Alexandre Maréchal

Financement

• Subvention. Understanding and targeting single-stranded DNA gap-filling mechanisms to improve the impact of chemotherapy. Cancer Research Society (Montreal, Canada). 135 000 $. (2025-2027).
  Numéro de subvention : 1454857.
• Subvention salariée. Mécanismes et ciblage de la réponse aux dommages à l'ADN dans les cellules cancéreuses humaines. Fonds de Recherche du Québec - Santé (QC, Canada). Research Scholar Senior. (2025-2029).
  Numéro de subvention : 356849.
• Subvention. Single-stranded DNA generation during UV-induced replicative stress in skin cancer. Canadian Institutes of Health Research (Ottawa, Canada). 845 326 $. (2024-2029).
  Numéro de subvention : 202403PJT. Voir plus
• Subvention. Uncovering Vulnerabilities of Alternative Telomere Maintenance Systems in Cancer. Canadian Institutes of Health Research (Ottawa, Canada). 768 825 $. (2024-2029).
  Numéro de subvention : 202309PJT. Voir plus
• Subvention. Roles of E3 Ubiquitin Ligases in Eukaryotic Genome Maintenance. Natural Sciences and Engineering Research Council (Ottawa, Canada). 45 000 $. (2023-2024).
  Numéro de subvention : grant.14453798. Voir plus
• Subvention. Roles of Transcriptional Regulators and RNA Maturation Factors in the Maintenance of Genomic Stability. Natural Sciences and Engineering Research Council (Ottawa, Canada). 31 000 $. (2021-2022).
  Numéro de subvention : grant.12999612. Voir plus
• Subvention. Étude du Maintien de la Stabilité Du Génome Humain par les E3 Ubiquitine Ligases. Fonds de Recherche du Québec - Santé (Montreal, Canada). 303 086 $. (2021-2025).
  Numéro de subvention : 298072. Voir plus
• Subvention. Ubiquitin-Dependent Regulation of DNA Replication during Stress. Canadian Institutes of Health Research (Ottawa, Canada). 770 795 $. (2020-2025).
  Numéro de subvention : 202003PJT. Voir plus
• Subvention. Acquisition of a focused-ultrasonicator system. Natural Sciences and Engineering Research Council (Ottawa, Canada). 124 105 $. (2020-2021).
  Numéro de subvention : grant.9862509. Voir plus
• Subvention. Roles of Transcriptional Regulators and RNA Maturation Factors in the Maintenance of Genomic Stability. Natural Sciences and Engineering Research Council (Ottawa, Canada). 31 000 $. (2020-2021).
  Numéro de subvention : grant.9868271. Voir plus
• Subvention. Acquisition of a Fluorescence and Chemiluminescence Imaging Platform. Natural Sciences and Engineering Research Council (Ottawa, Canada). 53 588 $. (2019-2020).
  Numéro de subvention : grant.9441696. Voir plus
• Subvention. Acquisition of an Automated High-Throughput Cell Imaging System. Natural Sciences and Engineering Research Council (Ottawa, Canada). 150 000 $. (2017-2018).
  Numéro de subvention : grant.7709323. Voir plus
• Subvention. Rôles des Régulateurs de l'Expression et de la Maturation des ARNs dans le Maintien de la Stabilité du Génome. Fonds de Recherche du Québec - Santé (Montreal, Canada). 267 401 $. (2017-2021).
  Numéro de subvention : 35268. Voir plus
• Subvention. Roles of the PRP19 complex in the Maintenance of Genome Stability. Canadian Institutes of Health Research (Ottawa, Canada). 441 241 $. (2017-2022).
  Numéro de subvention : 201610PJT. Voir plus
• Subvention. Rôles des Régulateurs de l'Expression et de la Maturation des ARNs dans le Maintien de la Stabilité du Génome. Fonds de Recherche du Québec - Santé (Montreal, Canada). 60 000 $. (2017-2020).
  Numéro de subvention : 36787. Voir plus
• Subvention. Acquisition of an in vivo imaging system. Natural Sciences and Engineering Research Council (Ottawa, Canada). 144 824 $. (2016-2017).
  Numéro de subvention : grant.6972810. Voir plus
• Subvention. Acquisition of a liquid scintillation counter. Natural Sciences and Engineering Research Council (Ottawa, Canada). 52 434 $. (2016-2017).
  Numéro de subvention : grant.6975877. Voir plus
• Subvention. Roles of Transcriptional Regulators and RNA Maturation Factors in the Maintenance of Genomic Stability. Natural Sciences and Engineering Research Council (Ottawa, Canada). 155 000 $. (2016-2023).
  Numéro de subvention : grant.6960892. Voir plus
• Subvention. Platform for the Study of the DNA Damage Response in Human Cells. Canada Foundation for Innovation (Ottawa, Canada). 149 840 $. (2016).
  Numéro de subvention : 35208. Voir plus
• Subvention. Un nouveau lien entre la réponse aux dommages à l'ADN et l'épissage de l'ARN. Fonds de Recherche du Québec - Santé (Montreal, Canada). 45 000 $. (2012-2013).
  Numéro de subvention : 25106. Voir plus
• Subvention. Establishment of molecular genetics laboratory on telomere protection and genome stability. Canada Foundation for Innovation (Ottawa, Canada). 99 922 $. (2011).
  Numéro de subvention : 28368. Voir plus
• Subvention. Rôles et interactions des complexes de liaison de l'ADN simple-brin durant la réponse aux dommages à l'ADN. Fonds de Recherche du Québec - Santé (Montreal, Canada). 90 000 $. (2010-2012).
  Numéro de subvention : 20346. Voir plus
• Subvention. Characterization of the pathways regulating the activity of the whirly transcription factors and identification of their genetic targets in arabidopsis thaliana. Natural Sciences and Engineering Research Council (Ottawa, Canada). 21 000 $. (2007-2008).
  Numéro de subvention : grant.2817543. Voir plus
• Subvention. Characterization of the pathways regulating the activity of the whirly transcription factors and identification of their genetic targets in arabidopsis thaliana. Natural Sciences and Engineering Research Council (Ottawa, Canada). 21 000 $. (2006-2007).
  Numéro de subvention : grant.2832594. Voir plus
• Subvention. PGSA. Natural Sciences and Engineering Research Council (Ottawa, Canada). 17 300 $. (2002-2003).
  Numéro de subvention : grant.2983224. Voir plus
• Subvention. PGSA. Natural Sciences and Engineering Research Council (Ottawa, Canada). 17 300 $. (2001-2002).
  Numéro de subvention : grant.2918700. Voir plus

Publications

Articles

• Gaëlle Lescalet, Alberto David Delgado Monterroso, Rima Kochman, Stéphane Coulon, Alexandre Maréchal. (2026). Single-stranded DNA-binding proteins at healthy and diseased telomeres. Trends in Biochemical Sciences. DOI
• Galloy M, Blondeau A, Vion É, Kim D, Bakker CA, Gaggioli V, Thomas M, Lavoie ÉG, Marois I, Delgado Monterroso AD, Masson JY, Taneja N, Miller KM, Maréchal A, Fradet-Turcotte A. (2025). Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress. Molecular cell. DOI
• Faraco CCF, Zhu W, Fortier AM, Ramdzan ZM, Vickridge E, Ong V, Goudreau F, Djerir B, Bellemare J, Gu S, Zhang H, Carroll BL, Krishnan SS, Leduy L, Guarné A, Park M, Maréchal A, Nepveu A. (2025). The function of MYC in base excision repair protects against RAS-induced senescence. Nucleic acids research. DOI
• Dubois JC, Bonnell E, Filion A, Frion J, Zimmer S, Riaz Khan M, Teplitz GM, Casimir L, Méthot É, Marois I, Idrissou M, Jacques PÉ, Wellinger RJ, Maréchal A. (2025). The single-stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Djerir B, Maréchal A. (2025). Detection of γ-H2A.X for Rapid Assessment of Genotoxic Agent-induced Double-strand DNA Breaks by Immunofluorescence. Methods in molecular biology (Clifton, N.J.). DOI
• Kochman R, Ba I, Yates M, Pirabakaran V, Gourmelon F, Churikov D, Lafaille M, Kermasson L, Hamelin C, Marois I, Jourquin F, Braud L, Bechara M, Lainey E, Nunes H, Breton P, Penhouet M, David P, Géli V, ... Coulon S. (2024). Heterozygous <i>RPA2</i> variant as a novel genetic cause of telomere biology disorders. Genes & development. DOI
• Djerir B, Marois I, Dubois JC, Findlay S, Morin T, Senoussi I, Cappadocia L, Orthwein A, Maréchal A. (2024). An E3 Ubiquitin Ligase Localization Screen Uncovers DTX2 as a Novel ADP-Ribosylation-Dependent Regulator of DNA Double-Strand Break Repair. The Journal of biological chemistry. DOI
• Yates M, Marois I, St-Hilaire E, Ronato DA, Djerir B, Brochu C, Morin T, Hammond-Martel I, Gezzar-Dandashi S, Casimir L, Drobetsky E, Cappadocia L, Masson JY, Wurtele H, Maréchal A. (2024). SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability. PLoS biology. DOI
• Vickridge E, Faraco CCF, Lo F, Rahimian H, Liu ZY, Tehrani PS, Djerir B, Ramdzan ZM, Leduy L, Maréchal A, Gingras AC, Nepveu A. (2024). The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene. Nucleic acids research. DOI
• Fauteux M, Côté N, Bergeron S, Maréchal A, Gaudreau L. (2023). Differential effects of pesticides on dioxin receptor signaling and p53 activation. Scientific reports. DOI
• Lisa Casimir, Samuel Zimmer, Félix Racine-Brassard, Félix Goudreau, Pierre-Étienne Jacques, Alexandre Maréchal. (2023). Chronic treatment with ATR and CHK1 inhibitors does not substantially increase the mutational burden of human cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. DOI
• Casimir L, Zimmer S, Racine-Brassard F, Jacques PÉ, Maréchal A. (2022). The mutational impact of Illudin S on human cells. DNA repair. DOI
• Mouhamed Idrissou, Alexandre Maréchal. (2022). The PRP19 Ubiquitin Ligase, Standing at the Cross-Roads of mRNA Processing and Genome Stability. Cancers. DOI
• Heath J, Cheyou ES, Findlay S, Luo VM, Carpio EP, Lee J, Djerir B, Chen X, Morin T, Lebeau B, Karam M, Bagci H, Grapton D, Ursini-Siegel J, Côté JF, Witcher M, Richard S, Maréchal A, Orthwein A. (2021). POGZ promotes homology-directed DNA repair in an HP1-dependent manner. EMBO reports. DOI
• Ramdzan ZM, Vickridge E, Li L, Faraco CCF, Djerir B, Leduy L, Maréchal A, Nepveu A. (2021). CUT Domains Stimulate Pol β Enzymatic Activities to Accelerate Completion of Base Excision Repair. Journal of molecular biology. DOI
• (2019). Human high-density lipoprotein microtranscriptome is unique and suggests an extended role in lipid metabolism. Epigenomics. DOI
• Maïlyn Yates, Alexandre Maréchal. (2018). Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication. International Journal of Molecular Sciences. DOI
• Lashgari A, Fauteux M, Maréchal A, Gaudreau L. (2018). Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells. Scientific reports. DOI
• Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Orthwein A. (2018). SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice. The EMBO journal. DOI
• Gaudreau-Lapierre A, Garneau D, Djerir B, Coulombe F, Morin T, Marechal A. (2018). Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation. Journal of visualized experiments : JoVE. DOI
• Dubois JC, Yates M, Gaudreau-Lapierre A, Clément G, Cappadocia L, Gaudreau L, Zou L, Maréchal A. (2017). A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic acids research. DOI
• Cox KE, Maréchal A, Flynn RL. (2016). SMARCAL1 Resolves Replication Stress at ALT Telomeres. Cell reports. DOI
• Maréchal A, Zou L. (2014). RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell research. DOI
• Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, Zou L. (2014). SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes & development. DOI
• Maréchal A, Zou L. (2014). A LARGe surprise links ATR and Rho. Cell cycle (Georgetown, Tex.). DOI
• Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. (2013). PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Molecular cell. DOI
• Maréchal A, Zou L. (2013). DNA damage sensing by the ATM and ATR kinases. Cold Spring Harbor perspectives in biology. DOI
• Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L. (2013). Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell reports. DOI
• Liu S, Shiotani B, Lahiri M, Maréchal A, Tse A, Leung CC, Glover JN, Yang XH, Zou L. (2011). ATR autophosphorylation as a molecular switch for checkpoint activation. Molecular cell. DOI
• Cappadocia L, Maréchal A, Parent JS, Lepage E, Sygusch J, Brisson N. (2010). Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair. The Plant cell. DOI
• Maréchal A, Brisson N. (2010). Recombination and the maintenance of plant organelle genome stability. The New phytologist. DOI
• Maréchal A, Parent JS, Véronneau-Lafortune F, Joyeux A, Lang BF, Brisson N. (2009). Whirly proteins maintain plastid genome stability in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. DOI
• Maréchal A, Parent JS, Sabar M, Véronneau-Lafortune F, Abou-Rached C, Brisson N. (2008). Overexpression of mtDNA-associated AtWhy2 compromises mitochondrial function. BMC plant biology. DOI
• Desveaux D, Maréchal A, Brisson N. (2005). Whirly transcription factors: defense gene regulation and beyond. Trends in plant science. DOI
• Maréchal A, Tanguay PL, Callejo M, Guérin R, Boileau G, Rokeach LA. (2004). Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin. The Biochemical journal. DOI

Autres contributions

Cours enseignés à l'UdeS

• BCL103 - La cellule eucaryote. (2024-2025). (3CR).
• BIM702 - Frontières de la biologie moléculaire. (2023-2024). (2CR).
• BCL102 - Biologie cellulaire. (2023). (3CR).
• PBI700 - Séminaire de recherche I. (2023). (1CR).
• PBI702 - Séminaire de recherche II. (2023). (1CR).
• PBI706 - Séminaire de recherche IV. (2023). (1CR).
• PBI708 - Séminaire de recherche V. (2023). (1CR).

Divers

• Orthwein A, Findlay S, Heath J, Luo V, Malina A, Li Z, Samiei A, Cheyou ES, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H. (2018). FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.