Conrad Florian Bentzinger

Prix et distinctions

• (2019) Mérite Estrien. La Tribune.
• (2019) Researcher of the Month. Centre hospitalier universitaire de Sherbrooke (CHUS).
• (2019) Sartorius & Science Prize for Regenerative Medicine & Cell Therapy (Finalist). Sartorius AG.
• (2017) Discovery Award. Banting Research Foundation.
• (2013) OHRI IMPACT (Identification of marketable products, applications and commercializable technologies) award (3rd place). Ottawa Hospital Research Institute.

Financement

• Subvention. Cellular Drivers of Skeletal Muscle Aging. Canadian Institutes of Health Research (Ottawa, Canada). 131 580 $. (2019-2024).
  Numéro de subvention : ba4df57d9bf8f34c5f7a890b69cad8bb. Voir plus
• Subvention. Régulation des cellules souches musculaires par leur microenvironnement. Fonds de Recherche du Québec - Santé (Montreal, Canada). (2017-2018).
  Numéro de subvention : f8cd7659. Voir plus
• Subvention. Extrinsic Regulation of Muscle Stem Cell Quiescence. Natural Sciences and Engineering Research Council (Ottawa, Canada). 39 000 $. (2017-2018).
  Numéro de subvention : 629230. Voir plus
• Subvention. Characterization of Novel PCP Signaling Components in Satellite Stem Cells. Swiss National Science Foundation (Bern, Suisse). (2012-2013).
  Numéro de subvention : 139670. Voir plus
• Subvention. Role of the Planar Cell Polarity Signaling Pathway in the Regulation of Muscle Stem Cell Homeostasis. Swiss National Science Foundation (Bern, Suisse). (2009-2011).
  Numéro de subvention : 127870. Voir plus

Publications

Articles

• Ancel S, Michaud J, Sizzano F, Tauzin L, Oliveira M, Migliavacca E, Schüler SC, Raja S, Dammone G, Karaz S, Sánchez-García JL, Metairon S, Jacot G, Bentzinger CF, Feige JN, Stuelsatz P. (2024). A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging. Stem cell reports. DOI
• Le Moal E, Liu Y, Collerette-Tremblay J, Dumontier S, Fabre P, Molina T, Dort J, Orfi Z, Denault N, Boutin J, Michaud J, Giguère H, Desroches A, Trân K, Ellezam B, Vézina F, Bedard S, Raynaud C, Balg F, ... Bentzinger CF. (2024). Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice. Science translational medicine. DOI
• Schüler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF. (2022). Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche. Frontiers in cell and developmental biology. DOI
• Mashinchian O, De Franceschi F, Nassiri S, Michaud J, Migliavacca E, Aouad P, Metairon S, Pruvost S, Karaz S, Fabre P, Molina T, Stuelsatz P, Hegde N, Le Moal E, Dammone G, Dumont NA, Lutolf MP, Feige JN, Bentzinger CF. (2022). An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs. The EMBO journal. DOI
• (2022). In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging. eLife. DOI
• Schüler SC, Dumontier S, Rigaux J, Bentzinger CF. (2021). Visualization of the Skeletal Muscle Stem Cell Niche in Fiber Bundles. Current protocols. DOI
• Lukjanenko, L., Karaz, S., Stuelsatz, P., Gurriaran-Rodriguez, U., Michaud, J., Dammone, G., Sizzano, F., Mashinchian, O., Ancel, S., Migliavacca, E., Liot, S., Jacot, G., Metairon, S., Raymond, F., Descombes, P., Palini, A., Chazaud, B., Rudnicki, M.A., Bentzinger, C.F., Feige, J.N. (2019). Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. Cell Stem Cell. DOI
• Bentzinger, C.F. (2019). Best supporting actors. Science. DOI
• Lacour, F., Vezin, E., Bentzinger, C.F., Sincennes, M.-C., Giordani, L., Ferry, A., Mitchell, R., Patel, K., Rudnicki, M.A., Chaboissier, M.-C., Chassot, A.-A., Le Grand, F. (2017). R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Reports. DOI
• Lukjanenko, L., Jung, M.J., Hegde, N., Perruisseau-Carrier, C., Migliavacca, E., Rozo, M., Karaz, S., Jacot, G., Schmidt, M., Li, L., Metairon, S., Raymond, F., Lee, U., Sizzano, F., Wilson, D.H., Dumont, N.A., Palini, A., Fässler, R., Steiner, P., ... Bentzinger, C.F. (2016). Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nature Medicine. DOI
• Dumont, N.A., Wang, Y.X., Von Maltzahn, J., Pasut, A., Bentzinger, C.F., Brun, C.E., Rudnicki, M.A. (2015). Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nature Medicine. DOI
• Chihara, D., Romer, A.I., Bentzinger, C.F., Rudnicki, M.A., Krauss, R.S. (2015). PAX7 is required for patterning the esophageal musculature. Skeletal Muscle. DOI
• Lopez, R.J., Mosca, B., Treves, S., Maj, M., Bergamelli, L., Calderon, J.C., Bentzinger, C.F., Romanino, K., Hall, M.N., Rüegg, M.A., Delbono, O., Caputo, C., Zorzato, F. (2015). Raptor ablation in skeletal muscle decreases cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal. DOI
• Dumont, N.A., Bentzinger, C.F., Sincennes, M.-C., Rudnicki, M.A. (2015). Satellite cells and skeletal muscle regeneration. Comprehensive Physiology. DOI
• Price, F.D., Von Maltzahn, J., Bentzinger, C.F., Dumont, N.A., Yin, H., Chang, N.C., Wilson, D.H., Frenette, J., Rudnicki, M.A. (2014). Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nature Medicine. DOI
• Bentzinger, C.F., Rudnicki, M.A. (2014). Rejuvenating aged muscle stem cells. Nature Medicine. DOI
• Bentzinger, C.F., von Maltzahn, J., Dumont, N.A., Stark, D.A., Wang, Y.X., Nhan, K., Frenette, J., Cornelison, D.D.W., Rudnicki, M.A. (2014). Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. Journal of Cell Biology. DOI
• Von Maltzahn, J., Zinoviev, R., Chang, N.C., Bentzinger, C.F., Rudnicki, M.A. (2013). A truncated Wnt7a retains full biological activity in skeletal muscle. Nature Communications. DOI
• Bentzinger, C.F., Wang, Y.X., Dumont, N.A., Rudnicki, M.A. (2013). Cellular dynamics in the muscle satellite cell niche. EMBO Reports. DOI
• Bentzinger, C.F., Lin, S., Romanino, K., Castets, P., Guridi, M., Summermatter, S., Handschin, C., Tintignac, L.A., Hall, M.N., Rüegg, M.A. (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle. DOI
• Bentzinger, C.F., Wang, Y.X., Von Maltzahn, J., Soleimani, V.D., Yin, H., Rudnicki, M.A. (2013). Fibronectin regulates Wnt7a signaling and satellite cell expansion. Cell Stem Cell. DOI
• Yin, H., Pasut, A., Soleimani, V.D., Bentzinger, C.F., Antoun, G., Thorn, S., Seale, P., Fernando, P., Van Ijcken, W., Grosveld, F., Dekemp, R.A., Boushel, R., Harper, M.-E., Rudnicki, M.A. (2013). MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metabolism. DOI
• Wang, Y.X., Bentzinger, C.F., Rudnicki, M.A. (2013). Molecular regulation of determination in asymmetrically dividing muscle stem cells. Cell Cycle. DOI
• Bentzinger, C.F., Wang, Y.X., von Maltzahn, J., Rudnicki, M.A. (2013). The emerging biology of muscle stem cells: Implications for cell-based therapies. BioEssays. DOI
• Wang, Y.X., Bentzinger, C.F., Rudnicki, M.A. (2013). Treating muscular dystrophy by stimulating intrinsic repair. Regenerative Medicine. DOI
• Bentzinger, C.F., Wang, Y.X., Rudnicki, M.A. (2012). Building muscle: molecular regulation of myogenesis. Cold Spring Harbor perspectives in biology. DOI
• Bentzinger, C.F., Wang, Y.X., Rudnicki, M.A. (2012). Building muscle: molecular regulation of myogenesis. Cold Spring Harbor perspectives in biology.
• von Maltzahn, J., Chang, N.C., Bentzinger, C.F., Rudnicki, M.A. (2012). Wnt signaling in myogenesis. Trends in Cell Biology. DOI
• Von Maltzahn, J., Bentzinger, C.F., Rudnicki, M.A. (2012). Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nature Cell Biology. DOI
• Romanino, K., Mazelin, L., Albert, V., Conjard-Duplany, A., Lin, S., Bentzinger, C.F., Handschin, C., Puigserver, P., Zorzato, F., Schaeffer, L., Gangloff, Y.-G., Rüegg, M.A. (2011). Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Bentzinger, C.F., Von Maltzahn, J., Rudnicki, M.A. (2010). Extrinsic regulation of satellite cell specification. Stem Cell Research and Therapy. DOI
• Scimè, A., Soleimani, V.D., Bentzinger, C.F., Gillespie, M.A., Le Grand, F., Grenier, G., Bevilacqua, L., Harper, M.-E., Rudnicki, M.A. (2010). Oxidative status of muscle is determined by p107 regulation of PGC-1α. Journal of Cell Biology. DOI
• Bentzinger, C.F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J.B., Oliveri, F., Xia, J., Casanova, E., Costa, C.F., Brink, M., Zorzato, F., Hall, M.N., Rüegg, M.A. (2008). Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy. Cell Metabolism. DOI
• Bentzinger, C.F., Barzaghi, P., Lin, S., Ruegg, M.A. (2005). Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-α2-deficient mice. FASEB Journal. DOI

Chapitres de livre

• Mashinchian, O., Pisconti, A., Le Moal, E., Bentzinger, C.F. (2018). The Muscle Stem Cell Niche in Health and Disease. Current Topics in Developmental Biology. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

• PHR615 - Projet d'intégration en pharmacologie. (2023-2024). (3CR).