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François Malouin

Professeur, Faculté des sciences
FSCI Département de biologie

Présentation

Expériences académiques

  • Professor. Université de Sherbrooke. Sherbrooke, Quebec, Canada.

Publications

Articles

  • Evelyne Lacasse, Renaud Binette, Héloïse Guibout, Riu Liu, Yun-Ming Lin, Manuka Ghosh, Pierre-Luc Boudreault, Marvin J. Miller, François Malouin. (2025). Unraveling the mechanisms behind the enhanced efficacy of β-lactam-based sideromycins. Communications Biology. DOI
  • E. Demontier, C. Ster, S. Chamberland, S. Ramanathan, S. Dufour, F. Malouin. (2025). Biofilm Formation in Dairy: A Food Safety Concern—Effect of biofilm production on antimicrobial susceptibility of Staphylococcus aureus bovine mastitis strains from the most prevalent Canadian spa types. Journal of Dairy Science. DOI
  • G. Tapp, P. Lacasse, F. Beaudoin, D.R. Ouellet, F. Malouin, C. Ster. (2025). Impact of a reduced metabolizable protein supply during the transition period on the immune and metabolic status of dairy cows. Journal of Dairy Science. DOI
  • Jean-Philippe Langlois, Audrey Larose, Eric Brouillette, Julien A. Delbrouck, Pierre-Luc Boudreault, François Malouin. (2024). Mode of Antibacterial Action of Tomatidine C3-Diastereoisomers. Molecules. DOI
  • Guillaume Millette, Evelyne Lacasse, Renaud Binette, Véronique Belley, Louis-Philippe Chaumont, Céline Ster, Francis Beaudry, Kumaraswamy Boyapelly, Pierre-Luc Boudreault, François Malouin. (2023). Rationally Designed Pyrimidine Compounds: Promising Novel Antibiotics for the Treatment of Staphylococcus aureus-Associated Bovine Mastitis. Antibiotics. DOI
  • Julien A. Delbrouck, Michael Desgagné, Christian Comeau, Kamal Bouarab, François Malouin, Pierre-Luc Boudreault. (2023). The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review. Molecules. DOI
  • S. Bennett, I. Fliss, L. Ben Said, F. Malouin, P. Lacasse. (2022). Efficacy of bacteriocin-based formula for reducing staphylococci, streptococci, and total bacterial counts on teat skin of dairy cows. Journal of Dairy Science. DOI
  • Samantha Bennett, Laila Ben Said, Pierre Lacasse, François Malouin, Ismail Fliss. (2021). Susceptibility to Nisin, Bactofencin, Pediocin and Reuterin of Multidrug Resistant Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis Causing Bovine Mastitis. Antibiotics. DOI
  • Céline Ster, Marianne Allard, Julie Côté-Gravel, Simon Boulanger, Pierre Lacasse, François Malouin. (2021). Immune and experimental infection responses of dairy cows vaccinated with the combination of six Staphylococcus aureus proteins that are expressed during bovine intramammary infection and a triple adjuvant. Veterinary Immunology and Immunopathology. DOI
  • (2020). In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics. Pharmaceutics. DOI
  • (2020). A Siderophore Analog of Fimsbactin from <i>Acinetobacter</i> Hinders Growth of the Phytopathogen <i>Pseudomonas syringae</i> and Induces Systemic Priming of Immunity in <i>Arabidopsis thaliana</i>. Pathogens (Basel, Switzerland). DOI
  • (2020). Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus. Frontiers in microbiology. DOI
  • (2020). Gram-scale Synthesis of Tomatidine, a Steroid Alkaloid with Antibiotic Properties Against Persistent Forms of Staphylococcus aureus. 2020. Normandin, C., Malouin, F., Marsault, É. Eur J Org Chem 2020, 2693–2698. https://doi.org/10.1002/ejoc.202000051.
  • (2020). Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada. PloS one. DOI
  • Julie Côté-Gravel, Eric Brouillette, François Malouin. (2019). Vaccination with a live-attenuated small-colony variant improves the humoral and cell-mediated responses against Staphylococcus aureus. PLOS ONE. DOI
  • (2019). Despite Antagonism in vitro, Pseudomonas aeruginosa Enhances Staphylococcus aureus Colonization in a Murine Lung Infection Model. Frontiers in microbiology. DOI
  • Auemphon Mordmuang, Eric Brouillette, Supayang Piyawan Voravuthikunchai, François Malouin. (2019). Evaluation of a Rhodomyrtus tomentosa ethanolic extract for its therapeutic potential on Staphylococcus aureus infections using in vitro and in vivo models of mastitis. Veterinary Research. DOI
  • Julie Jeukens, Luca Freschi, Irena Kukavica-Ibrulj, Jean-Guillaume Emond-Rheault, Christian Allard, Jean Barbeau, André Cantin, Steve J. Charette, Eric Déziel, François Malouin, Julie Milot, Dao Nguyen, Clara Popa, Brian Boyle, Roger C. Levesque. (2019). The Pseudomonas aeruginosa Population among Cystic Fibrosis Patients in Quebec, Canada: a Disease Hot Spot without Known Epidemic Isolates. Journal of Clinical Microbiology. DOI
  • Evelyne Lacasse, Eric Brouillette, Audrey Larose, Thomas R. Parr, Jr., Aileen Rubio, François Malouin. (2019). In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria. Antimicrobial Agents and Chemotherapy. DOI
  • S. Pichette-Jolette, G. Millette, E. Demontier, D. Bran-Barrera, M. Cyrenne, C. Ster, D. Haine, G. Keefe, F. Malouin, J.P. Roy. (2019). Partial prediction of the duration and the clinical status of Staphylococcus aureus bovine intramammary infections based on the phenotypic and genotypic analysis of isolates. Veterinary Microbiology. DOI
  • Isabelle Guay, Simon Boulanger, Charles Isabelle, Eric Brouillette, Félix Chagnon, Kamal Bouarab, Eric Marsault, François Malouin. (2018). Tomatidine and analog FC04–100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp. BMC Pharmacology and Toxicology. DOI
  • Hossein Jamali, Herman W. Barkema, Mario Jacques, Eve-Marie Lavallée-Bourget, François Malouin, Vineet Saini, Henrik Stryhn, Simon Dufour. (2018). Invited review: Incidence, risk factors, and effects of clinical mastitis recurrence in dairy cows. Journal of Dairy Science. DOI
  • (2018). Tomatidine, a lead antibiotic molecule that targets Staphylococcus aureus ATP synthase subunit C. Antimicrobial Agents Chemotherapy. DOI
  • Coralie Goetz, Yannick D.N. Tremblay, Daphnée Lamarche, Andréanne Blondeau, Annie M. Gaudreau, Josée Labrie, François Malouin, Mario Jacques. (2017). Coagulase-negative staphylococci species affect biofilm formation of other coagulase-negative and coagulase-positive staphylococci. Journal of Dairy Science. DOI
  • Abdelhamid Asli, Eric Brouillette, Céline Ster, Mariana Gabriela Ghinet, Ryszard Brzezinski, Pierre Lacasse, Mario Jacques, François Malouin. (2017). Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis. PLOS ONE. DOI
  • Muhammad A. Rehman, Catherine Carrillo, François Malouin, Moussa S. Diarra. (2017). Draft Whole-Genome Sequences of Multidrug-Resistant Escherichia coli O157:H7 Strains Isolated from Feedlot Cattle Treated with Growth-Promoting Agents. Genome Announcements. DOI
  • Côté-Gravel, J., Brouillette, E., Obradović, N., Ster, C., Talbot, B.G., Malouin, F. (2016). Characterization of a vraG mutant in a genetically stable Staphylococcus aureus small-colony variant and preliminary assessment for use as a live-attenuated vaccine against intrammamary infections. PLoS ONE. DOI
  • Asli, A., Brouillette, E., Krause, K.M., Nichols, W.W., Malouin, F. (2016). Distinctive binding of avibactam to penicillin-binding proteins of gram-negative and gram-positive bacteria. Antimicrobial Agents and Chemotherapy. DOI
  • Goetz, C., Dufour, S., Archambault, M., Malouin, F., Jacques, M. (2016). Importance and control of biofilm formation by staphylococci during intra-mammary infections in dairy cows: A review of literature | Importance et contrôle de biofilms formés par les staphylocoques lors d'infections intra-mammaires chez la vache laitière: Une revue bibliographique. Revue de Medecine Veterinaire.
  • King, A.M., King, D.T., French, S., Brouillette, E., Asli, A., Alexander, J.A.N., Vuckovic, M., Maiti, S.N., Parr, T.R., Brown, E.D., Malouin, F., Strynadka, N.C.J., Wright, G.D. (2016). Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chemical Biology. DOI
  • Klein, R.C., Fabres-Klein, M.H., Licursi De Oliveira, L., Feio, R.N., Malouin, F., De Oliveira Barros Ribon, A. (2015). A C-type lectin from Bothrops jararacussu venom disrupts staphylococcal biofilms. PLoS ONE. DOI
  • Daigle, F., Lerat, S., Bucca, G., Sanssouci, É., Smith, C.P., Malouin, F., Beaulieu, C. (2015). A terD domain-encoding gene (SCO2368) is involved in calcium homeostasis and participates in calcium regulation of a DosR-like regulon in Streptomyces coelicolor. Journal of Bacteriology. DOI
  • Boulanger, S., Mitchell, G., Bouarab, K., Marsault, É., Cantin, A., Frost, E.H., Déziel, E., Malouin, F. (2015). Bactericidal effect of tomatidine-tobramycin combination against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa is enhanced by interspecific small-molecule interactions. Antimicrobial Agents and Chemotherapy. DOI
  • Freschi, L., Jeukens, J., Kukavica-Ibrulj, I., Boyle, B., Dupont, M.-J., Laroche, J., Larose, S., Maaroufi, H., Fothergill, J.L., Moore, M., Winsor, G.L., Aaron, S.D., Barbeau, J., Bell, S.C., Burns, J.L., Camara, M., Cantin, A., Charette, S.J., Dewar, K., ... Levesque, R.C. (2015). Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology. DOI
  • Veh, K.A., Klein, R.C., Ster, C., Keefe, G., Lacasse, P., Scholl, D., Roy, J.-P., Haine, D., Dufour, S., Talbot, B.G., Ribon, A.O.B., Malouin, F. (2015). Genotypic and phenotypic characterization of Staphylococcus aureus causing persistent and nonpersistent subclinical bovine intramammary infections during lactation or the dry period. Journal of Dairy Science. DOI
  • Diarra, M.S., Malouin, F. (2014). Antibiotics in Canadian poultry productions and anticipated alternatives. Frontiers in Microbiology. DOI
  • Simmons, K., Rempel, H., Block, G., Forgetta, V., Vaillancourt, R., Malouin, F., Topp, E., Delaquis, P., Diarra, M.S. (2014). Duplex PCR methods for the molecular detection of Escherichia fergusonii isolates from broiler chickens. Applied and Environmental Microbiology. DOI
  • Fugère, A., Séguin, D.L., Mitchell, G., Déziel, E., Dekimpe, V., Cantin, A.M., Frost, E., Malouin, F. (2014). Interspecific small molecule interactions between clinical isolates of Pseudomonas aeruginosa and Staphylococcus aureus from adult cystic fibrosis patients. PLoS ONE. DOI
  • Gagnon, H., Beauchemin, S., Kwiatkowska, A., Couture, F., D'Anjou, F., Levesque, C., Dufour, F., Desbiens, A.R., Vaillancourt, R., Bernard, S., Desjardins, R., Malouin, F., Dory, Y.L., Day, R. (2014). Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin. Journal of Medicinal Chemistry. DOI
  • Chagnon, F., Guay, I., Bonin, M.-A., Mitchell, G., Bouarab, K., Malouin, F., Marsault, É. (2014). Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus. European Journal of Medicinal Chemistry. DOI
  • Pariseau, É., Massé, D.I., Masse, L., Topp, E., Burrus, V., Malouin, F. (2013). Coagulation-flocculation pre-treatment of surface water used on dairy farms and evaluation of bacterial viability and gene transfer in treatment sludge. Water Quality Research Journal of Canada. DOI
  • Fatima, M., Rempel, H., Kuang, X.T., Allen, K.J., Cheng, K.M., Malouin, F., Diarra, M.S. (2013). Effect of 3′,5′-cyclic diguanylic acid in a broiler Clostridium perfringens infection model. Poultry Science. DOI
  • Ster, C., Allard, M., Boulanger, S., Lamontagne Boulet, M., Mulhbacher, J., Lafontaine, D.A., Marsault, É., Lacasse, P., Malouin, F. (2013). Experimental treatment of Staphylococcus aureus bovine intramammary infection using a guanine riboswitch ligand analog. Journal of Dairy Science. DOI
  • Diarra, M.S., Block, G., Rempel, H., Oomah, B.D., Harrison, J., McCallum, J., Boulanger, S., Brouillette, É., Gattuso, M., Malouin, F. (2013). In vitro and in vivo antibacterial activities of cranberry press cake extracts alone or in combination with β-lactams against Staphylococcus aureus. BMC Complementary and Alternative Medicine. DOI
  • Mitchell, G., Fugère, A., Pépin Gaudreau, K., Brouillette, E., Frost, E.H., Cantin, A.M., Malouin, F. (2013). SigB Is a Dominant Regulator of Virulence in Staphylococcus aureus Small-Colony Variants. PLoS ONE. DOI
  • Allard, M., Ster, C., Jacob, C.L., Scholl, D., Diarra, M.S., Lacasse, P., Malouin, F. (2013). The expression of a putative exotoxin and an ABC transporter during bovine intramammary infection contributes to the virulence of Staphylococcus aureus. Veterinary Microbiology. DOI
  • Forgetta, V., Rempel, H., Malouin, F., Vaillancourt, R., Topp, E., Dewar, K., Diarra, M.S. (2012). Pathogenic and multidrug-resistant Escherichia fergusonii from broiler chicken. Poultry Science. DOI
  • Mitchell, G., Lafrance, M., Boulanger, S., Séguin, D.L., Guay, I., Gattuso, M., Marsault, E., Bouarab, K., Malouin, F. (2012). Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression. Journal of Antimicrobial Chemotherapy. DOI
  • Fatima, M., Ster, C., Rempel, H., Talbot, B.G., Allen, K.J., Malouin, F., Diarra, M.S. (2011). Effect of co-administration of 3',5'-Cyciic diguanylic acid with infectious bursal disease virus vaccine on serum antibody levels in broilers. Journal of Animal and Veterinary Advances. DOI
  • Mitchell, G., Grondin, G., Bilodeau, G., Cantin, A.M., Malouin, F. (2011). Infection of polarized airway epithelial cells by normal and small-colony variant strains of Staphylococcus aureus is increased in cells with abnormal cystic fibrosis transmembrane conductance regulator function and is influenced by NF-κB. Infection and Immunity. DOI
  • Mitchell, G., Gattuso, M., Grondin, G., Marsault, É., Bouarab, K., Malouin, F. (2011). Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells. Antimicrobial Agents and Chemotherapy. DOI
  • Pruneau, M., Mitchell, G., Moisan, H., Dumont-Blanchette, E., Jacob, C.L., Malouin, F. (2011). Transcriptional analysis of antibiotic resistance and virulence genes in multiresistant hospital-acquired MRSA. FEMS Immunology and Medical Microbiology. DOI
  • Bordeleau, E., Fortier, L.-C., Malouin, F., Burrus, V. (2011). c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases. PLoS Genetics. DOI
  • Jérôme Mulhbacher, Eric Brouillette, Marianne Allard, Louis-Charles Fortier, François Malouin, Daniel A. Lafontaine. (2010). Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways. PLoS Pathogens. DOI
  • Mitchell, G., Brouillette, E., Séguin, D.L., Asselin, A.-E., Jacob, C.L., Malouin, F. (2010). A role for sigma factor B in the emergence of Staphylococcus aureus small-colony variants and elevated biofilm production resulting from an exposure to aminoglycosides. Microbial Pathogenesis. DOI
  • Moisan, H., Pruneau, M., Malouin, F. (2010). Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy. DOI
  • Ster, C., Beaudoin, F., Diarra, M.S., Jacques, M., Malouin, F., Lacasse, P. (2010). Evaluation of some Staphylococcus aureus iron-regulated proteins as vaccine targets. Veterinary Immunology and Immunopathology. DOI
  • Lefebvre, B., Diarra, M.S., Fairbrother, J.M., Nadeau, É., Dubois, M., Malouin, F. (2010). Intestinal mucosa adherence and Cytotoxicity of a Sorbitol-fermenting, shiga-toxin-negative escherichia coli O157:NM isolate with an atypical type III secretion system. Foodborne Pathogens and Disease. DOI
  • Mulhbacher, J., Brouillette, E., Allard, M., Fortier, L.-C., Malouin, F., Lafontaine, D.A. (2010). Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. PLoS Pathogens.
  • Mitchell, G., Séguin, D.L., Asselin, A.-E., Déziel, E., Cantin, A.M., Frost, E.H., Michaud, S., Malouin, F. (2010). Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide. BMC Microbiology. DOI
  • Aurélien Lorin, Mathieu Noël, Marie-Éve Provencher, Mariza Gattuso, François Malouin, Normand Voyer, Michéle Auger. (2009). Biophysical Characterization And Membrane Interactions Of Peptides With Antimicrobial Potential. Biophysical Journal. DOI
  • MOUSSA S. DIARRA, KARINE GIGUÈRE, FRANÇOIS MALOUIN, BRIGITTE LEFEBVRE, SUSAN BACH, PASCAL DELAQUIS, MUEEN ASLAM, KIM A. ZIEBELL, GABRIEL ROY. (2009). Genotype, Serotype, and Antibiotic Resistance of Sorbitol-Negative Escherichia coli Isolates from Feedlot Cattle. Journal of Food Protection. DOI
  • Lefebvre, B., Gattuso, M., Moisan, H., Malouin, F., Diarra, M.S. (2009). Genotype comparison of sorbitol-negative Escherichia coli isolates from healthy broiler chickens from different commercial farms. Poultry Science. DOI
  • Diarra, M.S., Giguère, K., Malouin, F., Lefebvre, B., Bach, S., Delaquis, P., Aslam, M., Ziebell, K.A., Roy, G. (2009). Genotype, serotype, and antibiotic resistance of sorbitol-negative Escherichia coli isolates from feedlot cattle. Journal of Food Protection.
  • González-Lamothe, R., Mitchell, G., Gattuso, M., Diarra, M.S., Malouin, F., Bouarab, K. (2009). Plant antimicrobial agents and their effects on plant and human pathogens. International Journal of Molecular Sciences. DOI
  • Lefebvre, B., Diarra, M.S., Vincent, C., Moisan, H., Malouin, F. (2009). Relative cytotoxicity of escherichia coli O157:H7 isolates from beef cattle and humans. Foodborne Pathogens and Disease. DOI
  • Miller, M.J., Zhu, H., Xu, Y., Wu, C., Walz, A.J., Vergne, A., Roosenberg, J.M., Moraski, G., Minnick, A.A., McKee-Dolence, J., Hu, J., Fennell, K., Kurt Dolence, E., Dong, L., Franzblau, S., Malouin, F., Möllmann, U. (2009). Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents. BioMetals. DOI
  • BRIGITTE LEFEBVRE, MOUSSA S. DIARRA, HÉLÈNE MOISAN, FRANÇOIS MALOUIN. (2008). Detection of Virulence-Associated Genes in Escherichia coli O157 and Non-O157 Isolates from Beef Cattle, Humans, and Chickens. Journal of Food Protection. DOI
  • Atalla, H., Gyles, C., Jacob, C.L., Moisan, H., Malouin, F., Mallard, B. (2008). Characterization of a Staphylococcus aureus small colony variant (SCV) associated with persistent bovine mastitis. Foodborne Pathogens and Disease. DOI
  • Lefebvre, B., Diarra, M.S., Moisan, H., Malouin, F. (2008). Detection of virulence-associated genes in Escherichia coli O157 and non-O157 isolates from beef cattle, humans, and chickens. Journal of Food Protection.
  • Mitchell, G., Lamontagne, C.-A., Brouillette, E., Grondin, G., Talbot, B.G., Grandbois, M., Malouin, F. (2008). Staphylococcus aureus SigB activity promotes a strong fibronectin-bacterium interaction which may sustain host tissue colonization by small-colony variants isolated from cystic fibrosis patients. Molecular Microbiology. DOI
  • Karaolis, D.K.R., Means, T.K., Yang, D., Takahashi, M., Yoshimura, T., Muraille, E., Philpott, D., Schroeder, J.T., Hyodo, M., Hayakawa, Y., Talbot, B.G., Brouillette, E., Malouin, F. (2007). Bacterial c-di-GMP is an immunostimulatory molecule. Journal of Immunology.
  • Boulanger, D., Brouillette, E., Jaspar, F., Malouin, F., Mainil, J., Bureau, F., Lekeux, P. (2007). Helenalin reduces Staphylococcus aureus infection in vitro and in vivo. Veterinary Microbiology. DOI
  • Mitchell, G., Lamontagne, C.-A., Lebel, R., Grandbois, M., Malouin, F. (2007). Single-molecule dynamic force spectroscopy of the fibronectin-heparin interaction. Biochemical and Biophysical Research Communications. DOI
  • BRIGITTE LEFEBVRE, FRANÇOIS MALOUIN, GABRIEL ROY, KARINE GIGUÈRE, MOUSSA S. DIARRA. (2006). Growth Performance and Shedding of Some Pathogenic Bacteria in Feedlot Cattle Treated with Different Growth-Promoting Agents. Journal of Food Protection. DOI
  • Lefebvre, B., Malouin, F., Roy, G., Giguère, K., Diarra, M.S. (2006). Growth performance and shedding of some pathogenic bacteria in feedlot cattle treated with different growth-promoting agents. Journal of Food Protection.
  • Moisan, H., Brouillette, E., Jacob, C.L., Langlois-Bégin, P., Michaud, S., Malouin, F. (2006). Transcription of virulence factors in Staphylococcus aureus small-colony variants isolated from cystic fibrosis patients is influenced by SigB. Journal of Bacteriology. DOI
  • Allard, M., Moisan, H., Brouillette, E., Gervais, A.L., Jacques, M., Lacasse, P., Diarra, M.S., Malouin, F. (2006). Transcriptional modulation of some Staphylococcus aureus iron-regulated genes during growth in vitro and in a tissue cage model in vivo. Microbes and Infection. DOI
  • BRIGITTE LEFEBVRE, MOUSSA S. DIARRA, KARINE GIGUÈRE, GABRIEL ROY, SOPHIE MICHAUD, FRANÇOIS MALOUIN. (2005). Antibiotic Resistance and Hypermutability of Escherichia coli O157 from Feedlot Cattle Treated with Growth-Promoting Agents. Journal of Food Protection. DOI
  • Brouillette, E., Hyodo, M., Hayakawa, Y., Karaolis, D.K.R., Malouin, F. (2005). 3′,5′-cyclic diguanylic acid reduces the virulence of biofilm-forming Staphylococcus aureus strains in a mouse model of mastitis infection. Antimicrobial Agents and Chemotherapy. DOI
  • Lefebvre, B., Diarra, M.S., Giguère, K., Roy, G., Michaud, S., Malouin, F. (2005). Antibiotic resistance and hypermutability of Escherichia coli O157 from feedlot cattle treated with growth-promoting agents. Journal of Food Protection.
  • Bernier, G., Girijavallabhan, V., Murray, A., Niyaz, N., Ding, P., Miller, M.J., Malouin, F. (2005). Desketoneoenactin-siderophore conjugates for Candida: Evidence of iron transport-dependent species selectivity. Antimicrobial Agents and Chemotherapy. DOI
  • Malouin, F., Brouillette, E., Martinez, A., Boyll, B.J., Toth, J.L., Gage, J.L., Allen, N.E. (2005). Identification of antimicrobial compounds active against intracellular Staphylococcus aureus. FEMS Immunology and Medical Microbiology. DOI
  • Brouillette, E., Grondin, G., Talbot, B.G., Malouin, F. (2005). Inflammatory cell infiltration as an indicator of Staphylococcus aureus infection and therapeutic efficacy in experimental mouse mastitis. Veterinary Immunology and Immunopathology. DOI
  • Brouillette, E., Malouin, F. (2005). The pathogenesis and control of Staphylococcus aureus-induced mastitis: Study models in the mouse. Microbes and Infection. DOI
  • Brouillette, E., Grondin, G., Lefebvre, C., Talbot, B.G., Malouin, F. (2004). Mouse mastitis model of infection for antimicrobial compound efficacy studies against intracellular and extracellular forms of Staphylococcus aureus. Veterinary Microbiology. DOI
  • Brouillette, E., Martinez, A., Boyll, B.J., Allen, N.E., Malouin, F. (2004). Persistence of a Staphylococcus aureus small-colony variant under antibiotic pressure in vivo. FEMS Immunology and Medical Microbiology. DOI
  • Malouin, F., Blais, J., Chamberland, S., Hoang, M., Park, C., Chan, C., Mathias, K., Hakem, S., Dupree, K., Liu, E., Nguyen, T., Dudley, M.N. (2003). RWJ-54428 (MC-02,479), a new cephalosporin with high affinity for penicillin-binding proteins, including PBP 2a, and stability to staphylococcal beta-lactamases. Antimicrobial Agents and Chemotherapy. DOI
  • Brouillette, E., Talbot, B.G., Malouin, F. (2003). The fibronectin-binding proteins of Staphylococcus aureus may promote mammary gland colonization in a lactating mouse model of mastitis. Infection and Immunity. DOI
  • Chamberland, S., Blais, J., Hoang, M., Dinh, C., Cotter, D., Bond, E., Gannon, C., Park, C., Malouin, F., Dudley, M.N. (2001). In vitro activities of RWJ-54428 (MC-02,479) against multiresistant gram-positive bacteria. Antimicrobial Agents and Chemotherapy. DOI
  • R. M. FRONKO, J. C. LEE, J. G. GALAZZO, S. CHAMBERLAND, F. MALOUIN, M. D. LEE. (2000). New Pacidamycins Produced by Streptomyces coeruleorubidus, NRRL 18370. The Journal of Antibiotics. DOI
  • Fronko, R.M., Lee, J.C., Galazzo, J.G., Chamberland, S., Malouin, F., Lee, M.D. (2000). New pacidamycins produced by streptomyces coeruleorubidus, NRRL 18370. Journal of Antibiotics.
  • Diarra, M.S., Malouin, F., Jacques, M. (1999). Postantibiotic and physiological effects of tilmicosin, tylosin, and apramycin at subminimal and suprainhibitory concentrations on some swine and bovine respiratory tract pathogens. International Journal of Antimicrobial Agents. DOI
  • Hecker, S.J., Cho, I.-S., Glinka, T.W., Zhang, Z.J., Price, M.E., Lee, V.J., Christensen, B.G., Boggs, A., Chamberland, S., Malouin, F., Parr, T.R., Annamalai, T., Blais, J., Bond, E.L., Case, L., Chan, C., Crase, J., Frith, R., Griffith, D., ... Williams, R. (1998). Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant staphylococcus aureus. Journal of Antibiotics.
  • Diarra, M.S., Dolence, J.A., Dolence, E.K., Darwish, I., Miller, M.J., Malouin, F., Jacques, M. (1996). Growth of Actinobacillus pleuropneumoniae is promoted by exogenous hydroxamate and catechol siderophores. Applied and Environmental Microbiology.
  • Ghosh, A., Ghosh, M., Niu, C., Malouin, F., Moellmann, U., Miller, M.J. (1996). Iron transport-mediated drug delivery using mixed-ligand siderophore- β-lactam conjugates. Chemistry and Biology.
  • Arun Ghosh, Manuka Ghosh, Chuan Niu, François Malouin, Ute Moellmann, Marvin J. Miller. (1996). Iron transport-mediated drug delivery using mixed-ligand siderophore-β-lactam conjugates. Chemistry & Biology. DOI
  • Diarra, M.S., Lavoie, M.C., Jacques, M., Darwish, I., Dolence, E.K., Dolence, J.A., Ghosh, A., Ghosh, M., Miller, M.J., Malouin, F. (1996). Species selectivity of new siderophore-drug conjugates that use specific iron uptake for entry into bacteria. Antimicrobial Agents and Chemotherapy.
  • Cain, D., Malouin, F., Dargis, M., Harel, J., Gottschalk, M. (1995). Alterations in penicillin-binding proteins in strains of Streptococcus suis possessing moderate and high levels of resistance to penicillin. FEMS Microbiology Letters. DOI
  • M. Jacques, M. Belanger, M. S. Diarra, M. Dargis, F. Malouin. (1994). Modulation of Pasteurella multocida capsular polysaccharide during growth under ironrestricted conditions and in vivo. Microbiology. DOI
  • Sylvain Quessy, J.Daniel Dubreuil, Mario Jacques, François Malouin, Robert Higgins. (1994). Increase of capsular material thickness following in vivo growth of virulentStreptococcus suisserotype 2 strains. FEMS Microbiology Letters. DOI
  • Quessy, S., Dubreuil, J.D., Jacques, M., Malouin, F., Higgins, R. (1994). Increase of capsular material thickness following in vivo growth of virulent Streptococcus suis serotype 2 strains. FEMS Microbiology Letters.
  • Jacques, M., Belanger, M., Diarra, M.S., Dargis, M., Malouin, F. (1994). Modulation of Pasteurella multocida capsular polysaccharide during growth under iron-restricted conditions and in vivo. Microbiology.
  • Côté, S., Sanschagrin, F., Dargis, M., Simard, J.L., Roy, P.H., MacDonald, N.E., Rabin, H.R., Bergeron, M.G., Malouin, F. (1994). Molecular typing of Haemophilus influenzae using a DNA probe and multiplex PCR. Molecular and Cellular Probes. DOI
  • Dargis, M., Malouin, F. (1994). Use of biotinylated β-lactams and chemiluminescence for study and purification of penicillin-binding proteins in bacteria. Antimicrobial Agents and Chemotherapy.
  • Marvin J. Miller, Francois Malouin. (1993). Microbial iron chelators as drug delivery agents: the rational design and synthesis of siderophore-drug conjugates. Accounts of Chemical Research. DOI
  • Miller, M.J., Malouin, F. (1993). Microbial iron chelators as drug delivery agents: The rational design and synthesis of siderophore-drug conjugates. Accounts of Chemical Research.
  • Rousseau, N., Dargis, M., Gourde, P., Beauchamp, D., Malouin, F. (1992). Effect of β-lactams on peptidoglycan metabolism of Haemophilus influenzae grown in animals. Antimicrobial Agents and Chemotherapy.
  • Brochu, A., Brochu, N., Nicas, T.I., Parr Jr., T.R., Minnick Jr., A.A., Dolence, E.K., McKee, J.A., Miller, M.J., Lavoie, M.C., Malouin, F. (1992). Modes of action and inhibitory activities of new siderophore-β-lactam conjugates that use specific iron uptake pathways for entry into bacteria. Antimicrobial Agents and Chemotherapy.
  • Dargis, M., Gourde, P., Beauchamp, D., Foiry, B., Jacques, M., Malouin, F. (1992). Modification in penicillin-binding proteins during in vivo development of genetic competence of Haemophilus influenzae is associated with a rapid change in the physiological state of cells. Infection and Immunity.
  • Picard, M., Malouin, F. (1992). Molecular basis of the efficacy of cefaclor against Haemophilus influenzae. Antimicrobial Agents and Chemotherapy.
  • Clairoux, N., Picard, M., Brochu, A., Rousseau, N., Gourde, P., Beauchamp, D., Parr Jr., T.R., Bergeron, M.G., Malouin, F. (1992). Molecular basis of the non-β-lactamase-mediated resistance to β-lactam antibiotics in strains of Haemophilus influenzae isolated in Canada. Antimicrobial Agents and Chemotherapy.
  • M. Jacques, A. Lebrun, B. Foiry, M. Dargis, F. Malouin. (1991). Effects of antibiotics on the growth and morphology of Pasteurella multocida. Journal of General Microbiology. DOI
  • Jacques, M., Lebrun, A., Foiry, B., Dargis, M., Malouin, F. (1991). Effects of antibiotics on the growth and morphology of Pasteurella multocida. Journal of General Microbiology.
  • Malouin, F., Chamberland, S., Brochu, N., Parr Jr., T.R. (1991). Influence of growth media on Escherichia coli cell composition and ceftazidime susceptibility. Antimicrobial Agents and Chemotherapy.
  • Malouin, F., Parr Jr., T.R., Bryan, L.E. (1990). Identification of a group of Haemophilus influenzae penicillin-binding proteins that may have complementary physiological roles. Antimicrobial Agents and Chemotherapy.
  • Malouin, F., Campbell, G.D., Halpenny, M., Becker, G.W., Parr Jr., T.R. (1990). Outer membrane and porin characteristics of Serratia marcescens grown in vitro and in rat intraperitoneal diffusion chambers. Infection and Immunity.
  • Chamberland, S., Malouin, F., Rabin, H.R., Schollaardt, T., Parr, T.R., Bryan, L.E. (1990). Persistence of pseudomonas aeruginosa during ciprofloxacin therapy of a cystic fibrosis patient: Transient resistance to quinolones and protein f-deficiency. Journal of Antimicrobial Chemotherapy. DOI
  • Malouin, F., Bryan, L.E., Shewciw, P., Douglas, J., Li, D., Van den Elzen, H., Lapointe, J.-R. (1988). DNA probe technology for rapid detection of Haemophilus influenzae in clinical specimens. Journal of Clinical Microbiology.
  • Malouin, F., Bryan, L.E. (1988). Haemophilus influenzae penicillin-binding proteins 1a and 3 possess distinct and opposite temperature-modulated penicillin-binding activities. Antimicrobial Agents and Chemotherapy.
  • François Malouin, François Lamothe. (1987). The role of β-lactamase and the permeability barrier on the activity of cephalosporins against members of the Bacteroides fragilis group. Canadian Journal of Microbiology. DOI
  • Malouin, F., Schryvers, A.B., Bryan, L.E. (1987). Cloning and expression of genes responsible for altered penicillin-binding proteins 3a and 3b in Haemophilus influenzae. Antimicrobial Agents and Chemotherapy.
  • Malouin, F., Bryan, L.E. (1987). DNA probe technology for detection of Haemophilus influenzae. Molecular and Cellular Probes. DOI
  • Malouin, F., Lamothe, F. (1987). The role of β-lactamase and the permeability barrier on the activity of cephalosporins against members of the Bacteroides fragilis group. Canadian Journal of Microbiology.
  • Lamothe, F., Fualkowski, C., Malouin, F., Bourgault, A.-M., Delorme, L. (1986). Bacteroides fragilis resistant to both metronidazole and imipenem. Journal of Antimicrobial Chemotherapy. DOI
  • Malouin, F., Fijalkowski, C., Lamothe, F., Lacroix, J.-M. (1986). Inactivation of cefoxitin and moxalactam by Bacteroides bivius β-lactamase. Antimicrobial Agents and Chemotherapy.
  • Malouin, F., Bryan, L.E. (1986). Modification of penicillin-binding proteins as mechanisms of β-lactam resistance. Antimicrobial Agents and Chemotherapy.
  • Lacroix, J.-M., Lamothe, F., Malouin, F. (1984). Role of Bacteroides bivius β-lactamase in β-lactam susceptibility. Antimicrobial Agents and Chemotherapy.

Livres

  • LeThanh, B.V., Lebeau, C.J., Messier, S., Malouin, F., Scholl, D. (2008). Epidemiologic association of Staphylococcus aureus virulence markers with intramammary infection chronicity. Mastitis Control: From Science to Practice. DOI

Autres contributions

Cours enseignés à l'UdeS

  • MCB712 - Antibiotiques et résistance microbienne. (2023-2026). (2CR).
  • PTL601 - Aspects cliniques et moléculaires de pathogénie microbienne. (2026). (2CR).
  • PTL600 - Pathogenèse clinique et moléculaire. (2024-2025). (2CR).

Divers

  • A.M. King, D.T. King, S. French, E. Brouillette, A. Asli, A.N. Alexander, M. Vuckovic, S.N. Maiti, T.R. Parr, E.D. Brown, F. Malouin, N.C.J. Strynadka, G.D. Wright. (2016). CTX-M-15 in complex with FPI-1465.