Evan Andre Mercier

Prix et distinctions

• (2024) FRQS - Junior Research Scholar. Fonds de Recherche du Québec - Santé.
• (2008) Alberta Ingenuity Fund Student Scholar. Alberta Innovates.
• (2007) Canadian Graduate Scholarship - Doctorate. NSERC.

Financement

• Subvention. Conserved structural dynamics of outer-membrane channels in Acinetobacter baumannii as potential drug targets. Canadian Institutes of Health Research (Ottawa, Canada). 100 000 $. (2024-2025).
  Numéro de subvention : 202309ARB. Voir plus
• Subvention. Pompes à efflux polychimiothérapeutiques et leur rôle dans la résistance aux antimicrobiens. Fonds de Recherche du Québec - Santé (Montreal, Canada). 286 986 $. (2023-2027).
  Numéro de subvention : 329992. Voir plus
• Subvention. Pompes à efflux polychimiothérapeutiques et leur rôle dans la résistance aux antimicrobiens. Fonds de Recherche du Québec - Santé (Montreal, Canada). 20 000 $. (2023-2024).
  Numéro de subvention : 340163. Voir plus
• Subvention. Conserved structural dynamics of outer-membrane channels in Acinetobacter baumannii as potential drug targets. Canadian Institutes of Health Research (Ottawa, Canada). 100 000 $. (2023-2024).
  Numéro de subvention : 202209ARB. Voir plus
• Subvention. Multiscale structural dynamics of membrane protein complexes. Natural Sciences and Engineering Research Council (Ottawa, Canada). 39 000 $. (2022-2023).
  Numéro de subvention : RGPIN-2022-04177. Voir plus
• Subvention. Multiscale structural dynamics of membrane protein complexes. Natural Sciences and Engineering Research Council (Ottawa, Canada). 12 500 $. (2022-2023).
  Numéro de subvention : DGECR-2022-00203. Voir plus

Publications

Articles

• Bögeholz LAK, Mercier E, Wintermeyer W, Rodnina MV. (2023). Deformylation of nascent peptide chains on the ribosome. Methods in enzymology. DOI
• Mercier E, Wang X, Bögeholz LAK, Wintermeyer W, Rodnina MV. (2022). Cotranslational Biogenesis of Membrane Proteins in Bacteria. Frontiers in molecular biosciences. DOI
• Bögeholz LAK, Mercier E, Wintermeyer W, Rodnina MV. (2021). Kinetic control of nascent protein biogenesis by peptide deformylase. Scientific reports. DOI
• Mercier E, Wang X, Maiti M, Wintermeyer W, Rodnina MV. (2021). Lateral gate dynamics of the bacterial translocon during cotranslational membrane protein insertion. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Mercier E, Wintermeyer W, Rodnina MV. (2020). Co-translational insertion and topogenesis of bacterial membrane proteins monitored in real time. The EMBO journal. DOI
• Girodat D, Mercier E, Gzyl KE, Wieden HJ. (2019). Elongation Factor Tu's Nucleotide Binding Is Governed by a Thermodynamic Landscape Unique among Bacterial Translation Factors. Journal of the American Chemical Society. DOI
• Zaghouani M, Bögeholz LAK, Mercier E, Wintermeyer W, Roche SP. (2019). Total synthesis of (±)-fumimycin and analogues for biological evaluation as peptide deformylase inhibitors. Tetrahedron. DOI
• Mercier E, Rodnina MV. (2018). Co-Translational Folding Trajectory of the HemK Helical Domain. Biochemistry. DOI
• Mercier E, Holtkamp W, Rodnina MV, Wintermeyer W. (2017). Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence. Nucleic acids research. DOI
• Ranjan A, Mercier E, Bhatt A, Wintermeyer W. (2017). Signal recognition particle prevents N-terminal processing of bacterial membrane proteins. Nature communications. DOI
• De Laurentiis EI, Mercier E, Wieden HJ. (2016). The C-terminal Helix of Pseudomonas aeruginosa Elongation Factor Ts Tunes EF-Tu Dynamics to Modulate Nucleotide Exchange. The Journal of biological chemistry. DOI
• Rosler KS, Mercier E, Andrews IC, Wieden HJ. (2015). Histidine 114 Is Critical for ATP Hydrolysis by the Universally Conserved ATPase YchF. The Journal of biological chemistry. DOI
• Mercier E, Girodat D, Wieden HJ. (2015). A conserved P-loop anchor limits the structural dynamics that mediate nucleotide dissociation in EF-Tu. Scientific reports. DOI
• Friedt J, Leavens FM, Mercier E, Wieden HJ, Kothe U. (2013). An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation. Nucleic acids research. DOI
• Wieden HJ, Mercier E, Gray J, Steed B, Yawney D. (2010). A combined molecular dynamics and rapid kinetics approach to identify conserved three-dimensional communication networks in elongation factor Tu. Biophysical journal. DOI
• Dudding T, Kwon O, Mercier E. (2006). Theoretical rationale for regioselection in phosphine-catalyzed allenoate additions to acrylates, imines, and aldehydes. Organic letters. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

• MCR716 - Transcription et maturation post-transcriptionnelle. (2025). (2CR).

Activités professionnelles

• RNA Canada ARN. Membership & Analytics Committee. Chair. Sherbrooke, Canada. (2025-).