Claude Legault

Financement

• Subvention. Development and Understanding of Synthetic Methodologies Using an Experimental-Computational Strategy. Natural Sciences and Engineering Research Council of Canada (Ottawa, Canada). 60 000 $. (2014-2016).
  Numéro de subvention : 587505. Voir plus
• Subvention. Development of new methods of catalytic and enantioselective synthesis based on iodine (III). Fonds de Recherche du Québec (Montreal, Canada). 60 000 $. (2011-2013).
  Numéro de subvention : 145483. Voir plus
• Subvention. Development of asymmetric methods using an experimental-computational strategy. Natural Sciences and Engineering Research Council of Canada (Ottawa, Canada). 165 000 $. (2009-2014).
  Numéro de subvention : 528275. Voir plus
• Subvention. Facility for the Development of Catalytic Enantioselective Methods / Infrastructure pour le développement de méthodes énantiosélectives catalytiques. Canada Foundation for Innovation (Ottawa, Canada). 102 750 $. (2009).
  Numéro de subvention : CFI7913. Voir plus

Publications

Articles

• Julian Wolf, Meghana Poliyodath Mohanan, Raphaël Robidas, Revannath L. Sutar, Elric Engelage, Claude Y. Legault, Stefan M. Huber. (2025). Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors. Angewandte Chemie International Edition. DOI
• Josée Maurais, Clément Wespiser, Raphaël Robidas, Claude Y. Legault, Patrick Ayotte. (2025). Trapping intermediates of the NO2 hydrolysis reaction on ice. Faraday Discussions. DOI
• Amol P Jadhav, Claude Y Legault. (2024). Oxidative hydrolysis of aliphatic bromoalkenes: scope study and reactivity insights. Beilstein Journal of Organic Chemistry. DOI
• Chengtao Zhao, Tatiana Besset, Claude Y. Legault, Philippe Jubault. (2024). Experimental and Computational Studies for the Synthesis of Functionalized Cyclopropanes from 2‐Substituted Allylic Derivatives with Ethyl Diazoacetate. Chemistry – A European Journal. DOI
• Raphaël Robidas, Claude Y. Legault. (2024). How to obtain accurate results with molecular iodine and density functional theory?. International Journal of Quantum Chemistry. DOI
• Thi Mo Nguyen, Claude Y. Legault, Nicolas Blanchard, Vincent Bizet, Dominique Cahard. (2023). Tracking SF5I in the Iodopentafluorosulfanylation of Alkynes. Chemistry – A European Journal. DOI
• Yoann Schneider, Amol P. Jadhav, Claude Y. Legault. (2023). Synthesis of Indoles Using the Electrophilic Potential of Diazirines. The Journal of Organic Chemistry. DOI
• Raphaël Robidas, Claude Y. Legault. (2023). Gold(I)‐Mediated Isomerization of Spring‐loaded 1,7‐Enynes seen through the Lens of Density Functional Theory. Chemistry – A European Journal. DOI
• Claude Spino, Marine Latil, Roxanne Lessard, Quentin Fevre‐Renault, Claude Y. Legault. (2023). N‐Oxides as Control Element for the Direction of a Sigmatropic Rearrangement: Application as a Switch for Fluorescence. Chemistry – A European Journal. DOI
• Tommy Lussier, Claude Y. Legault. (2023). Iodine(III)-Mediated Enantioselective Oxidative Contraction of Dihydropyranones. Organic Letters. DOI
• Raphaël Robidas, Claude Y. Legault. (2023). Direct π‐Activation vs. O‐Activation in Halogen‐Bonding Catalysis. Angewandte Chemie. DOI
• Raphaël Robidas, Claude Y. Legault. (2023). Direct π‐Activation vs. O‐Activation in Halogen‐Bonding Catalysis. Angewandte Chemie International Edition. DOI
• Raphaël Robidas, Dominik L. Reinhard, Stefan M. Huber, Claude Y. Legault. (2023). A Quantum‐chemical Analysis on the Lewis Acidity of Diarylhalonium Ions. ChemPhysChem. DOI
• Pierre Baillargeon, Raphaël Robidas, Olivier Toulgoat, Zacharie Michaud, Claude Y. Legault, Tarik Rahem. (2022). Crystal Structures of Lignocellulosic Furfuryl Biobased Polydiacetylenes with Hydrogen-Bond Networks: Influencing the Direction of Solid-State Polymerization through Modification of the Spacer Length. Crystal Growth & Design. DOI
• Raphaël Robidas, Claude Y. Legault. (2022). CalcUS: An Open-Source Quantum Chemistry Web Platform. Journal of Chemical Information and Modeling. DOI
• Raphaël Robidas, Claude Y. Legault. (2021). Cyclic Haloiodanes: Syntheses, Applications and Fundamental Studies. Helvetica Chimica Acta. DOI
• Helen A. Clement, Mohamad Estaitie, You-Ri Kim, Dennis G. Hall, Claude Y. Legault. (2021). Mechanism of the Palladium-Catalyzed Asymmetric Borylative Migration of Enol Perfluorosulfonates: Insights into an Enantiofacial-Selective Transmetalation. ACS Catalysis. DOI
• Domenic P. Pace, Raphaël Robidas, Uyen P. N. Tran, Claude Y. Legault, Thanh Vinh Nguyen. (2021). Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights. The Journal of Organic Chemistry. DOI
• Vincent Guérin, Claude Y. Legault. (2021). Synthesis of NHC-Iridium(III) Complexes Based on N-Iminoimidazolium Ylides and Their Use for the Amine Alkylation by Borrowing Hydrogen Catalysis. Organometallics. DOI
• Raphaël Robidas, Claude Y. Legault, Stefan M. Huber. (2021). A low cost, high accuracy method for halogen bonding complexes. Physical Chemistry Chemical Physics. DOI
• Pierre Baillargeon, Raphaël Robidas, Claude Y. Legault, Tarik Rahem, Alexandra Paré Fouapon, Sarah-Maude Boivin. (2020). Correction to Rapid Access to Polychlorodiacetylene Single Crystals through H-Bond Templating and Computations on Helical PDA Oligomers. Crystal Growth & Design. DOI
• Julian Wolf, Florian Huber, Nikita Erochok, Flemming Heinen, Vincent Guérin, Claude Y. Legault, Stefan F. Kirsch, Stefan M. Huber. (2020). Activation of a Metal‐Halogen Bond by Halogen Bonding. Angewandte Chemie International Edition. DOI
• Julian Wolf, Florian Huber, Nikita Erochok, Flemming Heinen, Vincent Guérin, Claude Y. Legault, Stefan F. Kirsch, Stefan M. Huber. (2020). Aktivierung einer Metall‐Halogen‐Bindung durch Halogenbrücken. Angewandte Chemie. DOI
• Pierre Baillargeon, Raphaël Robidas, Claude Y. Legault, Tarik Rahem, Alexandra Paré Fouapon, Sarah-Maude Boivin. (2020). Rapid Access to Polychlorodiacetylene Single Crystals through H-Bond Templating and Computations on Helical PDA Oligomers. Crystal Growth & Design. DOI
• Robert J. Mayer, Armin R. Ofial, Herbert Mayr, Claude Y. Legault. (2020). Lewis Acidity Scale of Diaryliodonium Ions toward Oxygen, Nitrogen, and Halogen Lewis Bases. Journal of the American Chemical Society. DOI
• Zhensheng Zhao, Kevin C. Y. Ma, Claude Y. Legault, Graham K. Murphy. (2019). Denitrogenative Hydrotrifluoromethylation of Benzaldehyde Hydrazones: Synthesis of (2,2,2‐Trifluoroethyl)arenes. Chemistry – A European Journal. DOI
• Robin Dagenais, Tommy Lussier, Claude Y. Legault. (2019). Iodine(III)-Mediated Contraction of 3,4-Dihydropyranones: Access to Polysubstituted γ-Butyrolactones. Organic Letters. DOI
• Vincent Guérin, Alain Ménard, Hannah Guernon, Odile Moutounet, Claude Y. Legault. (2019). From Chelating to Bridging Ligands: N-Sulfonyliminoimidazolium Ylides as Precursors to Anionic N-Heterocyclic Carbene Ligands. Organometallics. DOI
• Andrei Nikolaev, Claude Y. Legault, Minhao Zhang, Arturo Orellana. (2018). The Acid-Free Cyclopropanol-Minisci Reaction Reveals the Catalytic Role of Silver–Pyridine Complexes. Organic Letters. DOI
• Raphaël Robidas, Vincent Guérin, Laurent Provençal, Marco Echeverria, Claude Y. Legault. (2017). Investigation of Iodonium Trifluoroborate Zwitterions as Bifunctional Arene Reagents. Organic Letters. DOI
• Axel Labattut, Pierre-Luc Tremblay, Odile Moutounet, Claude Y. Legault. (2017). Experimental and Theoretical Quantification of the Lewis Acidity of Iodine(III) Species. The Journal of Organic Chemistry. DOI
• Claude Legault, Robin Dagenais, Antoine Lauriers. (2017). Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Investigation of the Effect of Iodine(III) Reagents. Synthesis. DOI
• Chloé Cocaud, Cyril Nicolas, Thomas Poisson, Xavier Pannecoucke, Claude Y. Legault, Olivier R. Martin. (2017). Tunable Approach for the Stereoselective Synthesis of 1-C-Diethylphosphono(difluoromethyl) Iminosugars as Glycosyl Phosphate Mimics. The Journal of Organic Chemistry. DOI
• Antoine Jobin‐Des Lauriers, Claude Y. Legault. (2016). Enol and Ynol Surrogates: Promising Substrates for Hypervalent Iodine Chemistry. Asian Journal of Organic Chemistry. DOI
• Antoine Jobin-Des Lauriers, Claude Y. Legault. (2016). ChemInform Abstract: Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Access to α-Halo Ketones by a Release-and-Catch Mechanism. ChemInform. DOI
• Antoine Jobin-Des Lauriers, Claude Y. Legault. (2016). Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Access to α-Halo Ketones by a Release-and-Catch Mechanism. Org. Lett. DOI
• Benoit Basdevant, Claude Y. Legault. (2016). ChemInform Abstract: Enantioselective Iodine(III)-Mediated Synthesis of α-Tosyloxy Ketones: Breaking the Selectivity Barrier. ChemInform. DOI
• Benoit Basdevant, Claude Y. Legault. (2015). Enantioselective Iodine(III)-Mediated Synthesis of α-Tosyloxy Ketones: Breaking the Selectivity Barrier. Org. Lett. DOI
• Benoit Basdevant, Claude Y. Legault. (2015). ChemInform Abstract: Study of the Reactivity of [Hydroxy(tosyloxy)iodo]benzene Toward Enol Esters to Access α-Tosyloxy Ketones. ChemInform. DOI
• Benoit Basdevant, Claude Y. Legault. (2015). Study of the Reactivity of [Hydroxy(tosyloxy)iodo]benzene Toward Enol Esters to Access α-Tosyloxy Ketones. J. Org. Chem. DOI
• Samuel Beaulieu, Claude Y. Legault. (2015). Mechanistic Insights on the Iodine(III)-Mediated α-Oxidation of Ketones. Chem. Eur. J. DOI
• Steven M. Langdon, Claude Y. Legault, Michel Gravel. (2015). Origin of Chemoselectivity in N-Heterocyclic Carbene Catalyzed Cross-Benzoin Reactions: DFT and Experimental Insights. J. Org. Chem. DOI
• Petiot, P., Dansereau, J., Hébert, M., Khene, I., Ahmad, T., Samaali, S., Leroy, M., Pinsonneault, F., Legault, C.Y., Gagnon, A. (2015). Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents. DOI
• Antoine Jobin-Des Lauriers, Claude Legault. (2015). Metathetical Redox Reaction of (Diacetoxyiodo)arenes and Iodoarenes. Molecules. DOI
• Champagne, P.A., Drouin, M., Legault, C.Y., Audubert, C., Paquin, J.-F. (2015). Revised mechanistic explanation for the alcohol-promoted amination of benzylic fluorides under highly concentrated conditions: Computational and experimental evidence on a model substrate. DOI
• Yoann Schneider, Julie Prevost, Maelle Gobin, Claude Y. Legault. (2014). ChemInform Abstract: Diazirines as Potent Electrophilic Nitrogen Sources: Application to the Synthesis of Pyrazoles. ChemInform. DOI
• Marie-Eve Therien, Audrey-Anne Guilbault, Claude Y. Legault. (2014). ChemInform Abstract: New Chiral Iodooxazoline Catalysts for the I(III)-Mediated α-Tosyloxylation of Ketones: Refining the Stereoinduction Model. ChemInform. DOI
• Schneider, Y., Prévost, J., Gobin, M., Legault, C.Y. (2014). Diazirines as potent electrophilic Nitrogen sources: Application to the synthesis of Pyrazoles. DOI
• Haroune, L., Salaun, M., Ménard, A., Legault, C.Y., Bellenger, J.-P. (2014). Photocatalytic degradation of carbamazepine and three derivatives using TiO2 and ZnO: Effect of pH, ionic strength, and natural organic matter. DOI
• Ba, S., Haroune, L., Cruz-Morató, C., Jacquet, C., Touahar, I.E., Bellenger, J.-P., Legault, C.Y., Jones, J.P., Cabana, H. (2014). Synthesis and characterization of combined cross-linked laccase and tyrosinase aggregates transforming acetaminophen as a model phenolic compound in wastewaters. DOI
• Audrey-Anne Guilbault, Benoit Basdevant, Vincent Wanie, Claude Y. Legault. (2013). ChemInform Abstract: Catalytic Enantioselective α-Tosyloxylation of Ketones Using Iodoaryloxazoline Catalysts: Insights on the Stereoinduction Process. ChemInform. DOI
• Champagne, P.A., Pomarole, J., Thérien, M.-E., Benhassine, Y., Beaulieu, S., Legault, C.Y., Paquin, J.-F. (2013). Enabling nucleophilic substitution reactions of activated alkyl fluorides through hydrogen bonding. DOI
• Guernon, H., Legault, C.Y. (2013). N -acyliminoimidazolium ylides as precursors to anionic N -heterocyclic carbene ligands: Control of topology and reactivity. DOI
• Thérien, M.-E., Guilbault, A.-A., Legault, C.Y. (2013). New chiral iodooxazoline catalysts for the I(III)-mediated α-tosyloxylation of ketones: Refining the stereoinduction model. DOI
• Francis Beaumier, Marianne Dupuis, Claude Spino, Claude Y. Legault. (2012). ChemInform Abstract: Formal Intramolecular [4 + 1]-Cycloaddition of Dialkoxycarbenes: Control of the Stereoselectivity and a Mechanistic Portrait. ChemInform. DOI
• Legault, C.Y., Prévost, J. (2012). 1-Fluoro-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2] iodoxole. DOI
• Guilbault, A.-A., Basdevant, B., Wanie, V., Legault, C.Y. (2012). Catalytic enantioselective α-tosyloxylation of ketones using iodoaryloxazoline catalysts: Insights on the stereoinduction process. DOI
• Guilbault, A.-A., Legault, C.Y. (2012). Drastic enhancement of activity in iodane-based α-tosyloxylation of ketones: Iodine(III) does the hypervalent twist. DOI
• Beaumier, F., Dupuis, M., Spino, C., Legault, C.Y. (2012). Formal intramolecular (4 + 1)-cycloaddition of dialkoxycarbenes: Control of the stereoselectivity and a mechanistic portrait. DOI
• Paul Ha-Yeon Cheong, Claude Y. Legault, Joann M. Um, Nihan Celebi-Olcum, K. N. Houk. (2011). ChemInform Abstract: Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities. ChemInform. DOI
• Cheong, P.H.-Y., Legault, C.Y., Um, J.M., Çelebi-Ölçüm, N., Houk, K.N. (2011). Quantum mechanical investigations of organocatalysis: Mechanisms, reactivities, and selectivities. DOI
• Garcia, Y., Schoenebeck, F., Legault, C.Y., Merlic, C.A., Houk, K.N. (2009). Theoretical bond dissociation energies of halo-heterocycles: Trends and relationships to regioselectivity in palladium-catalyzed cross-coupling reactions. DOI
• Legault, C.Y., Charette, A.B., Cozzi, P.G. (2008). Iridium catalyzed enantioselective hydrogenation of N-iminopyridinium ylides: Mechanistic insights. DOI
• Yu, Z.-X., Cheong, P.H.-Y., Liu, P., Legault, C.Y., Wender, P.A., Houk, K.N. (2008). Origins of differences in reactivities of alkenes, alkynes, and allenes in [Rh(CO)2Cl]2-catalyzed (5 + 2) cycloaddition reactions with vinylcyclopropanes. DOI
• Legault, C.Y., Garcia, Y., Merlic, C.A., Houk, K.N. (2007). Origin of regioselectivity in palladium-catalyzed cross-coupling reactions of polyhalogenated heterocycles. DOI
• Claude Y. Legault, Andre B. Charette. (2005). Catalytic Asymmetric Hydrogenation of N-Iminopyridinium Ylides: Expedient Approach to Enantioenriched Substituted Piperidine Derivatives. ChemInform. DOI
• Andre B. Charette, Alessandro A. Boezio, Alexandre Cote, Elaine Moreau, Julien Pytkowicz, Jean-Nicolas Desrosiers, Claude Legault. (2005). Asymmetric Catalytic Addition of Diorganozinc Reagents to Imines: Scope and Application. ChemInform. DOI
• Charette, A.B., Boezio, A.A., Côté, A., Moreau, E., Pytkowicz, J., Desrosiers, J.-N., Legault, C. (2005). Asymmetric catalytic addition of diorganozinc reagents to imines: Scope and application. DOI
• Legault, C.Y., Charette, A.B. (2005). Catalytic asymmetric hydrogenation of N-iminopyridinium ylides: Expedient approach to enantioenriched substituted piperidine derivatives. DOI
• Legault, C.Y., Kendall, C., Charette, A.B. (2005). Structure and reactivity of a new anionic N-heterocyclic carbene silver(I) complex. DOI
• Claude Legault, Andre B. Charette. (2004). Highly Efficient Synthesis of O-(2,4-Dinitrophenyl)hydroxylamine. Application to the Synthesis of Substituted N-Benzoyliminopyridinium Ylides. ChemInform. DOI
• Charette, A.B., Legault, C., Bélanger-Gariépy, F. (2004). 3,3-Pentamethylenediaziridine. DOI
• Claude Legault, Andre B. Charette. (2003). Complexation Promoted Additions to N-Benzoyliminopyridinium Ylides. A Novel and Highly Regioselective Approach to Polysubstituted Piperidines. ChemInform. DOI
• Legault, C., Charette, A.B. (2003). Complexation promoted additions to N-benzoyliminopyridinium ylides. A novel and highly regioselective approach to polysubstituted piperidines. DOI
• Legault, C., Charette, A.B. (2003). Highly efficient synthesis of o-(2,4-dinitrophenyl)hydroxylamine. Application to the synthesis of substituted N-benzoyliminopyridinium ylides. DOI
• Faucher, A.-M., Brochu, C., Landry, S.R., Duchesne, I., Hantos, S., Roy, A., Myles, A., Legault, C. (1998). Chelation-controlled reduction of α- and β-oxygenated ketones with lithium tri-n-butylborohydride. DOI

Articles de conférence

• Vincent Ducharme, Richard Egli, Claude Y. Legault. (2012). Energy-based Artificial Chemistry Simulator. Artificial Life 13. DOI
• Ducharme, V., Egli, R., Legault, C.Y. (2012). Energy-based artificial chemistry simulator.

Autres contributions

Cours enseignés à l'UdeS

• CHM302 - Techniques de chimie organique et inorganique - Travaux pratiques. (2024-2025). (3CR).
• COR502 - Réactions péricycliques et radicalaires. (2024-2025). (3CR).
• COR741 - Orbitales moléculaires frontières en chimie organique. (2024-2025). (3CR).

Divers

• Yoann Schneider, Claude Y. Legault. (2016). Spiro[3H-diazirine-3,2′-tricyclo[3.3.1.1]decane]. Encyclopedia of Reagents for Organic Synthesis.
• Barry B. Snider, Alexandre Meunier, Claude Y. Legault. (2012). Manganese(III) Acetate. Encyclopedia of Reagents for Organic Synthesis.
• Claude Y. Legault. (2011). N -(Benzoylimino)pyridinium Betaine (NAPBz). Encyclopedia of Reagents for Organic Synthesis.