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Pedro D'Orléans-Juste

Professeur, Faculté de médecine et des sciences de la santé

FMSS Département de pharmacologie-physiologie


Sujet de recherche

Hypertension artérielle, Insuffisance cardiaque, Prothèses et substituts vasculaires, Système cardiovasculaire

Disciplines de recherche



Endothéline, endothélium, Enzymologie, microscopie confocale, organes perfusés, pharmacologie in vivo

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Espagnol (castillan), Français, Haïtien (créole haïtien), Portuguais


(1987). (Doctorat, Ph. D.). Université de Sherbrooke.

(1983). (Maîtrise avec mémoire, Maîtrise - Maîtrise). Université de Sherbrooke.

(1980). (Baccalauréat, Baccalauréat). Bishop's University.

Titres de compétence

(2015) Directeur.

Prix et distinctions

  • (2019) John C. Edwards Research Chair. (Prix / Récompense).
  • Among the 100 most cited pharmacologists worldwide in the last decade (1992-2002). (Distinction).
  • F1000 Prime for the manuscript by Houde et al.,'Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1., The Journal of Pharmacology and Experimental Therapeutics, 2013 (DOI: 10.3410/f.718003609.793475. (Distinction).
  • Prix Coeur Québec 2008. (Distinction).
  • Prix Rayonnement. (Distinction).


Articles de revue

  • Julie Boucher, Élie Simard; Ulrike Froehlich; Pedro D'Orléans-Juste ; Michel Grandbois. (2015). USING CARBOXYFLUORESCEIN DIACETATESUCCINIMIDYL ESTER TO MONITOR THE GLYCATION OF PROTEINS INVOLVED IN CELLCONTRACTION. Analytical Biochemistry: Methods in the Biological Sciences 478 73-81. (Article publié).
  • D'Orleans-Juste, P., Houde, M., Desbiens, L., Lo, Modou. (2015). Endothelium-derived ET-1, synthesis and vascular ETA and ETB receptors. Vascular Pharmacology (Article accepté).
  • Elie Simard , Thomas Söllradl , Jean-Sébastien Maltais , Julie Boucher , Pédro D’Orléans-Juste and Michel Grandbois. (2015). Activation of receptor for advanced glycation end-products interfere with the expression of the vascular smooth muscle cell contractile phenotype. PLOS One (Article sous presse).
  • Janaina A. Simplicio, Leonardo B. Resstel, Daniela P.C. Tirapelli, Pedro D’Orléans-Juste, Carlos R. Tirapelli. (2015). Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vascular Pharmacology (Article accepté).
  • Ghassan Bkaily, Levon Avedanian, Johny Al-Khoury, Marc Chamoun, Rana Semaan, Cynthia Jubinville-Leblanc, Pedro D'Orleans-Juste, Danielle Jacques. (2015). Nuclear membranes R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology 93 ((4)), 291-7. (Article accepté).
  • Walid Semaan, Louisane Desbiens, Martin Houde, Julie Labonté, Hugo Gagnon, Daisuke Yamamoto, Shinji Takai, Tanya Laidlaw, Ghassan Bkaily, Adel Schwertani, Gunnar Pejler, Christine Levesque, Roxane Desjardins, Robert Day, Pedro D'Orléans-Juste. (2014). CHYMASE INHIBITOR-SENSITIVE SYNTHESIS OF ENDOTHELIN-1 (1-31) BY RECOMBINANT MOUSE MAST CELL PROTEASE 4 OR HUMAN CHYMASE. Biochemical Pharmacology 94 ((2)), 91-100. (Article accepté).
  • D'Orléans-Juste P , Houde M , Semaan W. (2013). Are Sildenafil Derivatives Useful Even in Unborn Males?. Hypertension (Article publié).
  • Brochu I , Houde M , Desbiens L , Simard E , Gobeil F , Semaan W , Bkaily G , D'Orléans-Juste P. (2013). high salt induced hypertension in B2 knockout mice is corrected by the ETA ANTAGONIST, a127722. British journal of pharmacology (Article publié).
  • Alexa N. Bramall, Michael J. Szego1, Laura R. Pacione, Inik Chang, Eduardo Diez, Pedro D’Orleans-Juste, Duncan J. Stewart, William W. Hauswirth, Masashi Yanagisawa, Roderick R. McInnes. (2013). Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration. PLOS-1 (In press) (Article publié).
  • Houde M , Jamain MD , Labonte J , Desbiens L , Pejler G , Gurish M , Takai S , D'Orleans-Juste P. (2013). PIVOTAL ROLE OF MOUSE MAST CELL PROTEASE 4 IN THE CONVERSION AND PRESSOR PROPERTIES OF BIG-ENDOTHELIN-1. The Journal of pharmacology and experimental therapeutics (Article publié).
  • Savard M, Labonté J, Dubuc C, Neugebauer W, D'Orléans-Juste P, Gobeil F. (2013). Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist. Biological Chemistry 394 (3), (Article publié).
  • Bkaily G , Nader M , Avedanian L , Choufani S , Jacques D , D'Orléans-Juste P , Gobeil F , Chemtob S , Al-Khoury J. (2013). G-protein-coupled receptors, channels, and Na+-H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. Canadian journal of physiology and pharmacology 84 (3-4), (Article publié).
  • Joanna Lecka, Irina Gillerman, Michel Fausther, Mabrouka Salem, Mercedes N. Munkonda, Jean-Philippe Brosseau, Christine Cadot, Mireia Martín-Satué1, Pedro d'Orléans-Juste, Éric Rousseau, Donald Poirier, Beat Künzli, Bilha Fischer and Jean Sévigny. (2013). 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. British Journal of Pharmacology (In press) (Article publié).
  • Bkaily G , Nader M , Avedanian L , Jacques D , Perrault C , Abdel-Samad D , D'Orléans-Juste P , Gobeil F , Hazzouri KM. (2013). Immunofluorescence revealed the presence of NHE-1 in the nuclear membranes of rat cardiomyocytes and isolated nuclei of human, rabbit, and rat aortic and liver tissues. Canadian journal of physiology and pharmacology 82 (8-9), (Article publié).
  • Martin Houde, Walid Semaan, Giles Rae, Pedro D’Orléans-Juste. (2012). GPCR models of pain in cardiovascular diseases: Contributions of kinins and endothelins. Drug Discovery Today: Disease Models 9 (3), (Article publié).
  • You Z , Genest J , Barrette PO , Hafiane A , Behm DJ , D'Orleans-Juste P , Schwertani AG. (2012). Genetic and Pharmacological Manipulation of Urotensin II Ameliorate the Metabolic and Atherosclerosis Sequalae in Mice. Arteriosclerosis, thrombosis, and vascular biology (Article publié).
  • D'Orléans-Juste P , Bkaily G , Rae GA. (2012). Endothelin and bradykinin: 'brothers-in-arms' in Chagas vasculopathies?. British journal of pharmacology 165 (5), (Article publié).
  • Abdel-Samad D, Perreault C, Ahmarani L, Avedanian L, Bkaily G, Magder S, D'Orléans-Juste P, Jacques D. (2012). Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells. Neuropeptides 46 (6), (Article publié).
  • Bkaily G , Avedanian L , Al-Khoury J , Provost C , Nader M , D'Orléans-Juste P , Jacques D. (2011). Nuclear membrane receptors for ET-1 in cardiovascular function. American journal of physiology. Regulatory, integrative and comparative physiology 300 (2), (Article publié).
  • Kauffenstein G , Fürstenau CR , D'Orléans-Juste P , Sévigny J. (2011). The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation. British journal of pharmacology 159 (3), (Article publié).
  • Houde, M , Labonté J , D'Orléans-Juste P. (2011). Peptide and non-peptide antagonists targeting endothelin receptors in physiology and pathology. Current pharmaceutical design 17 (25), (Article publié).
  • Avedanian L , Riopel J , Bkaily G , Nader M , D'Orleans-Juste P , Jacques D. (2010). ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. Canadian journal of physiology and pharmacology 88 (8), (Article publié).
  • D'Orléans-Juste P , Benigni A , Davenport AP , Pollock DM. (2010). Introduction. The 11th International conference on Endothelin. Canadian journal of physiology and pharmacology 88 (6), (Article publié).

Articles de conférence

  • Martin Houde, Julie Labonté, Louisane Desbiens, Marc Jamain, Gunnar Pejler, Michael Gurish, Shinji Takai, Pedro D'Orléans-Juste. (2012). The Mouse Mast Mell Protease 4 is Involved in the Generation of Endothelin-1 In Vitro and In Vivo. American Heart Association Scientific Session 2012. (Article soumis).
  • Houde, M., Jamain, M., Labonté, J., Desbiens, L., Simard, E., Pejler, G., D’Orléans-Juste, P. (2011). Mouse mucosal mast cell protease 4 generates endothelin-1 in vitro and in vivo. (, (Article publié).
  • Louisane Desbiens, Robert Day, Martin Houde, Walid Semaan, Shinji Takai, Mizuo Miyazaki, Gunnar Pejler, Pedro D’Orléans-Juste. Mastocytes derived or recombinant mouse mast cell protease 4 (mMCP-4) converts Big-ET-1 to ET-1 (1-31). Proceedings of the 13th International Conference on Endothelin-1, (Article accepté).
  • Martin Houde, Walid Semaan, Louisane Desbiens, Zhipeng You, Adel G. Schwertani, Gunnar Pejler, Shinji Takai, Pedro D’Orléans-Juste. Mouse mast cell protease-4-dependent production of ET-1 (1-31) and of plaque progression in a apolipoprotein E knock-out mouse model of spontaneous atherosclerosis. Proceedings of the 13th International Conference on Endothelin-1, (Article accepté).

Propriétés intellectuelles


  • (2005). Discovery and development of specific R-type calcium channel blockers (European patent delivered in 2005; US patent delivered in 2006). 217088, 1997 Canada/USA. (Terminé).

Autres contributions


  • (2012). Chymase: the other Endothelin Converting Enzyme?. Lady Davis Research Institute, McGill University. Montréal