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Nathalie Perreault

Professeure, Faculté de médecine et des sciences de la santé
FMSS Département d’immunologie et de biologie cellulaire

Présentation

Sujets, disciplines ou intérêts de recherche

Subepithelial mesenchymal cells, Epithelial mesenchymal communication, Gastrointestinal microenvironment, Gut organoids, Matrix stiffness, Gastrointestinal ECM biodynamics, Mimetic Matrices, Extracellular vesicles, Gut-related diseases (IBD, CAC, CRC), Mechanotransduction

Adhésions

  • (2013-). AACR. Philadelphia, Pennsylvania, États-Unis.
  • (2003-). Canadian Association of Gastroenterology. Oakville, Ontario, Canada.

Diplômes

  • (1998-2002). Post doctoral fellow. Genetic. University of Pennsylvania. Philadelphia, PA, États-Unis.
  • (1994-1998). PhD. Anatomie et Biologie cellulaire. Universite de Sherbrooke. Sherbrooke, Québec, Canada.

Expériences académiques

  • Professor. (2014-). Université de Sherbrooke. Sherbrooke, QC, Canada.
  • Associate Professor. (2008-2014). Université de Sherbrooke. Sherbrooke, QC, Canada.
  • Assistant Professor. (2003-2008). Université de Sherbrooke. Sherbrooke, QC, Canada.

Prix et distinctions

  • (2020) CAG Fellow. Canadian Association of Gastroenterology.

Financement

  • Subvention. Training Researchers In the Next generation in Gastroenterology and Liver (TRIANGLE). Canadian Institutes of Health Research (Ottawa, Canada). 2 399 999 $. (2022-2027).
    Numéro de subvention : 202106RT8. Voir plus
  • Subvention. Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases. Canadian Institutes of Health Research (Ottawa, Canada). 1 131 170 $. (2019-2024).
    Numéro de subvention : 201903PJT. Voir plus
  • Subvention. Mechanisms regulating autophagy in intestinal epithelial secretory cells. Natural Sciences and Engineering Research Council (Ottawa, Canada). 96 000 $. (2018-2021).
    Numéro de subvention : RGPIN-2018-06115. Voir plus
  • Subvention. The Nuclear Receptor HNF4A as a Regulator of WNT Ligands: Biological Impact of this Novel Interaction in Gut Diseases. Canadian Institutes of Health Research (Ottawa, Canada). 1 105 055 $. (2018-2023).
    Numéro de subvention : 201709PJT. Voir plus
  • Subvention. Functional contribution of the Bone Morphogenetic Proteins signaling pathway in the reprogramming of gastrointestinal reactive mesenchyme. Canadian Institutes of Health Research (Ottawa, Canada). 768 180 $. (2014-2019).
    Numéro de subvention : 201403MOP. Voir plus

Publications

Articles

  • Dianne Pupo Gómez, Vilcy Reyes Nicolás, Gisela Cofino Marrero, Ariane Cristina De Castro, Christine Jones, Linnette Maria Leon Chirino, Nathalie Perreault, Alfredo Menendez, Francois Boudreau. (2026). HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella typhimurium infection. American Journal of Physiology-Gastrointestinal and Liver Physiology. DOI
  • Alain B. Alfonso, Véronique Pomerleau, Vilcy Reyes Nicolás, Jennifer Raisch, Carla-Marie Jurkovic, François-Michel Boisvert, Nathalie Perreault. (2022). Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1+-Telocytes. Biomedicines. DOI
  • Romain Girard, Sarah Tremblay, Christophe Noll, Stéphanie St-Jean, Christine Jones, Yves Gélinas, Faïza Maloum-Rami, Nathalie Perreault, Mathieu Laplante, André C. Carpentier, François Boudreau. (2022). The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage. Nature Communications. DOI
  • Vilcy Reyes Nicolás, Joannie M. Allaire, Alain B. Alfonso, Dianne Pupo Gómez, Véronique Pomerleau, Véronique Giroux, François Boudreau, Nathalie Perreault. (2021). Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling. Cells. DOI
  • Marie-Josée Langlois, Raphaëlle Servant, Vilcy Reyes Nicolás, Christine Jones, Sébastien A.B. Roy, Marilène Paquet, Julie C. Carrier, Nathalie Rivard, Francois Boudreau, Nathalie Perreault. (2019). Loss of PTEN Signaling in Foxl1+ Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice. Cellular and Molecular Gastroenterology and Hepatology. DOI
  • Nathalie Perreault. (2018). Ulcerative Colitis–Associated Carcinoma: Epithelial SMAD4-Mediated Signaling Is a Key Guardian. Cellular and Molecular Gastroenterology and Hepatology. DOI

Autres contributions

Cours enseignés à l'UdeS

  • BCL705 - Cytophysiologie gastro-intestinale. (2023-2024). (1CR).

Activités professionnelles

  • Canadian Association of Gastroenterology. Co-Chair GI Advocacy Committee. Oakville, Ontario, Canada. (2024-).
  • TRaIning A New generation of researchers in Gastroenterology and LivEr (TRIANGLE). Co-Chair Mentorship Committee. Toronto, Canada. (2022-).
  • Canadian Association of Gastroenterology. Vice President Research for CAG. Oakville, Ontario, Canada. (2020-2024).
  • Canadian Association of Gastroenterology. Co-Chair GI topics. Oakville, Ontario, Canada. (2018-2020).