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François Bachand

Professeur, Faculté de médecine et des sciences de la santé

FMSS Dép. de biochimie et de génomique fonction.

Présentation

Sujet de recherche

Cellule, Expression et régulation génique, Génomique, Génétique moléculaire, Protéomique fonctionnelle et structurale

Disciplines de recherche

Biologie moléculaire, Génétique

Mots-clés

Gene Regulation, Genomics, Polyadenylation, Proteomics, Ribosomal proteins, Ribosome, RNA-binding proteins, RNA decay, Yeast genetics

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(2005). (Postdoctorat, Fellow). Harvard Medical School.

(2002). (Doctorat, PhD in Cell Biology). McGill University.

(1998). (Maîtrise avec mémoire, M.Sc in Microbiology and Immunology - Maîtrise). Université de Montréal.

(1996). (Baccalauréat, B.Sc. in Microbiology and Immunology). McGill University.

Expérience académique

Full Professor. (2016-). Université de Sherbrooke. Canada.

Prix et distinctions

  • Alumni of the year. Riboclub Society. (Distinction).
  • Canada Research Chair in Quality Control of Gene Expression. Government of Canada. (Prix).
  • Career Development Award. Human Frontier Science Program organization (INTERNATIONAL). (Prix).
  • Director. Centre d'Excellence en Biologie de l'ARN de l'Université de Sherbrooke (CRBAUS). (Distinction).
  • Maud Menten New Investigator Prize. CIHR (Institute of Genetics). (Prix).
  • Prix Jean-de-Margerie for publication of the year (Genes & Development, 2020). Université de Sherbrooke. (Prix).
  • Prix Jean-de-Margerie for publication of the year (Nature Communications). Université de Sherbrooke. (Prix).
  • Prix Pierre-et-Danielle Bourgaux: Given to Professor for contribution to the advancement of science, the quality of his research, the impact of publications, and international recognition. Université de Sherbrooke. (Prix).
  • Robert H. Haynes Young Scientist Award in Genetics. Canadian Society for Molecular Biosciences (CSMB). (Prix).
  • Young Scientist Award. Nordrhein-Westfalen (NRW) Research Schools (GERMANY). (Prix).

Financement

  • Subvention. (En cours d’évaluation). Candidat principal. Specialized cellular fonctions of human ribosomal proteins beyond the ribosome. Instituts de Recherche en Santé du Canada (IRSC). Project Grant - Fall 2020. 1 225 000 $. (2021-2026)
  • Subvention. (Obtenu). Candidat principal. Characterization of a novel function for PABPN1: the product of the oculopharyngeal muscular dystrophy disease gene. Instituts de Recherche en Santé du Canada (IRSC). Project Grant. 906 526 $. (2020-2025)
  • Subvention. (Obtenu). Candidat principal. Using fission yeast to unravel co-transcriptional 3' end processing. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Discovery Grant. 250 000 $. (2017-2022)
  • Chaire de recherche. (Terminé). Candidat principal. Canada Research Chair in Quality Control of Gene Expression (70% USED FOR SALARY SUPPORT). Instituts de Recherche en Santé du Canada (IRSC). Canada Research Chair Tier 2. 500 000 $. (2016-2021)
  • Subvention. (Terminé). Candidat principal. Replacement for Microbial Growth Assay Cluster. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Research Tools and Instruments. 150 000 $. (2019-2020)
  • Subvention. (Terminé). Cocandidat. Transcriptomic Profiling of Non-coding Nuclear Small RNAs (EQUIPMENT SUPPORT). Fondation Canadienne pour l'Innovation (FCI). John R. Evans Leaders Fund. 886 952 $. (2017-2019)
  • Subvention. (Terminé). Cocandidat. High-throughput protein immunolocalization analysis through virtual fluorescence imaging.. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Research Tools and Instruments - Category 1. 147 500 $. (2015-2016)
  • Subvention. (Terminé). Cocandidat. Innovative and flexible tools for protein purification and molecule binding studies.. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Research Tools and Instruments - Category 1. 150 000 $. (2013-2014)
  • Subvention. (Terminé). Cocandidat. Development of department-wide bioinformatics solutions and their integration with experimental approaches. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Research Tools and Instruments - Category 1. 107 176 $. (2010-2011)
  • Subvention. (Terminé). Candidat principal. Acquisition of a highly efficient lysis and ultracentrifugation system. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). research Tools and Instruments - Category 1. 66 914 $. (2009-2010)
  • Subvention. (Terminé). Cocandidat. Confocal microscopy replacement. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Research Tools and Instruments - Category 1. 145 355 $. (2009-2010)
  • Subvention. (Obtenu). Candidat principal. Specialized cellular functions of human ribosomal proteins. Instituts de Recherche en Santé du Canada (IRSC). 937 126 $.

Publications

Articles de revue

  • (* = student/staff from my lab) Yague-Sanz C*, Duval M*, Larochelle M*, and BACHAND F. (2021). Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast. Genes & Development GENESDEV/2021 347215. (Article soumis).
  • (* = student/staff from my lab) Yague-Sanz C* and BACHAND F. (2021). Coupling mRNA 3' end processing with transcription in time and space (Review). RNA Biology RNABIOL0291 1-25. (Article soumis).
  • Landry-Voyer AM* and BACHAND F. (2021). In need to be chaperoned: ribosomal protein expression and transport into the nucleus. RNA Biology RNABIOL0291 1-25. (Article soumis).
  • Yague-Sanz C*, Vanrobaeys Y*, Fernandez R, Duval M*, Larochelle M*, Beaudoin J, Berro J, Labbé S, Jacques P-E, BACHAND F. (2020). Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation. Genes & Development 34 883-897. (Article publié).
  • Landry-Voyer AM*, Bergeron D*, Yague-Sanz C*, Baker B*, and BACHAND F. (2020). PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). Nucleic Acids Research 48 12900-12916. (Article publié).
  • Larochelle M*, Bergeron D*, Archand B*, BACHAND F. (2019). Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. J. Cell Science 132 jcs232249. (Article publié).
  • Rivosecchi J, Larochelle M*, Teste C, Grenier F*, Malapert A, Ricci EP, Bernard P, BACHAND F#, and V. Vanoosthuyse#. (2019). Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription (#, EQUAL CONTRIBUTIONS). EMBO Journal 38 e101955. (Article publié).
  • Dionne K*, Bergeron D*, Landry-Voyer AM*, BACHAND F. (2019). The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. J Biol Chem 294 1944-1955. (Article publié).
  • Larochelle M*, Robert M-A, Hébert J-N*, Liu X, Matteau D, Rodrigue S, Tian B, Jacques P-E, BACHAND F. (2018). Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast. Nature Communications 9 4364. (Article publié).
  • Atkinson SR, Marguerat S, Bitton DA, Rodríguez-López M, Rallis C, Lemay* JF, Cotobal C, Malecki M, Chen W, Mata J, BACHAND F, Bähler J. (2018). Long non-coding RNA repertoire and regulation by nuclear exosome, cytoplasmic exonuclease and RNAi in fission yeast. RNA 24 1195-1213. (Article publié).
  • Telekawa C*, Boisvert FM, BACHAND F. (2018). Proteomic profiling and functional characterization of post-translational modifications of the RNA exosome. Nucleic Acids Research 42 11169-11183. (Article publié).
  • Mallet* PL, BACHAND F. (2017). Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements by fission Yeast Pab2/PABPN1. Genetics 205 621-632. (Article publié).
  • Larochelle* M, Hunyadkürti* J, BACHAND F. (2017). Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein. Current Genetics 63 195-199. (Article publié).
  • Liu X, Hoque M, Larochelle* M, Lemay* JF, Yurko N, Manley JL, BACHAND F, Tian B. (2017). S. cerevisiae Comparative Analysis of Alternative Polyadenylation in and. Genome Research 27 1685-1695. (Article publié).
  • Landry-Voyer* A, Bilodeau* S, Bergeron* D, Dionne*, K, Port SA, Rouleau* C, Boisvert FM, Kehlenbach RH, BACHAND F. (2016). Human PDCD2L is an export substrate of CRM1 that associates with 40S ribosomal subunit precursors. Molecular and Cellular Biology 36 3019-3032. (Article publié).
  • Lemay* JF, Marguerat S, Larochelle* M, Liu X, van Nues R, Hunyadkürti* J, Hoque M, Granneman S, Tian B, Bähler J, and F. BACHAND. (2016). The Nrd1-like protein Seb1 coordinates co-transcriptional 3’ end processing and polyadenylation site selection. Genes & Development 30 1558-1572. (Article publié).
  • Nguyen* D, Grenier St-Sauveur* V, Dupuis-Sandoval F, Scott M, BACHAND F. (2015). A PABPN1-dependent 3' end maturation pathway is required for the synthesis of the human telomerase RNA. Cell Reports 13 1-14. (Article publié).
  • Lemay* JF, BACHAND F. (2015). Fail-safe transcription termination: Because one is never enough. RNA Biology 12 927-32. (Article publié).
  • Bergeron* D, Pal* G, Beaulieu* YB, Chabot B and BACHAND F. (2015). Regulated intron retention and nuclear pre-mRNA decay contribute to PABPN1 autoregulation. Mol. Cell. Biol 35 2503-17. (Article publié).
  • Bitton DA, Atkinson SR, Rallis C, Smith GC, Ellis DA, Chen YY, Malecki M, Codlin S, Lemay* JF, Cotobal C, BACHAND F, Marguerat S, Mata J, Bähler J. (2015). Widespread exon-skipping triggers degradation by nuclear RNA surveillance in fission yeast. Genome Research 25 884-96. (Article publié).
  • Mallet* PL, BACHAND F. (2014). A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1. Traffic 14 282-294. (Article publié).
  • Lemay* JF, Larochelle* M, Marguerat S, Atkinson S, Bahler J, BACHAND F. (2014). The RNA Exosome Promotes Transcription Termination of backtracked RNA Polymerase II. Nature Struc. Mol. Biol. 21 919-926. (Article publié).
  • Grenier St-Sauveur* V, Soucek S, Corbett AH, BACHAND F. (2013). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay. Mol. Cell. Biol 33 4718-4731. (Article publié).
  • Lemieux* C , Marguerat S , Lafontaine* J, Barbezier* N , Bähler J , BACHAND F. (2012). A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein PABPN1. Molecular Cell 44 (1), 108-119. (Article publié).
  • Beaulieu* YB , Kleinman CL , Landry-Voyer* AM , Majewski J , BACHAND F. (2012). Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1. PLoS Genetics 8 (11), e1003078. (Article publié).
  • Larochelle* M , Lemay* JF , BACHAND F. (2012). The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression. Nucleic Acids Research 40 (20), 10240-10253. (Article publié).
  • Lemay* JF , Lemieux* C , St-André* O , BACHAND F. (2011). Crossing the borders: poly(A)-binding proteins working on both sides of the fence. RNA Biology 7 (3), 291-5. (Article publié).
  • St-André* O , Lemieux* C , Perreault* A , Lackner DH , Bähler J , BACHAND F. (2011). Negative regulation of meiotic gene expression by the nuclear poly(A)-binding protein in fission yeast. The Journal of Biological Chemistry 285 (36), 27859-68. (Article publié).
  • Lemay* JF , D'Amours* A , Lemieux* C , Lackner DH , St-Sauveur* VG , Bähler J , BACHAND F. (2010). The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs. Molecular Cell 37 (1), 34-45. (Article publié).
  • Perreault A , Gascon S , D'Amours A , Aletta JM , BACHAND F. (2009). A methyltransferase-independent function for Rmt3 in ribosomal subunit homeostasis. The Journal of Biological Chemistry 284 (22), 15026-37. (Article publié).
  • Lemieux C , BACHAND F. (2009). Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs. Nucleic Acids Research 37 (10), 3418-30. (Article publié).
  • Perreault A , Bellemer C , BACHAND F. (2009). Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2. Nucleic acids research 36 (19), 6132-42. (Article publié).
  • Houchens CR , Perreault A , BACHAND F, Kelly TJ. (2009). Schizosaccharomyces pombe Noc3 is essential for ribosome biogenesis and cell division but not DNA replication. Eukaryotic cell 7 (9), 1433-40. (Article publié).
  • Bachand F. (2007). Protein arginine methyltransferases: from unicellular eukaryotes to humans. Eukaryotic cell 6 (6), 889-98. (Article publié).
  • Perreault A , Lemieux C , Bachand F. (2007). Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast. The Journal of biological chemistry 282 (10), 7552-62. (Article publié).
  • Bachand F* , Lackner DH , Bähler J , Silver PA. *corresponding author. (2006). Autoregulation of ribosome biosynthesis by a translational response in fission yeast. Molecular and cellular biology 26 (5), 1731-42. (Article publié).
  • Yu MC , Bachand F , McBride AE , Komili S , Casolari JM , Silver PA. (2004). Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes & development 18 (16), 2024-35. (Article publié).
  • Bah A , Bachand F , Clair E , Autexier C , Wellinger RJ. (2004). Humanized telomeres and an attempt to express a functional human telomerase in yeast. Nucleic acids research 32 (6), 1917-27. (Article publié).
  • Bachand F , Silver PA. (2004). PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. The EMBO journal 23 (13), 2641-50. (Article publié).
  • Boisvert FM , Cote J , Boulanger MC , Cleroux P , Bachand F , Autexier C , Richard S. (2002). Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. The Journal of cell biology 159 (6), 957-69. (Article publié).
  • Bachand F , Boisvert FM , Côté J , Richard S , Autexier C. (2002). The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Molecular biology of the cell 13 (9), 3192-3202. (Article publié).
  • Bachand F, Autexier C. (2001). Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol Cell Biol. 21 1888-97. (Article publié).
  • Bachand F, Triki I, Autexier C. (2001). Human telomerase RNA-protein interactions. Nucleic Acids Res. 29 3385-93. (Article publié).
  • Bachand F, Kukolj G, Autexier C. (2000). Expression of hTERT and hTR in cis reconstitutes and active human telomerase ribonucleoprotein. RNA 6 778-84. (Article publié).
  • Bachand F, Autexier C. (1999). Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae. J Biol Chem. 274 38027-31. (Article publié).
  • Bachand F, Yao XJ, Hrimech M, Rougeau N, Cohen EA. (1999). Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor. J Biol Chem. 274 9083-91. (Article publié).

Chapitres de livre

  • Landry-Voyer AM*, BACHAND F. (2021). Control of Ribosomal Protein Expression in Yeast and Humans. Denman, Robert B. RNA-binding proteins in development and diseases (Re-Edition, 1-28). Inde : Research Signpost. (Révision demandée).

Articles de conférence

  • Kwiatek L*, Bergeron D*, F. BACHAND. (2019). Elucidating the mechanism of polyadenylation-dependent nuclear degradation in human cells. 20th Ribo-Club Annual Meeting. (Article accepté).
  • Vanrobaeys Y*, Yague-Sanz C*, Fernandez R, Berro J, Jacques PE, BACHAND F. (2019). Transcription elongation rate influences gene expression by alternative polyadenylation (ORAL PRESENTATION). 10th International Fission Yeast Meeting. (Article accepté).
  • Landry-Voyer AM*, Bergeron D*, Dionne K*, Vanrobeays Y*, and BACHAND F. (2019). ZNF277 and PRMT3 control an antagonistic set of genes that function in the interferon antiviral response. 21st Ribo-Club Annual Meeting. (Article accepté).
  • Bergeron D*, Telekawa C*, Dionne K*, Vanrobaeys Y*, and BACHAND F. (2019). ZNF277 and PRMT3 control an antagonistic set of genes that function in the interferon antiviral response. 24th Annual Meeting of the RNA Society. (Article accepté).
  • Larochelle M*, Robert M-A, Hébert J-N*, Liu X, Matteau D, Rodrigue S, Tian B, Jacques P-E, BACHAND F. (2018). (ORAL) Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast. Ribo-Club annual meeting. (Article accepté).
  • Landry-Voyer AM*, Bergeron D*, Dionne K*, BACHAND F. (2018). Programmed Cell Death Protein 2 (PDCD2) is a novel uS5-associated protein required for ribosome biogenesis. Ribosynthesis meeting 2018. (Article accepté).
  • Vanrobaeys Y*, Fernandez R, Robert M-A, Berro J, Jacques PE, BACHAND F. (2018). Transcriptome-wide analysis of RNA polymerase II elongation kinetics in fission yeast. Ribo-Club Annual Meeting. (Article accepté).
  • Larochelle* M, Robert M-A, Hébert* J-N, Liu X, Tian B, Jacques P-E, BACHAND F. (2017). (ORAL) A comprehensive view of RNA polymerase II CTD phosphorylation and co-transcriptional 3’ end processing in fission yeast. Regulation of RNA 3' end formation across eukaryotic genomes. (Article accepté).
  • Nguyen* D, Bergeron* D, Dupuis-Sandoval F, Scott M, BACHAND F. (2017). Mechanism of human telomerase 3' end maturation and transcription termination. Telomeres & Telomerase. (Article accepté).
  • Landry-Voyer* A-M, Bilodeau* S, BACHAND F. (2017). PDCD2 froms an evolutionarily conserved complex with extra-ribosomal RPS2 and is important for the regulation of ribosome biogenesis. The 22nd Annual Meeting of the RNA Society. (Article accepté).
  • Dionne* K, Bergeron* D, Landry-Voyer* A-M, and F. BACHAND. (2016). Functional and biochemical characterization of the extra-ribosomal complex between PDCD2-RPS2-PRMT3. Ribo-Club annual meeting. (Article publié).
  • Landry-Voyer* A-M, Bilodeau* S, Bergeron* D, Dionne* K, Port SA, Rouleau* C, Boisvert F-M, Kehlenbach RH, and BACHAND F. (2016). Human PDCD2L is an export substrate of CRM1 that associates with 40S ribosomal subunit precursors. Ribo-Club annual meeting. (Article publié).
  • Telekawa* C, Boisvert F-M, and BACHAND F. (2016). Mapping a network of post-translational modifications on the RNA exosome; a functional study. Ribo-Club annual meeting. (Article publié).
  • Larochelle* M, Robert M-A, Jacques P-E, and F. BACHAND. (2016). Regulation of the fission yeast RNA Polymerase II CTD phosphorylation status by the conserved transcription termination factor Dhp1. TRANSCRIPTIONAL REGULATION BY CHROMATIN AND RNA POLYMERASE II (ASBMB meeting). (Article publié).
  • Larochelle* M, Robert M-A, Jacques P-E, and F. BACHAND. (2016). Regulation of the fission yeast RNA Polymerase II CTD phosphorylationstatus by the conserved transcription termination factor Dhp1 (ORAL Presentation). Ribo-Club annual meeting. (Article publié).
  • Duy Nguyen*, Valérie Grenier St-Sauveur*, Danny Bergeron*, Fabien Dupuis-Sandoval, Michelle S. Scott, and François Bachand. (2015). A polyadenylation-dependent 3’ end maturation pathway is required for the synthesis of the human telomerase RNA (oral presentation). Annual Ribo-Club meeting. (Article publié).
  • Jean-François Lemay*, Samuel Marguerat, Marc Larochelle*, Rob van Nues, Xiaochuan Lin, Sander Granneman, Bin Tian, Jürg Bähler & François Bachand. (2015). Seb1 is a novel factor required for co-transcriptinal 3' end processing of coding and noncoding RNAs (oral presentation). Cold Spring Harbor Meeting on Eukaryotic mRNA processing. (Article publié).
  • Gheorghe Pal*, Danny Bergeron*, Yves Beaulieu*, and Francois Bachand. (2014). Auto-regulation of PABPN1 expression via pre-mRNA decay in human cells. Post-Transcriptional Gene Regulation - Gordon Research Conference. (Article publié).
  • Anne-Marie Landry-Voyer*, Sarah Bilodeau*, Caroline Rouleau*, François-Michel Boisvert, François Bachand. (2014). PDCD2L is an RPS2-associated shuttling protein that interacts with the late small ribosomal subunit precursor. The Nineteenth Annual Meeting of the RNA Society. (Article publié).
  • Duy Nguyen*, Valérie Grenier St-Sauveur*, Francois Bachand. (2014). The Poly(A)-Binding Protein Nuclear 1 (PABPN1) and the Nuclear Exosome Promote 3? End Maturation of the Human Telomerase RNA. The Nineteenth Annual Meeting of the RNA Society. (Article publié).
  • Lafontaine* J. and BACHAND F. (2013). Auto-regulation of the ribosomal protein S2 (RPS2) in human cells. 14th RiboClub Annual Meeting. (Article publié).
  • Landry-Voyer* AM, Nguyen* D, Rouleau* C, Boisvert FM and BACHAND F. (2013). Human PRMT3 and RPS2 form an extraribosomal complex involved in ribosome biogenesis. 14th RiboClub Annual Meeting. (Article publié).
  • Lemay* JF, Larochelle* M, Marguerat S, Bahler J, and F. Bachand. (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. 7th International Fission Yeast Meeting. (Article publié).
  • Jean-François Lemay*, Marc Larochelle*, Samuel Marguerat, Jürg Bähler, François Bachand. (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. International RNA Society meeting. (Article publié).
  • Jean-François Lemay*, Marc Larochelle*, Samuel Marguerat, Jürg Bähler, François Bachand. (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. RNA 3' ends: Mechanism and Biological Function in Eukaryotic Genomes. (Article publié).
  • Atkinson S, Marguerat S, Lemay* JF, BACHAND F, and J. Bahler. (2013). The fission yeast non-coding transcriptome (oral presentation). 7th International Fission Yeast Meeting. (Article publié).
  • Mallet* PL and Bachand F. (2012). A PY-NLS nuclear targeting signal is required for the nuclear import of fission yeast Pab2, but not of human PABPN1. 13th Symposium on RNA Biology. (Article publié).
  • Grenier St-Sauveur* V. and Bachand F. (2012). Antagonistic regulation of a ribosomal protein-coding gene by independent nuclear poly(A)-binding proteins in fission yeast. 13th Symposium on RNA Biology. (Article publié).
  • Beaulieu* Y, Kleinman CL, Landry-Voyer* AM, Majewski J, and Bachand F. (2012). Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1. 13th Symposium on RNA Biology. (Article publié).
  • Marc Larochelle*, Jean-Francois Lemay*, Samuel Marguerat, Jurg Bahler, Francois Bachand. (2012). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. 14th RiboClub Annual Meeting. (Article publié).
  • Lemieux* C, Marguerat S, Lafontaine* J, Rodriguez* G, Bähler J, and Bachand F. (2011). Control of gene expression by polyadenylation-dependent pre-mRNA turnover. Cold Spring Harbor meeting on Eukaryotic mRNA processing. (Article publié).
  • Lemieux* C, Lafontaine* J, Marguerat S, Bahler J, and F. Bachand. (2011). Control of gene expression by pre-mRNA decay (oral presentation). 6th International Fission Yeast Meeting. (Article publié).
  • Lemay* JF, Larochelle* M, and Bachand F. (2011). Pab2-Rrp6 competes with TRAMP-dependent core exosome degradation during the biogenesis of snoRNAs. 12th Symposium on RNA Biology. (Article publié).
  • Larochelle* M and Bachand F. (2011). The THO complex controls snoRNA expression by maintaining the presence of the TRAMP complex at the 3’ end of snoRNA genes. Cold Spring Harbor meeting on Eukaryotic mRNA processing. (Article publié).
  • Larochelle* M and Bachand F. (2011). The THO complex controls snoRNA expression by promoting the co-transcriptional recruitment of the TRAMP complex. 12th Symposium on RNA Biology. (Article publié).
  • Lemieux C, Marguerat S, Lafontaine J, Rodriguez G, Bähler J, and Bachand F. (2010). Control of gene expression by polyadenylation-dependent pre-mRNA turnover. 11th Anniversary Symposium on RNA Biology. (Article publié).
  • Lemieux C, Marguerat S, Lafontaine J, Rodriguez G, Bähler J, and Bachand F. (2010). Control of gene expression by polyadenylation-dependent pre-mRNA turnover (oral presentation). 4th RNA Stability Meeting. (Article publié).
  • Bachand F. (2010). Molecular control of ribosome biogenesis by a protein arginine methyltransferase (oral presentation). FASEB summer conferences on Biological Methylation (Oral Presentation). (Article publié).
  • Mallet PL and Bachand F. (2010). Repression of retrotransponsons expression by a nuclear poly(A)-binding protein in fission yeast. 11th Anniversary Symposium on RNA Biology. (Article publié).
  • St-André O, Perreault A, Lemieux C, and Bachand F. (2009). The nuclear poly(A)-binding protein controls meiotic gene expression by posttranscriptional gene regulation of a meiosis-specific noncoding RNA in fission yeast. 5th International Fission Yeast meeting. (Article publié).
  • St-André O, Perreault A, Lemieux C, and Bachand F. (2009). The nuclear poly(A)-binding protein controls meiotic gene expression by posttranscriptional gene regulation of a meiosis-specific noncoding RNA in fission yeast. 10th Anniversary Symposium on RNA Biology. (Article publié).
  • Lemay, JF, D’Amours, A, Lemieux, C, Lackner, DH, St-Sauveur, VG, Bähler, J, Bachand F. (2009). The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs (oral presentation). 10th Anniversary Symposium on RNA Biology. (Article publié).
  • Yague-Sanz C*, Bergeron D*, and F. BACHAND. Negative regulation of lncRNAs by the poly(A)-binding nuclear 1 in muscle cells. 8th RNA Stability Conference.
  • Yague-Sanz C*, Bergeron D*, and F. BACHAND. Negative regulation of lncRNAs by the poly(A)-binding nuclear 1 in muscle cells. 20th Ribo-Club Annual Meeting.

Autres contributions

Présentations

  • (2020). INVITED SPEAKER (SEMINARS). Since 2006, I gave >35 seminars at Academic Institutions. Canadian Universities: McGill, Ottawa, Montreal, Concordia, UBC, Laval, York, Toronto, Calgary, Lethbridge; USA: Dartmouth, Emory, Buffalo, Rochester, NIH, Chicago; Cornell, Columbia, UCLA, UCSD; EUROPE: Oxford, UCL, Cambridge, Namur, Institut Curie. Several cities, France
  • (2019). Transcription elongation rate influences gene expression by alternative polyadenylation. 10th International Fission Yeast Meeting. Espagne
  • (2018). Polyadenylation-mediated RNA decay by PABPN1 in yeast and humans. Recent Advances in OPMD Research - European Neuro-Muscular Centre. Amsterdam, Pays-Bas
  • (2017). A comprehensive view of RNA polymerase II CTD phosphorylation and co-transcriptional 3’ end processing in fission yeast. EMBO Workshop - Regulation of RNA 3' end formation across eukaryotic genomes. Royaume-Uni
  • (2017). Functional Characterization of the human Senetaxin (SETX) homolog in fission yeast. 9th International Fission Yeast Meeting - Chair of the "Gene Regulation" session and Program Organizer. Canada
  • (2015). Seb1 is novel factor required for co-transcriptional 3' end processing of coding and noncoding RNAs. Cold Spring Harbor meeting on Eukaryotic mRNA Processing (Oral presentation). Cold Spring Harbor, États-Unis
  • (2014). Nuclear surveillance of coding and noncoding transcriptomes. RiboWest 2014 10th Anniversary. Lethbridge, Canada
  • (2014). Nuclear surveillance of coding and noncoding transcriptomes. Seminar associated with Robert H. Haynes Young Scientist Award in Genetics. Canadian Society for Molecular Biosciences (CSMB) 57th annual meeting. Banff, Canada
  • (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. EMBO Workshop - RNA 3' ends: Mechanism and Biological Functions in Eukaryotic Genomes. Oxford, Royaume-Uni
  • (2011). Control of Gene Expression by a pre-mRNA decay pathway. 6th International Fission Yeast Meeting (Session Chair). Boston, États-Unis
  • (2010). Control of Gene Expression by a novel pre-mRNA decay pathway. 4th RNA Stability Meeting. Montreal, Canada