Rony Chidiac

Financement

• Subvention. Harnessing pluripotent stem cell-derived choroidal endothelial cells for vascular regeneration in age-related macular degeneration. Réseau de recherche en sciences de la vision (Montréal, Canada). 50 000 $. (2025-2026). Voir plus
• Subvention. Novel Frizzled-4/LRP5 antibody-based agonist for neovascular macular degeneration. BrightFocus Foundation (Clarksburg, États-Unis). 200 000 USD. (2021-2023).
  Numéro de subvention : M2021003F.

Publications

Articles

• Vanderperre, B., Muraleedharan, A., Dorion, M.-F., Larroquette, F., Del Cid Pellitero, E., Rajakulendran, N., Chen, C.X.Q., Larivière, R., Michaud-Tardif, C., Goiran, T., Chidiac, R., Lipuma, D., MacLeod, G., Thomas, R., Wang, Z., Reintsch, W.E., Luo, W., Shlaifer, I., Zhang, F., ... Fon, E.A. (2025). Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils. Communications Biology. DOI
• Chidiac, R., Yang, A., Kubarakos, E., Mikolajewicz, N., Han, H., Almeida, M.P., Thibeault, P.E., Lin, S., MacLeod, G., Gratton, J.-P., Moffat, J., Angers, S. (2025). Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation. Stem Cell Reports. DOI
• Yang, A., Chidiac, R., Russo, E., Steenland, H., Pauli, Q., Bonin, R., Blazer, L.L., Adams, J.J., Sidhu, S.S., Goeva, A., Salahpour, A., Angers, S. (2024). Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. Development Cambridge. DOI
• El Bakkouri, Y., Chidiac, R., Delisle, C., Corriveau, J., Cagnone, G., Gaonac’h-Lovejoy, V., Chin, A., Lécuyer, É., Angers, S., Joyal, J.-S., Topisirovic, I., Hulea, L., Dubrac, A., Gratton, J.-P. (2024). ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis. Nature Communications. DOI
• O'Brien, S., Chidiac, R., Angers, S. (2023). Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges. Trends in Pharmacological Sciences. DOI
• Smith, T.L., Oubaha, M., Cagnone, G., Boscher, C., Kim, J.S., El Bakkouri, Y., Zhang, Y., Chidiac, R., Corriveau, J., Delisle, C., Andelfinger, G.U., Sapieha, P., Joyal, J.-S., Gratton, J.-P. (2022). eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity. Cellular and Molecular Life Sciences. DOI
• Chidiac, R., Abedin, M., Macleod, G., Yang, A., Thibeault, P.E., Blazer, L.L., Adams, J.J., Zhang, L., Roehrich, H., Jo, H.-N., Seshagiri, S., Sidhu, S.S., Junge, H.J., Angers, S. (2021). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Molecular Medicine. DOI
• Abu-Thuraia, A., Goyette, M.-A., Boulais, J., Delliaux, C., Apcher, C., Schott, C., Chidiac, R., Bagci, H., Thibault, M.-P., Davidson, D., Ferron, M., Veillette, A., Daly, R.J., Gingras, A.-C., Gratton, J.-P., Côté, J.-F. (2020). AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network. Nature Communications. DOI
• (2019). Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice. eLife. DOI
• Miloudi, K., Oubaha, M., Ménard, C., Dejda, A., Guber, V., Cagnone, G., Wilson, A.M., Tétreault, N., Mawambo, G., Binet, F., Chidiac, R., Delisle, C., Buscarlet, M., Cerani, A., Crespo-Garcia, S., Bentley, K., Rezende, F., Joyal, J.-S., Mallette, F.A., ... Sapieha, P. (2019). NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Ouadda, A.B.D., He, Y., Calabrese, V., Ishii, H., Chidiac, R., Gratton, J.-P., Roux, P.P., Lamarche-Vane, N. (2018). CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein. Oncotarget. DOI
• Hernández-Vásquez, M.N., Adame-García, S.R., Hamoud, N., Chidiac, R., Reyes-Cruz, G., Gratton, J.P., Côté, J.-F., Vázquez-Prado, J. (2017). Cell adhesion controlled by adhesion G protein–coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo–Dock. Journal of Biological Chemistry. DOI
• Zhang, Y., Chidiac, R., Delisle, C., Gratton, J.-P. (2017). Endothelial NO synthase-dependent S-nitrosylation of β-catenin prevents its association with TCF4 and inhibits proliferation of endothelial cells stimulated by Wnt3a. Molecular and Cellular Biology. DOI
• Chidiac, R., Zhang, Y., Tessier, S., Faubert, D., Delisle, C., Gratton, J.-P. (2016). Comparative phosphoproteomics analysis of VEGF and angiopoietin-1 signaling reveals ZO-1 as a critical regulator of endothelial cell proliferation. Molecular and Cellular Proteomics. DOI
• Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R.A., Gratton, J.-P., Côté, J.-F. (2015). Axl phosphorylates Elmo scaffold proteins to promote rac activation and cell invasion. Molecular and Cellular Biology. DOI
• Zgheib, C., Zouein, F.A., Chidiac, R., Kurdi, M., Booz, G.W. (2012). Calyculin a reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. Journal of Interferon and Cytokine Research. DOI
• Kurdi, M., Chidiac, R., Hoemann, C., Zouein, F., Zgheib, C., Booz, G.W. (2010). Hydrogels as a Platform for Stem Cell Delivery to the Heart. Congestive Heart Failure. DOI

Chapitres de livre

• Chidiac, R., Angers, S. (2023). Wnt signaling in stem cells during development and cell lineage specification. Current Topics in Developmental Biology. DOI