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Patrick McDonald

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de médecine

Présentation

Sujet de recherche

Gene Regulation and Expression, Cell Signaling and Infectious and Immune Diseases, Proteomics, Immune Mediators: Cytokines and Chemokines, Leukocytes

Disciplines de recherche

Immunology, Molecular Biology

Mots-clés

Apoptosis, Chemokines, Cytokines, Granulocytes, Inflammation, Monocytes, Neutrophils, Phagocytes, Signal transduction, Transcription factors

Intérêts de recherche

Investigation of transcriptional regulation in granulocytes, and of the upstream signaling pathways

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Allemand, Italien

Diplômes

(1999). (Post-doctorate, Post-doc).

(1996). (Post-doctorate, Post-doc). Universita degli studi di Verona.

(1993). (Doctorate, Ph.D.). Université Laval.

(1989). (Bachelor's, B.Sc.). Université Laval.

Prix et distinctions

  • (2020) Guest Editorial Board member (2012-2020), in recognition of being a key organizer of the Neutrophil international meetings (chairman, Neutrophil 2014; co-chair, Neutrophil 2016; co-chair, Neutrophil 2018). Journal of Leukocyte Biology. (Distinction).
  • paper recommended by F1000 (Ear et al, J. Immunol. 2010). Faculty of 1000. (Distinction).

Financement

  • Grant. (Awarded). Co-investigator. The Sherbrooke Personalized Cancer Avatar Model Initiative: A Feasibility Study of Treatment Guided by the Combination of DNA Profiling and Next-Generation Medical Avatars in Patients with Advanced Kidney Cancer. MEDTEQ-CQDM. Special Initiatives. 1 366 000 $. (2019-2022)
  • Grant. (Awarded). Principal Applicant. Regulation of neutrophil extracellular trap formation. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grants. 186 000 $. (2016-2022)
  • Grant. (Awarded). Principal Applicant. New molecular targets in rheumatoid arthritis. Canadian Institutes of Health Research (CIHR). Priority Announcement for Arthritis Health, IMHA. 100 000 $. (2019-2020)
  • Grant. (Completed). Co-applicant. Chronic Inflammation, Immunity and Cancer 2019. Canadian Institutes of Health Research (CIHR). Dissemination Grants. 15 000 $. (2019-2020)
  • Grant. (Completed). Principal Applicant. Neutrophil 2018 International Conference. Canadian Institutes of Health Research (CIHR). Dissemination Grants. 10 000 $. (2018-2018)
  • Grant. (Completed). Principal Applicant. Role of NETs in Kystic Fibrosis. Le Grand défi Pierre Lavoie. Maladies héréditaires orphelines. 25 000 $. (2017-2018)
  • Grant. (Completed). Co-applicant. The Sherbrooke Personalized Colorectal Cancer Avatar Models Initiative (COLOR project): A Feasibility Study of Treatment Guided by the Combination of a Living Organoids Biobank and Personalized Avatars in Patients with Advanced Colorectal Cancer. Merck Sharp & Dohme Research Laboratory. Translational Grants. 250 000 $. (2016-2018)

Publications

Articles de revue

  • Tatsiy O*, Mayer TZ*, Sylvain-Prévost S*, Isabel M*, Dubois CM, and McDonald PP. (2020). Front. Immunol. 10 2996. (Published).
  • A.M. Cantin, C. Ouellet, A. Cloutier*, P.P. McDonald. (2020). Airway mucins inhibit oxidative and non-oxidative bacterial killing by human neutrophils. Front. Pharmacol. 11 554353. (Published).
  • McDonald PP, Ye RD. (2020). Detection of Intact Transcription Factors in Human Neutrophils. Methods Mol Biol. 2087 261-275. (Published).
  • Palmieri V., A. Lazaris, S. Petrillo, H. Alamri, M. Rada, G. Jarrouj, W.Y. Park, Z.H. Gao, T.Z. Mayer, P.P. McDonald, P. Metrakos. (2020). Neutrophils expressing lysyl oxidase-like protein 4 are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy. J. Pathol. 251 213-223. (Published).
  • Archambault AS, Poirier S, Lefebvre JS, Robichaud PP, Larose MC, Turcotte C, Martin C, Provost V, Boudreau LH, McDonald PP, Laviolette M, Surette ME, Flamand N. (2019). 20-Hydroxy- and 20-carboxy-leukotriene B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils. J. Leuko. Biol. 105 1131-1142. (Published).
  • Tatsiy O*, McDonald PP. (2018). Physiological stimuli induce PAD4-dependent, ROS-independent NETosis, with early and late events controlled by discrete signaling pathways. Front Immunol 9 2036. (Published).
  • Guindi C, Cloutier A*, Gaudreau S, Zerif E, McDonald PP, Tatsiy O*, Asselin C, Dupuis G, Gris D, Amrani AA. (2018). Role of the p38 MAPK/C/EBPb Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells. Cells 7 E256. (Published).
  • Ear T.*, O. Tatsiy*, F.L. Allard*, P.P. McDonald. (2017). Regulation of discrete functional responses by Syk andSrc family tyrosine kinases in human neutrophils. J. Immune. Res. 2017 4347121. (Accepted).
  • Dumas L, Neagoe PE, McDonald PP, White M, Sirois MG. (2016). New insights on the pro-inflammatory activities of Ang1 on neutrophils: induction of Mip-1b synthesis and release. PLoS One 11 e0163140. (In Press).
  • Charbonneau M, Lavoie RR, Lauzier A, Harper K, McDonald PP, Dubois CM. (2016). Platelet-Derived Growth Factor Receptor Activation Promotes the Prodestructive Invadosome-Forming Phenotype of Synoviocytes from Patients with Rheumatoid Arthritis. J. Immunol. 196 (8), 3264-3275. (Published).
  • Sylvain-Prévost S*, Ear T*, Simard FA*, Fortin CF*, Dubois CM, Flamand N, McDonald PP. (2015). Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses. J. Immunol. 195 5393-5403. (Published).
  • Simard FA*, Cloutier A*, Ear T*, Vardhan H*, and McDonald PP. (2015). MEK-independent ERK activation in human neutrophils and its impact on functional responses. J Leukoc Biol 98 565-573. (Published).
  • McDonald PP, Ye RD. (2014). Detection of intact transcription factors in human neutrophils. Methods Mol Biol. 1124 485-498. (Published).
  • Poubelle PE , McDonald PP. (2013). Letter to the editor for the special issue on "The Neutrophil in Immunity". Journal of Leukocyte Biology 94 (4), 541-543. (Published).
  • Mayer TZ*, Simard FA*, Cloutier A*, Vardhan H*, Dubois CM , McDonald PP. (2013). The p38-MSK1 signaling cascade influences cytokine production through CREB and C/EBP factors in human neutrophils. Journal of Immunology 191 (8), 4299-4307. (Published).
  • Fortin CF*, Mayer TZ*, Cloutier A*, McDonald PP. (2013). Translational control of human neutrophil responses by MNK1. Journal of Leukocyte Biology 94 (4), 693-703. (Published).
  • Guindi C, Ménard M, Cloutier A*, Gaudreau S, Besin G, Larivée P, McDonald PP, Dupuis G, Amrani A. (2012). Differential role of NF-?B, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice. Cellular Immunology 272 (2), 259-268. (Published).
  • Fortin CF*, Cloutier A*, Ear T*, Sylvain-Prévost S*, Mayer TZ*, Bouchelaghem R*, McDonald PP. (2011). A class IA PI3K controls inflammatory cytokine production in human neutrophils. European Journal of Immunology 41 (6), 1709-1719. (Published).
  • Ear T*, Fortin CF*, Simard FA*, McDonald PP. (2010). Constitutive association of TAK1 with the IKK complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes. Journal of Immunology 184 (7), 3897-3906. (Published).
  • Fortin CF*, Sohail A, Sun Q, McDonald PP, Fridman R, Fülöp T. (2010). MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis. International Immunology 22 (8), 637-649. (Published).
  • Fortin CF*, McDonald PP, Fülöp T, Lesur O. (2010). Sepsis, leukocytes, and nitric oxide (NO): An intricate affair. Shock 33 (4), 344-352. (Published).

Articles de conférence

  • V. de Carvalho Oliveira and P.P. McDonald. (2020). Control of MSU-elicited responses in human neutrophils. ACFAS. (Accepted).
  • T.Z. Mayer* and P.P. McDonald. (2018). A chokehold of SOCS proteins upon STAT trancription factors in human neutrophil. Neutrophil 2018 International Conference. (Published).
  • O. Tatsiy* and P.P. McDonald. (2018). Early and late events in NETosis are controlled by discrete signaling pathways. Neutrophil 2018 International Conference. (Published).
  • F.L. Allard* and P.P. McDonald. (2018). Identification and production of neutrophil ectosomes. 23rd Provincial Immunology Meeting. (Published).
  • F.L. Allard* and P.P. McDonald. (2018). Isolation and characterization of neutrophil microvesicles. Medicine Faculty Research Day. (Published).
  • O. Tatsiy* and P.P. McDonald. (2016). Physiological stimuli induce ROS-independent NETosis, using PAD4 and discrete signalingpathways. Conference program, (Accepted).
  • T. Ear* and P.P. McDonald. (2016). Role of casein kinase2 (CK2) in neutrophil signaling and functional responses. Conference program, (Accepted).
  • T.Z. Mayer* and P.P. McDonald. (2016). STAT factors control the expression of discrete genes in human neutrophils, yet without much impact on functional responses. Conference program, (Accepted).
  • P.P. McDonald, S. Sylvain-Prévost*, T. Ear*, N. Flamand. (2015). Activation of TAK1 by chemoattractants and GM-CSF, and its impact on human neutrophil signaling and function. 4th European Congress of Immunology. (Published).
  • M.G. Sirois, E. Dumas, D. Chaar, S. Lavoie, P.E. Neagoe, P.P. McDonald and M. White. (2015). Angiopoietin-1 and-2: Full and differential agonists of neutrophil biological activities. 4th European Congress of Immunology. (Published).
  • O. Tatsiy*, T. Ear*, and P.P. McDonald. (2014). Involvement of TAK1 in cytokine production and NET formation in monosodium urate-activated human neutrophils. Neutrophil 2014 International Congress. (Published).
  • E. Dumas, K. Martel, P.E. Neagoe, P.P. McDonald, and M.G. Sirois. (2014). New insights into the pro-inflammatory activities of Ang1 on neutrophils; induction of Mip-1. Neutrophil 2014 International Congress. (Published).
  • T.Z. Mayer* and P.P. McDonald. (2014). STAT factors are activated by various stimuli in human neutrophils but hardly contribute to cytokine production or delayed apoptosis. 56th Meeting of CRCQ (Club de recherches cliniques du Québec). (Published).
  • T.Z. Mayer* and P.P. McDonald. (2014). STAT factors are activated by various stimuli in human neutrophils but hardly contribute to cytokine production or delayed apoptosis. Neutrophil 2014 International Congress. (Published).
  • E. Dumas, K. Martel, P.E. Neagoe, P.P. McDonald, and M.G. Sirois. (2013). New perspectives on pro-inflammatory Ang1 effects in neutrophils: Induction of Mip-1. Provincial Immunology Meeting. (Published).
  • T.Z. Mayer*, F.A. Simard*, A. Cloutier*, H. Vardhan*, and P.P. McDonald. (2013). The p38-MSK1signaling axis controls cytokine production through bZIP transcription factors in human neutrophils. International Congress of Immunology. (Published).
  • F.A. Simard* and P.P. McDonald. (2012). Intricacies of the MAPK cascades in human neutrophils. Neutrophil 2012 International Symposium. (Published).
  • T.Z. Mayer*, C.F.Fortin*, and P.P. McDonald. (2012). Post-transcriptional control of cytokine production in human neutrophils by MNK1. Neutrophil 2012 International Symposium. (Published).
  • T.Z. Mayer*, F.A. Simard*, A. Cloutier*, and P.P. McDonald. (2012). Role of CREB transcription factors in human neutrophil functional responses. European Congress of Immunology. (Published).
  • F.A. Simard*, A. Cloutier*, and P.P. McDonald. (2012). Uncoupling of the MEK/ERK signaling module in human neutrophils. 25th Meeting of the Canadian Society for Immunology. (Published).
  • T. Ear* and P.P. McDonald. (2011). Differential role of TAK1 in human neutrophils stimulated with various TLR ligands. Toll2011 Meeting. (Published).
  • F.A. Simard* and P.P. McDonald. (2011). Découplage du module MEK/ERK chez le neutrophile humain. 53rd Meeting of CRCQ (Club de recherches cliniques du Québec). (Published).
  • R. Bouchelaghem*, C.M. Dubois, and P.P. McDonald. (2011). Modulation du facteur HIF chez le neutrophile humain et son rôle dans ses réponses fonctionnelles. ACFAS. (Accepted).
  • S. Sylvain-Prévost*, T. Ear*, and P.P. McDonald. (2010). Activation of TAK1 by chemoattractants and GM-CSF, and its impact on human neutrophil signaling andfunction. 43rd Meeting of the Society for Leukocyte Biology. (Published).
  • T. Ear* and P.P. McDonald. (2010). Constitutive association of TAK1 with the IKK complex in human neutrophils, and its impact on downstream processes. Keystone Symposium on Innate Immunity. (Published).
  • C. Guindi, A. Cloutier*, M. Ménard, C. Asselin, P.P. McDonald, and A. Amrani. (2010). Key role of C/EBPb and CREB in tolerogenic function of dendritic cells. 43rd Meeting of the Society for Leukocyte Biology. (Published).
  • C.F. Fortin* and P.P. McDonald. (2010). Translational control of inflammatory chemokine production in human neutrophils. 23rd Meeting of the Canadian Society for Immunology. (Published).
  • CF Fortin* and PP McDonald. (2009). Contribution of the PI 3-kinase pathway to cytokine generation by human neutrophils. 42nd Meeting of the Society for Leukocyte Biology. (Published).
  • C. Guindi, A. Cloutier*, M. Ménard, P.P. McDonald, and A. Amrani. (2009). Role of C/EBP? and CREB in IL-10 production by tolerogenic dendritic cells. 42nd Meeting of the Society for Leukocyte Biology. (Published).

Autres contributions

Présentations

  • (2017). Identifying new molecular targets in human neutrophils. FAIS 2018 International Meeting (as speaker in plenary session). Hammamet, Tunisia
  • (2017). Physiological stimuli induce ROS-independent NETosis. Dept of Infectiology and Microbiology, Universität zu Lübeck, Lübeck, Germany (as invited speaker). Germany
  • (2016). A reliable way to assess neutrophil extracellular trap formation and its regulation. Centre de recherche en Rhumatologie et Immunologie, Université Laval (as invited speaker). Quebec City, Canada
  • (2015). Intracellular signaling and its impact on functional responses in human neutrophils. Dept of Microbiology & Immunology, University of Miami School of Medicine (as invited speaker). Miami, United States
  • O. Tatsiy* and P.P. McDonald. (2015). New and Expanded Tales on Neutrophil Extracellular Traps. Provincial Immunology Meeting. Eastman, Canada
  • T.Z. Mayer* and P.P. McDonald. (2015). STAT factors can be activated in human neutrophils but do not contribute to cytokine production, delayed apoptosis, or NETosis. Provincial Immunology Meeting. Eastman, Canada
  • T.Z. Mayer*, A. Cloutier*, and P.P. McDonald. (2013). The p38-MSK1 signaling cascade influences cytokine production through bZIP transcription factors in human neutrophils. Provincial Immunology Meeting. Eastman, Canada
  • (2012). Control of cytokine production in human neutrophils. Neutrophil 2012 International Meeting (as plenary session speaker). Quebec City, Canada
  • (2011). Signaling pathways controlling cytokine generation in human neutrophils. Faculty of Medicine, Università di Verona, Italy (as invited speaker). Italy
  • (2010). Transcriptional regulation in human neutrophil granulocytes. Dept of Chemical and Physical Sciences, University of Toronto (as invited speaker). Canada