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Benoit Laurent

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de biochimie et de génomique fonctionnelle

Présentation

Expériences académiques

  • Associate professor. Université de Sherbrooke. Sherbrooke, Quebec, Canada.

Publications

Articles

  • Guillaume Provost, Kamaryn Tanner, Véronique Legault, Luigi Ferrucci, Stefania Bandinelli, Linda P Fried, Daniel W Belsky, Benoit Laurent, Alan A Cohen. (2025). No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. DOI
  • Olivier Dionne, Benoit Laurent. (2025). Translational traffic jam in aging brains. Science. DOI
  • Muhammad Riaz Khan, Benoit Laurent. (2025). CyKILR splice variants: A double-edged sword in non-small cell lung cancer. Molecular Therapy Nucleic Acids. DOI
  • Mehdi Alami, Echarki Zerif, Abdelouahed Khalil, Nabil Hajji, Charles Ramassamy, Guy Lacombe, Benoit Laurent, Alan A Cohen, Jacek M Wikowski, Denis Gris, Ton Bunt, Olaf van Tellingen, Katsuiku Hirokawa, Tamas Fulop, Hicham Berrougui. (2025). Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ 1–42 -induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease. Journal of Alzheimer’s Disease. DOI
  • Porter RS, An S, Gavilan MC, Nagai M, Murata-Nakamura Y, Zhou B, Bonefas KM, Dionne O, Manuel JM, St-Germain J, Gascon S, Kim J, Browning L, Laurent B, Cho US, Iwase S. (2025). Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex. Cell reports. DOI
  • Olivier Dionne, Salomé Sabatié, Benoit Laurent. (2025). Deciphering the physiopathology of neurodevelopmental disorders using brain organoids. Brain. DOI
  • Dionne O, Sabatié S, Fortin F, Corbin F, Laurent B. (2024). Efficient generation of human induced pluripotent stem cells from urine samples of patients with Fragile X syndrome. Frontiers in cell and developmental biology. DOI
  • Eve Petit, Viktoriia Bavykina, Martin Thibault, André Bilodeau, William Choinière, Jean-Philippe Brosseau, Benoit Laurent, Marc-Antoine Lauzon. (2024). Assessing tissue mechanical properties: Development of a custom-made tensile device and application on rodents sciatic nerves. Journal of the Mechanical Behavior of Biomedical Materials. DOI
  • Mehdi Alami, Kaoutar Boumezough, Echarki Zerif, Nada Zoubdane, Abdelouahed Khalil, Ton Bunt, Benoit Laurent, Jacek Witkowski, Charles Ramassamy, Samira Boulbaroud, Tamas Fulop, Hicham Berrougui. (2024). In Vitro Assessment of the Neuroprotective Effects of Pomegranate (Punica granatum L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress. Nutrients. DOI
  • Muhammad Riaz Khan, Mariano Avino, Raymund J. Wellinger, Benoit Laurent. (2023). Distinct regulatory functions and biological roles of lncRNA splice variants. Molecular Therapy - Nucleic Acids. DOI
  • Manuel JM, Guilloy N, Khatir I, Roucou X, Laurent B. (2023). Re-evaluating the impact of alternative RNA splicing on proteomic diversity. Frontiers in genetics. DOI
  • Inès Khatir, Marie A. Brunet, Anna Meller, Florent Amiot, Tushar Patel, Xavier Lapointe, Jessica Avila Lopez, Noé Guilloy, Anne Castonguay, Mohammed Amir Husain, Joannie St. Germain, François-Michel Boisvert, Mélanie Plourde, Xavier Roucou, Benoit Laurent. (2023). Decoupling of mRNA and Protein Expression in Aging Brains Reveals the Age-Dependent Adaptation of Specific Gene Subsets. Cells. DOI
  • Joannie St-Germain, Muhammad Riaz Khan, Viktoriia Bavykina, Rebecka Desmarais, Micah Scott, Guylain Boissonneault, Marie A. Brunet, Benoit Laurent. (2023). Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome. Genes. DOI
  • Benoit Laurent, Bourgade K, Frost EH, Dupuis G, Witkowski JM, Laurent B, Calmettes C, Ramassamy C, Desroches M, Rodrigues S, Fülöp T Jr. (2022). Interaction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β. Journal of Alzheimer's disease reports. DOI
  • Benoit Laurent. (2022). Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes. European Journal of Applied Physiology. DOI
  • (2021). Exploring the Alternative Splicing of Long Noncoding RNAs. Trends in genetics : TIG. DOI
  • (2021). Lipid Transport and Metabolism at the Blood-Brain Interface: Implications in Health and Disease. Frontiers in physiology. DOI
  • (2021). APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in neuroscience. DOI
  • Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., Ramassamy, C., Barron, A.E., Cunnane, S., Beauregard, P.B., Bellenger, J.-P., Rodrigues, S., Desroches, M., Witkowski, J.M., Laurent, B., ... Fulop, T. (2021). Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease. Immunity and Ageing. DOI
  • Kaiser, K., Jang, A., Kompanikova, P., Lun, M.P., Prochazka, J., Machon, O., Dani, N., Prochazkova, M., Laurent, B., Gyllborg, D., Van Amerongen, R., Fame, R.M., Gupta, S., Wu, F., Barker, R.A., Bukova, I., Sedlacek, R., Kozmik, Z., Arenas, E., ... Bryja, V. (2021). MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development (Cambridge). DOI
  • Fulop, T., Tripathi, S., Rodrigues, S., Desroches, M., Bunt, T., Eiser, A., Bernier, F., Beauregard, P.B., Barron, A.E., Khalil, A., Plotka, A., Hirokawa, K., Larbi, A., Bocti, C., Laurent, B., Frost, E.H., Witkowski, J.M. (2021). Targeting impaired antimicrobial immunity in the brain for the treatment of alzheimer’s disease. Neuropsychiatric Disease and Treatment. DOI
  • Chen, H.-Y., Wang, M.-L., Laurent, B., Hsu, D.C.-H., Chen, M.-T., Lin, L.-T., Shen, J., Chang, W.-C., Hsu, J., Hung, M.-C., Chen, Y.-W., Huang, P.-I., Yang, Y.-P., Li, C.-P., Ma, H.-I., Chen, C.-H., Lin, W.-C., Chiou, S.-H. (2020). Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Theranostics. DOI
  • Guo, J., Dai, X., Laurent, B., Zheng, N., Gan, W., Zhang, J., Guo, A., Yuan, M., Liu, P., Asara, J.M., Toker, A., Shi, Y., Pandolfi, P.P., Wei, W. (2019). AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. Nature Cell Biology. DOI
  • Tsai, P.-H., Chien, Y., Wang, M.-L., Hsu, C.-H., Laurent, B., Chou, S.-J., Chang, W.-C., Chien, C.-S., Li, H.-Y., Lee, H.-C., Huo, T.-I., Hung, J.-H., Chen, C.-H., Chiou, S.-H. (2019). Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network. Nucleic acids research. DOI
  • Chau, K.F., Shannon, M.L., Fame, R.M., Fonseca, E., Mullan, H., Johnson, M.B., Sendamarai, A.K., Springel, M.W., Laurent, B., Lehtinen, M.K. (2018). Downregulation of ribosome biogenesis during early forebrain development. eLife. DOI
  • Iberg-Badeaux, A., Collombet, S., Laurent, B., van Oevelen, C., Chin, K.-K., Thieffry, D., Graf, T., Shi, Y. (2017). A transcription factor pulse can prime chromatin for heritable transcriptional memory. Molecular and Cellular Biology. DOI
  • Chen, H.-Y., Lin, L.-T., Wang, M.-L., Laurent, B., Hsu, C.-H., Pan, C.-M., Jiang, W.-R., Chen, P.-Y., Ma, H.-I., Chen, Y.-W., Huang, P.-I., Chiou, A., Chiou, S.-H. (2017). Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3. Scientific Reports. DOI
  • Xiang, Y., Laurent, B., Hsu, C.-H., Nachtergaele, S., Lu, Z., Sheng, W., Xu, C., Chen, H., Ouyang, J., Wang, S., Ling, D., Hsu, P.-H., Zou, L., Jambhekar, A., He, C., Shi, Y. (2017). RNA m<sup>6</sup> A methylation regulates the ultraviolet-induced DNA damage response. Nature. DOI
  • Laurent, B., Ruitu, L., Murn, J., Hempel, K., Ferrao, R., Xiang, Y., Liu, S., Garcia, B.A., Wu, H., Wu, F., Steen, H., Shi, Y. (2015). A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation. Molecular Cell. DOI
  • Chen, M., Zhu, N., Liu, X., Laurent, B., Tang, Z., Eng, R., Shi, Y., Armstrong, S.A., Roeder, R.G. (2015). JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors. Genes and Development. DOI
  • Brookes, E., Laurent, B., Õunap, K., Carroll, R., Moeschler, J.B., Field, M., Schwartz, C.E., Gecz, J., Shi, Y. (2015). Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity. Human Molecular Genetics. DOI
  • Rouch, I., Dorey, J.-M., Boublay, N., Henaff, M.-A., Dibie-Racoupeau, F., Makaroff, Z., Harston, S., Benoit, M., Barrellon, M.-O., Fédérico, D., Laurent, B., Padovan, C., Krolak-Salmon, P., Barrellon, M.O., Blanc, F., Bonnefoy, M., Brengarth, S., Coste, M.H., Croisile, B., ... Vighetto, A. (2014). Personality, Alzheimer's disease and behavioural and cognitive symptoms of dementia: The PACO prospective cohort study protocol. BMC Geriatrics. DOI
  • Mosammaparast, N., Kim, H., Laurent, B., Zhao, Y., Lim, H.J., Majid, M.C., Dango, S., Luo, Y., Hempel, K., Sowa, M.E., Gygi, S.P., Steen, H., Wade Harper, J., Yankner, B., Shi, Y. (2013). The histone demethylase LSD1/KDM1A promotes the DNA damage response. Journal of Cell Biology. DOI
  • Laurent, B., Randrianarison-Huetz, V., Frisan, E., Andrieu-Soler, C., Soler, E., Fontenay, M., Dusanter-Fourt, I., Duménil, D. (2012). A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-corest complex through the dimethylation of its SNAG domain. Journal of Cell Science. DOI
  • Randrianarison-Huetz, V., Laurent, B., Bardet, V., Blobe, G.C., Huetz, F., Duménil, D. (2010). Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-β signaling at the bipotent erythro-megakaryocytic progenitor stage. Blood. DOI
  • Laurent, B., Randrianarison-Huetz, V., Marćhal, V., Mayeux, P., Dusanter-Fourt, I., Duménil, D. (2010). High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription. Blood. DOI
  • Laurent, B., Randrianarison-Huetz, V., Marćhal, V., Mayeux, P., Dusanter-Fourt, I., Duménil, D. (2010). High-mobility group protein HMGB2 regulates human erythroid differentiation through transactivation of GFI1B transcription (Blood (2010) 115, 3, (687-695)). Blood. DOI
  • Laurent, B., Randrianarison-Huetz, V., Kadri, Z., Roméo, P.-H., Porteu, F., Duménil, D. (2009). Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells. Stem Cells. DOI
  • Laurent, B., Randrianarison, V., Duménil, D. (2006). The family of Gfi-1 zinc finger transcriptional repressor oncoproteins in hematopoiesis regulation,La famille des répresseurs transcriptionnels Gfi-1 dans la régulation de l'hématopoïèse. Hematologie. DOI

Chapitres de livre

  • Benoit Laurent. (2022). Immunosenescence and Alzheimer’s Disease. Healthy Ageing and Longevity. DOI
  • (2016). Expression, Purification, and Biochemical Analysis of the LSD1/KDM1A Histone Demethylase. Methods in enzymology. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

  • BIM501 - Biologie moléculaire du gène. (2023-2026). (3CR).

Divers

  • Kaiser, K., Jang, A., Lun, M.P., Procházka, J., Machon, O., Procházková, M., Laurent, B., Gyllborg, D., van Amerongen, R., Kompaníková, P., Wu, F., Barker, R.A., Uramová, I., Sedláček, R., Kozmík, Z., Arenas, E., Lehtinen, M.K., Bryja, V. (2020). MEIS-WNT5A axis regulates development of 4<sup>th</sup> ventricle choroid plexus. bioRxiv.