Louis-Philippe Picard

Financement

• Subvention. Structural Pharmacology: Regulation of G Proteins in Physio(patho)logy. Banting Research Foundation (Toronto, Canada). Discovery Award. 30 000 $. (2025-2026).
• Subvention. Regulation of Heterotrimeric G Proteins: Insights into Conformational Dynamics. NSERC (Ottawa, Canada). Discovery grant. 210 000 $. (2025-2030).
• Subvention. Regulation of Heterotrimeric G Proteins: Insights into Conformational Dynamics. NSERC (Ottawa, Canada). Discovery Launch Supplement. 12 500 $. (2025-2026).

Publications

Articles

• Louis-Philippe Picard, Dmitry Pichugin, Shuya Kate Huang, Motasem Suleiman, R. Scott Prosser. (2025). Reducing experimental time through spin-lattice relaxation enhancement via dissolved oxygen. Journal of Biomolecular NMR. DOI
• Larissa B. Teixeira, Marie-José Blouin, Christian Le Gouill, Louis-Philippe Picard, Claudio M. Costa-Neto, Michel Bouvier, Lucas T. Parreiras-e-Silva. (2025). Sustained Gα _s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent. Science Signaling. DOI
• Louis-Philippe Picard, Alexander Orazietti, Duy Phuoc Tran, Andrejs Tucs, Sari Hagimoto, Zhenzhou Qi, Shuya Kate Huang, Koji Tsuda, Akio Kitao, Adnan Sljoka, R. Scott Prosser. (2024). Balancing G protein selectivity and efficacy in the adenosine A2A receptor. Nature Chemical Biology. DOI
• Shuya Kate Huang, Louis-Philippe Picard, Rima S. M. Rahmatullah, Aditya Pandey, Ned Van Eps, Roger K. Sunahara, Oliver P. Ernst, Adnan Sljoka, R. Scott Prosser. (2023). Mapping the conformational landscape of the stimulatory heterotrimeric G protein. Nature Structural & Molecular Biology. DOI
• Shuya Kate Huang, Omar Almurad, Reizel J Pejana, Zachary A Morrison, Aditya Pandey, Louis-Philippe Picard, Mark Nitz, Adnan Sljoka, R Scott Prosser. (2022). Allosteric modulation of the adenosine A2A receptor by cholesterol. eLife. DOI
• Louis-Philippe Picard, Robert Scott Prosser. (2021). Advances in the study of GPCRs by 19F NMR. Current Opinion in Structural Biology. DOI
• Michael Overduin, Catharine Trieber, R. Scott Prosser, Louis-Philippe Picard, Joey G. Sheff. (2021). Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids. Membranes. DOI
• Louis-Philippe Picard, Anne-Marie Schonegge, Michel Bouvier. (2019). Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin. ACS Pharmacology & Translational Science. DOI
• Markus Stanek, Louis-Philippe Picard, Maximilian F. Schmidt, Jonas M. Kaindl, Harald Hübner, Michel Bouvier, Dorothée Weikert, Peter Gmeiner. (2019). Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. Journal of Medicinal Chemistry. DOI
• Hiroyuki Kobayashi, Louis-Philippe Picard, Anne-Marie Schönegge, Michel Bouvier. (2019). Bioluminescence resonance energy transfer–based imaging of protein–protein interactions in living cells. Nature Protocols. DOI
• Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma van der Westhuizen, Jacob P. Mahoney, João P. G. L. M. Rodrigues, Thomas J. Mildorf, Ron O. Dror, David E. Shaw, Michel Bouvier, Els Pardon, Jan Steyaert, Roger K. Sunahara, William I. Weis, Cheng Zhang, Brian K. Kobilka. (2018). Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist. Nature Chemical Biology. DOI
• Louis-Philippe Picard, Anne Marie Schönegge, Martin J. Lohse, Michel Bouvier. (2018). Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Communications Biology. DOI
• Anne-Marie Schönegge, Jonathan Gallion, Louis-Philippe Picard, Angela D. Wilkins, Christian Le Gouill, Martin Audet, Wayne Stallaert, Martin J. Lohse, Marek Kimmel, Olivier Lichtarge, Michel Bouvier. (2017). Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity. Nature Communications. DOI
• Silvana Jananji, Cristina Risi, Indeewari K.S. Lindamulage, Louis-Philippe Picard, Robert Van Sciver, Guillaume Laflamme, Abe Albaghjati, Gilles R.X. Hickson, Benjamin H. Kwok, Vitold E. Galkin. (2017). Multimodal and Polymorphic Interactions between Anillin and Actin: Their Implications for Cytokinesis. Journal of Molecular Biology. DOI

Autres contributions

Cours enseignés à l'UdeS

• PHR204 - Principes de pharmacologie II. (2026). (3CR).