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Kamal Bouarab

Professeur, Faculté des sciences

FAC. SCIENCES Biologie

Présentation

Sujet de recherche

Biological and Biochemical Mechanisms, Crop Production other than Forest Products

Disciplines de recherche

Agronomy, Biology and Related Sciences

Mots-clés

Cross talk between plant immune pathways, Molecular plant-microbe interactions, Small RNAs and plant immunity

Intérêts de recherche

Molecular plant-microbe interactions

Langues parlées et écrites

Arabe, Anglais, Français

Diplômes

(2000). (Doctorate, PhD). Université de Paris VI (P & M Curie).

(1995). (Master's Thesis, M.Sc.-Master). Université de Paris VI (P & M Curie).

(1994). (Bachelor's, B.Sc.). Université de Paris VI (P & M Curie).

Financement

  • Research Chair. (Awarded). Principal Investigator. CannaSher research chair on medical cannabis. CannaSher 10153192 Canada Inc-Université de Sherbrooke. 1 603 700 $. (2018-2023)
  • Grant. (Under Review). Principal Investigator. Natural defences of plants. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery grant. 340 800 $. (2018-2023)
  • Grant. (Awarded). Co-applicant. SEVE, Environmental health network. Fonds de recherche du Québec - Nature et technologies (FRQNT). Strategic network. 2 400 000 $. (2017-2022)
  • Grant. (Awarded). Co-applicant. Siderophores impact on human and plant diseases. Fonds de recherche du Québec - Nature et technologies (FRQNT). FRQNT-Team. 162 000 $. (2018-2021)
  • Grant. (Awarded). Collaborator. Accelerating Innovations to Adapt Agro-environments to Climate Change: The Eastern Canadian Plant Phenotyping Platform.. Canada Foundation for Innovation (CFI). 23 798 545 $. (2018-2021)
  • Grant. (Awarded). Co-applicant. SEVE Centre. Fonds Institutionel de Recherche de l'Université de Sherbrooke. 138 600 $. (2015-2018)
  • Grant. (Completed). Principal Investigator. Molecular plant-microbe interactions. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery grant. 235 000 $. (2013-2018)
  • Grant. (Completed). Principal Applicant. Production of hairy root lines for industrial uses. Natural Sciences and Engineering Research Council of Canada (NSERC). ENGAGE PLUS. 25 000 $. (2016-2017)
  • Grant. (Completed). Principal Applicant. Production of new hairy root lines for industrial uses.. NSERC. SEP-Engage. 25 000 $. (2015-2016)

Publications

Articles de revue

  • 2- Langlois, JP, Millette G, Guay I, Jacques PÉ, Rodrigue S, Bouarab K, Marsault E, Malouin F. (2019). Staphylococcus aureusBactericidal activity of tomatidine and of the combination of tomatidineand aminoglycoside against persistent and virulent forms of. Frontiers in Microbiology (Submitted).
  • Mohamed El Oirdi, Rocio Gonzalez-Lamothe, Taha Abd El Rahman, Alexandre Maréchal, Jan Bosak, Charles Després, Normand Brisson and Kamal Bouarab*. (2019). The transcriptional factor SEBF promotes disease caused by plant pathogens. Plant Physiology (Submitted).
  • Guay I*, Boulanger S, Isabelle C, Brouillette E, Chagnon F, Bouarab K*, Marsault E, Malouin F. (2018). Listeria, Bacillus Tomatidine and analog FC04-100 possess bactericidal activities against and. BMC Pharmacology and Toxicology 19 (1), 1-7. (Published).
  • Lamontagne Boulet M, Isabelle C, Guay I*, Brouillette E, Langlois JP, Jacques PE, Rodrigue S, Brzezinski B, Beauregard P, Bouarab K*, Boyapelly K, Boudreault PL, Marsault E, Malouin F. (2018). Tomatidine, a lead antibiotic molecule that targets Staphylococcus aureus ATP synthase subunit C. Antimicrob Agents Chemother 62 (6), pii: e02197-17. (Published).
  • Boulanger S, Mitchell G, Bouarab K*, Marsault E, Cantin A, Frost E, Déziel E, and Malouin F. (2015). The Bactericidal Effect of the Tomatidine and Tobramycin Combination Against MRSA and Pseudomonas aeruginosa is Enhanced by Interspecific Small Molecule Interactions. Antimicrob Agents Chemother 59 7458-7464. (Published).
  • Chagnon F, Guay I*, Bonin MA, Mitchell G, Bouarab K*, Malouin F, Marsault É. (2014). Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus. Eur J Med Chem (80), 605-620. (Published).
  • Baz M , Lahbabi D* , Samri S , Val F , Hamelin G , Madore I , Bouarab K* , Beaulieu C , Ennaji MM , Barakate M. (2012). Control of potato soft rot caused by Pectobacterium carotovorum and Pectobacterium atrosepticum by Moroccan actinobacteria isolates. World journal of microbiology & biotechnology 28 (1), 303-311. (Published).
  • Rahman TA* , Oirdi ME* , Gonzalez-Lamothe R* , Bouarab K*. (2012). Necrotrophic pathogens use the salicylic acid signaling pathway to promote disease development in tomato. Molecular plant-microbe interactions : MPMI 25 (12), 1584-1593. (Published).
  • González-Lamothe R* , El Oirdi M* , Brisson N , Bouarab K*. (2012). The conjugated auxin indole-3-acetic acid-aspartic acid promotes plant disease development. The Plant cell 24 (2), 762-777. (Published).
  • Mitchell G , Lafrance M , Boulanger S , Séguin DL , Guay I* , Gattuso M* , Marsault E , Bouarab K* , Malouin F. (2012). Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression. The Journal of antimicrobial chemotherapy 67 (3), 559-568. (Published).
  • El Oirdi M* , El Rahman TA* , Rigano L , El Hadrami A , Rodriguez MC , Daayf F , Vojnov A , Bouarab K*. (2011). Botrytis cinerea manipulates the antagonistic effects between immune pathways to promote disease development in tomato. The Plant cell 23 (6), 2405-2421. (Published).
  • Mitchell G , Gattuso M* , Grondin G , Marsault É , Bouarab K* , Malouin F. (2011). Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells. Antimicrobial agents and chemotherapy 55 (5), 1937-1945. (Published).
  • El Oirdi M , Trapani A , Bouarab K. (2010). The nature of tobacco resistance against Botrytis cinerea depends on the infection structures of the pathogen. Environmental microbiology 12 (1), (Published).
  • González-Lamothe R , Mitchell G , Gattuso M , Diarra MS , Malouin F , Bouarab K. (2009). Plant antimicrobial agents and their effects on plant and human pathogens. International journal of molecular sciences 10 (8),
  • Lerat S , Babana AH , El Oirdi M , El Hadrami A , Daayf F , Beaudoin N , Bouarab K , Beaulieu C. (2009). Streptomyces scabiei and its toxin thaxtomin A induce scopoletin biosynthesis in tobacco and Arabidopsis thaliana. Plant cell reports 28 (12),
  • Torres PS , Malamud F , Rigano LA , Russo DM , Marano MR , Castagnaro AP , Zorreguieta A , Bouarab K , Dow JM , Vojnov AA. (2007). Controlled synthesis of the DSF cell-cell signal is required for biofilm formation and virulence in Xanthomonas campestris. Environmental microbiology 9 (8),

Propriétés intellectuelles

Patents

  • Malouin F., Mitchell G., Bouarab K., Marsault E., Chagnon F., Boulanger S., Guay I. (2016). Use of steroid alkaloids thereof as antimicrobial agents against electron-transport-deficient microbes and as potentiators for antimicrobial agents against pathogenic bacteria and uses thereof. CA2012050087-US Patent No. 9457033. Canada. (Granted/Issued).

Autres contributions

Présentations

  • Fabrice Betoudji, Kamal Bouarab, Marvin J. Miller, Manuka Ghosh, Mario Jacques, François Malouin. (2019). A siderophore analog of fimsbactin from Acinetobacter hinders growth of the phytopathogen Pseudomonas syringae and induces systemic priming of immunity in Arabidopsis thaliana. 69th Annual Conference of the Canadian Society of Microbiologists. Sherbrooke, Canada
  • Fabrice Betoudji, Kamal Bouarab, Marvin J. Miller, Manuka Ghosh, Mario Jacques, François Malouin. (2019). A siderophore analog of fimsbactin from Acinetobacter hinders growth of the phytopathogen Pseudomonas syringae and induces systemic priming of immunity in Arabidopsis thaliana. ANTIMIC 2019. Lille, France
  • E. Lacasse, Y.-M. Lin, M. Ghosh, M. J. Miller, K. Bouarab, M. Jacques, F. Malouin. (2019). In vitro activity of Siderophore-beta-lactam conjugates against Gram-negative and Gram-positive pathogens. 69th Annual Conference of the Canadian Society of Microbiologists. Sherbrooke, Canada
  • R. Ajmi, M.B. Diam, T. Abd El Rahman and K. Bouarab. (2019). The involvement of two small-RNA degrading nucleases in the set-up of optimal immune responses. 69th Annual Conference of the Canadian Society of Microbiologists. Sherbrooke, Canada
  • Diam MB*, Abd El Rahman T*, Bouarab K*. (2017). Control of microRNA homeostasis and the establishment of effector-triggered immunity in Arabidopsis thaliana. the Canadian Phytopathological Society and the Canadian Society of Agronomy. Winnipeg, Canada
  • Ajmi R*, Abd El Rahman T*, Bouarab K*. (2017). Control of microRNA turnover contributes to plant immunity activated by flagelline. the Canadian Phytopathological Society and the Canadian Society of Agronomy. Winnipeg, Canada
  • Ajmi R, Abd El Rahman T, Bouarab K. (2017). Le rôle du contrôle de l’homéostasie des microARN dans la mise en place de la résistance basale et la résistance systémique acquise chez Arabidopsis thaliana. Journées SEVE. Canada
  • Diam MB, Abd El Rahman T, Bouarab K. (2017). Le rôle du contrôle de l’homéostasie des microARN dans la mise en place de la résistance hautement spécifique chez Arabidopsis thaliana. Journées SEVE. Canada
  • Isabelle C, Lamontagne Boulet M, Bouarab K*, É. Marsault E, Malouin F. (2017). The cellular target of tomatidine and analogs against Staphylococcus aureus is the bacterial ATP synthase. The 27th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, Australia
  • Lamontagne Boulet M, Guay I*, Rodrigue S, Jacques P-E, Brzezinski R, Bouarab K*, Marsault E, Malouin F. (2015). Identification of mutations associated with a reduced susceptibility of Staphylococcus aureus Small-Colony Variants to tomatidine. 25th European Congress of Clinical Microbiology and Infectious Diseases. Copenhagen, Denmark
  • Bouarab K. (2013). Auxin signalling and plant disease. INRA-CNRS-Paul Sabatier university invited speakers at Toulouse. Toulouse, France
  • El Mnouchi S*, Khalfaoui F*, Bouarab K*. (2013). Dicer-Like 1 promotes disease caused by Botrytis cinerea by suppressing jasmonic acid pathway. Canadian society of plant biology. Québec, Canada
  • Chagnon F, Marsault E, Guay I*, Mitchell G, Bouarab K*, Malouin F. (2013). Optimization of a novel steroid alkaloid antibiotic efficient against persistent forms of Staphylococcus aureus. 96th Canadian Chemistry Conference and Exhibition, Canadian Society for Chemistry. Québec, Canada
  • Bouarab K. (2013). Small RNAs and plant immunity. Canadian society of plant biology. Québec, Canada
  • Bouarab K. (2013). Small RNAs and plant immunity. INRA-CNRS-Paul Sabatier university invited speakers at Toulouse. Toulouse, France
  • Chagnon F, Marsault E, Frost E, Guay I*, Boulanger S, Mitchell G, Bouarab K*, Hmamouchi R, Jacques PE, Rodrigue S, Malouin F. (2013). Steroidal alkaloids as aminoglycoside-enhancing drugs. 96th Canadian Chemistry Conference and Exhibition, Canadian Society for Chemistry. Québec, Canada
  • Guay I*, Chagnon F, Mitchell G, Bouarab K*, Marsault E, Malouin F. (2012). Antibacterial Spectrum and Structure-Activity Relationship of Tomatidine Analogs. Interscience Conference on Antimicrobial Agents and Chemotherapy. San Fransisco, United States
  • Boulanger S, Mitchell G, Frost E, Marsault E, Bouarab K*, Malouin F. (2012). Tomatidine is Bactericidal Against Staphylococcus aureus in Co-culture With Pseudomonas aeruginosa Strains Producing HQNO. Interscience Conference on Antimicrobial Agents and Chemotherapy. San Fransisco, United States
  • Sansregret R*, Dufour V*, Langlois M* , Bouarab K*. (2011). Extreme resistance induced against tomato bush stunt virus requires an active RNA silencing pathway. Plant Canada. Halifax, Canada
  • El Mnouchi S*, Bouarab K*. (2011). Importance of the microRNAs pathway in the interaction between Arabidopsis thaliana and necrotrophic pathogens. Plant Canada. Halifax, Canada
  • Mitchell G, Lafrance M, Séguin DL, Boulanger S, Marsault E, Bouarab K*, Malouin F. (2011). Tomatidine Potentiates the Bactericidal Activity of Aminoglycosides Against Multi-Resistant Staphylococcus aureus Strains. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, United States
  • (2010). Elicitation and suppression of plant immunity. Agriculture and Agri- Food Canada and Carleton University seminars. Ottawa, Canada