Sébastien This

Financement

• Subvention. Clinical response biomarker discovery for bispecific T cell engager therapy in Diffuse Large B Cell Lymphoma. Université de Sherbrooke Cancer Research Institute (IRCUS) (Sherbrooke, Canada). 20 000 $. (2026-2028).
• Subvention. Leveraging T cell receptor signaling heterogeneity for improved adoptive cell therapies. Cancer Research Society (Montreal, Canada). 130 000 $. (2026-2028).
  Numéro de subvention : 26093.
• Subvention. Biomarker discovery in the context of mRNA-based in vivo CAR T cell therapy. McGill DNA to RNA (Montreal, Canada). Startup Funds. 150 000 $. (2026-2029).
• Subvention. Leveraging T cell receptor signaling heterogeneity for improved immunotherapies. Université de Sherbrooke (Sherbrooke, Canada). Startup Funds. 119 000 $. (2026-2028).
• Bourse. Artificial intelligence-assisted analysis of intracellular calcium dynamics as a novel approach to fast- track T cell receptor identification for adoptive T cell therapy. Cancer Research Society (Montreal, Canada). Postdoctoral Fellowship. 50 000 $. (2024-2025).
• Bourse. Functional consequences of asymmetric cell division during T cell development and its dysregulation during leukemogenesis. Fonds de Recherche du Québec - Santé (Montreal, Canada). Postdoctoral Fellowship. 135 000 $. (2022-2025).
• Bourse. Functional consequences of asymmetric cell division during T cell development and its dysregulation during leukemogenesis. Cole Foundation (QC, Canada). Postdoctoral Fellowship. 40 000 $. (2021-2023).

Publications

Articles

• Sébastien This, Clément Playout, Solenne Lacroix, Stefanie Valbon, Arnold Hayer, Santiago Costantino, Heather Melichar. (2026). Intracellular calcium dynamics are predictive of T cell receptor affinity for cognate antigen. Zenodo. DOI
• Barba T, Oberbarnscheidt M, Franck G, Gao C, This S, Rabeyrin M, Roufosse C, Moran L, Koenig A, Mathias V, Saison C, Dubois V, Pallet N, Anglicheau D, Lamarthée B, Hertig A, Morelon E, Hot A, Paidassi H, ... Thaunat O. (2025). Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection. The Journal of clinical investigation. DOI
• Andrew Dayton, Sébastien This, Ève Mallet Gauthier, Heather Melichar. (2025). Characterizing Signals Associated with the pre-TCR during T Cell Development. McGill Science Undergraduate Research Journal. DOI
• Sébastien This, Santiago Costantino, Heather J. Melichar. (2024). Machine learning predictions of T cell antigen specificity from intracellular calcium dynamics. Science Advances. DOI
• Heather Melichar, Santiago Costantino, Sébastien This. (2023). Machine learning predictions of T cell antigen-specificity from intracellular calcium dynamics. Zenodo. DOI
• Anastasiia Gainullina, Denis A. Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, ... Maxim N. Artyomov. (2023). Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes. Cell Reports. DOI
• Sébastien This, Dakota Rogers, Ève Mallet Gauthier, Judith N. Mandl, Heather J. Melichar. (2023). What’s self got to do with it: Sources of heterogeneity among naive T cells. Seminars in Immunology. DOI
• Sébastien This, Helena Paidassi. (2022). New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ. Frontiers in Immunology. DOI
• Sébastien This, Stefanie F. Valbon, Marie-Ève Lebel, Heather J. Melichar. (2021). Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance. Cells. DOI
• Lainé, A., Labiad, O., Hernandez-Vargas, H., This, S., Sanlaville, A., Léon, S., Dalle, S., Sheppard, D., Travis, M.A., Paidassi, H., Marie, J.C. (2021). Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation. Nature Communications. DOI
• Nakawesi, J., This, S., Hütter, J., Boucard-Jourdin, M., Barateau, V., Muleta, K.G., Gooday, L.J., Thomsen, K.F., López, A.G., Ulmert, I., Poncet, D., Malissen, B., Greenberg, H., Thaunat, O., Defrance, T., Paidassi, H., Lahl, K. (2021). αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus. Mucosal Immunology. DOI
• Aguilar, S.V., Aguilar, O., Allan, R., Amir, E.A.D., Angeli, V., Artyomov, M.N., Asinovski, N., Astarita, J., Austen, K.F., Bajpai, G., Barrett, N., Baysoy, A., Benoist, C., Bellemare-Pelletier, A., Berg, B., Best, A., Bezman, N., Blair, D., Blander, J.M., ... Ziemkiewicz, C. (2020). ImmGen at 15. Nature Immunology. DOI
• Webster, B., Werneke, S.W., Zafirova, B., This, S., Coléon, S., Décembre, E., Paidassi, H., Bouvier, I., Joubert, P.-E., Duffy, D., Walzer, T., Albert, M.L., Dreux, M. (2018). Plasmacytoid dendritic cells control dengue and chikungunya virus infections via IRF7-regulated interferon responses. eLife. DOI
• Hegazy, A.N., West, N.R., Stubbington, M.J.T., Wendt, E., Suijker, K.I.M., Datsi, A., This, S., Danne, C., Campion, S., Duncan, S.H., Owens, B.M.J., Uhlig, H.H., McMichael, A., Bergthaler, A., Teichmann, S.A., Keshav, S., Powrie, F. (2017). Circulating and Tissue-Resident CD4⁺ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. DOI
• West, N.R., Hegazy, A.N., Owens, B.M.J., Bullers, S.J., Linggi, B., Buonocore, S., Coccia, M., Görtz, D., This, S., Stockenhuber, K., Pott, J., Friedrich, M., Ryzhakov, G., Baribaud, F., Brodmerkel, C., Cieluch, C., Rahman, N., Müller-Newen, G., Owens, R.J., ... Uhlig, H. (2017). Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease. Nature Medicine. DOI
• Blanc, P., Moro-Sibilot, L., Barthly, L., Jagot, F., This, S., De Bernard, S., Buffat, L., Dussurgey, S., Colisson, R., Hobeika, E., Fest, T., Taillardet, M., Thaunat, O., Sicard, A., Mondière, P., Genestier, L., Nutt, S.L., Defrance, T. (2016). Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge. Nature Communications. DOI
• Moro-Sibilot, L., This, S., Blanc, P., Sanlaville, A., Sisirak, V., Bardel, E., Boschetti, G., Bendriss-Vermare, N., Defrance, T., Dubois, B., Kaiserlian, D. (2016). Plasmacytoid dendritic cells are dispensable for noninfectious intestinal IgA responses in vivo. European Journal of Immunology. DOI
• Boucard-Jourdin, M., Kugler, D., Ahanda, M.-L.E., This, S., De Calisto, J., Zhang, A., Mora, J.R., Stuart, L.M., Savill, J., Lacy-Hulbert, A., Paidassi, H. (2016). β8 integrin expression and activation of tgf-β by intestinal dendritic cells are determined by both tissue microenvironment and cell lineage. Journal of Immunology. DOI
• Pérès, E., Bagdassarian, E., This, S., Villaudy, J., Rigal, D., Gazzolo, L., Dodon, M.D. (2015). From immunodeficiency to humanization: The contribution of mouse models to explore HTLV-1 leukemogenesis. Viruses. DOI

Autres contributions

Présentations

• Sébastien This. (2026). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Hôpital Maisonneuve Rosemont research day.
• Sébastien This. (2025). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Hôpital Maisonneuve Rosemont research day.
• Sébastien This. (2025). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Canadian Society for Immunology annual meeting.
• Sébastien This. (2024). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Goodman Cancer Institute Spotlight presentation.
• Sébastien This. (2024). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. 17th annual HMR Foundation Award for Excellence in Publication.
• Sébastien This. (2024). PredictingT cell activation based on intracellular calcium fluctuations: a novel approach for antigen-specific T cell identification. Hôpital Maisonneuve Rosemont research day.
• Sébastien This. (2023). Back dans les bacs: rehabilitating the contribution of cDCs subsets in the maintenance of mucosal tolerance. CFCD (Club Francophone des Cellules Dendritiques) annual symposium, Bordeaux, France,.
• Sébastien This. (2023). Predicting T cell activation based on intracellular calcium fluctuations: novel approach for antigen-specific T cell isolations. Centre International de Recherche en Infectiologie external seminars.
• Sébastien This. (2023). Prediction of T cell activation based on intracellular calcium fluctuations: microscopy-based approach for the isolation of antigen specific T cells. Quebec BioImaging Network 2023 Scientific days, Quebec,.
• Sébastien This. (2022). Predicting T cell fate from TCR signaling dynamics: ongoing and putative applications. Dynamics of Immune Repertoires: Exploration and Translation, Dresden, Germany.
• Sébastien This. (2020). avb8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus. Keystone symposia, B Cell Renaissance: Epigenetics, Regulation and Immunotherapy, Banff, Canada.
• Sébastien This. (2019). Regulation of B cell responses by αvβ8 integrin. Immunology days, Centre International de Recherche en Infectiologie, Lyon, France.

Affiches pour une conférence

• Sébastien This. (2026). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. BioCanRx Summit 4 Cancer Immunotherapy.
• Sébastien This. (2025). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Hôpital Maisonneuve Rosemont research day, Canada.
• Sébastien This. (2025). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Montreal Immunology Meetings annual meeting.
• Sébastien This. (2025). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. DNA to RNA Research Symposium 2025.
• Sébastien This. (2024). Development of a versatile, multidisciplinary approach to identifying antigen- specific T cell receptors across the affinity spectrum. Montreal Immunology Meetings annual meeting.
• Sébastien This. (2024). Predicting T cell activation based on intracellular calcium fluctuations: a novel approach for antigen-specific T cell identification. Canadian Society for Immunology annual meeting.
• Sébastien This. (2023). Predicting T cell activation based on intracellular calcium fluctuations: novel approach for antigen-specific T cell isolations. Montreal Immunology Meetigns annual symposium.
• Sébastien This. (2023). Single Cell Magneto-Optical Capture (scMOCa): Developing a new method for antigen-specific T cell isolation. Canadian society for Immunology annual meeting, Orford, Canada.
• Sébastien This. (2023). entre International de Recherche en Infectiologie external seminars. Hopital Maisonneuve Rosemont Research Days, Montreal, Canada.
• Sébastien This. (2022). Single Cell Magneto-Optical Capture (scMOCa): Developing a new method for antigen-specific T cell isolation. Canadian Society for Immunology Annual Symposium, Halifax, Canada.
• Sébastien This. (2022). Single Cell Magneto-Optical Capture (scMOCa): Developing a new method for antigen-specific T cell isolation. Montreal Immunology netweork annual symposium, Montreal, Canada.
• Sébastien This. (2022). Single Cell Magneto-Optical Capture (scMOCa): Developing a new method for antigen-specific T cell isolation. Cole Foundation research days, Montreal, Canada.
• Sébastien This. (2021). Development of single cell magneto-Optical Capture (scMOCa) technology for the isolation of asymmetrically dividing immune cells. Hopital Maisonneuve Rosemont Research days, Montreal, Canada.
• Sébastien This. (2021). Single cell Magneto-Optical Capture (scMOCa): a versatile technology for the spatio-temporal study of immune cells in vitro. Hôpital Maisonneuve Rosemont (CR-HMR) internal seminars, Montreal, Canada.
• Sébastien This. (2021). Single cell Magneto-Optical Capture (scMOCa): a versatile technology for the spatio-temporal study of immune cells in vitro. Montreal Immunology Meetings annual symposiums,.
• Sébastien This. (2021). Αvβ8 integrin-expression by batf3-dependent dendritic cells facilitates iga responses to rotavirus. Canadian Society for Immunology Annual Symposium, Online, Canada.
• Sébastien This. (2019). avb8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus. Annual symposium for the French Society of Immunology (SFI), Nantes, France.
• Sébastien This. (2018). Role of avb8 integrin on mucosal dendritic cells for regulation of intestinal TGFb-dependent immune responses. Mucosal Immunology Course and Symposium (MICS), Oxford, United Kingdom.
• Sébastien This. (2017). Deciphering the role of the TGFb activating avb8 integrin on mucosal immune responses. nternational Symposium on Immune responses in Cancer and Infection, Lyon, France.
• Sébastien This. (2017). Deciphering the role of αvβ8 integrin in mucosal IgA response. Annual symposium for the French Society of Immunology (SFI), Reims, France.