKININS. BIOPOLYMERS. DOI
(1988). BRADYKININ ANTAGONISM - DIFFERENTIATION BETWEEN PEPTIDE ANTAGONISTS AND ANTIINFLAMMATORY AGENTS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1988). CHARACTERIZATION OF KININ RECEPTORS ON BOVINE AORTIC ENDOTHELIAL-CELLS. BRITISH JOURNAL OF PHARMACOLOGY.
(1988). NEUROKININ SELECTIVE AGONISTS - DISCOVERY AND PHARMACOLOGIC APPLICATIONS. REGULATORY PEPTIDES. DOI
(1988). PRESSOR EFFECTS OF CIRCULATING ENDOTHELIN ARE LIMITED BY ITS REMOVAL IN THE PULMONARY CIRCULATION AND BY THE RELEASE OF PROSTACYCLIN AND ENDOTHELIUM-DERIVED RELAXING FACTOR. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
(1988). RECEPTORS FOR NEUROKININS, TACHYKININS, AND BOMBESIN - A PHARMACOLOGICAL STUDY. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES. DOI
(1987). CHARACTERIZATION OF NEUROKININ RECEPTORS IN VARIOUS ISOLATED ORGANS BY THE USE OF SELECTIVE AGONISTS. LIFE SCIENCES. DOI
(1987). H-3 NEUROKININ A LABELS A SPECIFIC TACHYKININ-BINDING SITE IN THE RAT DUODENAL SMOOTH-MUSCLE. MOLECULAR PHARMACOLOGY.
(1987). INTERACTION OF TACHYKININS WITH THEIR RECEPTORS STUDIED WITH CYCLIC ANALOGS OF SUBSTANCE-P AND NEUROKININ-B. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. DOI
(1987). PHARMACOLOGICAL RECEPTORS FOR SUBSTANCE-P AND NEUROKININS. LIFE SCIENCES. DOI
(1987). RECEPTORS FOR SUBSTANCE-P AND NEUROKININS - CORRELATION BETWEEN BINDING AND BIOLOGICAL-ACTIVITIES. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1987). SELECTIVE AGONISTS FOR SUBSTANCE-P AND NEUROKININ RECEPTORS. NEUROPEPTIDES. DOI
(1987). SPECIFIC AGONISTS FOR NEUROKININ B-RECEPTORS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1987). THE RAT ISOLATED PORTAL-VEIN - A PREPARATION SENSITIVE TO NEUROKININS, PARTICULARLY NEUROKININ-B. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1986). CONVERSION OF KININS AND THEIR ANTAGONISTS INTO-B-1 RECEPTOR ACTIVATORS AND BLOCKERS IN ISOLATED VESSELS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1986). DIFFERENT RECEPTORS ARE INVOLVED IN THE ENDOTHELIUM-MEDIATED RELAXATION AND THE SMOOTH-MUSCLE CONTRACTION OF THE RABBIT PULMONARY-ARTERY IN RESPONSE TO SUBSTANCE-P AND RELATED NEUROKININS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1986). THE ACTIONS OF KININ ANTAGONISTS ON B-1 AND B-2 RECEPTOR SYSTEMS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1985). ACTIVITIES AND ANTAGONISM OF BOMBESIN ON URINARY SMOOTH MUSCLES. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1985). EFFECTS OF PEPTIDES AND NON-PEPTIDES ON ISOLATED ARTERIAL SMOOTH MUSCLES - ROLE OF ENDOTHELIUM. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1985). SUBSTANCE-P ANTAGONISTS SHOWING SOME SELECTIVITY FOR DIFFERENT RECEPTOR TYPES. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1985). TACHYKININ RECEPTORS IN SMOOTH MUSCLES - A STUDY WITH AGONISTS (SUBSTANCE-P, NEUROKININ-A) AND ANTAGONISTS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1984). A SUBSTANCE-P ANTAGONIST NOT CONTAINING D-TRYPTOPHAN. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1984). NEW AGONIST AND ANTAGONIST ANALOGS OF BRADYKININ. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1984). PARTIAL AGONISTS AND ANTAGONISTS FOR SUBSTANCE-P. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1984). RECEPTORS FOR SUBSTANCE-P .1. THE PHARMACOLOGICAL PREPARATIONS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1984). RECEPTORS FOR SUBSTANCE-P .2. CLASSIFICATION BY AGONIST FRAGMENTS AND HOMOLOGS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1984). RECEPTORS FOR SUBSTANCE-P .3. CLASSIFICATION BY COMPETITIVE ANTAGONISTS. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1984). UNDECA-PEPTIDE AND OCTA-PEPTIDE ANTAGONISTS FOR SUBSTANCE-P, A STUDY ON THE GUINEA-PIG TRACHEA. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1983). PARTIAL AGONISTS AND ANTAGONISTS FOR SUBSTANCE-P. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1982). ANTAGONISTS OF SUBSTANCE-P. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI
(1982). DIRECT AND INDIRECT EFFECTS OF SUBSTANCE-P ON SMOOTH MUSCLES. FEDERATION PROCEEDINGS.
(1982). EFFECTS OF KININS ON ISOLATED BLOOD-VESSELS - ROLE OF ENDOTHELIUM. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. DOI
(1982). EFFECTS OF PEPTIDES AND AMINES ON ISOLATED GUINEA-PIG TRACHEAE AS INFLUENCED BY INHIBITORS OF THE METABOLISM OF ARACHIDONIC-ACID. PHARMACOLOGY. DOI
(1982). SUBSTANCE ANTAGONISTS ACTIVE INVITRO AND INVIVO. EUROPEAN JOURNAL OF PHARMACOLOGY. DOI

Propriétés intellectuelles

Brevets

Pedro D'Orléans-Juste. Discovery and Development of Specific R-Type Calcium Channel Blockers (European Patent Delivered in 2005; US Patent Delivered in 2006). 217088. (2005).

Autres contributions

Cours enseignés ou supervisés à l'UdeS

PHR502 - Pharmacologie cardiovasculaire. (2023-2026). (3CR).

Présentations

Pedro D'Orléans-Juste. (2017). Surprenante réponse cardiovasculaire aux agents vasoactifs chez la souris consciente et non restreinte. Présentation donnée à l'Institut de Cardiologie de Montréal, Montréal. Canada.
Pedro D'Orléans-Juste. (2016). New Indications for Endothelin Antagonists in Cardiovascular Diseases. 4th Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators, Sherbrooke. Canada.
Pedro D'Orléans-Juste. (2016). Role of Chymases in Cardiovascular Diseases. Invited Speaker at the Cuban Cardiology Society Meeting, Havanna. Cuba.
Pedro D'Orléans-Juste. (2016). Roles of Chymases in Mouse Models of Heart Failure and Atherosclerosis. Annual Conference of the Institute of Cardiovascular Sciences, St-Boniface Hospital Research Centre, Winnipeg. Canada.
Pedro D'Orléans-Juste. (2015). Endothelins in Cardiovascular Diseases: Established and Emerging Targets. Annual Meeting of the International Academy of Cardiovascular Sciences (IACS): North American Section, Omaha. États-Unis.
Pedro D'Orléans-Juste. (2015). Is There a Role for Mast Cells Dependent Synthesis of Endothelin 1 in Neurodegenerative Diseases?. 5th International Society for Neurovascular Disease (ISNVD) Meeting, Naples. Italie.