Philippe Dauphin Ducharme

Financement

• Subvention. Plateforme de biocapteurs pour le suivi pharmacocinétique de molécules psychoactives. Fonds de Recherche du Québec - Santé (Montreal, Canada). 277 526 $. (2024-2028).
  Numéro de subvention : 347328. Voir plus
• Subvention. Multi-détection d'anesthésiques dans des matrices complexes à l'aide de biocapteurs électrochimiques. Fonds de Recherche du Québec – Nature et Technologies (Montreal, Canada). 90 000 $. (2024-2027).
  Numéro de subvention : 359972. Voir plus
• Subvention. Aptamer-based Electrochemical Biosensors for the Detection of Anesthetics. Natural Sciences and Engineering Research Council (Ottawa, Canada). 45 000 $. (2023-2024).
  Numéro de subvention : 571442-2021. Voir plus
• Subvention. Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery. Natural Sciences and Engineering Research Council (Ottawa, Canada). 177 000 $. (2023-2024).
  Numéro de subvention : 575320-2023. Voir plus
• Subvention. Electrochemical sensing in complex matrices. Natural Sciences and Engineering Research Council (Ottawa, Canada). 24 000 $. (2022-2023).
  Numéro de subvention : RGPIN-2021-03974. Voir plus
• Subvention. Infrastructure for the Development of Electrochemical Biosensors. Canada Foundation for Innovation (Ottawa, Canada). 130 000 $. (2021).
  Numéro de subvention : 40695. Voir plus
• Subvention. Electrochemical Aptamer-Based Biosensors for Salivary Molecular Measurements. Natural Sciences and Engineering Research Council (Ottawa, Canada). 25 000 $. (2021-2022).
  Numéro de subvention : 566687-2021. Voir plus
• Subvention. Biophysique d'oligonucléotides sur des électrodes pour le développement de biocapteurs électrochimiques. Fonds de Recherche du Québec – Nature et Technologies (Montreal, Canada). 60 000 $. (2021-2023).
  Numéro de subvention : 296396. Voir plus
• Subvention. Electrochemical sensing in complex matrices. Natural Sciences and Engineering Research Council (Ottawa, Canada). 12 500 $. (2021-2022).
  Numéro de subvention : DGECR-2021-00272. Voir plus
• Subvention. Biocapteurs électrochimiques à base d'aptamères pour la détection d'anesthésiques. Fonds de Recherche du Québec – Nature et Technologies (Montreal, Canada). 90 000 $. (2021-2024).
  Numéro de subvention : 314055. Voir plus
• Subvention. Electrochemical platform for the characterization of biosensors, advanced materials and environmental samples. Natural Sciences and Engineering Research Council (Ottawa, Canada). 149 500 $. (2020-2021).
  Numéro de subvention : RTI-2021-00426. Voir plus
• Subvention. Development of a New Class of Single-step, Biology-inspired, Electrochemical Biosensors. Natural Sciences and Engineering Research Council (Ottawa, Canada). 45 000 $. (2017-2018).
  Numéro de subvention : 487592-2016. Voir plus
• Subvention. Développement d'une nouvelle classe de biosenseurs électrochimiques inspirés de la nature pour la détection d’ions et molécules en une seule étape. Fonds de Recherche du Québec – Nature et Technologies (Montreal, Canada). 36 480 $. (2015-2017).
  Numéro de subvention : 188935. Voir plus
• Subvention. Études par SECM d'alliages de magnésium placés en couple galvanique avec des alliages d'acier et d'aluminium afin de développer des mécanismes anti-corrosion en vue de leur utilisation industrielle. Natural Sciences and Engineering Research Council (Ottawa, Canada). 21 000 $. (2013-2014).
  Numéro de subvention : 444259-2013. Voir plus
• Subvention. Études par SECM d'alliages de magnésium/acier et de magnésium/aluminium afin de développer des mécanismes anti-corrosion en vue de leur utilisation industrielle. Natural Sciences and Engineering Research Council (Ottawa, Canada). 17 500 $. (2011-2012).
  Numéro de subvention : grant.2870412. Voir plus
• Subvention. Études par SECM d’alliages de magnésium/acier et de magnésium/aluminium afin de développer des mécanismes anti-corrosion en vue de leur utilisation industrielle. Fonds de Recherche du Québec – Nature et Technologies (Montreal, Canada). 15 334 $. (2011-2014).
  Numéro de subvention : 145647. Voir plus
• Subvention. Photocatalytic hydrogen production. Natural Sciences and Engineering Research Council (Ottawa, Canada). 4 500 $. (2010-2011).
  Numéro de subvention : grant.2849104. Voir plus
• Subvention. New complexes for molecular switching. Natural Sciences and Engineering Research Council (Ottawa, Canada). 4 500 $. (2009-2010).
  Numéro de subvention : grant.2860300. Voir plus

Publications

Articles

• Naïla Corcoran, Philippe Dauphin-Ducharme. (2026). Impedimetric Interrogation to Reduce the Degradation of Electrochemical Aptamer-Based Biosensors. Journal of The Electrochemical Society. DOI
• Minh‐Dat Nguyen, Samin Tavakoli, Sofia Mittelstedt, Philip E. Johnson, Philippe Dauphin‐Ducharme. (2026). Solution‐Based Biophysical Methods for Guiding Design of Aptamers into Electrochemical Biosensors. Analysis & Sensing. DOI
• Philippe Dauphin-Ducharme, Essam M. Dief, Naïla Corcoran, J. Justin Gooding. (2025). Reading the Pulse of Electrochemical Aptamer-Based Biosensors: Implications of Different Interrogation Methods. ACS Electrochemistry. DOI
• Lisa Deflandre, Philippe Dauphin-Ducharme. (2025). Role of Electrode Microstructuration in Electrochemical Aptamer-Based Biosensors for Localized Measurements. Langmuir. DOI
• Andrii Byrka, Léo Boivin, Élodie V. d’Astous, Rahul Singhal, Paul-Ludovic Karsenti, Philippe Dauphin-Ducharme, Bernhard Witulski, Ganesh D. Sharma, Pierre D. Harvey. (2025). Simple A-D2-A Nonfullerene Acceptors for Efficient Binary Bulk Heterojunction Organic Solar Cells. ACS Applied Materials & Interfaces. DOI
• Byoung-jin Jeon, Matteo M. Guareschi, Jaimie Marie Stewart, Emily Wu, Ashwin Gopinath, Netzahualcóyotl Arroyo-Currás, Philippe Dauphin-Ducharme, Kevin W. Plaxco, Philip S. Lukeman, Paul W. K. Rothemund. (2025). Modular DNA origami–based electrochemical detection of DNA and proteins. Proceedings of the National Academy of Sciences. DOI
• Nicolas Fontaine, Arielle Dauphin, Miriam Gaida, Rosalie Simard, Philippe Dauphin-Ducharme. (2025). Electrochemical and plasmonic detection methods yield comparable analytical performance for DNA hybridization. The Analyst. DOI
• Minh-Dat Nguyen, Guy Terence Prevot, Nicolas Fontaine, Philippe Dauphin-Ducharme. (2024). Corrigendum: Whole Blood Theophylline Measurements Using an Electrochemical DNA Aptamer-based Biosensor [ECS Sens. Plus, 3, 030601 (2024)]. ECS Sensors Plus. DOI
• Yunus A. Kaiyum, Emily Hoi Pui Chao, Lakshmi Dhar, Aron A. Shoara, Minh‐Dat Nguyen, Cameron D. Mackereth, Philippe Dauphin‐Ducharme, Philip E. Johnson. (2024). Ligand‐Induced Folding in a Dopamine‐Binding DNA Aptamer. ChemBioChem. DOI
• Minh-Dat Nguyen, Meghan T. Osborne, Guy Terence Prevot, Zachary R. Churcher, Philip E. Johnson, Lena Simine, Philippe Dauphin-Ducharme. (2024). Truncations and in silico docking to enhance the analytical response of aptamer-based biosensors. Biosensors and Bioelectronics. DOI
• Lisa Deflandre, Philippe Dauphin-Ducharme. (2024). “Binding” or “Binding and Switching”? A Perspective on Resolving Conformational Changes of Surface-Attached Biomolecular Receptors. ACS Sensors. DOI
• Minh-Dat Nguyen, Guy Terence Prevot, Nicolas Fontaine, Philippe Dauphin-Ducharme. (2024). Whole Blood Theophylline Measurements Using an Electrochemical DNA Aptamer-based Biosensor. ECS Sensors Plus. DOI
• Léo Boivin, Élodie V. d’Astous, Adrien Schlachter, Daniel Fortin, Paul-Ludovic Karsenti, Christophe Lescop, Philippe Dauphin-Ducharme, Pierre D. Harvey. (2024). From a simple push–pull dye to a broad-band absorbing and photoconducting material by assembly with CuBr. Journal of Materials Chemistry C. DOI
• Sophie R. Eisen, Philippe Dauphin-Ducharme, Philip E. Johnson. (2024). Solution-based biophysical characterization of conformation change in structure-switching aptamers. Quarterly Reviews of Biophysics. DOI
• Élodie V. d’Astous, Philippe Dauphin-Ducharme. (2024). Whole blood multiplex measurements using electrochemical aptamer-based biosensors. Chemical Communications. DOI
• Minh-Dat Nguyen, Khoa-Nam Nguyen, Samuel Malo, Indrani Banerjee, Donghui Wu, Laurence Du-Thumm, Philippe Dauphin-Ducharme. (2023). Electrochemical Aptamer-Based Biosensors for Measurements in Undiluted Human Saliva. ACS Sensors. DOI
• Nicolas Fontaine, Philippe Dauphin-Ducharme. (2023). Confounding effects on the response of electrochemical aptamer-based biosensors. Current Opinion in Electrochemistry. DOI
• Philippe Dauphin‐Ducharme, Zachary R. Churcher, Aron A. Shoara, Erfan Rahbarimehr, Sladjana Slavkovic, Nicolas Fontaine, Olivia Boisvert, Philip E. Johnson. (2023). Redox Reporter ‐ Ligand Competition to Support Signaling in the Cocaine‐Binding Electrochemical Aptamer‐Based Biosensor. Chemistry – A European Journal. DOI
• Julian Gerson, Murat Kaan Erdal, Matthew H. McDonough, Kyle L. Ploense, Philippe Dauphin-Ducharme, Kevin M. Honeywell, Kaylyn K. Leung, Netzahualcoyotl Arroyo-Curras, Jenny M. Gibson, Nicole A. Emmons, Wendy Meiring, Joao P. Hespanha, Kevin W. Plaxco, Tod E. Kippin. (2023). High-precision monitoring of and feedback control over drug concentrations in the brains of freely moving rats. Science Advances. DOI
• Erfan Rahbarimehr, Hoi Pui Chao, Zachary R. Churcher, Sladjana Slavkovic, Yunus A. Kaiyum, Philip E. Johnson, Philippe Dauphin-Ducharme. (2023). Finding the Lost Dissociation Constant of Electrochemical Aptamer-Based Biosensors. Analytical Chemistry. DOI
• Élodie V. d’Astous, Philippe Dauphin-Ducharme. (2022). Harnessing host–guest chemistry for electrochemical sensing in complex matrices. Current Opinion in Electrochemistry. DOI
• Jean Lessard, Philippe Dauphin-Ducharme, Janine Mauzeroll. (2020). Preface—JES Focus Issue on Organic and Inorganic Molecular Electrochemistry. Journal of The Electrochemical Society. DOI
• Alex M. Downs, Julian Gerson, Kyle L. Ploense, Kevin W. Plaxco, Philippe Dauphin-Ducharme. (2020). Subsecond-Resolved Molecular Measurements Using Electrochemical Phase Interrogation of Aptamer-Based Sensors. Analytical Chemistry. DOI
• Philippe Dauphin Ducharme. (2020). In Brain and in Vein Detection of Antibiotics Using Electrochemical-DNA Biosensors. ECS Meeting Abstracts. DOI
• Netzahualcoyotl Arroyo-Currás, Philippe Dauphin-Ducharme, Karen Scida, Jorge L. Chávez. (2020). From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors. Analytical Methods. DOI
• Philippe Dauphin-Ducharme, Kyungae Yang, Netzahualcóyotl Arroyo-Currás, Kyle L. Ploense, Yameng Zhang, Julian Gerson, Martin Kurnik, Tod E. Kippin, Milan N. Stojanovic, Kevin W. Plaxco. (2019). Electrochemical Aptamer-Based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-Controlled Drug Delivery. ACS Sensors. DOI
• Philippe Dauphin-Ducharme, Netzahualcóyotl Arroyo-Currás, Kevin W. Plaxco. (2019). Correction to “High-Precision Electrochemical Measurements of the Guanine-, Mismatch-, and Length-Dependence of Electron Transfer from Electrode-Bound DNA Are Consistent with a Contact-Mediated Mechanism”. Journal of the American Chemical Society. DOI
• Gabriel Ortega, Martin Kurnik, Philippe Dauphin‐Ducharme, Hui Li, Netzahualcóyotl Arroyo‐Currás, Amanda Caceres, Kevin W. Plaxco. (2019). Surface Attachment Enhances the Thermodynamic Stability of Protein L. Angewandte Chemie International Edition. DOI
• Gabriel Ortega, Martin Kurnik, Philippe Dauphin‐Ducharme, Hui Li, Netzahualcóyotl Arroyo‐Currás, Amanda Caceres, Kevin W. Plaxco. (2019). Surface Attachment Enhances the Thermodynamic Stability of Protein L. Angewandte Chemie. DOI
• Philippe Dauphin-Ducharme, Netzahualcóyotl Arroyo-Currás, Kevin W. Plaxco. (2019). High-Precision Electrochemical Measurements of the Guanine-, Mismatch-, and Length-Dependence of Electron Transfer from Electrode-Bound DNA Are Consistent with a Contact-Mediated Mechanism. Journal of the American Chemical Society. DOI
• Philippe Dauphin-Ducharme, Netzahualcóyotl Arroyo-Currás, Ramesh Adhikari, Jacob Somerson, Gabriel Ortega, Dmitrii E. Makarov, Kevin W. Plaxco. (2018). Chain Dynamics Limit Electron Transfer from Electrode-Bound, Single-Stranded Oligonucleotides. The Journal of Physical Chemistry C. DOI
• Martin Kurnik, Gabriel Ortega, Philippe Dauphin-Ducharme, Hui Li, Amanda Caceres, Kevin W. Plaxco. (2018). Quantitative measurements of protein−surface interaction thermodynamics. Proceedings of the National Academy of Sciences. DOI
• Netzahualcóyotl Arroyo-Currás, Philippe Dauphin-Ducharme, Gabriel Ortega, Kyle L. Ploense, Tod E. Kippin, Kevin W. Plaxco. (2018). Subsecond-Resolved Molecular Measurements in the Living Body Using Chronoamperometrically Interrogated Aptamer-Based Sensors. ACS Sensors. DOI
• Hui Li, Philippe Dauphin-Ducharme, Gabriel Ortega, Kevin W. Plaxco. (2017). Calibration-Free Electrochemical Biosensors Supporting Accurate Molecular Measurements Directly in Undiluted Whole Blood. Journal of the American Chemical Society. DOI
• Philippe Dauphin-Ducharme, Netzahualcóyotl Arroyo-Currás, Martin Kurnik, Gabriel Ortega, Hui Li, Kevin W. Plaxco. (2017). Simulation-Based Approach to Determining Electron Transfer Rates Using Square-Wave Voltammetry. Langmuir. DOI
• Li, H., Dauphin-Ducharme, P., Arroyo-Currás, N., Tran, C.H., Vieira, P.A., Li, S., Shin, C., Somerson, J., Kippin, T.E., Plaxco, K.W. (2017). A Biomimetic Phosphatidylcholine-Terminated Monolayer Greatly Improves the In Vivo Performance of Electrochemical Aptamer-Based Sensors. Angewandte Chemie - International Edition. DOI
• Polcari, D., Dauphin-Ducharme, P., Mauzeroll, J. (2016). Scanning Electrochemical Microscopy: A Comprehensive Review of Experimental Parameters from 1989 to 2015. Chemical Reviews. DOI
• Dauphin-Ducharme, P., Kuss, C., Rossouw, D., Payne, N.A., Danis, L., Botton, G.A., Mauzeroll, J. (2015). Corrosion product formation monitored using the feedback mode of scanning electrochemical microscopy with carbon microelectrodes. Journal of the Electrochemical Society. DOI
• Dauphin-Ducharme, P., Binns, W.J., Snowden, M.E., Shoesmith, D.W., Mauzeroll, J. (2015). Determination of the local corrosion rate of magnesium alloys using a shear force mounted scanning microcapillary method. Faraday Discussions. DOI
• Dauphin-Ducharme, P., Asmussen, R.M., Shoesmith, D.W., Mauzeroll, J. (2015). In-situ Mg²⁺ release monitored during magnesium alloy corrosion. Journal of Electroanalytical Chemistry. DOI
• Tefashe, U.M., Dauphin-Ducharme, P., Danaie, M., Cano, Z.P., Kish, J.R., Botton, G.A., Mauzeroll, J. (2015). Localized corrosion behavior of AZ31B magnesium alloy with an electrodeposited poly (3,4-Ethylenedioxythiophene) Coating. Journal of the Electrochemical Society. DOI
• Dauphin-Ducharme, P., Rosati, F., Greschner, A., De Bruijn, A.D., Salvatore, D., Toader, V., Lau, K.L., Mauzeroll, J., Sleiman, H. (2015). Modulation of charge transport across double-stranded DNA by the site-specific incorporation of copper bis-phenanthroline complexes. Langmuir. DOI
• Asmussen, R.M., Binns, W.J., Jakupi, P., Dauphin-Ducharme, P., Tefashe, U.M., Mauzeroll, J., Shoesmith, D. (2015). Reducing the corrosion rate of magnesium alloys using ethylene glycol for advanced electrochemical imaging. Corrosion Science. DOI
• Dauphin-Ducharme, P., Mauzeroll, J. (2015). Surface Analytical Methods Applied to Magnesium Corrosion. Analytical Chemistry. DOI
• Pal, A.K., Ducharme, P.D., Hanan, G.S. (2014). Enhanced stereoselectivity in a di-Ru(II) complex of an achiral bis-bidentate ligand. Chemical Communications. DOI
• Cottenye, N., Carbajal, G., Cui, Z.-K., Ducharme, P.D., Mauzeroll, J., Lafleur, M. (2014). Formation, stability, and pH sensitivity of free-floating, giant unilamellar vesicles using palmitic acid-cholesterol mixtures. Soft Matter. DOI
• Tefashe, U.M., Snowden, M.E., Ducharme, P.D., Danaie, M., Botton, G.A., Mauzeroll, J. (2014). Local flux of hydrogen from magnesium alloy corrosion investigated by scanning electrochemical microscopy. Journal of Electroanalytical Chemistry. DOI
• Dauphin-Ducharme, P., Asmussen, R.M., Tefashe, U.M., Danaie, M., Binns, W.J., Jakupi, P., Botton, G.A., Shoesmith, D.W., Mauzeroll, J. (2014). Local hydrogen fluxes correlated to microstructural features of a corroding sand cast AM50 magnesium alloy. Journal of the Electrochemical Society. DOI
• Ducharme, P.D. (2013). Assessment of magnesium alloy corrosion using potentiometric mode of scanning electrochemical microscopy. Electrochemical Society Interface.
• Trinh, D., Dauphin Ducharme, P., Mengesha Tefashe, U., Kish, J.R., Mauzeroll, J. (2012). Influence of edge effects on local corrosion rate of magnesium alloy/mild steel galvanic couple. Analytical Chemistry. DOI
• Nag, S., Ferreira, J.G., Chenneberg, L., Ducharme, P.D., Hanan, G.S., La Ganga, G., Serroni, S., Campagna, S. (2011). Changing the role of 2,2′-bipyridine from secondary ligand to protagonist in [Ru(bpy)<inf>2</inf>(N-N)]²⁺ complexes: Low-energy, red emission from a ruthenium(II)-to-2,2′-bipyridine ³MLCT state. Inorganic Chemistry. DOI

Autres contributions

Cours enseignés à l'UdeS

• CAN505 - Électrochimie analytique et physique. (2025-2026). (3CR).
• CAN728 - Techniques électrochimiques de caractérisation. (2023, 2025-2026). (3CR).
• BCM300 - Biochimie. (2023-2024). (3CR).
• CAN305 - Méthodes quantitatives de la chimie - Travaux pratiques. (2023). (2CR).