Rony Chidiac

Financement

• Subvention. Targeting NOTCH1-dependent endocardial endothelial dysfunction in the rare disorder hypoplastic left heart syndrome. The Center of Excellence in Research on Orphan Diseases – Fondation Courtois (CERMO-FC) (Montréal, Canada). 25 000 $. (2026-2027).
• Subvention. Unveiling mechanisms governing tissue-specific endothelial cell differentiation from human pluripotent stem cells. Natural Sciences and Engineering Research Council of Canada (Ottawa, Canada). 232 500 $. (2026-2031).
• Subvention. Identification of de novo secreted proteins by endothelial cells during cardiac ischemia. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke (Sherbrooke, Canada). 10 000 $. (2026-2027).
• Subvention. Harnessing pluripotent stem cell-derived choroidal endothelial cells for vascular regeneration in age-related macular degeneration. Réseau de recherche en sciences de la vision (Montréal, Canada). 50 000 $. (2025-2026). Voir plus
• Subvention. Novel Frizzled-4/LRP5 antibody-based agonist for neovascular macular degeneration. BrightFocus Foundation (Clarksburg, États-Unis). 200 000 USD. (2021-2023).
  Numéro de subvention : M2021003F.

Publications

Articles

• Shaymaa Khazaal, Abdoul-Razak Sango, Kawtar Zouine, Alexa Silva Sosa, Ariane Vanessa Megne, Rony Chidiac, Kiran Bora, Gaelle Mawambo, Jing Chen, Malika Oubaha. (2026). Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression. Angiogenesis. DOI
• Vanderperre, B., Muraleedharan, A., Dorion, M.-F., Larroquette, F., Del Cid Pellitero, E., Rajakulendran, N., Chen, C.X.Q., Larivière, R., Michaud-Tardif, C., Goiran, T., Chidiac, R., Lipuma, D., MacLeod, G., Thomas, R., Wang, Z., Reintsch, W.E., Luo, W., Shlaifer, I., Zhang, F., ... Fon, E.A. (2025). Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils. Communications Biology. DOI
• Chidiac, R., Yang, A., Kubarakos, E., Mikolajewicz, N., Han, H., Almeida, M.P., Thibeault, P.E., Lin, S., MacLeod, G., Gratton, J.-P., Moffat, J., Angers, S. (2025). Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation. Stem Cell Reports. DOI
• Yang, A., Chidiac, R., Russo, E., Steenland, H., Pauli, Q., Bonin, R., Blazer, L.L., Adams, J.J., Sidhu, S.S., Goeva, A., Salahpour, A., Angers, S. (2024). Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. Development Cambridge. DOI
• El Bakkouri, Y., Chidiac, R., Delisle, C., Corriveau, J., Cagnone, G., Gaonac’h-Lovejoy, V., Chin, A., Lécuyer, É., Angers, S., Joyal, J.-S., Topisirovic, I., Hulea, L., Dubrac, A., Gratton, J.-P. (2024). ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis. Nature Communications. DOI
• O'Brien, S., Chidiac, R., Angers, S. (2023). Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges. Trends in Pharmacological Sciences. DOI
• Smith, T.L., Oubaha, M., Cagnone, G., Boscher, C., Kim, J.S., El Bakkouri, Y., Zhang, Y., Chidiac, R., Corriveau, J., Delisle, C., Andelfinger, G.U., Sapieha, P., Joyal, J.-S., Gratton, J.-P. (2022). eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity. Cellular and Molecular Life Sciences. DOI
• Chidiac, R., Abedin, M., Macleod, G., Yang, A., Thibeault, P.E., Blazer, L.L., Adams, J.J., Zhang, L., Roehrich, H., Jo, H.-N., Seshagiri, S., Sidhu, S.S., Junge, H.J., Angers, S. (2021). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Molecular Medicine. DOI
• Abu-Thuraia, A., Goyette, M.-A., Boulais, J., Delliaux, C., Apcher, C., Schott, C., Chidiac, R., Bagci, H., Thibault, M.-P., Davidson, D., Ferron, M., Veillette, A., Daly, R.J., Gingras, A.-C., Gratton, J.-P., Côté, J.-F. (2020). AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network. Nature Communications. DOI
• (2019). Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice. eLife. DOI
• Miloudi, K., Oubaha, M., Ménard, C., Dejda, A., Guber, V., Cagnone, G., Wilson, A.M., Tétreault, N., Mawambo, G., Binet, F., Chidiac, R., Delisle, C., Buscarlet, M., Cerani, A., Crespo-Garcia, S., Bentley, K., Rezende, F., Joyal, J.-S., Mallette, F.A., ... Sapieha, P. (2019). NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Ouadda, A.B.D., He, Y., Calabrese, V., Ishii, H., Chidiac, R., Gratton, J.-P., Roux, P.P., Lamarche-Vane, N. (2018). CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein. Oncotarget. DOI
• Hernández-Vásquez, M.N., Adame-García, S.R., Hamoud, N., Chidiac, R., Reyes-Cruz, G., Gratton, J.P., Côté, J.-F., Vázquez-Prado, J. (2017). Cell adhesion controlled by adhesion G protein–coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo–Dock. Journal of Biological Chemistry. DOI
• Zhang, Y., Chidiac, R., Delisle, C., Gratton, J.-P. (2017). Endothelial NO synthase-dependent S-nitrosylation of β-catenin prevents its association with TCF4 and inhibits proliferation of endothelial cells stimulated by Wnt3a. Molecular and Cellular Biology. DOI
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.-P. (2016). Comparative phosphoproteomics analysis of VEGF and angiopoietin-1 signaling reveals ZO-1 as a critical regulator of endothelial cell proliferation. Molecular and Cellular Proteomics. DOI
• Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R.A., Gratton, J.-P., Côté, J.-F. (2015). Axl phosphorylates Elmo scaffold proteins to promote rac activation and cell invasion. Molecular and Cellular Biology. DOI
• Zgheib, C., Zouein, F.A., Chidiac, R., Kurdi, M., Booz, G.W. (2012). Calyculin a reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. Journal of Interferon and Cytokine Research. DOI
• Kurdi, M., Chidiac, R., Hoemann, C., Zouein, F., Zgheib, C., Booz, G.W. (2010). Hydrogels as a Platform for Stem Cell Delivery to the Heart. Congestive Heart Failure. DOI

Chapitres de livre

• Chidiac, R., Angers, S. (2023). Wnt signaling in stem cells during development and cell lineage specification. Current Topics in Developmental Biology. DOI

Articles de conférence

• Vanderperre, B., Muraleedharan, A., Larroquette, F., Chidiac, R., Tardif, C., Rajakulendran, N., Macleod, G., Lariviere, R., Pellitero, E., Thomas, R., Durcan, T., Angers, S., Fon, E. (2023). A genome-wide CRISPR/Cas9 screening identifies genetic modifers of alpha synuclein aggregates uptake. IBRO 11th World Congress of Neuroscience.
• Chidiac, R., Yang, A., Kubarakos, E., Blazer, L., Adams, J., Sidhu, S., Angers, S. (2020). Rational activation of Wnt signalling circuits to promote directed differentiation of human embryonic stem cells. Medicine by Design symposium, University of Toronto.
• Chidiac, R., Kubarakos, E., Yang, A., Angers, S. (2019). Rational activation of Wnt signalling circuits to promote directed differentiation of human embryonic stem cells. Gordon Research Conferences (GRC) Wnt signaling.
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2015). L’effet de la phosphorylation de ZO-1 dans la régulation de son activité aux jonctions intercellulaires endothéliales et de la prolifération cellulaire. – Journée de la recherche Gabriel Plaa, Université de Montréal.
• Zgheib, C., Sebastian, T., Chidiac, R., Keen, H., Kurdi, M., Booz, G.W. (2010). Protein Phosphatase 2A (PP2A) Plays a Critical Role Determining the Endothelial Cell Gene Expression Profile of Leukemia Inhibitory Factor (LIF). Washington D.C., USA.

Autres contributions

Présentations

• Chidiac, Rony. (2025). Innovations thérapeutiques en régénération vasculaire. Institut de cardiologie.
• Chidiac, Rony. (2025). Mechanisms of endothelial regeneration and vascular repair: application to regenerative medicine. Institut de recherches cliniques de Montreal (IRCM).
• Chidiac, Rony. (2025). Stratégies thérapeutiques innovantes de régénération vasculaire pour les rétinopathies. École d'Optométrie, Université de Montréal.
• Chidiac, Rony. (2025). Stratégies thérapeutiques innovantes de régénération vasculaire pour les rétinopathies. Journée annuelle ThéCell.
• Chidiac, Rony. (2024). Innovations thérapeutiques en régénération vasculaire. Institut National de la Recherche Scientifique (INRS).
• Chidiac, Rony. (2024). Innovations thérapeutiques en régénération vasculaire. Centre de Recherche du CHU de Québec, Université Laval.
• Chidiac, Rony. (2024). Mécanismes de régénération endothéliale et de reparation vasculaire: Applications en médecine régénératrice. Universite du Quebec a Trois-Rivieres (UQTR).
• Chidiac, Rony. (2024). Régénération Endothéliale et Réparation Vasculaire : Vers de Nouvelles Stratégies Thérapeutiques. Université de Sherbrooke.
• Chidiac, Rony. (2024). The cell junction protein ZO-1 interacts with RNA-binding proteins in endothelial cells to regulate stress granule formation during angiogenesis. 2e symposium scientifique du centre d’innovation biomédicale.
• Chidiac, Rony. (2023). Rational activation of Wnt signaling in stem cells and diseases. Pause-conférence : Le Centre d'Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois (CERMO-FC).
• Chidiac, Rony. (2021). Therapeutic Frizzled4/LRP5 antibody activating Wnt signaling for the treatment of vascular retinopathies. Molecular Pharmacology and Pharmacokinetics Seminars, University of Toronto.
• Chidiac, Rony. (2021). Therapeutic Frizzled4/LRP5 antibody activating Wnt signaling for the treatment of vascular retinopathies. Medicine by Design and PRiME joint symposium, Cell and Gene Therapies Innovation Showcase Event.
• Chidiac, Rony. (2019). Rational activation of Wnt signalling circuits to promote directed differentiation of human embryonic stem cells. PRiME research rounds.
• Chidiac, R., Angers, S. (2019). Rational activation of Wnt signalling circuits to promote directed differentiation of human embryonic stem cells. Gordon Research Conference on Wnt signaling.
• Chidiac, R., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2017). Étude Protéomique de l’implication de la voie p38 MAPK dans la régulation de ZO-1 aux jonctions des cellules endothéliales. Journée de la recherche Gabriel Plaa, Département de pharmacologie et physiologie, Université de Montréal.
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2016). Comparative phosphoproteomics analysis of VEGF and Angiopoietin-1 signaling reveals ZO-1 as a critical regulator of endothelial cell proliferation. Canadian National Proteomics Network.

Affiches pour une conférence

• Chidiac, R., Yang, A., Kubarakos, E., Mikolajewicz, N., Han, H., Almeida, M., Thibeault, P., Lin, S., MacLeod, G., Moffat, J., Angers, S. (2025). Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation. GPCR retreat.
• Chidiac, R., El Bakkouri, Y., Delisle, C., Corriveau, J., Gaonach-Lovejoy, V., Gratton, J.P. (2025). ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis. 13th Conference on Signalling in Normal and Cancer Cells.
• Chidiac, R., Abedin, Md, MacLeod, G., Yang, A., Thibeualt, P., Blazer, L., Adams, J., Zhang, L., Roehrich, H., Jo, H.N., Seshagiri, S., Sidhu, S., Junge, H., Angers, S. (2024). A Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. Reseau de recherche en sciences de la vision.
• Chidiac, R., Yang, A., Kubarakos, E., Mikolajewicz, N., Han, H., Almeida, M., Thibeault, P., Lin, S., MacLeod, G., Moffat, J., Angers, S. (2023). Rational activation of Wnt signalling reveals distinct functions for FZD2 and FZD7 receptors in mesoderm differentiation. Gordon Research Conferences (GRC) Wnt meeting.
• Chidiac, R., Abedin, Md, MacLeod, G., Yang, A., Thibeualt, P., Blazer, L., Adams, J., Zhang, L., Roehrich, H., Jo, H.N., Seshagiri, S., Sidhu, S., Junge, H., Angers, S. (2022). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. PRiME Symposium.
• Chidiac, R., Abedin, Md, MacLeod, G., Yang, A., Thibeualt, P., Blazer, L., Adams, J., Zhang, L., Roehrich, H., Jo, H.N., Seshagiri, S., Sidhu, S., Junge, H., Angers, S. (2022). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. Donnelly Center Retreat.
• Chidiac, R., Philpott, D., Yang, A., Kubarakos, E., Atwal, R., Kelley, S., Angers, S. (2022). Genome-wide CRISPR-Cas9 screen in human embryonic stem cells to identify regulators of hemogenic endothelium differentiation. Medicine by Design Symposium.
• Chidiac, R., Philpott, D., Yang, A., Kubarakos, E., Atwal, R., Kelley, S., Angers, S. (2021). Genome-wide CRISPR-Cas9 screen in human embryonic stem cells to identify regulators of hemogenic endothelium differentiation. Till and McCulloch meetings - Stem Cell Network Conference.
• Chidiac, R., Zhang, Y., Delisle, C., Gratton, J.P. (2017). Étude Protéomique de l’implication de la voie p38 MAPK dans la régulation de ZO-1 aux jonctions des cellules endothéliales. 10ème journée scientifique du GRUM (Groupe de recherche universitaire sur le médicament).
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2016). Comparative phosphoproteomics analysis of VEGF and Angiopoietin-signaling reveals ZO1 is a critical regulator of endothelial cell proliferation. Canadian National Proteomics Network.
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2016). L’analyse par phosphoprotéomique comparative des voies de signalisation activées par le VEGF et l’Ang-1 révèle que ZO-1 régule la prolifération des cellules endothéliales. Signalisation Québec 7ème édition.
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2015). L’analyse par phosphoprotéomique comparative des voies de signalisation activées par le VEGF et l’Ang-1 révèle que ZO-1 régule la prolifération des cellules endothéliales. Journée scientifique du département de pathologie et biologie cellulaire, UdeM.
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2014). Analyse par phosphoprotéomique comparative des voies de signalisation activées par le VEGF et l’Ang-1 révèle un rôle pour les protéines de jonctions dans la prolifération cellulaire. Signalisation Québec 6ème édition.
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.P. (2014). Analyse par phosphoprotéomique comparative des voies de signalisation endothéliales activées par les facteurs angiogéniques. – Journée de la recherche Gabriel Plaa, Université de Montréal.

Activités professionnelles

• Montreal Heart Institute. Member, PhD Thesis Examination Committee : Chloé David, Laboratoire du Pr Matthieu Ruiz. Montreal, Quebec, Canada. (2026-).
• Université de Montréal. External Member, PhD Comprehensive Examination Committee : Guillaume Bellemare, Lab Dr Sergio Crespo-Garcia. Montreal, Quebec, Canada. (2026-).
• Université du Québec à Montréal. External Member, PhD Comprehensive Examination Committee : Kawtar Zouine, Lab Dr Malika Oubaha. Montreal, Quebec, Canada. (2026-).
• Université de Sherbrooke. Chair, PhD Thesis Examination Committee - Hoaran Geng, Lab Dr Christine Lavoie. Sherbrooke, Quebec, Canada. (2026-).
• Université de Sherbrooke. Member, PhD Thesis Examination Committee : Olivier Dionne, Lab Dr Benoît Laurent. Sherbrooke, Quebec, Canada. (2026-).
• Université de Sherbrooke. External Member, PhD Thesis Examination Committee - Maude Hamilton, Laboratoire du Pr Véronique Giroux. Sherbrooke, Quebec, Canada. (2026-).
• Gordon Research Conferences. Chair - Gordon Research Seminars. Kingston, Rhode Island, États-Unis. (2023-).