Karl Fernandes

Publications

Articles

• Hector A, Leduc T, da Costa Caiado MJ, Delignat-Lavaud B, Dufort-Gervais J, Daneault C, Des Rosiers C, Bourguignon C, Lina JM, Fernandes K, Brouillette J, Mongrain V. (2026). Electrocorticographic, astrocytic and transcriptomic signatures in the triple transgenic mouse model of Alzheimer's disease submitted to stearoyl-CoA desaturase inhibition. Neuropharmacology. DOI
• Paule E H M’Bra, Laura K Hamilton, Gaël Moquin-Beaudry, Chenicka L Mangahas, Federico Pratesi, Anne Castonguay, Sophia Mailloux, Manon Galoppin, Jessica Avila Lopez, Megan Bernier, Marta Turri, Marian Mayhue, Anne Aumont, Martine Tetreault, Stephen C Cunnane, Karl J L Fernandes. (2026). Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer’s disease. Brain. DOI
• Paule E. H. M’Bra, Isaura Suárez-Uribe, Mariano Avino, Evelyne Ng Kwan Lim, Marian Mayhue, Philippe Balthazar, Anne Aumont, Karine Prévost, Eric Massé, Karl J. L. Fernandes. (2025). Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer’s disease mice. Communications Biology. DOI
• Melanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks, Jeroen F. J. Bogie. (2024). Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders. Molecular Neurodegeneration. DOI
• Hamilton LK, Moquin-Beaudry G, Mangahas CL, Pratesi F, Aubin M, Aumont A, Joppé SE, Légiot A, Vachon A, Plourde M, Mounier C, Tétreault M, Fernandes KJL. (2022). Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model. Nature communications. DOI
• Cochard LM, Levros LC Jr, Joppé SE, Pratesi F, Aumont A, Fernandes KJL. (2021). Manipulation of EGFR-Induced Signaling for the Recruitment of Quiescent Neural Stem Cells in the Adult Mouse Forebrain. Frontiers in neuroscience. DOI
• Sandra E Joppé, Loïc M Cochard, Louis-Charles Levros, Jr, Laura K Hamilton, Pierre Ameslon, Anne Aumont, Fanie Barnabé-Heider, Karl JL Fernandes. (2020). Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium. Life Science Alliance. DOI
• Flamier A, El Hajjar J, Adjaye J, Fernandes KJ, Abdouh M, Bernier G. (2018). Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency. Cell reports. DOI
• Grégoire CA, Tobin S, Goldenstein BL, Samarut É, Leclerc A, Aumont A, Drapeau P, Fulton S, Fernandes KJL. (2018). RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus. Frontiers in molecular neuroscience. DOI
• Laura K. Hamilton, Karl J. L. Fernandes. (2018). Neural stem cells and adult brain fatty acid metabolism: Lessons from the 3xTg model of Alzheimer's disease. Biology of the Cell. DOI
• Li X, Floriddia EM, Toskas K, Fernandes KJL, Guérout N, Barnabé-Heider F. (2016). Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time. EBioMedicine. DOI
• Joppé SE, Hamilton LK, Cochard LM, Levros LC, Aumont A, Barnabé-Heider F, Fernandes KJ. (2015). Bone morphogenetic protein dominantly suppresses epidermal growth factor-induced proliferative expansion of adult forebrain neural precursors. Frontiers in neuroscience. DOI
• Hamilton LK, Dufresne M, Joppé SE, Petryszyn S, Aumont A, Calon F, Barnabé-Heider F, Furtos A, Parent M, Chaurand P, Fernandes KJ. (2015). Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease. Cell stem cell. DOI
• Grégoire CA, Goldenstein BL, Floriddia EM, Barnabé-Heider F, Fernandes KJ. (2015). Endogenous neural stem cell responses to stroke and spinal cord injury. Glia. DOI
• Lacroix S, Hamilton LK, Vaugeois A, Beaudoin S, Breault-Dugas C, Pineau I, Lévesque SA, Grégoire CA, Fernandes KJ. (2014). Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. PloS one. DOI
• Grégoire CA, Bonenfant D, Le Nguyen A, Aumont A, Fernandes KJ. (2014). Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. PloS one. DOI
• El-Helou V, Chabot A, Gosselin H, Villeneuve L, Clavet-Lanthier ME, Tanguay JF, Enikolopov G, Fernandes KJ, Jasmin JF, Calderone A. (2013). Cardiac resident nestin(+) cells participate in reparative vascularisation. Journal of cellular physiology. DOI
• Hamilton LK, Joppé SE, M Cochard L, Fernandes KJ. (2013). Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here. The European journal of neuroscience. DOI
• Paliouras GN, Hamilton LK, Aumont A, Joppé SE, Barnabé-Heider F, Fernandes KJ. (2012). Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. DOI
• Bouab M, Paliouras GN, Aumont A, Forest-Bérard K, Fernandes KJ. (2010). Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood. Neuroscience. DOI
• Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJ. (2010). Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. The European journal of neuroscience. DOI
• Bednarczyk MR, Hacker LC, Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJ. (2010). Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment. Hippocampus. DOI
• Bednarczyk MR, Aumont A, Décary S, Bergeron R, Fernandes KJ. (2009). Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice. Hippocampus. DOI
• Hamilton LK, Truong MK, Bednarczyk MR, Aumont A, Fernandes KJ. (2009). Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells in the adult mammalian spinal cord. Neuroscience. DOI
• Fernandes KJ, Miller FD. (2009). Isolation, expansion, and differentiation of mouse skin-derived precursors. Methods in molecular biology (Clifton, N.J.). DOI
• El-Helou V, Beguin PC, Assimakopoulos J, Clement R, Gosselin H, Brugada R, Aumont A, Biernaskie J, Villeneuve L, Leung TK, Fernandes KJ, Calderone A. (2008). The rat heart contains a neural stem cell population; role in sympathetic sprouting and angiogenesis. Journal of molecular and cellular cardiology. DOI
• Fernandes KJ, Toma JG, Miller FD. (2008). Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. DOI
• Fernandes KJ, Kobayashi NR, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD. (2006). Analysis of the neurogenic potential of multipotent skin-derived precursors. Experimental neurology. DOI
• Barnabé-Heider F, Wasylnka JA, Fernandes KJ, Porsche C, Sendtner M, Kaplan DR, Miller FD. (2005). Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron. DOI
• Nadeau S, Hein P, Fernandes KJ, Peterson AC, Miller FD. (2005). A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Molecular and cellular neurosciences. DOI
• Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabé-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD. (2004). A dermal niche for multipotent adult skin-derived precursor cells. Nature cell biology. DOI
• McPhail LT, Fernandes KJ, Chan CC, Vanderluit JL, Tetzlaff W. (2004). Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons. Experimental neurology. DOI
• Vanderluit JL, McPhail LT, Fernandes KJ, Kobayashi NR, Tetzlaff W. (2003). In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons. Cell death and differentiation. DOI
• Toma JG, Akhavan M, Fernandes KJ, Barnabé-Heider F, Sadikot A, Kaplan DR, Miller FD. (2001). Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nature cell biology. DOI
• Vanderluit JL, McPhail LT, Fernandes KJ, McBride CB, Huguenot C, Roy S, Robertson GS, Nicholson DW, Tetzlaff W. (2000). Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents. The European journal of neuroscience. DOI
• Pataky DM, Borisoff JF, Fernandes KJ, Tetzlaff W, Steeves JD. (2000). Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro. Experimental neurology. DOI
• Fernandes KJ, Fan DP, Tsui BJ, Cassar SL, Tetzlaff W. (1999). Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. The Journal of comparative neurology. DOI
• Fernandes KJ, Kobayashi NR, Jasmin BJ, Tetzlaff W. (1998). Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms. The Journal of neuroscience : the official journal of the Society for Neuroscience. DOI