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Ayman Oweida

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département des sciences de l’imagerie médicale et des radiations

Présentation

Sujets, disciplines ou intérêts de recherche

research, science, medicine, biology, cancer, teaching, writing, editing

Diplômes

  • (2015-2019). Postdoctoral Fellow. Department of Radiation Oncology. University of Colorado Anschutz Medical Campus. Aurora, États-Unis.
  • (2010-2014). PhD. Experimental Medicine. McGill University. Montreal, QC, Canada.
  • (2004-2006). Master of Science. Medical Biophysics. University of Western Ontario. London, ON, Canada.
  • (2002-2004). Writing Diploma. Arts. University of Western Ontario. London, ON, Canada.
  • (2000-2004). Bachelor of Medical Science. Biophysics. University of Western Ontario. London, ON, Canada.

Expériences académiques

  • Associate Professor. (2025-). Université de Sherbrooke. Sherbrooke, Quebec, Canada.
  • Assistant Professor. (2019-). Université de Sherbrooke. Sherbrooke, Canada.
  • Writer and Editor. (2010-2014). EBSCO Information Services Inc. Ipswich, MA, États-Unis.
  • Editor in-chief. (2012-2014). McGill University. Montreal, QC, Canada.
  • Research Assistant. (2006-2007). Robarts Research Institute. London, ON, Canada.

Financement

  • Subvention. Targeting immunosuppressive chemokines for enhanced response to radiotherapy in squamous cell cancers. Canadian Institutes of Health Research (Ottawa, Canada). 60 000 $. (2021-2023).
    Numéro de subvention : 202103CRP. Voir plus
  • Subvention. Radiotherapy for stimulation of anti-tumor immunity. Canada Foundation for Innovation (Ottawa, Canada). 490 087 $. (2021).
    Numéro de subvention : 40723. Voir plus
  • Subvention. Anti-Tumor Immunity by Radiotherapy. Canadian Institutes of Health Research (Ottawa, Canada). 600 000 $. (2021-2026).
    Numéro de subvention : 202004CRC. Voir plus
  • Subvention. Development of an immune imaging method to accurately determine the immune status of tumors. Natural Sciences and Engineering Research Council (Ottawa, Canada). 24 000 $. (2020-2021).
    Numéro de subvention : RGPIN-2020-06156. Voir plus
  • Subvention. Compréhension des mécanismes impliqués dans la réponse aux traitements anti-cancéreux combinant immunothérapie et radiothérapie. Fonds de Recherche du Québec - Santé (Montreal, Canada). 225 075 $. (2020-2024).
    Numéro de subvention : 283276. Voir plus
  • Subvention. Compréhension des mécanismes impliqués dans la réponse aux traitements anti-cancéreux combinant immunothérapie et radiothérapie. Fonds de Recherche du Québec - Santé (Montreal, Canada). 20 000 $. (2020-2021).
    Numéro de subvention : 295653. Voir plus
  • Subvention. Development of an immune imaging method to accurately determine the immune status of tumors. Natural Sciences and Engineering Research Council (Ottawa, Canada). 12 500 $. (2020-2021).
    Numéro de subvention : DGECR-2020-00219. Voir plus
  • Subvention. Identifier les Mechanismes de synergie entre la radiotherapie et I'immunotherapie dans le cancer des voies aerodigestives superieures. Fonds de Recherche du Québec - Santé (Montreal, Canada). 55 000 $. (2019-2020).
    Numéro de subvention : 269708. Voir plus
  • Subvention. Identifier les Mechanismes de synergie entre la radiotherapie et I’immunotherapie dans le cancer des voiesaerodigestives superieures. Fonds de Recherche du Québec - Santé (Montreal, Canada). 15 000 $. (2019-2020).
    Numéro de subvention : 293743. Voir plus
  • Subvention. Identifier les Mécanismes de synergie entre la radiothérapie et l'immunothérapie dans le cancer des voies aérodigestives supérieures. Fonds de Recherche du Québec - Santé (Montreal, Canada). 96 210 $. (2017-2019).
    Numéro de subvention : 35991. Voir plus
  • Subvention. Le fondement biologique des images TEP pour le cancer du poumon: l'impact sur le pronostic et la radiothérapie. Fonds de Recherche du Québec - Santé (Montreal, Canada). 40 000 $. (2011-2013).
    Numéro de subvention : 23401. Voir plus

Publications

Articles

  • Ryma Haroun, Sahar Naasri, Ayman J. Oweida. (2023). Toll-Like Receptors and the Response to Radiotherapy in Solid Tumors: Challenges and Opportunities. Vaccines. DOI
  • Bickett, T.E., Knitz, M.W., Piper, M., Oweida, A.J., Gadwa, J., Darragh, L.B., Nguyen, D., Bhatia, S., Bhuvane, S., Phan, A.V., Van Court, B., Corbo, S., Pham, T., Dent, A.L., Lenz, L., Karam, S.D. (2022). Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Molecular Therapy. DOI
  • Rutihinda, C., Haroun, R., Saidi, N.E., Ordoñez, J.P., Naasri, S., Lévesque, D., Boisvert, F.-M., Fortier, P.-H., Belzile, M., Fradet, L., Hubert-Tremblay, V., Turgeon, G.A., Wang, C.S., Delage, P., Rousseau, É., Paquette, B., Oweida, A.J. (2022). Inhibition of the CCR6-CCL20 axis prevents regulatory T cell recruitment and sensitizes head and neck squamous cell carcinoma to radiation therapy. Cancer Immunology, Immunotherapy. DOI
  • Knitz, M.W., Darragh, L.B., Bickett, T.E., Bhatia, S., Bukkapatnam, S., Gadwa, J., Piper, M., Corbo, S., Nguyen, D., Van Court, B., Oweida, A., Karam, S.D. (2022). Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma. Cancer Immunology, Immunotherapy. DOI
  • Michael W Knitz, Thomas E Bickett, Laurel B Darragh, Ayman J Oweida, Shilpa Bhatia, Benjamin Van Court, Shiv Bhuvane, Miles Piper, Jacob Gadwa, Adam C Mueller, Diemmy Nguyen, Varuna Nangia, Douglas G Osborne, Xiyuan Bai, Sarah E Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A Burchill, Beth A Jirón Tamburini, ... Sana D Karam. (2021). Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. Journal for ImmunoTherapy of Cancer. DOI
  • Mueller, A.C., Piper, M., Goodspeed, A., Bhuvane, S., Williams, J.S., Bhatia, S., Phan, A.V., van Court, B., Zolman, K.L., Peña, B., Oweida, A.J., Zakem, S., Meguid, C., Knitz, M.W., Darragh, L., Bickett, T.E., Gadwa, J., Mestroni, L., Taylor, M.R.G., ... Karam, S.D. (2021). Induction of ADAM10 by radiation therapy drives fibrosis, resistance, and epithelial-to-mesenchyal transition in pancreatic cancer. Cancer Research. DOI
  • Oweida, A., Paquette, B. (2021). Reconciling two opposing effects of radiation therapy: stimulation of cancer cell invasion and activation of anti-cancer immunity. International Journal of Radiation Biology. DOI
  • Oweida, A.J., Mueller, A.C., Piper, M., Milner, D., Van Court, B., Bhatia, S., Phan, A., Bickett, T., Jordan, K., Proia, T., Schulick, R., Messersmith, W.A., Del Chiaro, M., Clambey, E., Gough, M.J., Williams, J., Hansen, K., Goodman, K., Karam, S.D. (2021). Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunology, Immunotherapy. DOI
  • Korpela, S.P., Hinz, T.K., Oweida, A., Kim, J., Calhoun, J., Ferris, R., Nemenoff, R.A., Karam, S.D., Clambey, E.T., Heasley, L.E. (2021). Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. Journal of Translational Medicine. DOI
  • Ma’mon M. Hatmal, Walhan Alshaer, Mohammad A. I. Al-Hatamleh, Malik Hatmal, Othman Smadi, Mutasem O. Taha, Ayman J. Oweida, Jennifer C. Boer, Rohimah Mohamud, Magdalena Plebanski. (2020). Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2. Cells. DOI
  • Hararah, M.K., Stokes, W.A., Oweida, A., Patil, T., Amini, A., Goddard, J., Bowles, D.W., Karam, S.D. (2020). Epidemiology and treatment trends for primary tracheal squamous cell carcinoma. Laryngoscope. DOI
  • Hernandez, A.L., Young, C.D., Bian, L., Weigel, K., Nolan, K., Frederick, B., Han, G., He, G., Devon Trahan, G., Rudolph, M.C., Jones, K.L., Oweida, A.J., Karam, S.D., Raben, D., Wang, X.-J. (2020). PARP inhibition enhances radiotherapy of SMAD4-deficient human head and neck squamous cell carcinomas in experimental models. Clinical Cancer Research. DOI
  • Bhatia, S., Bukkapatnam, S., Van Court, B., Phan, A., Oweida, A., Gadwa, J., Mueller, A.C., Piper, M., Darragh, L., Nguyen, D., Gilani, A., Knitz, M., Bickett, T., Green, A., Venkataraman, S., Vibhakar, R., Cittelly, D., Karam, S.D. (2020). The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Molecular Carcinogenesis. DOI
  • Bravo-Filho, V., Logan, P., Zoroquiain, P., Aldrees, S., Vilà, N., Oweida, A., Neto, R.B., Burnier, M.N. (2019). Effects of ranibizumab and amfenac on the functional abilities and radiosensitivity of uveal melanoma cells,Efeitos do ranibizumabe e do amfenac nas habilidades funcionais e na radiossensibilidade de células de melanoma uveal. Arquivos Brasileiros de Oftalmologia. DOI
  • Pierce, A.M., Witt, D.A., Donson, A.M., Gilani, A., Sanford, B., Sill, M., Van Court, B., Oweida, A., Prince, E.W., Steiner, J., Danis, E., Dorris, K., Hankinson, T., Handler, M.H., Jones, K.L., Karam, S.D., Serkova, N.J., Vibhakar, R., Foreman, N.K., Griesinger, A.M. (2019). Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro-Oncology. DOI
  • Bhatia, S., Oweida, A., Lennon, S., Darragh, L.B., Milner, D., Phan, A.V., Mueller, A.C., Van Court, B., Raben, D., Serkova, N.J., Wang, X.-J., Jimeno, A., Clambey, E.T., Pasquale, E.B., Karam, S.D. (2019). Inhibition of EphB4-Ephrin-B2 signaling reprograms the tumor immune microenvironment in head and neck cancers. Cancer Research. DOI
  • Oweida, A.J., Bhatia, S., van Court, B., Darragh, L., Serkova, N., Karam, S.D. (2019). Intramucosal inoculation of squamous cell carcinoma cells in mice for tumor immune profiling and treatment response assessment. Journal of Visualized Experiments. DOI
  • Darragh, L.B., Oweida, A.J., Karam, S.D. (2019). Overcoming resistance to combination radiation-immunotherapy: A focus on contributing pathways within the tumor microenvironment. Frontiers in Immunology. DOI
  • Lennon, S., Oweida, A., Milner, D., Phan, A.V., Bhatia, S., Van Court, B., Darragh, L., Mueller, A.C., Raben, D., Martínez-Torrecuadrada, J.L., Pitts, T.M., Somerset, H., Jordan, K.R., Hansen, K.C., Williams, J., Messersmith, W.A., Schulick, R.D., Owens, P., Goodman, K.A., Karam, S.D. (2019). Pancreatic tumor microenvironment modulation by EphB4-ephrinB2 inhibition and radiation combination. Clinical Cancer Research. DOI
  • Oweida, A.J., Darragh, L., Phan, A., Binder, D., Bhatia, S., Mueller, A., Van Court, B., Milner, D., Raben, D., Woessner, R., Heasley, L., Nemenoff, R., Clambey, E., Karam, S.D. (2019). STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. Journal of the National Cancer Institute. DOI
  • Karam, S.D., Reddy, K., Blatchford, P.J., Waxweiler, T., DeLouize, A.M., Oweida, A., Somerset, H., Marshall, C., Young, C., Davies, K.D., Kane, M., Tan, A.C., Wang, X.J., Jimeno, A., Aisner, D.L., Bowles, D.W., Raben, D. (2018). Final report of a phase I trial of olaparib with cetuximab and radiation for heavy smoker patients with locally advanced head and neck cancer. Clinical Cancer Research. DOI
  • Oweida, A., Phan, A., Vancourt, B., Robin, T., Hararah, M.K., Bhatia, S., Milner, D., Lennon, S., Pike, L., Raben, D., Haugen, B., Pozdeyev, N., Schweppe, R., Karam, S.D. (2018). Hypofractionated radiotherapy is superior to conventional fractionation in an orthotopic model of anaplastic thyroid cancer. Thyroid. DOI
  • Bhatia, S., Sharma, J., Bukkapatnam, S., Oweida, A., Lennon, S., Phan, A., Milner, D., Uyanga, N., Jimeno, A., Raben, D., Somerset, H., Heasley, L., Karam, S.D. (2018). Inhibition of EphB4–ephrin-B2 signaling enhances response to cetuximab–radiation therapy in head and neck cancers. Clinical Cancer Research. DOI
  • Hararah, M.K., Stokes, W.A., Jones, B.L., Oweida, A., Ding, D., McDermott, J., Goddard, J., Karam, S.D. (2018). Nomogram for preoperative prediction of nodal extracapsular extension or positive surgical margins in oropharyngeal squamous cell carcinoma. Oral Oncology. DOI
  • Oweida, A., Hararah, M.K., Phan, A., Binder, D., Bhatia, S., Lennon, S., Bukkapatnam, S., Van Court, B., Uyanga, N., Darragh, L., Kim, H.M., Raben, D., Tan, A.C., Heasley, L., Clambey, E., Nemenoff, R., Karam, S.D. (2018). Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration. Clinical Cancer Research. DOI
  • Oweida, A., Sabri, S., Al-Rabea, A., Ebrahimi, M., Ruo, R., Fraser, R., Seuntjens, J., Abdulkarim, B. (2018). Response to stereotactic ablative radiotherapy in a novel orthotopic model of non-small cell lung cancer. Oncotarget. DOI
  • Bhatia, S., Griego, A., Lennon, S., Oweida, A., Sharma, J., Rohmer, C., Uyanga, N., Bukkapatnam, S., Van Court, B., Raben, D., Young, C., Heasley, L., Karam, S.D. (2018). Role of EPHB3 receptor in mediating head and neck tumor growth, cell migration, and response to PI3K inhibitor. Molecular Cancer Therapeutics. DOI
  • Azoulay, M., Santos, F., Shenouda, G., Petrecca, K., Oweida, A., Guiot, M.C., Owen, S., Panet-Raymond, V., Souhami, L., Abdulkarim, B.S. (2017). Benefit of re-operation and salvage therapies for recurrent glioblastoma multiforme: results from a single institution. Journal of Neuro-Oncology. DOI
  • Bhatia, S., Hirsch, K., Bukkapatnam, S., Baig, N.A., Oweida, A., Griego, A., Calame, D., Sharma, J., Donson, A., Foreman, N., Albanese, C., Venkataraman, S., Vibhakar, R., Karam, S.D. (2017). Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma. Cancer Cell International. DOI
  • Stokes, W.A., Binder, D.C., Jones, B.L., Oweida, A.J., Liu, A.K., Rusthoven, C.G., Karam, S.D. (2017). Impact of immunotherapy among patients with melanoma brain metastases managed with radiotherapy. Journal of Neuroimmunology. DOI
  • Oweida, A., Lennon, S., Calame, D., Korpela, S., Bhatia, S., Sharma, J., Graham, C., Binder, D., Serkova, N., Raben, D., Heasley, L., Clambey, E., Nemenoff, R., Karam, S.D. (2017). Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. OncoImmunology. DOI
  • Sumner, W.A., Stokes, W.A., Oweida, A., Berggren, K.L., McDermott, J.D., Raben, D., Abbott, D., Jones, B., Gan, G., Karam, S.D. (2017). Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy. Journal of Translational Medicine. DOI
  • William A. Stokes, Bernard L. Jones, Shilpa Bhatia, Ayman J. Oweida, Daniel W. Bowles, David Raben, Julie A. Goddard, Jessica D. McDermott, Sana D. Karam. (2016). A comparison of overall survival for patients with T4 larynx cancer treated with surgical versus organ-preservation approaches: A National Cancer Data Base analysis. Cancer. DOI
  • Ayman Oweida, Shilpa Bhatia, Kellen Hirsch, Dylan Calame, Anastacia Griego, Steve Keysar, Todd Pitts, Jaspreet Sharma, Gail Eckhardt, Antonio Jimeno, Xiao Jing Wang, Gill Parkash, Joseph Califano, Sana Karam. (2016). Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors. Molecular Carcinogenesis. DOI
  • Ayman Oweida, Zeinab Sharifi, Hani Halabi, Yaoxian Xu, Siham Sabri, Bassam Abdulkarim. (2016). Differential response to ablative ionizing radiation in genetically distinct non-small cell lung cancer cells. Cancer Biology & Therapy. DOI
  • A Oweida, B Abdulkarim. (2016). Ablative versus fractionated radiation therapy: a controversial role in cancer invasion and metastasis. Oncogene. DOI
  • Shilpa Bhatia, Kellen Hirsch, Jaspreet Sharma, Ayman Oweida, Anastacia Griego, Stephen Keysar, Antonio Jimeno, David Raben, Valery Krasnoperov, Parkash S. Gill, Elena B. Pasquale, Xiao-Jing Wang, Sana D. Karam. (2016). Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas. Scientific Reports. DOI
  • Ayman J. Oweida, Zeinab Sherifi, Yaoxian Xu, Siham Sabri, Bassam Abdulkarim. (2014). Abstract 865: Evolving biological and clinical concepts of radiation delivery in NSCLC: response to ablative versus fractionated radiotherapy. Cancer Res. DOI
  • Oweida, A.J., Dunn, E.A., Karlik, S.J., Dekaban, G.A., Foster, P.J. (2007). Iron-oxide labeling of hematogenous macrophages in a model of experimental autoimmune encephalomyelitis and the contribution to signal loss in fast imaging employing steady state acquisition (FIESTA) images. Journal of Magnetic Resonance Imaging. DOI
  • Oweida, A.J., Dunn, E.A., Foster, P.J. (2004). Cellular imaging at 1.5 T: Detecting cells in neuroinflammation using active labeling with superparamagnetic iron oxide. Molecular Imaging. DOI

Autres contributions

Cours enseignés ou supervisés à l'UdeS

  • IML600 - Immunologie moléculaire. (2026). (2CR).
  • RBL501 - Études pharmacologiques en imagerie biomédicale et radiothérapie. (2024-2026). (2CR).
  • RBL745 - Avancées technologiques, biologiques et médicales en radiothérapie. (2026). (1CR).