Mélanie Plourde

Financement

• Subvention. Fatty acid metabolism in carrier of apolipoprotein E epsilon 4 allele: determining the blood-to-brain link. Canadian Institutes of Health Research (Ottawa, Canada). operating. 864 450 $. (2020-2025).
  Numéro de subvention : 427884. Voir plus

Publications

Articles

• Insaf Loukil, David Ku, Annick Vachon, Adam Metherel, Mélanie Plourde. (2025). Omega-3 supplementation increases 13C-EPA but not 13C-DHA kinetics in healthy older adults after 13C-DHA single dose intake: A secondary analysis. Nutrition. DOI
• Bijou Andriambelo, Annick Vachon, Marc-André Dansereau, Benoit Laurent, Mélanie Plourde. (2025). Providing lysophosphatidylcholine-bound omega-3 fatty acids increased eicosapentaenoic acid, but not docosahexaenoic acid, in the cortex of mice with the apolipoprotein E3 or E4 allele. Prostaglandins, Leukotrienes and Essential Fatty Acids. DOI
• Yohann Chaudron, Constance Boyer, Corinne Marmonier, Mélanie Plourde, Annick Vachon, Bernadette Delplanque, Mohammed Taouis, Fabien Pifferi. (2024). A vegetable fat-based diet delays psychomotor and cognitive development compared with maternal dairy fat intake in infant gray mouse lemurs. Communications Biology. DOI
• Loukil I, Cisneros Aguilera E, Vachon A, Léveillé P, Plourde M. (2024). Sex, BMI, and APOE4 increase plasma PL-EPA response during an omega-3 fatty acids supplementation: a secondary analysis. The Journal of nutrition. DOI
• Mélanie Plourde, Michael Stiffel. (2023). In randomized controlled trials with nutrient supplementation, participants with subjective memory complaints should not be combined with those having a mild cognitive impairment diagnosis. The American Journal of Clinical Nutrition. DOI
• Hamilton LK, Moquin-Beaudry G, Mangahas CL, Pratesi F, Aubin M, Aumont A, Joppé SE, Légiot A, Vachon A, Plourde M, Mounier C, Tétreault M, Fernandes KJL. (2023). Author Correction: Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model. Nature communications. DOI
• Khatir I, Brunet MA, Meller A, Amiot F, Patel T, Lapointe X, Avila Lopez J, Guilloy N, Castonguay A, Husain MA, Germain JS, Boisvert FM, Plourde M, Roucou X, Laurent B. (2023). Decoupling of mRNA and Protein Expression in Aging Brains Reveals the Age-Dependent Adaptation of Specific Gene Subsets. Cells. DOI
• Andriambelo B, Stiffel M, Roke K, Plourde M. (2023). New perspectives on randomized controlled trials with omega-3 fatty acid supplements and cognition: A scoping review. Ageing research reviews. DOI
• Janani Balakrishnan, Mohammed Amir Husain, Annick Vachon, Raphaël Chouinard-Watkins, Pauline Léveillé, Mélanie Plourde. (2022). Omega-3 supplementation increases omega-3 fatty acids in lipid compartments that can be taken up by the brain independent of APOE genotype status: A secondary analysis from a randomised controlled trial1. Nutrition and Healthy Aging. DOI
• Aguilera EC, Vachon A, Plourde M. (2022). Comparative Pharmacokinetic of Curcuminoids Formulations with an Omega-3 Fatty Acids Monoglyceride Carrier: A Randomized Cross-Over Triple-Blind Study. Nutrients. DOI
• Lagacé JC, Paquin J, Tremblay R, St-Martin P, Tessier D, Plourde M, Riesco E, Dionne IJ. (2022). The Influence of Family History of Type 2 Diabetes on Metabolism during Submaximal Aerobic Exercise and in the Recovery Period in Postmenopausal Women. Nutrients. DOI
• Husain MA, Vachon A, Chouinard-Watkins R, Vandal M, Calon F, Plourde M. (2022). Investigating the plasma-liver-brain axis of omega-3 fatty acid metabolism in mouse knock-in for the human apolipoprotein E epsilon 4 allele. The Journal of nutritional biochemistry. DOI
• Abolghasemi A, Carullo MP, Aguilera EC, Laroui A, Plantefeve R, Rojas D, Benachenhou S, Ramírez MV, Proteau-Lemieux M, Lepage JF, Corbin F, Plourde M, Farez M, Cogram P, Çaku A. (2022). Alteration of Fatty Acid Profile in Fragile X Syndrome. International journal of molecular sciences. DOI
• Duchaine CS, Fiocco AJ, Carmichael PH, Cunnane SC, Plourde M, Lampuré A, Allès B, Belleville S, Gaudreau P, Presse N, Ferland G, Laurin D. (2022). Serum ω-3 Fatty Acids and Cognitive Domains in Community-Dwelling Older Adults from the NuAge Study: Exploring the Associations with Other Fatty Acids and Sex. The Journal of nutrition. DOI
• Chappus-McCendie H, Poulin MA, Chouinard-Watkins R, Vandal M, Calon F, Lauzon MA, Plourde M. (2022). A diet rich in docosahexaenoic acid enhances reactive astrogliosis and ramified microglia morphology in apolipoprotein E epsilon 4-targeted replacement mice. Aging brain. DOI
• Hamilton LK, Moquin-Beaudry G, Mangahas CL, Pratesi F, Aubin M, Aumont A, Joppé SE, Légiot A, Vachon A, Plourde M, Mounier C, Tétreault M, Fernandes KJL. (2022). Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model. Nature communications. DOI
• Maltais M, Lorrain D, Léveillé P, Viens I, Vachon A, Houeto A, Presse N, Plourde M. (2022). Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: A 6-month randomized controlled trial. Prostaglandins, leukotrienes, and essential fatty acids. DOI
• Beaulieu S, Vachon A, Plourde M. (2022). Women have higher levels of CoQ₁₀ than men when supplemented with a single dose of CoQ₁₀ with monoglycerides omega-3 or rice oil and followed for 48 h: a crossover randomised triple blind controlled study. Journal of nutritional science. DOI
• Lessard-Beaudoin M, M Gonzalez L, AlOtaibi M, Chouinard-Watkins R, Plourde M, Calon F, Graham RK. (2021). Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice. The European journal of neuroscience. DOI
• Chevalier L, Vachon A, Plourde M. (2021). Pharmacokinetics of Supplemental Omega-3 Fatty Acids Esterified in Monoglycerides, Ethyl Esters, or Triglycerides in Adults in a Randomized Crossover Trial. The Journal of nutrition. DOI
• Laurie Chevalier, Mélanie Plourde. (2021). Comparison of pharmacokinetics of omega-3 fatty acid supplements in monoacylglycerol or ethyl ester in humans: a randomized controlled trial. European Journal of Clinical Nutrition. DOI
• Pifferi F, Laurent B, Plourde M. (2021). Lipid Transport and Metabolism at the Blood-Brain Interface: Implications in Health and Disease. Frontiers in physiology. DOI
• Husain MA, Laurent B, Plourde M. (2021). APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in neuroscience. DOI
• Racey M, MacFarlane A, Carlson SE, Stark KD, Plourde M, Field CJ, Yates AA, Wells G, Grantham A, Bazinet RP, Ma DWL. (2021). Dietary Reference Intakes based on chronic disease endpoints: outcomes from a case study workshop for omega 3's EPA and DHA. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. DOI
• Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC. (2020). The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment. Prostaglandins, leukotrienes, and essential fatty acids. DOI
• Chappus-McCendie H, Chevalier L, Roberge C, Plourde M. (2019). Omega-3 PUFA metabolism and brain modifications during aging. Progress in neuro-psychopharmacology & biological psychiatry. DOI
• Brenna JT, Plourde M, Stark KD, Jones PJ, Lin YH. (2018). Best practices for the design, laboratory analysis, and reporting of trials involving fatty acids. The American journal of clinical nutrition. DOI
• Léveillé- P, Hamel M, Ardilouze JL, Pasquier JC, Deacon C, Whittingstall K, Plourde M. (2018). Pilot study of EEG in neonates born to mothers with gestational diabetes mellitus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. DOI
• Coulombe K, Kerdiles O, Tremblay C, Emond V, Lebel M, Boulianne AS, Plourde M, Cicchetti F, Calon F. (2017). Impact of DHA intake in a mouse model of synucleinopathy. Experimental neurology. DOI
• Arguin G, Bourzac JF, Placet M, Molle CM, Paquette M, Beaudoin JF, Rousseau JA, Lecomte R, Plourde M, Gendron FP. (2017). The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Scientific reports. DOI
• Nock TG, Chouinard-Watkins R, Plourde M. (2017). Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochimica et biophysica acta. Molecular and cell biology of lipids. DOI
• Léveillé P, Chouinard-Watkins R, Windust A, Lawrence P, Cunnane SC, Brenna JT, Plourde M. (2017). Metabolism of uniformly labeled ¹³C-eicosapentaenoic acid and ¹³C-arachidonic acid in young and old men. The American journal of clinical nutrition. DOI
• Chouinard-Watkins R, Vandal M, Léveillé P, Pinçon A, Calon F, Plourde M. (2017). Docosahexaenoic acid prevents cognitive deficits in human apolipoprotein E epsilon 4-targeted replacement mice. Neurobiology of aging. DOI
• Léveillé P, Rouxel C, Plourde M. (2017). Diabetic pregnancy, maternal and fetal docosahexaenoic acid: a review of existing evidence. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. DOI
• Ma DW, Bertolo RF, Robbins S, Marchand V, Duncan AM, Plourde M, Grantham A. (2017). Discussion of The Impact of CIHR Reforms on the Funding of Nutritional Sciences in Canada. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. DOI
• Léveillé P, Ardilouze JL, Pasquier JC, Deacon C, Whittingstall K, Plourde M. (2016). Fatty acid profile in cord blood of neonates born to optimally controlled gestational diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. DOI
• Chouinard-Watkins R, Pinçon A, Coulombe JD, Spencer R, Massenavette L, Plourde M. (2016). A Diet Rich in Docosahexaenoic Acid Restores Liver Arachidonic Acid and Docosahexaenoic Acid Concentrations in Mice Homozygous for the Human Apolipoprotein E ε4 Allele. The Journal of nutrition. DOI
• Pinçon A, Coulombe JD, Chouinard-Watkins R, Plourde M. (2016). Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. The Journal of nutritional biochemistry. DOI
• Chouinard-Watkins R, Conway V, Minihane AM, Jackson KG, Lovegrove JA, Plourde M. (2015). Interaction between BMI and APOE genotype is associated with changes in the plasma long-chain-PUFA response to a fish-oil supplement in healthy participants. The American journal of clinical nutrition. DOI
• Dang TM, Conway V, Plourde M. (2014). Disrupted fatty acid distribution in HDL and LDL according to apolipoprotein E allele. Nutrition (Burbank, Los Angeles County, Calif.). DOI
• Chouinard-Watkins R, Plourde M. (2014). Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher risk of cognitive decline and coronary heart disease?. Nutrients. DOI
• Conway V, Larouche A, Alata W, Vandal M, Calon F, Plourde M. (2014). Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice. Prostaglandins, leukotrienes, and essential fatty acids. DOI
• Conway V, Allard MJ, Minihane AM, Jackson KG, Lovegrove JA, Plourde M. (2014). Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?. Lipids in health and disease. DOI
• Plourde M, Chouinard-Watkins R, Rioux-Perreault C, Fortier M, Dang MT, Allard MJ, Tremblay-Mercier J, Zhang Y, Lawrence P, Vohl MC, Perron P, Lorrain D, Brenna JT, Cunnane SC. (2014). Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals. The American journal of clinical nutrition. DOI
• Vandal M, Alata W, Tremblay C, Rioux-Perreault C, Salem N Jr, Calon F, Plourde M. (2014). Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. Journal of neurochemistry. DOI
• Castellano CA, Plourde M, Briand SI, Angers P, Giguère A, Matte JJ. (2013). Safety of dietary conjugated α-linolenic acid (CLNA) in a neonatal pig model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. DOI
• Hennebelle M, Plourde M, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P, Cunnane SC. (2013). Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. The Proceedings of the Nutrition Society. DOI
• Castellano CA, Baillargeon JP, Plourde M, Briand SI, Angers P, Giguère A, Matte JJ. (2013). Dietary conjugated α-linolenic acid did not improve glucose tolerance in a neonatal pig model. European journal of nutrition. DOI
• Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L. (2013). A variant in the LRRFIP1 gene is associated with adiposity and inflammation. Obesity (Silver Spring, Md.). DOI
• Joseph SV, Jacques H, Plourde M, Mitchell PL, McLeod RS, Jones PJ. (2011). Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men. The Journal of nutrition. DOI
• Bégin ME, Plourde M, Pifferi F, Cunnane SC. (2011). What Is the Link between Docosahexaenoic Acid, Cognitive Impairment, and Alzheimer’s Disease in the Elderly?.
• Plourde M, Chouinard-Watkins R, Vandal M, Zhang Y, Lawrence P, Brenna JT, Cunnane SC. (2011). Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly. Nutrition & metabolism. DOI
• Marc I, Plourde M, Lucas M, Sterescu A, Piedboeuf B, Dufresne A, Nuyt AM, Lévy E, Dodin S. (2010). Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants. The Journal of nutrition. DOI
• Tremblay-Mercier J, Tessier D, Plourde M, Fortier M, Lorrain D, Cunnane SC. (2010). Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. The Journal of pharmacology and experimental therapeutics. DOI
• Plourde M, Vohl MC, Vandal M, Couture P, Lemieux S, Cunnane SC. (2009). Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men. The British journal of nutrition. DOI
• Lucas M, Asselin G, Plourde M, Cunnane SC, Dewailly E, Dodin S. (2009). n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. Public health nutrition. DOI
• Plourde M, Tremblay-Mercier J, Fortier M, Pifferi F, Cunnane SC. (2008). Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly. Nutrition (Burbank, Los Angeles County, Calif.). DOI
• Pifferi F, Tremblay S, Plourde M, Tremblay-Mercier J, Bentourkia M, Cunnane SC. (2008). Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate. Epilepsia. DOI
• Vandal M, Freemantle E, Tremblay-Mercier J, Plourde M, Fortier M, Bruneau J, Gagnon J, Bégin M, Cunnane SC. (2008). Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. Lipids. DOI
• Plourde M, Jew S, Cunnane SC, Jones PJ. (2008). Conjugated linoleic acids: why the discrepancy between animal and human studies?. Nutrition reviews. DOI
• Plourde M, Fortier M, Vandal M, Tremblay-Mercier J, Freemantle E, Bégin M, Pifferi F, Cunnane SC. (2007). Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. Prostaglandins, leukotrienes, and essential fatty acids. DOI
• Plourde M, Cunnane SC. (2007). Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. DOI
• Cunnane SC, Plourde M, Stewart K, Crawford MA. (2007). Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal. American journal of human biology : the official journal of the Human Biology Council. DOI
• Plourde M, Sergiel JP, Chardigny JM, Grégoire S, Angers P, Sébédio JL. (2006). Absorption and metabolism of conjugated alpha-linolenic acid given as free fatty acids or triacylglycerols in rats. Nutrition & metabolism. DOI

Autres contributions

Cours enseignés à l'UdeS

• BCM606 - Endocrinologie moléculaire. (2026). (2CR).
• NSC702 - Neurophysiopathologie. (2023-2025). (2CR).
• PHS708 - Physiologie des systèmes. (2024-2025). (2CR).