Mathieu Quesnel-Vallières

Financement

• Subvention. Investigating the functions of a neural-specific splicing regulator in the developing and adult mammalian nervous system. Canadian Institutes of Health Research (Ottawa, Canada). Scholarship. 105 000 $. (2011-2014).

Publications

Articles

• Manuel Torres-Diz, Clara Reglero, Catherine D. Falkenstein, Annette Castro, Katharina E. Hayer, Caleb M. Radens, Mathieu Quesnel-Vallières, Zhiwei Ang, Priyanka Sehgal, Marilyn M. Li, Yoseph Barash, Sarah K. Tasian, Adolfo Ferrando, Andrei Thomas-Tikhonenko. (2024). An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. Cancer Research. DOI
• Liu, X., Devadiga, S.A., Stanley, R.F., Morrow, R.M., Janssen, K.A., Quesnel-Vallières, M., Pomp, O., Moverley, A.A., Li, C., Skuli, N., Carroll, M., Huang, J., Wallace, D.C., Lynch, K.W., Abdel-Wahab, O., Klein, P.S. (2024). A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. Journal of Clinical Investigation. DOI
• Quesnel-Vallières, M., Jewell, S., Lynch, K.W., Thomas-Tikhonenko, A., Barash, Y. (2024). MAJIQlopedia:ãn encyclopedia of RNA splicing vãr iations in human tissuesãnd cancer. Nucleic Acids Research. DOI
• Wang, D., Quesnel-Vallieres, M., Jewell, S., Elzubeir, M., Lynch, K., Thomas-Tikhonenko, A., Barash, Y. (2023). A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers. Nature Communications. DOI
• Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023). The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of Developmental Biology. DOI
• Cortés-López, M., Schulz, L., Enculescu, M., Paret, C., Spiekermann, B., Quesnel-Vallières, M., Torres-Diz, M., Unic, S., Busch, A., Orekhova, A., Kuban, M., Mesitov, M., Mulorz, M.M., Shraim, R., Kielisch, F., Faber, J., Barash, Y., Thomas-Tikhonenko, A., Zarnack, K., ... König, J. (2022). High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance. Nature Communications. DOI
• Wakabayashi, A., Kihiu, M., Sharma, M., Thrasher, A.J., Saari, M.S., Quesnel-Vallières, M., Abdulmalik, O., Peslak, S.A., Khandros, E., Keller, C.A., Giardine, B.M., Barash, Y., Hardison, R.C., Shi, J., Blobel, G.A. (2022). Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Advances. DOI
• Jha, A., Quesnel-Vallières, M., Wang, D., Thomas-Tikhonenko, A., Lynch, K.W., Barash, Y. (2022). Identifying common transcriptome signatures of cancer by interpreting deep learning models. Genome Biology. DOI
• Zheng, S., Gillespie, E., Naqvi, A.S., Hayer, K.E., Ang, Z., Torres-Diz, M., Quesnel-Vallières, M., Hottman, D.A., Bagashev, A., Chukinas, J., Schmidt, C., Asnani, M., Shraim, R., Taylor, D.M., Rheingold, S.R., O'Brien, M.M., Singh, N., Lynch, K.W., Ruella, M., ... Thomas-Tikhonenko, A. (2022). Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies. Blood Cancer Discovery. DOI
• Peart, N.J., Johnson, T.A., Lee, S., Sears, M.J., Yang, F., Quesnel-Vallieres, M., Feng, H., Recinos, Y., Barash, Y., Zhang, C., Hermann, B.P., Wang, P.J., Geyer, C.B., Carstens, R.P. (2022). The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice. PLoS Genetics. DOI
• Peart, N.J., Hwang, J.Y., Quesnel-Vallières, M., Sears, M.J., Yang, Y., Stoilov, P., Barash, Y., Park, J.W., Lynch, K.W., Carstens, R.P. (2022). The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function. iScience. DOI
• Rivera, O.D., Mallory, M.J., Quesnel-Vallières, M., Chatrikhi, R., Schultz, D.C., Carroll, M., Barash, Y., Cherry, S., Lynch, K.W. (2021). Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Gonatopoulos-Pournatzis, T., Niibori, R., Salter, E.W., Weatheritt, R.J., Tsang, B., Farhangmehr, S., Liang, X., Braunschweig, U., Roth, J., Zhang, S., Henderson, T., Sharma, E., Quesnel-Vallières, M., Permanyer, J., Maier, S., Georgiou, J., Irimia, M., Sonenberg, N., Forman-Kay, J.D., ... Blencowe, B.J. (2020). Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions. Molecular Cell. DOI
• Barbieri, E., Hill, C., Quesnel-Vallières, M., Zucco, A.J., Barash, Y., Gardini, A. (2020). Rapid and Scalable Profiling of Nascent RNA with fastGRO. Cell Reports. DOI
• Quesnel-Vallières, M., Weatheritt, R.J., Cordes, S.P., Blencowe, B.J. (2019). Autism spectrum disorder: insights into convergent mechanisms from transcriptomics. Nature Reviews Genetics. DOI
• Fiordaliso, S.K., Iwata-Otsubo, A., Ritter, A.L., Quesnel-Vallières, M., Fujiki, K., Nishi, E., Hancarova, M., Miyake, N., Morton, J.E.V., Lee, S., Hackmann, K., Bando, M., Masuda, K., Nakato, R., Arakawa, M., Bhoj, E., Li, D., Hakonarson, H., Takeda, R., ... Izumi, K. (2019). Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment. American Journal of Human Genetics. DOI
• Tapial, J., Ha, K.C.H., Sterne-Weiler, T., Gohr, A., Braunschweig, U., Hermoso-Pulido, A., Quesnel-Vallières, M., Permanyer, J., Sodaei, R., Marquez, Y., Cozzuto, L., Wang, X., Gómez-Velázquez, M., Rayon, T., Manzanares, M., Ponomarenko, J., Blencowe, B.J., Irimia, M. (2017). An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms. Genome Research. DOI
• Quesnel-Vallières, M., Dargaei, Z., Irimia, M., Gonatopoulos-Pournatzis, T., Ip, J.Y., Wu, M., Sterne-Weiler, T., Nakagawa, S., Woodin, M.A., Blencowe, B.J., Cordes, S.P. (2016). Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders. Molecular Cell. DOI
• Quesnel-Vallières, M., Irimia, M., Cordes, S.P., Blencowe, B.J. (2015). Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Genes and Development. DOI
• Irimia, M., Weatheritt, R.J., Ellis, J.D., Parikshak, N.N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O'Hanlon, D., Barrios-Rodiles, M., Sternberg, M.J.E., Cordes, S.P., Roth, F.P., Wrana, J.L., Geschwind, D.H., Blencowe, B.J. (2014). A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. DOI
• Larouche, A., Gaëtan, G., El-Bilali, N., Quesnel-Vallières, M., Martin, S.R., Alvarez, F., Shoukry, N.H., Soudeyns, H. (2012). Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission. Journal of Clinical Microbiology. DOI
• Quesnel-Vallières, M., Kouzayha, I., Tran, E., Barry, I., Lasgi, C., Merindol, N., Monteil, V., Ransy, D.G., Boucher, M., Lapointe, N., Soudeyns, H. (2011). Novel HIV-1 recombinant forms in antenatal cohort, Montreal, Quebec, Canada. Emerging Infectious Diseases. DOI
• Quesnel-Vallières, M., Lemay, M., Lapointe, N., Martin, S.R., Soudeyns, H. (2008). HCV quasispecies evolution during treatment with interferon alfa-2b and ribavirin in two children coinfected with HCV and HIV-1. Journal of Clinical Virology. DOI

Autres contributions

Divers

• Liu, X., Devadiga, S.A., Stanley, R.F., Morrow, R., Janssen, K., Quesnel-Vallières, M., Pomp, O., Moverley, A.A., Li, C., Skuli, N., Carroll, M.P., Huang, J., Wallace, D.C., Lynch, K.W., Abdel-Wahab, O., Klein, P.S. (2023). A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. bioRxiv.
• Torres-Diz, M., Reglero, C., Falkenstein, C.D., Castro, A., Hayer, K.E., Radens, C.M., Quesnel-Vallières, M., Ang, Z., Sehgal, P., Li, M.M., Barash, Y., Tasian, S.K., Ferrando, A., Thomas-Tikhonenko, A. (2023). An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Thiopurine Resistance in Acute Lymphoblastic Leukemia. bioRxiv.
• Cortes-Lopez, M., Schulz, L., Enculescu, M., Paret, C., Spiekermann, B., Busch, A., Orekhova, A., Kielisch, F., Quesnel-Vallieres, M., Torres-Diz, M., Faber, J., Barash, Y., Thomas-Tikhonenko, A., Zarnack, K., Legewie, S., Konig, J. (2021). High-throughput mutagenesis identifies mutations and RNAbinding proteins controlling CD19 splicing and CART-19 therapy resistance. bioRxiv.
• Jha, A., Quesnel-Vallières, M., Thomas-Tikhonenko, A., Lynch, K.W., Barash, Y. (2021). Identifying common transcriptome signatures of cancer by interpreting deep learning models. bioRxiv.
• Rivera, O.D., Mallory, M.J., Quesnel-Vallières, M., Schultz, D.C., Carroll, M., Barash, Y., Cherry, S., Lynch, K.W. (2020). Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. bioRxiv.
• Barbieri, E., Hill, C., Quesnel-Vallieres, M., Barash, Y., Gardini, A. (2020). Rapid and scalable profiling of nascent RNA with fastGRO. bioRxiv.