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Épisode 38 : Étude FIDELIO-DKD

Finérénone chez les sujets avec diabète type 2, albuminurie et insuffisance rénale chronique (étude FIDELIO-DKD)

Diffusé le 21 décembre 2020

Dans cette 38e baladodiffusion, le Dr Luc Lanthier discute de l’efficacité de la finérénone dans le traitement des sujets avec diabète type 2, albuminurie et insuffisance rénale chronique, en plus de réviser la littérature médicale d’octobre et novembre 2020.

Quiz clinique (4 min 21), article principal (4 min 44), critique (24 min 31), autres articles (29 min 32), réponse au quiz clinique (34 min 33)

Référence principale

Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, et al. Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes. N Engl J Med. 2020;383(23):2219-29. PubMed PMID: 33264825.


Article résumé

Lanthier L, Plourde MÉ, Cauchon M. Chez les sujets avec diabète type 2, insuffisance rénale chronique et albuminurie, est-ce que la finérénone, un antagoniste sélectif des récepteurs minéralocorticoïdes, est efficace et sécuritaire afin de ralentir la progression de l’IRC ? Rev Med Interne. 2021;42(2):144-145. PubMed PMID: 33455835.

Articles associés

Ingelfinger JR, Rosen CJ. Finerenone - Halting Relative Hyperaldosteronism in Chronic Kidney Disease. N Engl J Med. 2020;383(23):2285-2286. PubMed PMID: 33095527.

Filippatos G, Anker SD, Agarwal R, Pitt B, Ruilope LM, Rossing P, Kolkhof P, Schloemer P, Tornus I, Joseph A, Bakris GL; FIDELIO-DKD Investigators. Finerenone and Cardiovascular Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes. Circulation. 2020 Nov 16. doi: 10.1161/CIRCULATIONAHA.120.051898. PubMed PMID: 33198491.

Ruilope LM, Agarwal R, Anker SD, Bakris GL, Filippatos G, Nowack C, Kolkhof P, Joseph A, Mentenich N, Pitt B; FIGARO-DKD study investigators. Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial. Am J Nephrol. 2019;50(5):345-356. PubMed PMID: 31665733.

Horwitz LI, Jones SA, Cerfolio RJ, Francois F, Greco J, Rudy B, et al. Trends in COVID-19 Risk-Adjusted Mortality Rates. J Hosp Med. 2020. PubMed PMID: 33147129.

Group RC, Horby P, Mafham M, Linsell L, Bell JL, Staplin N, et al. Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med. 2020;383(21):2030-40. PubMed PMID: 33031652.

Horby PW, Mafham M, Bell JL, Linsell L, Staplin N, Emberson J, et al. Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2020;396(10259):1345-52. PubMed PMID: 33031764.

Consortium WHOST, Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, et al. Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results. N Engl J Med. 2020. PubMed PMID: 33264556.

Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, Foulkes AS, et al. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. N Engl J Med. 2020;383(24):2333-44. PubMed PMID: 33085857.

Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020 Dec 10. doi: 10.1056/NEJMoa2034577. PubMed PMID: 33301246.

Rubin EJ, Longo DL. SARS-CoV-2 Vaccination - An Ounce (Actually, Much Less) of Prevention. N Engl J Med. 2020 Dec 10. doi: 10.1056/NEJMe2034717. Epub ahead of print. PubMed PMID: 33301245.

Bouabdallaoui N, Tardif JC, Waters DD, Pinto FJ, Maggioni AP, Diaz R, et al. Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT). Eur Heart J. 2020;41(42):4092-9. PubMed PMID: 32860034.

Samuel M, Tardif JC, Khairy P, Roubille F, Waters DD, Gregoire JC, et al. Cost-Effectiveness of Low-Dose Colchicine after Myocardial Infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT). Eur Heart J Qual Care Clin Outcomes. 2020. PubMed PMID: 32407460.

Roubille F, Tardif JC. Colchicine for Secondary Cardiovascular Prevention in Coronary Disease. Circulation. 2020;142(20):1901-4. PubMed PMID: 33196312.

Samuel M, Waters DD. Will Colchicine Soon Be Part of Primary and Secondary Cardiovascular Prevention? Can J Cardiol. 2020;36(11):1697-9. PubMed PMID: 32585327.

Lopes RD, Alexander KP, Stevens SR, Reynolds HR, Stone GW, Pina IL, et al. Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial. Circulation. 2020;142(18):1725-35. PubMed PMID: 32862662.

Li N, Zhao G, Wu W, Zhang M, Liu W, Chen Q, et al. The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(11):e2023644. PubMed PMID: 33136134.

Autres articles d'intérêt récents

Carlsson LMS, Sjoholm K, Jacobson P, Andersson-Assarsson JC, Svensson PA, Taube M, et al. Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study. N Engl J Med. 2020;383(16):1535-43. PubMed PMID: 33053284.

Richards T, Baikady RR, Clevenger B, Butcher A, Abeysiri S, Chau M, et al. Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial. Lancet. 2020;396(10259):1353-61. PubMed PMID: 32896294.

Okumura K, Akao M, Yoshida T, Kawata M, Okazaki O, Akashi S, Eshima K, Tanizawa K, Fukuzawa M, Hayashi T, Akishita M, Lip GYH, Yamashita T; ELDERCARE-AF Committees and Investigators. Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. N Engl J Med. 2020;383(18):1735-1745. PubMed PMID: 32865374.

Lamb SE, Bruce J, Hossain A, Ji C, Longo R, Lall R, et al. Screening and Intervention to Prevent Falls and Fractures in Older People. N Engl J Med. 2020;383(19):1848-59. PubMed PMID: 33211928.

Gencer B, Marston NA, Im K, Cannon CP, Sever P, Keech A, et al. Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials. Lancet. 2020;396(10263):1637-43. PubMed PMID: 33186535.

Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort. Lancet. 2020;396(10263):1644-52. PubMed PMID: 33186534.

Guimaraes HP, Lopes RD, de Barros ESPGM, Liporace IL, Sampaio RO, Tarasoutchi F, et al. Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve. N Engl J Med. 2020;383(22):2117-26. PubMed PMID: 33196155.

Guide de pratique récents

Diabetes Canada Clinical Practice Guidelines Expert C, Lipscombe L, Butalia S, Dasgupta K, Eurich DT, MacCallum L, et al. Pharmacologic Glycemic Management of Type 2 Diabetes in Adults: 2020 Update. Can J Diabetes. 2020;44(7):575-91. PubMed PMID: 32972640.

Diabetes Canada Clinical Practice Guidelines Steering C, Senior PA, Houlden RL, Kim J, Mackay D, Nagpal S, et al. Pharmacologic Glycemic Management of Type 2 Diabetes in Adults: 2020 Update - The User's Guide. Can J Diabetes. 2020;44(7):592-6. PubMed PMID: 32972641.

de Boer IH, Caramori ML, Chan JCN, Heerspink HJL, Hurst C, Khunti K, et al. Executive summary of the 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment. Kidney Int. 2020;98(4):839-48. PubMed PMID: 32653403.

Kidney Disease: Improving Global Outcomes Diabetes Work G. KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2020;98(4S):S1-S115. PubMed PMID: 32998798.

Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood Adv. 2020;4(19):4693-738. PubMed PMID: 33007077.

Saag MS, Gandhi RT, Hoy JF, Landovitz RJ, Thompson MA, Sax PE, et al. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2020;324(16):1651-69. PubMed PMID: 33052386.

Jacobs SS, Krishnan JA, Lederer DJ, Ghazipura M, Hossain T, Tan AM, et al. Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020;202(10):e121-e41. PubMed PMID: 33185464.

Shoesmith C, Abrahao A, Benstead T, Chum M, Dupre N, Izenberg A, et al. Canadian best practice recommendations for the management of amyotrophic lateral sclerosis. CMAJ. 2020;192(46):E1453-E68. PubMed PMID: 33199452.

Référence du quiz clinique

The Curious Clinicians – A Medical Podcast that asks Why?

Atkinson S, Fox SB. Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing. J Pathol. 2004 Jun;203(2):721-8. PubMed PMID: 15141388.