Michel Boutin

Prix et distinctions

• (2005) Postdoctoral Scholarship. Fonds de recherche du Québec-Nature et technologies (FRQNT).
• (2005) Postdoctoral Scholarship. Natural Sciences and Engineering Research Council of Canada.
• (2002) Ph.D. Scholarship in research. Natural Sciences and Engineering Research Council of Canada.
• (2002) Ph.D. Scholarship for research in Health and Safety at Work. Institut de recherche Robert-Sauvé en santé et en sécurité du travail.
• (2002) Ph.D. Scholarship. Fonds de recherche du Québec-Nature et technologies (FRQNT).
• (2002) Ph.D. Scholarship at workplace. Fonds pour la Formation de Chercheurs et l'Aide à la Recherche (FCAR-MRST).
• (2000) M.Sc. Scholarship in research. The Natural Sciences and Engineering Research Council of Canada (NSERC).
• (2000) M.Sc. Scholarship in research. Fonds pour la Formation de Chercheurs et l'Aide à la Recherche (FCAR).
• (2000) M.Sc. Scholarship for research in Health and Safety at Work. Institut de recherche Robert-Sauvé en santé et en sécurité du travail.

Financement

• Subvention. Fabry disease biomarkers. Kidney for Life (London, Royaume-Uni). Travel. 909 GBP. (2017).

Publications

Articles

• Cyr D, Boutin M, Maranda B, Waters PJ. (2024). Enhanced differentiation between 3-hydroxyglutaric and 2-hydroxyglutaric acids facilitates diagnostic testing for glutaric aciduria type 1. JIMD reports. DOI
• Boutin M, Maranda B, Waters PJ. (2024). Analysis of Globotriaosylceramide (Gb3) in Liquid Urine: A Straightforward Assay Using Tandem Mass Spectrometry. Current protocols. DOI
• Menkovic I, Boutin M, Lavoie P, Auray-Blais C. (2023). Multiplex Quantification of Plasma Biomarkers for Patients with Gaucher Disease Type 1. Current protocols. DOI
• Michel Boutin, Pamela Lavoie, Margot Beaudon, Georges Kabala Ntumba, Daniel G. Bichet, Bruno Maranda, Christiane Auray-Blais. (2023). Mass Spectrometry Analysis of Globotriaosylsphingosine and Its Analogues in Dried Blood Spots. International Journal of Molecular Sciences. DOI
• Michel Boutin. (2022). Vitamin B-12 Intake from Dairy But Not Meat is Associated with Decreased Risk of Low Vitamin B-12 Status and Deficiency in Older Adults from Quebec, Canada. The Journal of nutrition. DOI
• Michel Boutin. (2022). Quantitation of a Urinary Profile of Biomarkers in Gaucher Disease Type 1 Patients Using Tandem Mass Spectrometry. Diagnostics (Basel, Switzerland). DOI
• Michel Boutin. (2022). Methylmalonic acid analysis using urine filter paper samples to screen for metabolic vitamin B₁₂ deficiency in older adults. Bioanalysis. DOI
• Michel Boutin. (2022). Metabolomic Study Using Time-of-Flight Mass Spectrometry Reveals Novel Urinary Biomarkers for Gaucher Disease Type 1. Journal of proteome research. DOI
• Michel Boutin. (2022). Lysosphingolipid urine screening test using mass spectrometry for the early detection of lysosomal storage disorders. Bioanalysis. DOI
• Michel Boutin. (2022). Quantitation of a plasma biomarker profile for the early detection of Gaucher disease type 1 patients. Bioanalysis. DOI
• Christiane Auray-Blais, Michel Boutin, Pamela Lavoie, Bruno Maranda. (2021). Neonatal Urine Screening Program in the Province of Quebec: Technological Upgrade from Thin Layer Chromatography to Tandem Mass Spectrometry. International Journal of Neonatal Screening. DOI
• (2021). Lentivirus-mediated gene therapy for Fabry disease. Nature communications. DOI
• (2020). Globotriaosylsphingosine (lyso-Gb3) and analogues in plasma and urine of patients with Fabry disease and correlations with long-term treatment and genotypes in a nationwide female Danish cohort. Journal of medical genetics. DOI
• (2020). Assessing the role of glycosphingolipids in the phenotype severity of Fabry disease mouse model. Journal of lipid research. DOI
• (2020). Diurnal Variation of Urinary Fabry Disease Biomarkers during Enzyme Replacement Therapy Cycles. International journal of molecular sciences. DOI
• (2020). Therapeutic challenges in two adolescent male patients with Fabry disease and high antibody titres. Molecular genetics and metabolism reports. DOI
• (2020). Effects of orally delivered alpha-galactosidase A on gastrointestinal symptoms in patients with Fabry disease. Gastroenterology. DOI
• (2020). Mass spectrometry analysis of urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older adults. Bioanalysis. DOI
• (2020). Mass Spectrometry Evaluation of Biomarkers in the Vitreous Fluid in Gaucher Disease Type 3 with Disease Progression Despite Long-Term Treatment. Diagnostics (Basel, Switzerland). DOI
• (2020). Identification of a Reliable Biomarker Profile for the Diagnosis of Gaucher Disease Type 1 Patients using a Mass Spectrometry-Based Metabolomic Approach. Int. J. Mol. Sci.
• (2019). High-risk screening for Fabry disease in a Canadian cohort of chronic kidney disease patients. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2019). Neonatal Mass Urine Screening Approach for Early Detection of Mucopolysaccharidoses by UPLC-MS/MS. Diagnostics (Basel, Switzerland). DOI
• (2019). The clinical utility of total concentration of urinary globotriaosylsphingosine plus its analogues in the diagnosis of Fabry disease. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2019). Mutation-specific Fabry disease patient-derived cell model to evaluate the amenability to chaperone therapy. Journal of medical genetics. DOI
• (2019). Distribution of heparan sulfate and dermatan sulfate in mucopolysaccharidosis type II mouse tissues pre- and post-enzyme-replacement therapy determined by UPLC-MS/MS. Bioanalysis. DOI
• (2019). Tandem mass spectrometry analysis of urinary podocalyxin and podocin in the investigation of podocyturia in women with preeclampsia and Fabry disease patients. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2019). Altered immune phenotypes in subjects with Fabry disease and responses to switching from agalsidase alfa to agalsidase beta. American journal of translational research.
• (2018). Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction. Journal of the American Heart Association. DOI
• (2018). Analysis of globotriaosylceramide (Gb3) isoforms/analogs in unfractionated leukocytes, B lymphocytes and monocytes from Fabry patients using ultra-high performance liquid chromatography/tandem mass spectrometry. Analytica chimica acta. DOI
• (2018). Globotriaosylsphingosine (Lyso-Gb3) as a biomarker for cardiac variant (N215S) Fabry disease. Journal of inherited metabolic disease. DOI
• (2017). The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein. Neurobiology of disease. DOI
• (2017). Separation and Analysis of Lactosylceramide, Galabiosylceramide, and Globotriaosylceramide by LC-MS/MS in Urine of Fabry Disease Patients. Analytical chemistry. DOI
• (2017). Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34+ Cells for Correction of Fabry Disease. Molecular therapy. Methods & clinical development. DOI
• (2017). [Identification of proteins associated with transcription factors HOXA9 and E2A-PBX1 by tandem affinity purification]. Molekuliarnaia biologiia. DOI
• (2017). High-Risk Screening for Fabry Disease: Analysis by Tandem Mass Spectrometry of Globotriaosylceramide (Gb3 ) in Urine Collected on Filter Paper. Current protocols in human genetics. DOI
• (2017). Biomarkers associated with clinical manifestations in Fabry disease patients with a late-onset cardiac variant mutation. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2016). Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion. Future science OA. DOI
• (2016). High-Risk Screening of Fabry Disease: Analysis of Fifteen Urinary Methylated and Non-Methylated Gb3 Isoforms Using Tandem Mass Spectrometry. Current protocols in human genetics. DOI
• (2016). Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry. Bioanalysis. DOI
• (2016). Fabry Disease Biomarkers: Analysis of Urinary Lyso-Gb3 and Seven Related Analogs Using Tandem Mass Spectrometry. Current protocols in human genetics. DOI
• (2016). Tandem Mass Spectrometry Quantitation of Lyso-Gb3 and Six Related Analogs in Plasma for Fabry Disease Patients. Current protocols in human genetics. DOI
• (2016). Maternal inhaled fluticasone propionate intake during pregnancy is detected in neonatal cord blood. Bioanalysis. DOI
• (2016). Diagnosis of late-onset Pompe disease and other muscle disorders by next-generation sequencing. Orphanet journal of rare diseases. DOI
• (2016). Evaluation of urinary keratan sulfate disaccharides in MPS IVA patients using UPLC-MS/MS. Bioanalysis. DOI
• (2016). Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson Disease. Analytical chemistry. DOI
• (2015). Tandem mass spectrometry multiplex analysis of methylated and non-methylated urinary Gb3 isoforms in Fabry disease patients. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2015). Variations in the GLA gene correlate with globotriaosylceramide and globotriaosylsphingosine analog levels in urine and plasma. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2015). Metabolomic discovery of novel urinary galabiosylceramide analogs as Fabry disease biomarkers. Journal of the American Society for Mass Spectrometry. DOI
• (2014). Urinary biomarker investigation in children with Fabry disease using tandem mass spectrometry. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2014). Multiplex tandem mass spectrometry analysis of novel plasma lyso-Gb₃-related analogues in Fabry disease. Analytical chemistry. DOI
• (2013). A metabolomic study to identify new globotriaosylceramide-related biomarkers in the plasma of Fabry disease patients. Analytical chemistry. DOI
• (2013). Multiplex analysis of novel urinary lyso-Gb3-related biomarkers for Fabry disease by tandem mass spectrometry. Analytical chemistry. DOI
• (2012). LC-MS/MS analysis of plasma lyso-Gb3 in Fabry disease. Clinica chimica acta; international journal of clinical chemistry. DOI
• (2012). Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress. Nucleic acids research. DOI
• (2012). Urinary globotriaosylsphingosine-related biomarkers for Fabry disease targeted by metabolomics. Analytical chemistry. DOI
• (2009). NanoLC-MS/MS analyses of urinary desmosine, hydroxylysylpyridinoline and lysylpyridinoline as biomarkers for chronic graft-versus-host disease. Analytical chemistry. DOI
• (2009). High-sensitivity nanoLC-MS/MS analysis of urinary desmosine and isodesmosine. Analytical chemistry. DOI
• (2007). Negative-charge driven fragmentations for evidencing zwitterionic forms from doubly charged coppered peptides. Journal of mass spectrometry : JMS. DOI
• (2006). Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops. The Annals of occupational hygiene. DOI
• (2005). Validation of a solvent-free sampler for the determination of low molecular weight aliphatic isocyanates under thermal degradation conditions. Journal of occupational and environmental hygiene. DOI
• (2004). Temperature-programmed pyrolysis hyphenated with metastable atom bombardment ionization mass spectrometry (TPPy/MAB-MS) for the identification of additives in polymers. Journal of the American Society for Mass Spectrometry. DOI
• (2004). Identification of the isocyanates generated during the thermal degradation of a polyurethane car paint. Journal of Analytical and Applied Pyrolysis. DOI
• (2003). Comparison of EI and metastable atom bombardment ionization for the identification of polyurethane thermal degradation products. Journal of Analytical and Applied Pyrolysis. DOI
• (2003). Investigating the thermal degradation of polymers: a systematic approach. Applied occupational and environmental hygiene. DOI

Autres contributions

Affiches pour une conférence

• Michel Boutin. (2022). From the discovery of novel Fabry disease biomarkers in plasma by untargeted metabolomics to their analysis in dried blood spots. 18th International Conference of the Metabolomics Society.
• (2019). Simple and Rapid Tandem Mass Spectrometry Method for the Analysis of Methylmalonic Acid in Urine. Mass Spectrometry: Applications to the Clinical Lab.
• (2019). Tandem Mass Spectrometry Analysis of Urinary Methylmalonic Acid as Marker of Metabolic Vitamin B12 Deficiency in Older Adults. 15th International Conference of the Metabolomics Society, The Haye.
• (2017). Evaluation of the distribution of Gb3 isoforms and analogues in Fabry mouse tissues using a tandem mass spectrometry approach. 5th Nephropathy Update.
• (2017). Tandem mass spectrometry analysis of Gb3 isoforms and analogues in different NOD/SCID Fabry mouse tissues. 13rd Annual International Conference of the Metabolomics Society.
• (2016). UPLC-MS/MS Analysis of Glucosylceramide and Galactosylceramide Isoforms in Parkinson’s Disease Brain Tissues. 12nd Annual International Conference of the Metabolomics Society.
• (2015). Discovery of Novel Urinary Galabiosylceramide-Related Biomarkers for Fabry Disease Using a Q-Tof Mass Spectrometry Metabolomic Approach. 63rd ASMS Conference on Mass Spectrometry and Allied Topics.
• (2015). Mass spectrometry analysis of alpha-Galactosidase A metabolites, globotriaosylceramide and globotriaosylsphingosine, in Parkinson disease brain tissues. 11st Annual International Conference of the Metabolomics Society.
• (2014). Discovery of Galabiosylceramide-Related Fabry Disease Urinary Biomarkers Using a Mass Spectrometry-Based Metabolomic Approach. 10th Annual International Conference of the Metabolomics Society.
• (2013). 13C16-Palmitic Acid Metabolization into Ceramide for the Determination of Ceramide Synthesis in Type 2 Diabetes Patients. 9th Annual International Conference of the Metabolomics Society.
• (2013). Discovery of Novel Gb3-Related Biomarkers of Fabry Disease. Garrod-AMGQ Symposium.
• (2012). Quantitative Analysis of Ceramides in Urines and Plasma of Fabry Patients. 8th WORLD SymposiumTM.
• (2010). Quantification of Poly(ADP-ribose)-Binding Proteins Using Multiple Reaction Monitoring (MRM). Canadian National Protreomics Network Symposium.
• (2009). NanoLC-MS/MS Analysis of Urinary Biomarkers of Chronic Graft-Versus-Host Disease. 57th ASMS Conference on Mass Spectrometry and Allied Topics.
• (2008). High Sensitivity Nano-LC-MS/MS Analysis of Urinary Hydroxylysylpyridinoline and Lysylpyridinoline as Measurement of Collagen Turnover. 56th ASMS Conference on Mass Spectrometry and Allied Topics.
• (2007). High Sensitivity Analysis of Urinary Desmosine and Isodesmosine Using Nano-LC-MS/MS. 55th ASMS Conference on Mass Spectrometry and Allied Topics.
• (2006). Behavior of Peptide/Copper Complexes in the Gas Phase: Evidencing of Zwitterionic Forms from Doubly Charged Species. 54th ASMS Conference on Mass Spectrometry and Allied Topics.
• (2006). Comportement des complexes peptide/cuivre(II) en phase gazeuse : mise en évidence de zwitterions. 23ièmes Journées Françaises de Spectrométrie de Masse.
• (2004). Determination of the Aliphatic Isocyanates Generated During the Thermal Degradation of a Polyurethane Car Paint as 1-(2-Methoxyphenyl)piperazine Derivatives Using HPLC/ESI-MS/MS. 52nd ASMS Conference on Mass Spectrometry and Allied Topics.
• (2004). Temperature-Programmed Pyrolysis Hyphenated with Metastable Atom Bombardment Ionization Mass Spectrometry (TPPy/MAB-MS) for the Identification of Additives in Polymers. 52nd ASMS Conference on Mass Spectrometry and Allied Topics.
• (2003). Identification of Isocyanates Generated During the Thermal Degradation of a Polyurethane Paint Using HPLC/MS/MS. 51st ASMS Conference on Mass Spectrometry and Allied Topics.
• (2002). Identification of Products Generated During the Pyrolysis of Polyurethane-Based Car Paint Using Py-MAB-Tof Analysis. 50th ASMS Conference on Mass Spectrometry and Allied Topics.
• (2001). A Comparative Study of EI and MAB Ionization for the Analysis of Thermal Degradation Products for a MDI-Based Polyurethane. 49th ASMS Conference on Mass Spectrometry and Allied Topics.
• (2001). Identification des produits émis lors de la combustion d’une peinture automobile par spectrométrie de masse. Colloque thématique de l’IRSST (Institut de recherche Robert-Sauvé en santé et en sécurité du travail) portant sur les mutations des milieux de travail et les changements de paradigme dans la recherche en santé et en sécurité du travail.