Marie-Josée Boucher
Professeure, Faculté de médecine et des sciences de la santé
FMSS Département de médecine - Service de gastroentérologie
Présentation
Publications
Articles
- Marjorie Rolland, Benoît Marchand, Laure Bessy, Florence McDuff, Marie-Josée Boucher. (2026). TFEB confers resistance against the chemotherapeutic agent CX-5461. Autophagy Reports. DOI
- Benoît Marchand, Marc-Antoine Poulin, Christine Lawson, Lee-Hwa Tai, Steve Jean, Marie-Josée Boucher. (2023). Gemcitabine promotes autophagy and lysosomal function through ERK- and TFEB-dependent mechanisms. Cell Death Discovery. DOI
- Blain, J., Bédard, J., Thompson, M., Boisvert, F.-M., Boucher, M.-J. (2017). C-terminal deletion of NOTCH1 intracellular domain (N1<sup>ICD</sup>) increases its stability but does not amplify and recapitulate N1<sup>ICD</sup>-dependent signalling /631/67 /631/80/86 /13 /13/95 /38 /38/109 /96 article. Scientific Reports. DOI
- Klionsky, D.J., Abdelmohsen, K., Abe, A., Abedin, M.J., Abeliovich, H., Arozena, A.A., Adachi, H., Adams, C.M., Adams, P.D., Adeli, K., Adhihetty, P.J., Adler, S.G., Agam, G., Agarwal, R., Aghi, M.K., Agnello, M., Agostinis, P., Aguilar, P.V., Aguirre-Ghiso, J., ... Zughaier, S.M. (2016). Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356. Autophagy. DOI
- Klionsky, D.J., Abdelmohsen, K., Abe, A., Abedin, M.J., Abeliovich, H., Arozena, A.A., Adachi, H., Adams, C.M., Adams, P.D., Adeli, K., Adhihetty, P.J., Adler, S.G., Agam, G., Agarwal, R., Aghi, M.K., Agnello, M., Agostinis, P., Aguilar, P.V., Aguirre-Ghiso, J., ... Zughaier, S.M. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. DOI
- Marchand, B., Arsenault, D., Raymond-Fleury, A., Boisvert, F.-M., Boucher, M.-J. (2015). Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells. Journal of Biological Chemistry. DOI
- Tremblay, I., Paré, E., Arsenault, D., Douziech, M., Boucher, M.-J. (2013). The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells. PLoS ONE. DOI
- Marchand, B., Tremblay, I., Cagnol, S., Boucher, M.-J. (2012). Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. Carcinogenesis. DOI
- Lemieux, E., Boucher, M., Mongrain, S., Boudreau, F., Asselin, C., Rivard, N. (2011). Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation. American Journal of Physiology - Gastrointestinal and Liver Physiology. DOI
- Mysliwiec, P., Boucher, M.J. (2009). Targeting Notch signaling in pancreatic cancer patients - Rationale for new therapy. Advances in Medical Sciences. DOI
- Boucher, M.-J., Simoneau, M., Edlund, H. (2009). The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity. Endocrinology. DOI
- Boucher, M.-J., Selander, L., Carlsson, L., Edlund, H. (2006). Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms. Journal of Biological Chemistry. DOI
- Boucher, M.-J., Laprise, P., Rivard, N. (2005). Cyclic AMP-dependent protein kinase A negatively modulates adherens junction integrity and differentiation of intestinal epithelial cells. Journal of Cellular Physiology. DOI
- Laprise, P., Langlois, M.-J., Boucher, M.-J., Jobin, C., Rivard, N. (2004). Down-Regulation of MEK/ERK Signaling by E-Cadherin-Dependent PI3K/Akt Pathway in Differentiating Intestinal Epithelial Cells. Journal of Cellular Physiology. DOI
- Boucher, M.-J., Jean, D., Vézina, A., Rivard, N. (2004). Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. American Journal of Physiology - Gastrointestinal and Liver Physiology. DOI
- Laprise, P., Chailler, P., Houde, M., Beaulieu, J.-F., Boucher, M.-J., Rivard, N. (2002). Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation. Journal of Biological Chemistry. DOI
- Charland, S., Boucher, M.-J., Houde, M., Rivard, N. (2001). Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells. Endocrinology. DOI
- Boucher, M.-J., Duchesne, C., Rivard, N., Lainé, J., Morisset, J. (2001). cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. Biochemical and Biophysical Research Communications. DOI
- Boucher, M.-J., Morisset, J., Vachon, P.H., Reed, J.C., Lain, J., Rivard, N. (2000). MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. Journal of Cellular Biochemistry. DOI
- Rivard, N., Boucher, M.-J., Asselin, C., L'allemain, G. (1999). MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells. American Journal of Physiology - Cell Physiology.
- Constitutive activation of MEK-ERK signalling pathway in human intestinal crypt cells provokes cell cycle arrest associated with accumulation of p21Cip. DOI
- Differential expression and regulation of p42 and p44 map kinase isoforms in human enterocytes. DOI
- Inhibition of the MEK-ERK pathway by E-cadherin-dependent Akt activity during enterocyte differentiation. DOI
- M1643 GSK3 Activity Regulates Proliferation and Survival of Human Pancreatic Cancer Cells. DOI
- M1967 Inhibition of GSK3 Activity Sensitizes Pancreatic Cancer Cells to TNFα-Induced Apoptosis. DOI
- MEK/ERK signaling pathway regulates the expression of Bcl‐2, Bcl‐XL, and Mcl‐1 and promotes survival of human pancreatic cancer cells. DOI
- Regulation and role of brush border-associated ERK1/2 in intestinal epithelial cells. DOI
- The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. DOI
- W1929 Interplay Between GSK3 and JNK Pathways Regulates Human Pancreatic Cancer Cell Survival. DOI
- cAMP inhibits cell cycle progression and negatively modulates human intestinal cell differentiation. DOI