Danielle Jacques

Prix et distinctions

• (2014) Editor-in-chief /Revue Médecine Sciences Amérique. Revue Médecine Sciences Amérique. (Distinction).
• (2008) Chercheur boursier/New Investigator Research Award. Heart and Stroke Foundation of Canada. (Prize / Award).
• (2005) Prize Alfred B. Grossman. Heart and Stroke Foundation of Canada. (Prize / Award).
• (2002) Chercheur boursier Junior 1. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
• (1998) Postdoctoral Fellowship. Fonds de la recherche en santé du Canada. (Prize / Award).
• (1994) Ph.D. Research Fellowship. Heart and Stroke Foundation of Canada. (Prize / Award).
• (1993) Ph.D. Research Fellowship. FCAR. (Prize / Award).
• 6 articles among the 10 most cited in the field of AngII and ET-1. BioMedLib. (Distinction).
• Associate editor and guest editor for three special issues/ Canadian Journal of Physiology and Pharmacology. Canadian Journal of Physiology and Pharmacology. (Distinction).
• C.J.P.P. Annual Award 2004. Pharmacological Society of Canada. (Distinction).
• Certificat: Qualité d'enseignement remarquable. Université de Sherbrooke. (Honor).
• Distinguished Service Award in Cardiovascular Science, Medicine and Surgery. International Academy of Cardiovascular Sciences. (Prize / Award).
• Editorial. Circulation Research. (Distinction).
• Fellow of the International Academy of Cardiovascular Sciences. International Academy of Cardiovascular Sciences. (Honor).
• Member of the Editorial Board/Molecular and Cellular Biochemistry. Molecular and Cellular Biochemistry. (Distinction).
• Member of the Editorial Board/Nutrients. Nutrients Editorial Office (MDPI). (Distinction).
• Prix -George Fodor Feature Symposium. CIHR Young Investigator Forum. (Distinction).
• Secretary of the local organizing committee of the Annual meeting of the International Academy of Cardiovascular Sciences- North American Section to be held in Sherbrooke, September 2016. International Academy of Cardiovascular Sciences- North American Section. (Distinction).

Financement

• Grant. (Awarded). Principal Applicant. Rôle d'un supplément de taurine pour la prévention de la nécrose, l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire.. Canadian Institutes of Health Research (CIHR). Project grant. 830 025 $. (2023-2028)
• (Under Review). Collaborator. High sodium salt and human vascular smooth muscle cells remodeling: role of Na+/Ca2+ and Na+/H+ exchangers.. Canadian Institutes of Health Research (CIHR). Project Grant - Fall 2020 and Spring 2021. 1 150 000 $. (2022-2027)
• (Under Review). Co-applicant. In utero treatment with a Na+/H+ exchanger inhibitor for the prevention of heart failure and early death in Duchenne muscular dystrophy.. Canadian Institutes of Health Research (CIHR). Project Grant - Fall 2020 and Spring 2021. 1 310 000 $. (2022-2027)
• (Under Review). Principal Applicant. Role of endocardial endothelium in the development of hereditary cardiomyopathy.. Canadian Institutes of Health Research (CIHR). Project Grant - Fall 2020 and Spring 2021. 1 205 000 $. (2022-2027)
• (Under Review). Principal Applicant. Rôle d'un supplément de taurine dans la diète pour la prévention de la nécrose, de l'hypertrophie et de la défaillance cardiaque.. Canadian Institutes of Health Research (CIHR). Project Grant - Fall 2020 and Spring 2021. 1 435 000 $. (2022-2027)
• Grant. (Completed). Principal Applicant. Modulation of cytosolic and nuclear calcium in endocardial endothelium by Endothelin-1.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant Program. 125 000 $. (2017-2023)
• (Completed). Principal Applicant. Fonds de dépannage- Faculté de médecine des sciences de la santé. Faculté de médecine des sciences de la santé. Cell biology. 15 500 $. (2020-2022)
• (Completed). Principal Applicant. Fonds de dépannage-Faculté de médecine des sciences de la santé. Faculté de médecine des sciences de la santé. Cell biology. 5 400 $. (2021-2022)
• (Completed). Principal Applicant. Fonds de dépannage- Faculté de médecine des sciences de la santé. Faculté de médecine des sciences de la santé. Cell biology. 19 000 $. (2020-2022)
• Grant. (Completed). Co-applicant. Role of ET-1 and Ang II induced cytosolic and nuclear ROS generation in nuclear T-tubules formation in hypertrophy and ageing of human vascular smooth muscle cells.. (2013-2020)
• Grant. (Completed). Principal Applicant. Role d'un dialogue entre les récepteurs du neuropeptide Y et de l'endothéline-1 dans le couplage excitation-sécrétion et le remodelage des cellules endothéliales endocardiques.. University of Sherbrooke. Fonds de dépannage. 23 166 $. (2019-2019)
• Grant. (Completed). Co-applicant. Role of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy.. (2012-2019)
• Grant. (Completed). Co-applicant. Stress, platelet NPY and remodeling. (2008-2018)
• Grant. (Completed). Co-applicant. Modulation du tubule-T nucléaire dans l'hypertrophie et le vieillissement du muscle lisse vasculaire.. (2013-2016)
• Grant. (Completed). Principal Applicant. Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y.. (2013-2016)
• Grant. (Completed). Principal Applicant. Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y.. (2011-2016)
• Grant. (Completed). Principal Applicant. Modulation of nuclear T-tubules in endocardial endothelium by ET-1.. (2010-2015)
• Grant. (Completed). Principal Applicant. Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y.. (2010-2013)
• Grant. (Completed). Principal Applicant. Regulation of cytosolic and nuclear calcium by Angiotensin II in endocardial endothelial cells.. (2007-2010)
• Grant. (Completed). Principal Applicant. Role of neuropeptide Y and neuropeptide Y receptors in regulation of cardiac endocardial endothelial cells function.. (2009-2010)
• Grant. (Completed). Principal Applicant. Modulation of cytosolic and nuclear calcium in endocardial endothelium by ET-1.. (2003-2009)
• Grant. (Completed). Co-applicant. Regulation of vascular smooth muscle cell function by sarcolemma and nuclear membranes' endothelin-1 receptors.. (2003-2009)
• Grant. (Completed). Principal Applicant. Role of NPY and NPY receptors in regulation of cardiac endocardial endothelial cell function.. (2004-2009)

Publications

Articles de revue

• Bkaily G., Jazzar, A.*, Jacques, D. I am corresponding author NSERC. (2025). Exogenous and endogenous antioxidants (ROS) in Physiology and Pathology of the Cardiovascular System. Canadian Journal of Physiology and Pharmacology Oct 14. doi: 10.1139/cjpp-2025-0240. Online ahead of print. (Published).
• Jazzar A.*, Jacques, D., Abou-Aichi, A.*, Bkaily, G. I am corresponding author. CIHR and NSERC. (2025). In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner. Pathophysiology 32 (1), 12. (Published).
• Bkaily G, Jazzar A.,* Abou-Aichi, A.*, Jacques D I am corresponding author. CIHR and NSERC. (2025). Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System. Biomedicines 13 (8), 1842. (Published).
• Bkaily, G., *Simon, Y., *Abou Abdallah, J., *Ouertane,C., *Essalhi, A., Khalil, A., Jacques, D. (2024). Taurine long-term treatment prevents the development of cardiac hypertrophy and premature death in hereditary cardiomyopathy of the hamster is sex-independent. Nutrients 16 (7), 946. (Published).
• Jacques, D., Bkaily, G. I am corresponding author. CIHR and NSERC. (2024). Taurine prevents Angiotensin II-induced human endcardial endothelium morphological remodeling and the increase in cytosolic and nuclear calcium and ROS. Nutrients 16 (5), 745. (Published).
• Bkaily, G., Jacques D. (2023). Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System. International Journal of Molecular Sciences 24 (10), 8803. (Published).
• *Simon Y, Jacques D, Bkaily G. (2023). High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory. Can J Physiol Pharmacol. 101 (9), 437-446. (Published).
• Bkaily G. and Jacques D. (2023). Morphological and functional remodeling of the endothelium in cardiovascular diseases. International Journal of Molecular Sciences 24 (3), 1998. (Published).
• Bkaily, G, *Alshahrani, M, Nader, M, Jacques D. (2022). Age-depend effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes. Can J. Physiol. Pharmacol. 100 (12), 1106-1114. (Published).
• Al-Khoury, J., Jacques, D., Bkaily, G. (2022). Hypotension in hereditary cardiomyopathy. Pflugers Arch 474 (5), 517-527. (Published).
• Bkaily G, *Simon Y, *Normand A, *Jazzar A*, *Najibeddine H, Khalil, A, Jacques D I am corresponding author. CIHR. (2022). Short-term treatment with taurine prevents the development of cardiac hypertrophy and early death in hereditary cardiomyopathy and sex dependency. Nutrients 14 (16), 3287. (Published).
• Bkaily, G., *Simon, Y., *Jazzar, A., *Najibeddine, H., *Normand, A., Jacques, D. (2021). High Na+ Salt Diet and Remodeling of Vascular Smooth Muscleand Endothelial Cells. Biomedicines 9 (8), 883. (Published).
• *Jazzar, A., Jacques, D., Bkaily, G. (2021). Insulin-induced cardiomyocytes hypertrophy that is prevented by taurine via beta-alanine-sensitive Na+-Taurine symporters. Nutrients 13 (11), 3686. (Published).
• Bkaily, G, *Abou Abdallah, N, *Simon, Y, *Jazzar, A and Jacques, D. (2021). Vascular smooth muscle remodeling in health and disease. Canadian Journal of Physiology and Pharmacology 99 (2), 171-178. (Published).
• Bkaily, G and Jacques D. (2020). Flaxseed as an antiocardiotoxicity agent in breast cancer therapy. J. of Nutrition 150 (9), 2231-32. (Published).
• Bkaily, G. *Jazzar, A., *Normand, A., *Simon, Y., Al-Khoury, J., Jacques, D. (2020). Taurine and cardiac disease: state of the art and perspectives. Canadian Journal of Physiology and Pharmacology 98 (2), 67-73. (Published).
• Jacques, D., *Provost, C., *Normand, A., *Abou Abdallah, N., Al-Khoury, J., Bkaily, G. I am corresponding author. NSERC. (2019). Angiotensin II induces apoptosis of human right and left ventricular endocardial endothelial cells by activating the AT2 receptor. Canadian Journal of Physiology and Pharmacology 97 (6), 581-588. (Published).
• Jacques D. and Bkaily G. I am corrresponding author CIHR. (2019). Endocardial endothelial cell hypertrophy takes place during the development of hereditary cardiomyopathy. Molecular and Cellular Biochemistry 453 (1-2), 157-161. (Published).
• *Chamoun, M., Jacques, D., and Bkaily, G. I am corresponding author CIHR and NSERC. (2019). Extracellular and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells. Canadian Journal of Physiology and Pharmacology 97 (9), 820-828. (Published).
• Bkaily, G., *Najibeddine, W., Jacques, D. (2019). Increase of NADPH oxidase 3 in heart failure of hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology 97 (9), 902-908. (Published).
• Bkaily G., *Simon, Y., *Menkovic, I., Bkaily, C. and Jacques, D. (2018). High salt-induced hypertrophy of human vascular smooth muscle cells associated with a decrease in glycocalyx. Journal of Cellular and Molecular Cardiology 125 1-5. (Published).
• Houde M, Schwertani AG, Touil H, Desbien L, Sarrhini O, Lecomte R, Lepage M, , Gagnon H, Takai S, Pejler G, Jacques D, Gobeil Jr F, Day R, and D'Orleans-Juste P. (2018). Mouse mast cell protease 4 deletion protects heart function and survival after acute myocardial infarction. Frontiers in Pharmacology 9 868. (Published).
• Hassan, G.S., Jacques, D. D'Orléans-Juste, P., Magder, S., and Bkaily, G. (2018). Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis. Canadian Journal of Physiology and Pharmacology 96 (7), 655-661. (Published).
• *Kamal M, Jacques D, and Bkaily G. (2017). Angiotensin II receptors' modulation of calcium homeostasis in human vascular endothelial cells. Canadian Journal of Physiology and Pharmacology 95 (10), 1289-1297. (Published).
• Jacques D, *Abdel-Karim Abdel-Malak N, *Abou Abdallah N, Al-Khoury J, and Bkaily. (2017). Difference in the response to angiotensin II between left and right ventricular endocardial endothelial cells. Canadian Journal of Physiology Pharmacology 95 (10), 1271-82. (Published).
• Bkaily G and Jacques D. (2017). Na+-H+ exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies. Canadian Journal of Physiology and Pharmacology 95 (10), 1213-23. (Published).
• Jacques D, D'Orleans-Juste P, Magder S, and Bkaily G. (2017). Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology 95 (10), 1224-29. (Published).
• Mikhail M, Vachon PH, D'Orleans-Juste P, Jacques D, and Bkaily G. (2017). Role of endothelin-1 and its receptors ETA and ETB in the survival of human vascular endothelial cells. Canadian Journal of Physiology and Pharmacology 95 (10), 1298-1305. (Published).
• *Dima Abdel-Samad, Ghassan Bkaily, Sheldon Magder and Danielle Jacques. (2016). ETA and ETB receptors contribute to Neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. Neuropeptides 55 145-53. (Published).
• Ghassan Bkaily, Mirna Chahine, Johny Al-Khoury, *Levon Avedanian, Norbert Beier, Wolfgang Scholz and Danielle Jacques. (2015). Na+-H+ exchanger inhibitor prevents early death in hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology 93 (11), 923-34. (Published).
• *Farah Jules, *Levon Avedanian, Johny Al-Khoury, *Ramatoulaye Keita, *Alexandre Normand, Ghassan Bkaily and Danielle Jacques. (2015). Nuclear membranes ETB receptors mediate ET-1-induced increase of nuclear calcium in human left ventricular endocardial endothelial cells. Journal of Cardiovascular Pharmacology 66 (1), 50-7. (Published).
• Ghassan Bkaily, *Levon Avedanian, Johny Al-Khoury, *Marc Chamoun, *Rana Semaan, *Cynthia Jubinville-Leblanc, Pedro D'Orléans-Juste and Danielle Jacques. (2015). Nuclear membranes R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Canadian Journal Physiology and Pharmacology 93 (4), 291-7. (Published).
• Bkaily, G., Al-Khoury, J., Jacques, D. (2014). Nuclear membranes GPCRs: possible implication in cardiovascular health and disease. Current Vascular Pharmacology 12 (2), 215-22. (Published).
• Jacques, D. (2013). Entrevue éditoriale avec Monsieur le Ministre de la Santé, Dr Réjean Hébert. Revue Médecine Sciences Amérique 2 (3), 3-9. (Published).
• *Ahmarani L, *Avedanian L, *Al-Khoury J, *Perreault C, Jacques D, Bkaily G. (2013). Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial vascular smooth muscle, and vascular endothelial cells. Canadian Journal of Physiology and Pharmacology 91 (1), 71-9. (Published).
• *Adbel-Samad D, *Perreault C, *Ahmarani L, *Avedanian L, Bkaily G, Magder S, D'Orléans-Juste P, Jacques D. (2012). Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells. Neuropeptides 46 (6), 373-382. (Published).
• Jacques, D. (2012). Entrevue Éditoriale: La recherche au Québec vue par le premier scientifique en chef, le Pr Rémi Quirion. Revue Médecine Sciences Amérique 1 (1), 1-5. (Published).
• Jacques, D. (2012). Entrevue Éditoriale avec le Dr Alain Beaudet, Président des Instituts de Recherche en Santé au Canada. Revue Médecine Sciences Amérique 1 (3), 1-6. (Published).
• Jacques, D. (2012). Entrevue Éditoriale avec le Dr Gérard Eugène Plante. Revue Médecine Sciences Amérique 1 (4), 27-32. (Published).
• Bkaily G, *Avedanian L, *Al-Khoury J, *Ahmarani L, *Perreault C, Jacques D. (2012). Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions. Canadian Journal of Physiology and Pharmacology 90 (8), 953-65. (Published).
• Bkaily G , *Avedanian L , *Al-Khoury J , *Provost C , Nader M , D'Orléans-Juste P , Jacques D. (2011). Nuclear membrane receptors for ET-1 in cardiovascular function. American Journal of Physiology 300 (2), R251-63. (Published).
• *Avedanian L , Jacques D , Bkaily G. (2011). Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology 50 (1), 175-86. (Published).
• *Avedanian L , Riopel J , Bkaily G , Nader M , D'Orleans-Juste P , Jacques D. (2010). ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. Canadian Journal of Physiology and Pharmacology 88 (8), 817-29. (Published).
• *Provost C , Choufani S , *Avedanian L , Bkaily G , Gobeil F , Jacques D. (2010). Nitric oxide and reactive oxygen species in the nucleus revisited. Canadian Journal of Physiology and Pharmacology 88 (3), 296-304. (Published).
• Der-Boghossian AH , Saad SR , *Perreault C , *Provost C , Jacques D , Kadi LN , Issa NG , Sibai AM , El-Majzoub NW , Bikhazi AB. (2010). Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats. Canadian Journal of Physiology and Pharmacology 88 (7), 753-9. (Published).
• Bkaily G , Jacques D. (2009). L-type calcium channel antagonists and suppression of expression of plasminogen receptors: is the missing link the L-type calcium channel?. Circulation Research 105 (2), 112-3. (Published).
• Bkaily G , Avedanian L , Jacques D. (2009). Nuclear membrane receptors and channels as targets for drug development in cardiovascular diseases. Canadian Journal of Physiology and Pharmacology 87 (2), 108-19. (Published).
• Pons J , Kitlinska J , Jacques D , Perreault C , Nader M , Everhart L , Zhang Y , Zukowska Z. (2008). Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. Canadian Journal of Physiology and Pharmacology 86 (7), (Published).
• Bkaily G , Choufani S , Avedanian L , Ahmarani L , Nader M , Jacques D , D'Orléans-Juste P , Al-Khoury J. (2008). Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology 86 (8), (Published).
• Abdel-Samad D , Jacques D , Perreault C , Provost C. (2007). NPY regulates human endocardial endothelial cell function. Peptides 28 (2), (Published).
• Jacques D , Abdel-Samad D. (2007). Neuropeptide Y (NPY) and NPY receptors in the cardiovascular system: implication in the regulation of intracellular calcium. Canadian Journal of Physiology and Pharmacology 85 (1), (Published).
• Gaudreau P , Morais JA , Shatenstein B , Gray-Donald K , Khalil A , Dionne I , Ferland G , Fülöp T , Jacques D , Kergoat MJ , Tessier D , Wagner R , Payette H. (2007). Nutrition as a determinant of successful aging: description of the Quebec longitudinal study Nuage and results from cross-sectional pilot studies. Rejuvenation Research 10 (3), 377-86. (Published).
• Jacques D , Sader S , Perreault C , Abdel-Samad D. (2006). NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function. EXS - NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: From Genes to Therapeutics (95), (Published).

Chapitres de livre

• Jacques D, and Bkaily G. (2022). Cardiovascular Physiopathology of Angiotensin II and Its Plasma and Nuclear Envelop Membranes’ Receptors. Edited by Naranjan S. Dhalla, Sukhwinder K. Bhullar, Anureet K. Shah. Renin-Angiotensin System in Cardiovascular Disease, Advs.in Biochemistry (24, 0). Switzerland : Springer Nature, Switzerland. (Published).
• Ghassan Bkaily, Johny Al-Khoury, *Yanick Simon, Danielle Jacques. (2016). Intracellular free calcium measurement using confocal imaging. Rhian M. Touyz and Ernesto L. Schffrin (Eds). Methods Molecular Biology, Vol. 1527, Rhian M. Touyz and Ernesto L. Schffrin (Eds) : Hypertension 2017 (Rhian M. Touyz & Ernesto L. Schiffrin (Eds), 1527, 177-187). United Kingdom : Springer Nature. (Published).
• Ghassan Bkaily and Danielle Jacques. (2016). Intracellular sodium overload in hereditary cardiomyopathy. Narosa Publishing. Adaptative Biology & Medicine, XI International Society of Adaptative Medicine ( ISAM) World Congress Proceedings (Narosa Publishing, 8, -). Japan : Narosa Publishing. (Published).
• Ghassan Bkaily and Danielle Jacques. (2013). Use of confocal microscopy to investigate cell structure and function. P. Michael Conn. Techniques in confocal microscopy (P. Michael Conn, 105-122). United Kingdom : Elsevier. (Published).
• Jacques, D., Sader, S., Perreault, C. and Abdel-Samad, D. (2006). NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function. Z. Zukowska and G.Z. Feuerstein. EXS- Series on NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics (Z. Zukowska & G. Z. Feuerstein Edt., 77-87). Switzerland : Birkhauser Verlag. (Published).

Articles de conférence

• Bkaily, G. and Jacques, D. (2024). A diet rich in sodium salt induces remodeling of contractile human vascular smooth muscle cells in a sex-dependent manner. International forum on cardiovascular disease, Stem cells and tissue engineering: the first Asian branch meeting of the International Academy of Cardiovascular Sciences. (Published).
• Bkaily, G. and Jacques, D. (2024). High sodium salt induced remodeling of human vascular smooth muscle cells and sex-independency: Effect of taurine. 10th Annual meeting of the European section of the International Academy of Cardiovascular Sciences (IACS-ES). (Published).
• *Jazzar, A., Jacques D., Bkaily, G. (2024). Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented byTaurine via β-alanine-Sensitive Na+ -Taurine Symporter. International Academy of cardiovascular Sciences (IACS)- European section, October 28-30th 2024, Bratislava, Slovakia. (Published).
• Bkaily G and Jacques D. (2022). High Salt-Induced Human Vascular Endothelial and Smooth Muscle Remodeling. 8th European Section Meeting of the International Academy of Cardiovascular Sciences (IACS-ES), Szeged, Hungary September 28 and October 1 2022. (In Press).
• Bkaily G and Jacques D. (2022). Short- and long-term effect of high insulin level on aging ventricular cardiac cells. 9th North American Section International Academy of Cardiovascular Sciences (IACS) Conference.Winnipeg, Manitoba, Canada September 6, 2022 – September 9, 2022. (Published).
• Bkaily G and Jacques D. (2022). Taurine a cardiac and vascular preventive remodeler. 13th World Congress of International Society for Adaptive Medicine, Orlando,Florida, USA, October 27th - 30th 2022. (Published).
• Menkovic I*, Simon Y*, Bkaily C*, Jacques D, Bkaily G Dr Istok Menkovic presented a poster and did an oral presentation as he was selected amongs the best student at the meeting. He also received a travel award to go to this meeting. (2019). Time-dependenteffect of high salt on hypertrophy and glycocalyx of human vascular smooth musclecells. 6th Meeting of European Section and 7th Meeting of North American Section of the International Academy of Cardiovascular Sciences (IACS), September 11-14th 2019. (Published).
• *Abou Abdallah, N., Hassan, G., *Simon, Y., Jacques, D., Bkaily, G. (2018). Physical contact between vascular endothelial and smooth muscle cells mediate increase in intracellular calcium. 37th Annual conference of the North American Section of the International Society of Heart Research, Halifax, Nova Scotia, May 29th-June 1st 2018. (Published).
• *Simon Y, *Abou Abdallah N, Al-Khoury J, Jacques D, Bkaily, G. (2017). Regulation of cytosolic and nuclear ROS and calcium by endothelin-1 in cardiovascular cells. 5th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual meeting of the North American Section of the International Academy of Cardiovascular Sciences (IACS). (Published).
• Johny Al-Khoury, Danielle Jacques, Ghassan Bkaily. (2016). Angiotensin II receptors modulation of calcium homeostasis in human vascular endothelial cells. 4th Annual meeting of the International Academy of Cardiovascular Sciences, Sherbrooke, Qc, September 22-24th 2016. (Published).
• *Cynthia Jubinville-Leblanc, *Dima Abdel-Samad, *Alexandre Normand, Ghassan Bkaily, Danielle Jacques. (2016). ETA and ETB receptors contribute to neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. 4th Annual meeting of the International Academy of Cardiovascular Sciences, Sherbrooke, Qc, September 22-24th 2016. (Published).
• *Chamoun Marc, *Abdel-Karim Abdel-Malak Nelly, *Provost Chantale, *Simon Yanick, Bkaily Ghassan and Jacques Danielle. (2015). Angiotensin II receptor distribution, internalization and modulation of intracellular calcium: differences between human right and left ventricular endocardial endothelial cells. Annual meeting of the International Academy of Cardiovascular Sciences, North American Section. (Published).
• *Keita Ramatoulaye, *Jules Farah, Al-Khoury Johny, Bkaily Ghassan, and Jacques Danielle. (2015). Nuclear membranes ETB receptors mediate ET-1-induced increase of nuclear calcium in human endocardial endothelial cells. Annual meeting of the International Academy of Cardiovascular Sciences, North American Section. (Published).
• Jacques, D. and Bkaily, G. (2014). Role of sodium-hydrogen exchange in vascular failure in hereditary cardiomyopathy. Cardiovascular Research, S126. (Published).
• *Keita R, *Najibeddine W, *Normand A, D'Orléans-Juste P, Magder S, Jacques D. (2013). Differences in excitation-secretion coupling exist between left and right human endocardial endothelial cells. International Society for Heart Research (ISHR) XXI World Congress. (Published).
• *Al-Khoury J, Semaan W, *Najibeddine W, D'Orléans-Juste P, Magder S, Jacques D, Bkaily G. (2013). ET-1 and NHE1 in vascular failure in hereditary cardiomyopathy. International Society for Heart Research (ISHR) XXI World Congress. (Published).
• Bkaily G, Jacques D. (2013). Hereditary cardiomyopathy is also a vascular disease: the sodium-hydrogen exchanger a key common player?. International Academy of Cardiovascular Sciences, Slovakia. (Published).
• *Najibeddine W, *Jules F, *Normand A, *Keita R, Jacques D. (2013). Nuclear membranes ETB receptors mediate ET-1 induced increase of nuclear calcium in human right and left ventricular endocardial endothelial cells. International Society for Heart Research (ISHR) XXI World Congress. (Published).
• Al-Khoury J, *Ahmarani L, *Chamoun M, *Najibeddine W, Jacques D, Bkaily G. (2013). Presence of NOX1-5 in human vascular smooth muscle and endothelial cells: regulation of nuclear calcium. International Society for Heart Research (ISHR) XXI World Congress. (Published).
• Jacques, D., Magder, S., D'Orléans-Juste, P., Bkaily, G. (2012). Human endocardial endothelial cells hypertrophy and release of endothelin-1: Role of Neuropeptide Y and Angiotensin II. 10th International NPY-PYY-PP Meeting. (Published).
• *Ahmarani L , *Perreault C , Bkaily G , Magder S , D'Orléans-Juste P , Jacques D. (2012). Neuropeptide Y receptors and neuropeptide Y-induced secretion are different in left compared to right ventricular human endocardial cells. 10th International NPY-PYY-PP Meeting. (Published).
• Bkaily G , Jacques D. (2012). Regulation of nuclear ROS by ET-1 and AngII in human vascular smooth muscle and endothelial cells. 7th Meeting of the Canadian Oxidative Stress Consortium. (Published).
• *Avedanian L, Jacques D, D'Orléans-Juste P, Bkaily G. (2011). ET-1 modulates tubular and reticular structures in the nucleus. 12th International Conference on Endothelin. (Published).
• *Al-Khoury J, *Abdel-Samad D, *Provost C, Magder S, D'Orléans-Juste P, Bkaily G, Jacques D. (2011). Modulation of release of endothelin-1 in hypertrophic human endocardial and vascular endothelial cells. 12th International Conference on Endothelin. (Published).
• Jacques D, Bkaily G. (2011). Neuropeptide Y and Angiotensin II induce human endocardial endothelial cell hypertrophy and release of endothelin-1. International Society for Heart Research Meeting - European Section. (Published).
• Bkaily G, Jacques D. (2011). Nuclear membrane G-protein coupled receptors and nuclear T-tubules contribute to normal and pathological cell function. Winnipeg Heart International - Institute of Cardiovascular Sciences. (Published).
• Bkaily G, Jacques D. (2011). Nuclear membranes G-proteins coupled receptors and nuclear T-tubules contribute to vascular smooth muscle cells function. International Society for Heart Research Meeting - European Section. (Published).
• Provost C, El-Helou G, Hantouche C, Perreault C, Bkaily G, Jacques D. (2009). Angiotensin II, a cardiac hypertrophic factor, also induces hypertrophy of human endocardial endothelial cells. 5th International Symposium on Peptide Receptors and Kinins. (Published).
• El-Helou G, Provost C, Perreault C, Bkaily G, Jacques D. (2009). Angiotensin II, a modulator of the survival of human endocardial endothelial cells. 5th International Symposium on Peptide Receptors and Kinins. (Published).
• Al-Khoury J, Kamal M, Issa N, Choufani F, El-Khoury C, D'Orléans-Juste P, Jacques D, Bkaily G. (2009). Angiotension II receptors AT1 but not AT2 undergo internalization and modulate cytosolic and nuclear calcium in human vascular endothelial cells. 5th International Symposium on Peptide Receptors and Kinins. (Published).
• Provost C, Abdel-Samad D, El-Helou G, Perreault C, Jacques D. (2009). Crosstalk between endothelin-1 and neuropeptide Y in human endocardial endothelial cells. ET-11: APS International Conference on Endothelin. (Published).
• Al-Khoury J, El-Khoury C, Chahine M, Jacques D, Bkaily G. (2009). ET-1 abnormalities in hereditary cardiomyopathy. ET-11: APS International Conference on Endothelin. (Published).
• Avedanian L, Choufani F, Issa N, Nader M, Jacques D, D'Orléans-Juste P, Bkaily G. (2009). ETB receptor is responsible for nuclear calcium regulation by ET-1. ET-11: APS International Conference on Endothelin. (Published).

Autres contributions

Gestion d'évènements

• Secretary of the local organizing committee. (2016) Annual meeting of the International Academy of Cardiovascular Sciences, North American Section, September 22-24th 2016. (Conference).
• Chair. (2012) 10th International NPY-PYY-PP Meeting. (Conference).
• Member of the Local Organizing Committee. (2012) 10th International NPY-PYY-PP Meeting, Montréal, Qc. (Conference).
• Organizer. (2011) Symposium in Cardiovascular Physiopathology, ACFAS, Sherbrooke, Qc. (Conference).
• Chairman. (2011) Symposium on Cardiovascular Pharmacology, ACFAS, Sherbrooke, Qc. (Conference).

Présentations

• (2023). Taurine supplementation and heart function. International Conference on Adaptations and Nutrition in Sports (ICANS) 2023, July 19-21st. Singapore
• Jacques, D. (2018). Cardiac hypertrophy: endocardial endothelial cells are not simple bystanders. 5th meeting of the International Academy of Cardiovascular Sciences –European Section-Advances ?n card?ovascular research: from basic mechanisms to therapeutic strategies, Congress Center of the Slovak Academy of Sciences, Bratislava, May 23-26. Slovakia
• Jacques , D. (2018). Role of taurine in the regulation of excitation-secretion coupling and remodeling of human endocardial endothelial cells. International Conference for Adaptations and Nutrition in Sports (ICANS)”, July 18-20, 2018, Chonburi, Thailand. Thailand
• Jacques , D. (2017). Endocardial endothelium in cardiac physiopathology: Neuropeptide Y is a new key player. 5th Annual meeting of the International Academy of Cardiovascular Sciences, Orlando, August 31st- September 2nd 2017. Orlando, United States of America
• Jacques , D. (2017). Endocardial endothelium in cardiac physiopathology : implication of Neuropeptide Y. Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. Halifax, Canada
• Jacques , D. (2017). Neuropeptide Y and ROS generation in human endocardial endothelial cells. VI International Symposium on Oxidative Stress and Cardiovascular Diseases, to be held at the Federal University of Rio Grande do Sul, Porto Alegre, Brazil, on November 17th., 2017. Porto Alegre, Brazil
• Jacques, D. (2016). Crosstalk between the NPY and ET-1 systems in human endocardial endothelial cells. 4th Annual meeting of the International Academy of Cardiovascular Sciences, Sherbrooke, Qc, September 22-24th 2016. Sherbrooke, Canada
• Jacques, D. (2015). Endocardial endothelium and cardiac hypertrophic factors. Congress Center of the Slovak Academy of Sciences, Smolenice Castle. September 2-5th 2015. Bratislava, Slovakia
• Jacques, D. (2015). NPY receptors in the nucleus: What are they doing there?. 7th International Conference on «Recent Avances in Cardiovascular Sciences, March 10-11 2015, Amity University, Uttar Pradesh, India. Uttar Pradesh, New Dehli, India
• Jacques, D. (2015). Role of endocardial endothelium in cardiac physiopathology. Indo-Canadian Symposium on Heart Failure: Progress & prospects, March 12-14 2015, Trivandium, India. Trivandium, India
• Jacques, D. (2014). Excitation-ET-1 secretion coupling in human endocardial endothelial cells. 2nd Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators. Winnipeg, Canada
• Jacques, D. (2014). Role of endocardial endothelium in hypertrophy and heart failure. Cuban Congress of Cardiology. La Havana, Cuba
• Bkaily, G. and Jacques, D. (2013). Role of NHE1 in the development of heart failure in hereditary cardiomyopathy. KFSH Cardiac Center, AlFaisal University. Riyadh, Saudi Arabia
• Jacques, D. (2013). What are neuropeptide Y and its receptors doing in the nucleus of endocardial endothelial cells?. Faculty of medicine, AlFaisal University. Riyadh, Saudi Arabia
• Jacques, D. (2012). Human endocardial endothelial cells hypertrophy and release of endothelin-1: Role of neuropeptide Y and angiotensin II. 10th International NPY-PYY-PP Meeting. Montréal, Canada
• Jacques, D. (2011). Neuropeptide Y and Angiotensin II induce human endocardial endothelial cells hypertrophy and release of endothelin-1. International Society for Heart Research Meeting - European Section. Haifa, Israel
• (2010). What are neuropeptide Y and neuropeptide Y receptors doing in the nucleus of endocardial endothelial cells?. Faculty of Medicine, University of Ottawa. Ottawa, Canada